17,393 results match your criteria intervening processes

Age and Year of HIV Diagnosis are Associated with Perceptions of Discrimination and Internalized Stigma Among Sexual Minority Men Who Use Substances.

AIDS Behav 2021 Jun 12. Epub 2021 Jun 12.

Department of Psychiatry, Massachusetts General Hospital, Behavioral Medicine, One Bowdoin Square, 7th Floor, Boston, MA, 02114, USA.

Discrimination and internalized stigma are barriers to engagement in HIV self-care among men who have sex with men (MSM) living with HIV. However, differences in perceptions of discrimination and internalized stigmas by age, year of HIV-diagnosis, and race are poorly understood. We assessed differences in reported discrimination related to HIV, race, sexual orientation, and substance use and internalized stigmas among 202 MSM living with HIV who use substances. Read More

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A practical toolkit to support Australian mental health clinicians to manage Metabolic Syndrome: A pilot study.

Int J Ment Health Nurs 2021 Jun 12. Epub 2021 Jun 12.

School of Health & Human Sciences, Southern Cross University, Lismore, NSW, Australia.

Metabolic syndrome (MetS) results in poor physical health outcomes and reduced life expectancy of up to 20 years less for people living with severe mental illness. The aim of this pilot study was to evaluate a locally developed practical toolkit (Let's Get Physical-Improved Physical Health in Mental Health Services-A Practical Toolkit) to support mental health clinicians to manage MetS. The study explored clinician's knowledge and attitudes towards managing MetS, confidence to screen for and intervene in MetS, and improvement in documentation. Read More

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Phylogenomic Analysis Reveals Dispersal-Driven Speciation and Divergence with Gene Flow in Lesser Sunda Flying Lizards (Genus Draco).

Syst Biol 2021 Jun 12. Epub 2021 Jun 12.

Museum of Vertebrate Zoology and Department of Integrative Biology, University of California, Berkeley, CA 94720, USA.

The Lesser Sunda Archipelago offers exceptional potential as a model system for studying the dynamics of dispersal-driven diversification. The geographic proximity of the islands suggests the possibility for successful dispersal, but this is countered by the permanence of the marine barriers and extreme intervening currents that are expected to hinder gene flow. Phylogenetic and species delimitation analyses of flying lizards (genus Draco) using single mitochondrial genes, complete mitochondrial genomes, and exome-capture data sets identified 9-11 deeply divergent lineages including single-island endemics, lineages that span multiple islands, and parapatrically-distributed non-sister lineages on the larger islands. Read More

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Day versus night consolidation of implicit sequence learning using manual and oculomotor activation versions of the serial reaction time task: reaction time and anticipation measures.

Psychol Res 2021 Jun 11. Epub 2021 Jun 11.

Department of Psychology, Leslie and Susan Gonda (Goldschmied) Multidisciplinary Brain Research Center, Bar-Ilan University, 52900, Ramat-Gan, Israel.

This study presents two experiments that explored consolidation of implicit sequence learning based on two dependent variables-reaction time (RT) and correct anticipations to clarify the role of sleep, and whether the manual component is necessary for consolidation processes. Experiment 1 (n = 37) explored the performance of adults using an ocular variant of the serial reaction time task (O-SRT) with manual activation (MA), and Experiment 2 (n = 37) used the ocular activation (OA) version of the task. Each experiment consisted of a Day and a Night group that performed two sessions of the O-SRT with an intervening 12-h offline period (morning/evening in Day group, evening/following morning in Night group). Read More

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Competing Nodal d-Wave Superconductivity and Antiferromagnetism.

Phys Rev Lett 2021 May;126(21):217002

Department of Physics, University of California at San Diego, La Jolla, California 92093, USA.

