8,677,352 results match your criteria intervention

Non-steroidal anti-inflammatory drugs (NSAIDs) for trigger finger.

Cochrane Database Syst Rev 2021 Apr 14;4:CD012789. Epub 2021 Apr 14.

Cochrane Singapore, Singapore, Singapore.

Background: Trigger finger is a common hand condition that occurs when movement of a finger flexor tendon through the first annular (A1) pulley is impaired by degeneration, inflammation, and swelling. This causes pain and restricted movement of the affected finger. Non-surgical treatment options include activity modification, oral and topical non-steroidal anti-inflammatory drugs (NSAIDs), splinting, and local injections with anti-inflammatory drugs. Read More

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Feeding friend and foe: ample pollen mitigates the effects of pollen theft for a gynodioecious plant, Polemonium foliosissimum (Polemoniaceae).

Ann Bot 2021 Apr 13. Epub 2021 Apr 13.

Rocky Mountain Biological Laboratory, Crested Butte, CO USA.

Background And Aims: Most angiosperms rely on pollinators to transport pollen and effect fertilization. While some floral visitors are effective pollinators, others act as thieves-consuming pollen but effecting little pollination in return. The importance of pollen theft to male and female reproductive success has received little attention. Read More

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Characteristic chemical probing patterns of loop motifs improve prediction accuracy of RNA secondary structures.

Jingyi Cao Yi Xue

Nucleic Acids Res 2021 Apr 13. Epub 2021 Apr 13.

School of Life Sciences, Tsinghua-Peking Joint Center for Life Sciences, Beijing Advanced Innovation Center for Structural Biology, Tsinghua University, Beijing 100084, China.

RNA structures play a fundamental role in nearly every aspect of cellular physiology and pathology. Gaining insights into the functions of RNA molecules requires accurate predictions of RNA secondary structures. However, the existing thermodynamic folding models remain less accurate than desired, even when chemical probing data, such as selective 2'-hydroxyl acylation analyzed by primer extension (SHAPE) reactivities, are used as restraints. Read More

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Bimodal regulation of the PRC2 complex by USP7 underlies tumorigenesis.

Nucleic Acids Res 2021 Apr 13. Epub 2021 Apr 13.

Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China.

Although overexpression of EZH2, a catalytic subunit of the polycomb repressive complex 2 (PRC2), is an eminent feature of various cancers, the regulation of its abundance and function remains insufficiently understood. We report here that the PRC2 complex is physically associated with ubiquitin-specific protease USP7 in cancer cells where USP7 acts to deubiquitinate and stabilize EZH2. Interestingly, we found that USP7-catalyzed H2BK120ub1 deubiquitination is a prerequisite for chromatin loading of PRC2 thus H3K27 trimethylation, and this process is not affected by H2AK119 ubiquitination catalyzed by PRC1. Read More

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Extra-thoracic rupture of giant subclavian artery aneurysm.

Eur J Cardiothorac Surg 2021 Apr;59(3):714-716

Department of General Surgery, Post Graduate Institute of Medical Education and Research, Chandigarh, Chandigarh, India.

Subclavian artery aneurysms are rare, but they are frequently responsible for limb or life-threatening complications. The clinical presentation, as supraclavicular mass to rupture, has been reported in literature, with management strategies being endovascular intervention to open conventional surgery. We report a case of giant subclavian artery aneurysm measuring 10 cm × 12 cm, which presented with a large anterior chest wall lump and massive bleed to our emergency department. Read More

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Risk factors for non-cancer death after surgery in patients with stage I non-small-cell lung cancer.

Eur J Cardiothorac Surg 2021 Apr;59(3):633-640

Department of General Thoracic Surgery, Osaka University Graduate School of Medicine, Suita, Japan.

Objectives: With improvements in the outcome of treatment for non-small-cell lung cancer (NSCLC), other diseases may account for a high death rate after surgery in patients with stage I NSCLC. In the present study, we analysed the associations between the clinical factors and non-cancer death after surgery in these patients.

