608,448 results match your criteria interval [ci]

Pathological Response and Survival after Neoadjuvant Therapy for Her-2 Positive Breast Cancer.

Chirurgia (Bucur) 2021 Mar-Apr;116(2 Suppl):91-97

Pathological complete response (pCR) after neoadjuvant systemic treatment represents a good surrogate marker for the prognosis of Her-2 positive Breast Cancer (BCs). The results improved after adding anti-Her-2 therapy to chemotherapy in neoadjuvant setting. Our retrospective study enrolled a cohort of 56 invasive Her-2 positive non-metastatic BCs treated with neoadjuvant systemic therapy between 2001 and 2018. Read More

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Development and validation of MRI-based deep learning models for prediction of microsatellite instability in rectal cancer.

Cancer Med 2021 May 8. Epub 2021 May 8.

Department of Radiology, West China Hospital, Sichuan University, Chengdu, China.

Background: Microsatellite instability (MSI) predetermines responses to adjuvant 5-fluorouracil and immunotherapy in rectal cancer and serves as a prognostic biomarker for clinical outcomes. Our objective was to develop and validate a deep learning model that could preoperatively predict the MSI status of rectal cancer based on magnetic resonance images.

Methods: This single-center retrospective study included 491 rectal cancer patients with pathologically proven microsatellite status. Read More

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Impact of P-wave indices in prediction of atrial fibrillation-Insight from loop recorder analysis.

Ann Noninvasive Electrocardiol 2021 May 7:e12854. Epub 2021 May 7.

University Hospital St Josef Hospital, Cardiology and Rhythmology, Ruhr University, Bochum, Germany.

Background: Several P-wave indices are associated with the development of atrial fibrillation (AF). However, previous studies have been limited in their ability to reliably diagnose episodes of AF. Implantable loop recorders allow long-term, continuous, and therefore more reliable detection of AF. Read More

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Predicting QT interval prolongation in patients diagnosed with the 2019 novel coronavirus infection.

Ann Noninvasive Electrocardiol 2021 May 7:e12853. Epub 2021 May 7.

Department of Internal Medicine, Ascension St. John Hospital, Detroit, MI, USA.

Introduction: 2019 novel coronavirus (COVID-19) patients frequently develop QT interval prolongation that predisposes them to Torsades de Pointes and sudden cardiac death. Continuous cardiac monitoring has been recommended for any COVID-19 patient with a Tisdale Score of seven or more. This recommendation, however, has not been validated. Read More

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Hepatitis C virus eradication decreases the risks of liver cirrhosis and cirrhosis-related complications (T-COACH).

J Gastroenterol Hepatol 2021 May 7. Epub 2021 May 7.

Division of Gastroenterology and Hepatology, Department of Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.

Background And Aims: It is currently unknown how hepatitis C virus (HCV) eradication with pegylated interferon and ribavirin (PR) therapy affects the incidence of new-onset liver cirrhosis (LC) in patients without cirrhosis and the incidence of decompensated liver disease (DLD) or hepatocellular carcinoma (HCC) in patients with cirrhosis.

Methods: Taiwanese chronic hepatitis C cohort (T-COACH) is a nationwide HCV registry cohort from 23 hospitals in Taiwan recruited between 2003 and 2015. This study enrolled 10,693 patients with chronic hepatitis C (CHC), linked to the Taiwan National Health Insurance Research Database, receiving PR therapy for at least 4 weeks for new-onset LC and liver-related complications (DLD or HCC). Read More

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Reference data for hop tests used in pediatric ACL injury rehabilitation: A cross-sectional study of healthy children.

Scand J Med Sci Sports 2021 May 8. Epub 2021 May 8.

Department of Midwifery, Occupational Therapy and Psychomotor Therapy, Faculty of Health, University College Copenhagen, Copenhagen, Denmark.

In rehabilitation, four single leg hop tests are frequently used for evaluation of ACL injured children. However, reference values on single leg hop performance and the corresponding limb symmetry indexes (LSIs) of healthy children younger than 15 years of age are lacking. Thus, the purpose was to describe hop performance and LSIs in healthy Danish children, and to quantify the proportion of participants passing LSI values of ≥85% as well as ≥90%. Read More

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Population pharmacokinetics of free flucloxacillin in patients treated with oral flucloxacillin plus probenecid.