Competing unconventional superconductivity and antiferromagnetism widely exist in several strongly correlated quantum materials whose direct simulation generally suffers from fermion sign problem. Here, we report unbiased quantum Monte Carlo (QMC) simulations on a sign-problem-free repulsive toy model with same on site symmetries as the standard Hubbard model on a 2D square lattice. Using QMC simulations, supplemented with mean-field and continuum field-theory arguments, we find that it hosts three distinct phases: a nodal d-wave phase, an antiferromagnet, and an intervening phase which hosts coexisting antiferromagnetism and nodeless d-wave superconductivity. Read More

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Soil arsenic but not rice arsenic increasing with arsenic in irrigation water in the Punjab plains of Pakistan.

Plant Soil 2020 May 24;450(1-2):601-611. Epub 2020 Apr 24.

Lamont Doherty Earth Observatory, Columbia University, Palisades, New York, USA.

Aim: Irrigating rice with groundwater can lead to As accumulation in soil and rice grains. Matched sets of irrigation water, paddy soil, and rice grains were collected to assess the scale of the problem in the Punjab plains of Pakistan.

Methods: From a total of 60 sites, irrigation water and rice grains as well as 103 soil samples were collected and analyzed in the laboratory. Read More

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Structural and functional characterization of a plant alpha-actinin.

FEBS Open Bio 2021 Jun 10. Epub 2021 Jun 10.

Departments of Chemistry, Umeå University, SE-901 87, Umeå, Sweden.

The Australian tree malletwood (Rhodamnia argentea) is unique. The genome of malletwood is the only known plant genome that contains a gene coding for an α-actinin-like protein. Several organisms predating the animal-plant bifurcation express an α-actinin or α-actinin-like protein. Read More

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Defining genome architecture at base-pair resolution.

Nature 2021 Jun 9. Epub 2021 Jun 9.

MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.

In higher eukaryotes, many genes are regulated by enhancers that are 10-10 base pairs (bp) away from the promoter. Enhancers contain transcription-factor-binding sites (which are typically around 7-22 bp), and physical contact between the promoters and enhancers is thought to be required to modulate gene expression. Although chromatin architecture has been mapped extensively at resolutions of 1 kilobase and above; it has not been possible to define physical contacts at the scale of the proteins that determine gene expression. Read More

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Personal barriers to addressing intimate partner abuse: a qualitative meta-synthesis of healthcare practitioners' experiences.

BMC Health Serv Res 2021 Jun 9;21(1):567. Epub 2021 Jun 9.

Department of General Practice, The University of Melbourne, Melbourne, Victoria, Australia.

Background: Healthcare practitioners (HCPs) play a crucial role in recognising, responding to, and supporting female patients experiencing intimate partner abuse (IPA). However, research consistently identifies barriers they perceive prevent them from doing this work effectively. These barriers can be system-based (e. Read More

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Lessons Learned: Developing an Online Training Program for Cultural Sensitivity in an Academic Psychiatry Department.

Psychiatr Serv 2021 Jun 9:appips202000015. Epub 2021 Jun 9.

Department of Psychiatry, Harvard Medical School, Boston (Trinh, Emmerich, Rubin, Wozniak); Depression Clinical and Research Program (Trinh, O'Hair, Dean), Primary Care Psychiatry (Emmerich), Division of Child and Adolescent Psychiatry (Rubin, Wozniak), Massachusetts General Hospital, Boston; Harvard Graduate School of Education, Cambridge, Massachusetts (Agrawal). Roberto Lewis-Fernández, M.D., is editor of this column.

This column describes the development and impact of an innovative three-part online cultural sensitivity training program for faculty and staff of an academic medical center's psychiatry department. The goal of the training was to equip faculty and staff with skills to address issues of diversity in their clinical practice. Three online modules were offered. Read More

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Recruiting patients to a digital self-management study whilst in hospital for a chronic obstructive pulmonary disease exacerbation: A feasibility analysis.

Digit Health 2021 Jan-Dec;7:20552076211020876. Epub 2021 May 27.

Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.