Methods: The records of 514 patients with stage I NSCLC who underwent surgery were retrospectively reviewed; a proportional hazards model for the subdistribution of a competing risk was conducted to define the risk factors for non-cancer death. Read More

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Acute and short-term efficacy of sauna treatment on cardiovascular function: Ameta-analysis.

Eur J Cardiovasc Nurs 2021 Apr;20(2):96-105

Laboratory of Biomechanical Engineering, Department of Applied Mechanics, College of Architecture & Environment, Sichuan University, Chengdu, China.

Objective: The role of sauna bathing in cardiovascular function treatment has been increasingly explored, but insufficient attention has been paid to its efficacy. We performed a meta-analysis to provide more evidence for the efficacy of sauna treatment in cardiovascular nursing.

Methods: Sixteen peer-reviewed journal articles were screened to summarize the efficacy of the sauna on cardiovascular function. Read More

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Caregiver experiences of paediatric inpatient cardiac services: A qualitative systematic review.

Eur J Cardiovasc Nurs 2021 Apr;20(2):147-159

Newcastle Upon Tyne Hospitals NHS Foundation Trust, UK.

Background: Advances in paediatric care have contributed to an increasing survival of children with complex heart disease. Yet, life-saving management demands prolonged inpatient admissions, which contribute to emotional and psychological distress for parents and other caregivers in a role of main custody.

Aim: The purpose of this study was to identify, appraise and synthesise qualitative studies exploring caregivers' experiences of paediatric inpatient cardiac services, generating an understanding of their needs in hospital and informing priorities for change in healthcare delivery. Read More

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Early risk stratification of acute myocardial infarction using a simple physiological prognostic scoring system: insights from the REACP study.

Eur J Cardiovasc Nurs 2021 Apr;20(2):167-174

Department of Cardiology, West China Hospital, Sichuan University, China.

Background: A more accurate and simpler scoring systems for early risk stratification of acute myocardial infarction at admission can accelerate and improve decision-making.

Aim: To develop and validate a simple physiological prognostic scoring system for early risk stratification in patients with acute myocardial infarction.

Methods: Easily accessible physiological vital signs and demographic characteristics of patients with acute myocardial infarction at the time of presentation in the multicentre Retrospective Evaluation of Acute Chest Pain study were used to develop a multivariate logistic regression model predicting 12 and 24-month mortality. Read More

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Flash mob studies: a novel method to accelerate the research process.

Philip Moons

Eur J Cardiovasc Nurs 2021 Apr;20(2):175-178

KU Leuven Department of Public Health and Primary Care, KU Leuven, Kapucijnenvoer 35, Box 7001, B-3000, Leuven, Belgium.

Because the time between study conception and dissemination of findings generally takes long, efforts to reduce this lag are important. A solution to accelerate the research process can be found in flash mob research. This is a method to study clinically relevant questions on a large scale in a very short course of time. Read More

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Practice Patterns and Pain Outcomes for Targeted Muscle Reinnervation: An Informed Approach to Targeted Muscle Reinnervation Use in the Acute Amputation Setting.

J Bone Joint Surg Am 2021 Apr;103(8):681-687

USU-Walter Reed Department of Surgery, Walter Reed National Military Medical Center, Bethesda, Maryland.

Background: Targeted muscle reinnervation (TMR) and regenerative peripheral nerve interface (RPNI) procedures have been shown to improve patient-reported outcomes for the treatment of symptomatic neuromas after amputation; however, the specific indications and comparative outcomes of each are unclear. The primary research questions were what complement of nerves most frequently requires secondary pain intervention after conventional amputation, whether this information can guide the focused application of TMR and RPNI to the primary amputation setting, and how the outcomes compare in both settings.

Methods: We performed a retrospective review of records for patients who had undergone lower-extremity TMR and/or RPNI at our institution. Read More

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Prediction of Nonunion After Nonoperative Treatment of a Proximal Humeral Fracture.