Br J Clin Pharmacol 2021 May 7. Epub 2021 May 7.

Department of Infectious Diseases, Christchurch Hospital, Christchurch, New Zealand.

Aim: Oral flucloxacillin may be co-administered with probenecid to reduce flucloxacillin clearance and increase attainment of pharmacokinetic-pharmacodynamic (PK/PD) targets. The aims of this study were to develop a population PK model of free flucloxacillin when administered orally with probenecid, and to identify optimal dosing regimens for this combination.

Methods: We performed a prospective observational study of adults (45 participants) treated with oral flucloxacillin 1000 mg and probenecid 500 mg 8-hourly for proven or probable staphylococcal infections. Read More

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Nonfunctional adrenal adenomas and impaired glucose metabolism: a systematic review and meta-analysis.

Endocrine 2021 May 7. Epub 2021 May 7.

First Department of Internal Medicine, Unit of Endocrinology, Laiko Hospital, National and Kapodistrian University of Athens, Athens, Greece.

Purpose: Evidence on nonfunctioning adrenal incidentaloma's (NFAI) associated comorbidities and in particular, glucose disorders, is unclear in contrast to adrenal tumors with mild autonomous cortisol secretion. The current systematic review and meta-analysis aimed to assess the burden of impaired glucose metabolism including diabetes mellitus type 2 (T2DM), fasting blood glucose (FBG), and fasting blood insulin (FBI) levels in patients with NFAI and 1-mg overnight dexamethasone suppression test (ODST) ≤ 1.8 μg/dl across published studies. Read More

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Safety of intravenous thrombolysis in stroke of unknown time of onset: A systematic review and meta-analysis.

J Thromb Thrombolysis 2021 May 7. Epub 2021 May 7.

Cerebrovascular Disease Center, Department of Neurology, People's Hospital, China Medical University. Address, 33 Wenyi Road, Shenhe District, Shenyang, 110016, People's Republic of China.

The safety of intravenous tissue plasminogen activator (IV-tPA) in patients with stroke of unknown time of onset (SUTO) was unclear and mostly concerned. We sought to investigate the safety in terms of symptomatic intracranial hemorrhage (sICH) and death in SUTO patients treated with IV-tPA. We searched PubMed and EMBASE from inception to 2 December 2020 for eligible studies reporting IV-tPA in SUTO patients compared to conservative medical therapy, or to stroke of known onset time (SKOT) treated with IV-tPA within standard time window. Read More

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Application of Near-Infrared Spectroscopy for the Detection of Delayed Cerebral Ischemia in Poor-Grade Subarachnoid Hemorrhage.

Neurocrit Care 2021 May 7. Epub 2021 May 7.

Genetic and Research Inc., Chuncheon, Republic of Korea.

Background: The objective of this study was to investigate the clinical feasibility of near-infrared spectroscopy (NIRS) for the detection of delayed cerebral ischemia (DCI) in patients with poor-grade subarachnoid hemorrhage (SAH) treated with coil embolization.

Methods: Cerebral regional oxygen saturation (rSO) was continuously monitored via two-channel NIRS for 14 days following SAH. The rSO levels according to DCI were analyzed by using the Mann-Whitney U-test. Read More

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β -Glucan Improves Protective Qi Status in Adults with Protective Qi Deficiency-A Randomized, Placebo-Controlled, and Double-Blinded Trial.

Chin J Integr Med 2021 May 8. Epub 2021 May 8.

Research and Development Department, USANA Health Science, Inc., Salt Lake City, UT, 84121, USA.

Objective: To test the hypothesis that β -glucan enhances protective qi (PQi), an important Chinese medicine (CM) concept which stipulates that a protective force circulates throughout the body surface and works as the first line of defense against "external pernicious influences".

Methods: A total of 138 participants with PQi deficiency (PQD) were randomized to receive β -glucan (200 mg daily) or placebo for 12 weeks. Participants' PQi status was assessed every 2 weeks via conventional diagnosis and a standardized protocol from which a PQD severity and risk score was derived. Read More

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Bridging the gap: a pre-post feasibility study of embedding exercise therapy into a co-located cancer unit.