Background: Patients with chronic obstructive pulmonary disease (COPD) are often hospitalised with acute exacerbations (AECOPD) and many patients get readmitted. Intervening with hospitalised patients may be optimal timing to provide support. Our previous work demonstrated use of a digital monitoring and self-management support tool in the community. Read More

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Redesigning Family Medicine Training to Meet the Emerging Health Care Needs of Patients and Communities: Be the Change We Wish to See.

Norman B Kahn

Fam Med 2021 Jun 8. Epub 2021 Jun 8.

Department of Family Medicine, University of Kansas School of Medicine, Kansas City, KS.

This paper reflects a vision of how family medicine residency training will be redesigned to prepare graduates to meet the health care needs of their patient populations and regional communities. Family physicians are needed to serve as personal physicians and as the patient's usual source of care, as recognized in historic documents that have defined the specialty's enduring role in society as the foundation of the health care system. Modern residency practices will include residents as junior partners and members of multidisciplinary faculty teams. Read More

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Endovascular balloon-assisted liquid embolisation of soft tissue vascular malformations: technical feasibility and safety.

CVIR Endovasc 2021 Jun 8;4(1):49. Epub 2021 Jun 8.

Interventional Radiology Service, Department of Radiology, Austin Hospital, Melbourne, Australia.

Purpose: Arteriovenous malformations (AVMs) are abnormal communications between arteries and veins without an intervening capillary system. The best endovascular treatment option for these is unclear and may involve multiple staged procedures using a variety of embolic materials. We report our initial experience using a modified version of a previously published neurointerventional technique to treat soft tissue AVMs with single-stage curative intent. Read More

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Daytime sleepiness underlies the link between adverse parenting and youth psychopathology among adolescent girls.

J Adolesc 2021 Jun 4;90:32-44. Epub 2021 Jun 4.

Department of Psychological Science, Daemen College, 4380 Main St, Amherst, NY, 14226, USA. Electronic address:

Introduction: Adverse parenting is associated with sleep problems in adolescence, including sleep quality, inadequate sleep, and daytime sleepiness. Adolescents who experience sleep problems are at greater risk for developing internalizing and externalizing problems. However, research on the intervening role of sleep in the link between adverse parenting and youth psychopathology remains limited. Read More

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The Immunomodulatory Effect of the Gut Microbiota in Kidney Disease.

J Immunol Res 2021 15;2021:5516035. Epub 2021 May 15.

Reproductive & Women-Children Hospital, School of Medical and Life Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, China.

The human gut microbiota is a complex cluster composed of 100 trillion microorganisms, which holds a symbiotic relationship with the host under normal circumstances. Intestinal flora can facilitate the treatment of human metabolic dysfunctions and interact with the intestinal tract, which could influence intestinal tolerance, immunity, and sensitivity to inflammation. In recent years, significant interests have evolved on the association of intestinal microbiota and kidney diseases within the academic circle. Read More

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Acquired antithrombin deficiency is a risk factor for venous thromboembolism after major trauma.

Thromb Res 2021 May 28;204:9-12. Epub 2021 May 28.

The University of Texas Health Science Center, McGovern School of Medicine, Department of Surgery, Division of Acute Care Surgery and Center for Translational Injury Research, Houston, TX, United States of America. Electronic address:

Background: Up to 30% of severely injured patients on prophylactic anticoagulation experience venous thromboembolism (VTE). Our previous work shows that acquired antithrombin (AT) deficiency [AT<80%] occurs in approximately 20% of trauma patients upon admission and drives poor responsiveness to enoxaparin. However, changes in AT over time and its association with VTE remain unknown. Read More

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Store-operated Ca entry as a key oncogenic Ca signaling driving tumor invasion-metastasis cascade and its translational potential.

Cancer Lett 2021 Jun 2;516:64-72. Epub 2021 Jun 2.

