J Pharm Biomed Anal 2021 May 7;201:114126. Epub 2021 May 7.
Department of Analytical Chemistry, Medical University of Lodz, Łódź, ul. Muszyńskiego 1, 90-151, Poland. Electronic address:
RP-18 TLC chromatography was used to evaluate the pharmacokinetic properties (volume of distribution, V; plasma protein binding, %PPB; the ability to cross the blood-brain barrier expressed as log PS and log BB) of several cosmetic raw materials - sunscreen and preservatives. The majority of these compounds are intended for topical use on skin and their drug-likeness and the ability to cross biological barriers are undesired. The retention parameters R, S, PC and R obtained for mobile phases containing six organic modifiers (methanol, acetonitrile, THF, acetone, dioxane, DMF) were used as the sole descriptors or combined with calculated physicochemical properties (PSA, M, V) of studied compounds. Read More