J Bone Joint Surg Am 2021 Apr;103(8):668-680

The Edinburgh Shoulder Clinic, New Royal Infirmary of Edinburgh, Edinburgh, United Kingdom.

Background: The prevalence of nonunion after a proximal humeral fracture (PHF) and the risk factors for its occurrence are poorly defined. We aimed to estimate the rate of nonunion in nonoperatively treated patients and to produce a clinical model for its prediction.

Methods: Two thousand two hundred and thirty adult patients (median age, 72 years [range, 18 to 103 years]; 75. Read More

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Comparison of Revision Risk Based on Timing of Knee Arthroscopy Prior to Total Knee Arthroplasty.

J Bone Joint Surg Am 2021 Apr;103(8):660-667

Department of Orthopaedic Surgery, Washington University School of Medicine and Barnes-Jewish Hospital, St. Louis, Missouri.

Background: Knee arthroscopy may be performed prior to total knee arthroplasty (TKA) in patients with symptomatic degenerative knee changes that do not yet warrant TKA. The purpose of this study was to determine whether the time interval between knee arthroscopy and subsequent primary TKA is associated with increased rates of revision and certain complications following TKA.

Methods: Data from 2006 to 2017 were collected from a national insurance database. Read More

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Fast Automated Stereo-EEG Electrode Contact Identification and Labeling Ensemble.

Stereotact Funct Neurosurg 2021 Apr 13:1-12. Epub 2021 Apr 13.

Division of Neurology, Comprehensive Epilepsy Center, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.

Introduction: Stereotactic electroencephalography (SEEG) has emerged as the preferred modality for intracranial monitoring in drug-resistant epilepsy (DRE) patients being evaluated for neurosurgery. After implantation of SEEG electrodes, it is important to determine the neuroanatomic locations of electrode contacts (ECs), to localize ictal onset and propagation, and integrate functional information to facilitate surgical decisions. Although there are tools for coregistration of preoperative MRI and postoperative CT scans, identification, sorting, and labeling of SEEG ECs is often performed manually, which is resource intensive. Read More

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Concurrence of 1- and 3-Min Sit-to-Stand Tests with the 6-Min Walk Test in Idiopathic Pulmonary Fibrosis.

Respiration 2021 Apr 13:1-9. Epub 2021 Apr 13.

Department of Respiratory Medicine and Physiology, Pôle Thorax et Vaisseaux, Centre Hospitalier Universitaire Grenoble Alpes, Grenoble, France.

Background: In idiopathic pulmonary fibrosis (IPF), some physiological parameters measured during a 6-min walk test (6-MWT) impart reliable prognostic information. Sit-to-stand tests (STSTs) are field exercise tests that are easier to implement than the 6-MWT in daily practice.

Objectives: The aims of the study were to test the reproducibility and compare 2 STSTs (the 1-min STST [1-STST] and the semi-paced 3-min chair rise test [3-CRT]) in IPF, and to determine if selected physiological parameters (speed of displacement and changes in pulse oxygen saturation [SpO2]) are interchangeable between the STSTs and the 6-MWT. Read More

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The "Flying Intervention Team": A Novel Stroke Care Concept for Rural Areas.

Cerebrovasc Dis 2021 Apr 13:1-8. Epub 2021 Apr 13.

Department of Neurology, TEMPiS Telemedical Stroke Center, München Klinik Harlaching, Academic Teaching Hospital of the University of Munich, Munich, Germany.

Background: Endovascular treatment of large vessel occlusion in acute ischemic stroke patients is difficult to establish in remote areas, and time dependency of treatment effect increases the urge to develop health care concepts for this population.

Summary: Current strategies include direct transportation of patients to a comprehensive stroke center (CSC) ("mothership model") or transportation to the nearest primary stroke center (PSC) and secondary transfer to the CSC ("drip-and-ship model"). Both have disadvantages. Read More

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Hypercapnia in COPD Patients Undergoing Endobronchial Ultrasound under Local Anaesthesia and Analgosedation: A Prospective Controlled Study Using Continuous Transcutaneous Capnometry.