Department of Otolaryngology & Head and Neck, The People's Hospital of Guangxi Zhuang Autonomous Region, Guangxi Academy of Medical Sciences, 6 Taoyuan Road, Nanning, 530021, China. Electronic address:

Tumor metastasis is the primary cause of treatment failure and cancer-related deaths. Store-operated Ca entry (SOCE), which is mediated by stromal interaction molecules (STIM) and ORAI proteins, has been implicated in the tumor invasion-metastasis cascade. Epithelial-mesenchymal transition (EMT) is a cellular program that enables tumor cells to acquire the capacities needed for migration and invasion and the formation of distal metastases. Read More

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Structure and mechanism of polynucleotide phosphorylase.

RNA 2021 Jun 4. Epub 2021 Jun 4.

Sloan-Kettering Institute

Polynucleotide phosphorylase (PNPase) catalyzes stepwise phosphorolysis of the 3'-terminal phosphodiesters of RNA chains to yield nucleoside diphosphate products. In the reverse reaction PNPase acts as a polymerase, using NDPs as substrates to add NMPs to the 3'-OH terminus of RNA chains while expelling inorganic phosphate. The apparent essentiality of PNPase for growth of militates for mycobacterial PNPase as a potential drug target. Read More

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The efficacy of acupuncture and moxibustion for early and middle-stage osteonecrosis of the femeral head: A systematic review and meta-analysis of randomized controlled trials.

Medicine (Baltimore) 2021 Jun;100(22):e26210

Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine, Nanchang City, Jiangxi Province, China.

Background: Osteonecrosis of the femeral head (ONFH) occurs predominantly in young- and middle-aged people, and the disability rate is high in the late stage of the disease and most patients have to undergo total hip replacement. Clinically, increasing attention is paid to intervening early and middle-stage ONFH so as to delay its progress. Acupuncture and moxibustion (AM) is a unique method for treating ONFH in China. Read More

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Helping as prosocial practice: Longitudinal relations among children's shyness, helping behavior, and empathic response.

J Exp Child Psychol 2021 Jun 1;209:105154. Epub 2021 Jun 1.

Department of Psychology, Neuroscience, and Behaviour, McMaster University, Hamilton, Ontario L8S 4K1, Canada.

Although shyness has been found to be a concurrent constraint on young children's empathy and instrumental helping, there is limited evidence to suggest that this temperamental profile has longitudinal effects on prosocial behaviors. Here, we examined the concurrent and longitudinal relations between children's shyness and prosocial behaviors, as well as the intervening impact of instrumental helping behavior on later empathic response in typically developing children (N = 86; 45 female). Shyness was coded from direct observations and reported by parents at Time 1 (M = 54. Read More

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Cholesterol metabolism: a new molecular switch to control inflammation.

Clin Sci (Lond) 2021 Jun;135(11):1389-1408

Centre for Inflammation Biology and Cancer Immunology, Department of Inflammation Biology, King's College London, London, U.K.

The immune system protects the body against harm by inducing inflammation. During the immune response, cells of the immune system get activated, divided and differentiated in order to eliminate the danger signal. This process relies on the metabolic reprogramming of both catabolic and anabolic pathways not only to produce energy in the form of ATP but also to generate metabolites that exert key functions in controlling the response. Read More

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CXCL2/10/12/14 are prognostic biomarkers and correlated with immune infiltration in hepatocellular carcinoma.

Biosci Rep 2021 Jun 4. Epub 2021 Jun 4.

Shenzhen Traditional Chinese Medicine Hospital, Shenzhen, China.

Background: C-x-C motif chemokine ligands (CXCLs) are critical regulators of cancer immunity and angiogenesis, which affect disease progression and treatment responses. The character of each CXCL in the prognosis and immune infiltration of HCC patients is unclear yet.

Methods: Differentially expressed CXCLs between HCC and normal control were screened by Oncomine and GEPIA2. Read More

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Multicultural Adaptation of Mighty Girls for Widespread Dissemination: Pilot Study, App Development and Usability Testing, and Gauging Parent Support With Focus Groups.