Support Care Cancer 2021 May 8. Epub 2021 May 8.

School of Allied Health, Human Services and Sport, La Trobe University, Melbourne, VIC, Australia.

Purpose: To establish the feasibility of embedding a flexible, exercise-based rehabilitation program into a cancer treatment unit to allow cancer survivors early exercise support.

Method: A pre-post study was conducted using Bowen's Framework to describe key domains of feasibility: demand (referrals), acceptability (uptake, attendance, satisfaction), implementation (resources), practicality (adverse events, costs) and limited-efficacy (function, quality of life, self-efficacy). Participants were medically stable, adult cancer survivors receiving curative or palliative treatment for cancer at the health service. Read More

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Comparison of 2D and 3D quiescent-interval slice-selective non-contrast MR angiography in patients with peripheral artery disease.

MAGMA 2021 May 8. Epub 2021 May 8.

Department of Radiology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.

Objective: To evaluate the potential clinical benefit of the superior spatial resolution of 3D prototype thin-slab stack-of-stars (tsSOS) quiescent-interval slice-selective (QISS) MRA over standard 2D-QISS MRA for the detection peripheral artery disease (PAD), using computed tomography angiography (CTA) as reference.

Materials And Methods: Twenty-three patients (70 ± 8 years, 18 men) with PAD who had previously undergone run-off CTA were prospectively enrolled. Patients underwent non-contrast MRA using 2D-QISS and tsSOS-QISS at 1. Read More

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Clinicopathological and prognostic significance of programmed cell death ligand 1 expression in patients diagnosed with breast cancer: meta-analysis.

Br J Surg 2021 May 8. Epub 2021 May 8.

Lambe Institute for Translational Research, National University of Ireland, Galway, Ireland.

Background: Uncertainty exists regarding the clinical relevance of programmed cell death ligand 1 (PD-L1) expression in breast cancer. This systematic review and meta-analysis evaluated the clinicopathological and prognostic role of PD-L1 in breast cancer.

Methods: A systematic review was performed in accordance with PRISMA guidelines. Read More

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Lowering cholesterol, blood pressure, or both to prevent cardiovascular events: results of 8.7 years of follow-up of Heart Outcomes Evaluation Prevention (HOPE)-3 study participants.

Eur Heart J 2021 May 8. Epub 2021 May 8.

The Population Health Research Institute, Hamilton Health Sciences, 237 Barton Street East, Hamilton, Ontario L8L 2X2, Canada.

Aims: Rosuvastatin (10 mg per day) compared with placebo reduced major adverse cardiovascular (CV) events by 24% in 12 705 participants at intermediate CV risk after 5.6 years. There was no benefit of blood pressure (BP) lowering treatment in the overall group, but a reduction in events in the third of participants with elevated systolic BP. Read More

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Neuroprotective strategies in acute aortic dissection: an analysis of the UK National Adult Cardiac Surgical Audit.

Eur J Cardiothorac Surg 2021 May 8. Epub 2021 May 8.

South Tees Hospitals NHS Trust, Middlesbrough, UK.

Objectives: The risk of brain injury following surgery for type A aortic dissection (TAAD) remains substantial and no consensus has still been reached on which neuroprotective technique should be preferred. We aimed to investigate the association between neuroprotective strategies and clinical outcomes following TAAD repair.

Methods: Using the UK National Adult Cardiac Surgical Audit, we identified 1929 patients undergoing surgery for TAAD (2011-2018). Read More

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Comparison of radiomic feature aggregation methods for patients with multiple tumors.

Sci Rep 2021 May 7;11(1):9758. Epub 2021 May 7.

Department of Therapeutic Radiology, Yale School of Medicine, New Haven, USA.

Radiomic feature analysis has been shown to be effective at analyzing diagnostic images to model cancer outcomes. It has not yet been established how to best combine radiomic features in cancer patients with multifocal tumors. As the number of patients with multifocal metastatic cancer continues to rise, there is a need for improving personalized patient-level prognosis to better inform treatment. Read More

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Mobile Apps for Drug-Drug Interaction (DDI) Check in Chinese App Stores: A Systematic Review and Content Analysis.

JMIR Mhealth Uhealth 2021 May 7. Epub 2021 May 7.