Respiration 2021 Apr 13:1-11. Epub 2021 Apr 13.

Department of Thoracic Surgery, Faculty of Health, University Witten/Herdecke, Witten, Germany.

Background: Flexible bronchoscopy (FB) in analgosedation causes alveolar hypoventilation and hypercapnia, the more so if patients suffer from COPD. Nonetheless, neither is capnometry part of standard monitoring nor is there evidence on how long patients should be monitored after sedation.

Objectives: We investigated the impact of COPD on hypercapnia during FB with endobronchial ultrasound (EBUS) in sedation and how the periprocedural monitoring should be adapted. Read More

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Variable Learning Curve of Basic Rigid Bronchoscopy in Trainees.

Respiration 2021 Apr 13:1-8. Epub 2021 Apr 13.

Beckman Laser Institute, Division of Pulmonary and Critical Care Medicine, University of California Irvine, Irvine, California, USA.

Background: Despite increased use of rigid bronchoscopy (RB) for therapeutic indications and recommendations from professional societies to use performance-based competency, an assessment tool has not been utilized to measure the competency of trainees to perform RB in clinical settings.

Objectives: The aim of the study was to evaluate a previously developed assessment tool - Rigid Bronchoscopy Tool for Assessment of Skills and Competence (RIGID-TASC) - for determining the RB learning curve of interventional pulmonary (IP) trainees in the clinical setting and explore the variability of learning curve of trainees.

Methods: IP fellows at 4 institutions were enrolled. Read More

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Safety and Efficacy of Trans-Perineal Urethroplasty for Management of Post-Traumatic Urethral Strictures in Pediatric Age-Group.

Urol Int 2021 Apr 13:1-5. Epub 2021 Apr 13.

Department of Urology, TNMC & BYL Nair Hospital, Mumbai, India.

Introduction: Trans-perineal urethroplasty is the preferred treatment for distraction urethral injuries in adults. However, management of such injuries in children is challenging because of functional implications in a growing child. In the present study, we aim to evaluate the safety and efficacy of perineal urethroplasty for distraction urethral injuries in children. Read More

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Age-Stratified Outcome in Treatment of Left Main Coronary Artery Stenosis: A NOBLE Trial Substudy.

Cardiology 2021 Apr 13:1-10. Epub 2021 Apr 13.

Department of Cardiology, Aarhus University Hospital, Skejby, Aarhus, Denmark.

Background: In the treatment of left main coronary artery (LMCA) disease, patients' age may affect the clinical outcome after percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG). This study stratified the clinical outcome according to the age of patients treated for LMCA stenosis with PCI or CABG in the Nordic-Baltic-British Left Main Revascularization (NOBLE) study.

Methods: Patients with LMCA disease were enrolled in 36 centers in northern Europe and randomized 1:1 to treatment by PCI or CABG. Read More

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Real-World Experience with Artificial Intelligence-Based Triage in Transferred Large Vessel Occlusion Stroke Patients.

Cerebrovasc Dis 2021 Apr 13:1-6. Epub 2021 Apr 13.

Department of Neurosurgery, Icahn School of Medicine at Mount Sinai, New York, New York, New York, USA.

Background And Purpose: Randomized controlled trials have demonstrated the importance of time to endovascular therapy (EVT) in clinical outcomes in large vessel occlusion (LVO) acute ischemic stroke. Delays to treatment are particularly prevalent when patients require a transfer from hospitals without EVT capability onsite. A computer-aided triage system, Viz LVO, has the potential to streamline workflows. Read More

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Curcumin Reduces Neuroinflammation and Improves the Impairments of Anesthetics on Learning and Memory by Regulating the Expression of miR-181a-5p.

Neuroimmunomodulation 2021 Apr 13:1-9. Epub 2021 Apr 13.

Department of Anesthesiology, Laiyang Central Hospital, Yantai City, China.