JMIR Form Res 2021 Jun 2;5(6):e24937. Epub 2021 Jun 2.

REAL Prevention, LLC, Clifton, NJ, United States.

Background: Taking evidence-based interventions to scale is a challenge for prevention science. Mighty Girls is an evidence-based sexual health intervention program that combines classroom sessions with novel, cutting-edge technology (digital puppetry). The program was developed for 7th grade Latinas, but US school and community demographics rarely allow interventions targeting a single ethnic group. Read More

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Top-down causation in psychiatric disorders: a clinical-philosophical inquiry.

Psychol Med 2021 Jun 2:1-6. Epub 2021 Jun 2.

Department of History and Philosophy of Science, University of Pittsburgh, Pittsburgh, PA, USA.

Psychiatry has long debated whether the causes of mental illness can be better explained by reductionist or pluralistic accounts. Although the former relies on commonsense scientific bottom-up causal models, the latter (which typically include environmental, psychological, and/or socio-cultural risk factors) requires top-down causal processes often viewed with skepticism, especially by neuroscientists. We begin with four clinical vignettes which illustrate self-interventions wherein high-order psychological processes (e. Read More

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Intraneural hemangioma of spinal nerve roots: a Case Report and literature review.

Br J Neurosurg 2021 Jun 1:1-3. Epub 2021 Jun 1.

Department of Neurosurgery and Laboratory of Neurosurgery, Lanzhou University Second Hospital, Lanzhou, Gansu, China.

Intraneural hemangiomas are rare benign neoplasms. We report the case of a 53‑year‑old female with a hemangioma in a spinal nerve root. The patient presented with muscular atropy of the right arm wihout obvious predisposing factors one year ago. Read More

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Predictive Factors of Radiation-Induced Changes Following Single-Session Gamma Knife Radiosurgery for Arteriovenous Malformations.

J Clin Med 2021 May 19;10(10). Epub 2021 May 19.

Department of Neurosurgery, Brain Research Institute, Yonsei University College of Medicine, Yonsei-ro 50-1, Seodamungu, Seoul 03722, Korea.

We evaluated for possible predictors of radiation-induced changes (RICs) after gamma knife radiosurgery (GKRS) for arteriovenous malformations (AVMs). We identified the nidal component within AVMs to analyze the correlation between the volume of brain parenchyma within the 50% isodose line (IDL) and RICs. We retrospectively reviewed patients with AVMs who underwent a single-session of GKRS at our institution between 2007 and 2017 with at least a 2-year minimum follow-up. Read More

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A Framework of Vehicular Security and Demand Service Prediction Based on Data Analysis Integrated with Blockchain Approach.

Sensors (Basel) 2021 May 11;21(10). Epub 2021 May 11.

Department of Computer Engineering, Institute of Information Science Technology, Jeju National University, Jejusi 63243, Korea.

The prediction of taxi demand service has become a recently attractive area of research along with large-scale and potential applications in the intelligent transportation system. The demand process is divided into two main parts: Picking-up and dropping-off demand based on passenger habit. Taxi demand prediction is a great concept for drivers and passengers, and is designed platforms for ride-hailing and municipal managers. Read More

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Response Surface Methods Used for Optimization of Abrasive Waterjet Machining of the Stainless Steel X2 CrNiMo 17-12-2.

Materials (Basel) 2021 May 11;14(10). Epub 2021 May 11.

Department of Industrial Engineering and Management, Transilvania University of Brasov, 500036 Brasov, Romania.

Abrasive waterjet machining (AWJM) has a particularly high potential for the machining of stainless steels. One of the main optimization objectives of the machining of X2 CrNiMo 17-12-2 stainless steel is obtaining a minimal surface roughness. This entails selecting an optimum configuration of the main influencing factors of the machining process. Read More

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