Department of Pharmacy, Minhang Hospital, Fudan University, Shanghai, 201203, PR China., 826 Zhangheng Road,, Shanghai, CN.

Background: As the computerized drug-drug interaction (DDI) alert system is not widely implemented in China, healthcare providers are relying on mobile health (mHealth) apps as references for checking drug information such as DDI.

Objective: The main objective of this study was to evaluate the quality and content of mHealth apps supporting DDI checking in Chinese App stores.

Methods: A systematical review was carried out in November 2020, to identify mHealth apps providing DDI checking in both Chinese iOS and Android platforms. Read More

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A Systematic Review and Network Meta-analysis of Randomized Data on Efficacy of Novel Therapy Combinations in Patients with Lenalidomide-refractory Multiple Myeloma.

Clin Lymphoma Myeloma Leuk 2021 Mar 26. Epub 2021 Mar 26.

Division of Hematologic Malignancies and Cellular Therapeutics, The University of Kansas Medical Center, Kansas City, KS.

Introduction: Lenalidomide use in nearly all induction regimens for multiple myeloma (MM) has led to the treatment of lenalidomide-refractory disease becoming one of the most important clinical questions in its treatment. Given the lack of direct comparisons of treatment regimens for lenalidomide-refractory MM, we used a systematic review to identify randomized controlled trials (RCTs) that included lenalidomide-refractory subgroup analysis.

Methods: We performed a systematic review to identify RCTs for MM that enrolled patients with lenalidomide-refractory disease, then performed a network meta-analysis (NMA) using random effects model to compare regimens. Read More

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Preoperative chronic opioid use and its impact on early complications in bariatric surgery: a Swedish nationwide cohort study of 56,183 patients.

Surg Obes Relat Dis 2021 Apr 20. Epub 2021 Apr 20.

Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.

Background: The association between severe obesity and chronic pain makes opioid use common among bariatric patients. Preoperative opioid use has been identified as a risk factor in other surgical procedures.

Objectives: To examine the impact of preoperative opioid use on complications after primary bariatric surgery. Read More

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Multiple comorbidities increase the risk of death from invasive pneumococcal disease under the age of 65 years.

J Infect Chemother 2021 May 4. Epub 2021 May 4.

Department of Infectious Diseases, Keio University School of Medicine, Japan; Department of Microbiology, Tokyo Medical University, Japan; Center for General Medicine Education, Keio University School of Medicine, Japan. Electronic address:

Introduction: Risk factors for death from invasive pneumococcal disease (IPD) have not been clearly established in patients aged under 65 years. We aimed to evaluate contributions of host and bacterial factors to the risk of death from IPD in patients aged under 65 years in Japan.

Methods: In this prospective, observational, multicenter cohort study, patients with IPD (n = 581) aged 6-64 years were enrolled between 2010 and 2017. Read More

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Safety, immunogenicity, and efficacy of NDV-3A against Staphylococcus aureus colonization: A phase 2 vaccine trial among US Army Infantry trainees.

Vaccine 2021 May 4. Epub 2021 May 4.

NovaDigm Therapeutics, Inc., Grand Forks, ND, United States.

Background: Military trainees are at increased risk for Staphylococcus aureus colonization and infection. Disease prevention strategies are needed, but a S. aureus vaccine does not currently exist. Read More

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Assisted therapy with platelet-rich plasma for burn patients: A meta-analysis and systematic review.

Burns 2020 Dec 24. Epub 2020 Dec 24.

Division of Plastic Surgery, Department of Surgery, Taipei Municipal Wanfang Hospital, Taipei Medical University, Taipei, Taiwan; Department of Surgery, School of Medicine, College of Medicine, Taipei Medical University, Taipei City, Taiwan. Electronic address:

Introduction: Platelet-rich plasma (PRP) therapy has been used in different medical fields, but its effectiveness in burn wound healing remains debatable. In this study, we performed a systematic review and meta-analysis of the available evidence on burn patients treated with PRP to evaluate the safety and efficacy of the treatment.

Methods: Randomized controlled trials evaluating the efficacy of PRP in patients with burn injuries were selected. Read More

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December 2020

Impact of Clotrimazole Fungal Prophylaxis on Tacrolimus Exposure in Kidney Transplant Recipients: A Retrospective Study.