Objective: The purpose of this study was to explore the role of curcumin (Cur) in isoflurane (ISO)-induced learning and memory dysfunction in Sprague-Dawley rats and further elucidate the mechanism of the protective effect produced by Cur.

Methods: Rat models of cognitive impairment were established by inhaling 3% ISO. The Morris water maze test was used to assess the cognitive function of rats. Read More

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Comparison of Follow-Up Length-Matched Single-Center Myelomeningocele Postnatal Closure Cohort to the Management of Myelomeningocele Study (MOMS) Trial Results.

Pediatr Neurosurg 2021 Apr 13:1-10. Epub 2021 Apr 13.

Department of Neurosurgery, Children's Hospital of Pittsburgh University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.

Objective: We sought to compare our large single-institution cohort of postnatal myelomeningocele closure to the 2 arms of the Management of Myelomeningocele Study (MOMS) trial at the designated trial time points, as well as assess outcomes at long-term follow-up among our postnatal cohort.

Methods: A single-institutional retrospective review of myelomeningocele cases presenting from 1995 to 2015 at Children's Hospital of Pittsburgh was performed. We compared outcomes at 12 and 30 months to both arms of the MOMS trial and compared our cohort's outcomes at those designated time points to our long-term outcomes. Read More

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Trimetazidine Protects from Mercury-Induced Kidney Injury.

Pharmacology 2021 Apr 13:1-9. Epub 2021 Apr 13.

Pharmacology, Faculty of Biochemical and Pharmaceutical Sciences. National University of Rosario, CONICET, Rosario, Argentina.

Introduction: The presence of mercury in the environment is a worldwide concern. Inorganic mercury is present in industrial materials, is employed in medical devices, is widely used in batteries, is a component of fluorescent light bulbs, and it has been associated with human poisoning in gold mining areas. The nephrotoxicity induced by inorganic mercury is a relevant health problem mainly in developing countries. Read More

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Machine Learning Algorithms for Predicting Fatty Liver Disease.

Ann Nutr Metab 2021 Apr 13:1-8. Epub 2021 Apr 13.

Department of Geriatrics, The First People's Hospital of Xiangtan City, Xiangtan, China.

Background: Fatty liver disease (FLD) has become a rampant condition. It is associated with a high rate of morbidity and mortality in a population. The condition is commonly referred as FLD. Read More

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Residual Hearing Affects Contralateral Routing of Signals in Cochlear Implant Users.

Audiol Neurootol 2021 Apr 13:1-8. Epub 2021 Apr 13.

Department of Otorhinolaryngology, Leiden University Medical Center, Leiden, The Netherlands.

Introduction: Contralateral routing of signals (CROS) can be used to eliminate the head shadow effect. In unilateral cochlear implant (CI) users, CROS can be achieved with placement of a microphone on the contralateral ear, with the signal streamed to the CI ear. CROS was originally developed for unilateral CI users without any residual hearing in the nonimplanted ear. Read More

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Development of a Checklist Tool to Assess the Quality of Skin Lesion Images Acquired by Consumers Using Sequential Mobile Teledermoscopy.

Dermatology 2021 Apr 13:1-8. Epub 2021 Apr 13.

Centre of Health Services Research, Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia.

Background: Mobile teledermoscopy is an emerging technology that involves imaging and digitally sending dermoscopic images of skin lesions to a clinician for assessment. High-quality, consistent images are required for accurate telediagnoses when monitoring lesions over time. To date there are no tools to assess the quality of sequential images taken by consumers using mobile teledermoscopy. Read More

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Current Status and Quality of Machine Learning-Based Radiomics Studies for Glioma Grading: A Systematic Review.

Oncology 2021 Apr 13:1-11. Epub 2021 Apr 13.

Department of Radiology, University of Alabama at Birmingham (UAB), Birmingham, Alabama, USA.

Introduction: Radiomics now has significant momentum in the era of precision medicine. Glioma is one of the pathologies that has been extensively evaluated by radiomics. However, this technique has not been incorporated into clinical practice. Read More

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