Transplant Proc 2021 May 4. Epub 2021 May 4.

Department of Pharmacy, Einstein Medical Center Philadelphia, Philadelphia, Pennsylvania. Electronic address:

Tacrolimus, an immunosuppressant prescribed to reduce the risk of organ rejection, is metabolized by cytochrome P450 and is a substrate for P-glycoprotein. Many medications affect tacrolimus concentrations, making it difficult to maintain exposure within its narrow therapeutic index. Clotrimazole troches, prescribed to posttransplant recipients immediately for the first 30 days for oral candidiasis prevention, are considered nonsystemic. Read More

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Palliative Care Services in Patients Admitted With Cardiogenic Shock in the United States: Frequency and Predictors of 30-Day Readmission.

J Card Fail 2021 May;27(5):560-567

Division of Cardiology, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, California; Division of Cardiology, VA Greater Los Angeles Healthcare System, Los Angeles, California. Electronic address:

Background: Patients admitted with cardiogenic shock (CS) have high mortality rates, readmission rates, and healthcare costs. Palliative care services (PCS) may be underused, and the association with 30-day readmission and other predictive factors is unknown. We studied the frequency, etiologies, and predictors of 30-day readmission in CS admissions with and without PCS in the United States. Read More

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The Dietary Approaches to Stop Hypertension (DASH) Diet Pattern and Incident Heart Failure.

J Card Fail 2021 May;27(5):512-521

Department of Epidemiology, University of Alabama at Birmingham, Birmingham, Alabama.

Background: The Dietary Approaches to Stop Hypertension (DASH) diet pattern has shown some promise for preventing heart failure (HF), but studies have been conflicting.

Objective: To determine whether the DASH diet pattern was associated with incident HF in a large biracial and geographically diverse population.

Methods And Results: Among participants in the REasons for Geographic And Racial Differences in Stroke (REGARDS) cohort study of adults aged ≥45 years who were free of suspected HF at baseline in 2003-2007, the DASH diet score was derived from the baseline food frequency questionnaire. Read More

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Coronavirus disease 2019 outbreak in Beijing's Xinfadi Market, China: a modeling study to inform future resurgence response.

Infect Dis Poverty 2021 May 7;10(1):62. Epub 2021 May 7.

Beijing Research Center for Preventive Medicine, Beijing Center for Disease Prevention and Control, Beijing, China.

Background: A local coronavirus disease 2019 (COVID-19) case confirmed on June 11, 2020 triggered an outbreak in Beijing, China after 56 consecutive days without a newly confirmed case. Non-pharmaceutical interventions (NPIs) were used to contain the source in Xinfadi (XFD) market. To rapidly control the outbreak, both traditional and newly introduced NPIs including large-scale management of high-risk populations and expanded severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) PCR-based screening in the general population were conducted in Beijing. Read More

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Helicopter emergency medical service dispatch in older trauma: time to reconsider the trigger?

Scand J Trauma Resusc Emerg Med 2021 May 7;29(1):62. Epub 2021 May 7.

Air Ambulance Kent Surrey Sussex, Hanger 10 Redhill Aerodrome, Redhill, Surrey, RH1 5YP, UK.

Background: Helicopter Emergency Medical Services (HEMS) respond to serious trauma and medical emergencies. Geographical disparity and the regionalisation of trauma systems can complicate accurate HEMS dispatch. We sought to evaluate HEMS dispatch sensitivity in older trauma patients by analysing critical care interventions and conveyance in a well-established trauma system. Read More

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Prognostic Value of D-dimer in patients with acute coronary syndrome treated by percutaneous coronary intervention: a retrospective cohort study.

Thromb J 2021 May 7;19(1):30. Epub 2021 May 7.

Fuwai Hospital, Chinese Academy of Medical Sciences, Shenzhen, China.

Background: Associations between D-dimer and outcomes of patients with acute coronary syndromes (ACS) remain controversial. This study aimed to investigate the prognostic value of D-dimer in ACS patients treated by percutaneous coronary intervention (PCI).

Methods: In this observational study, 3972 consecutive patients with ACS treated by PCI were retrospectively recruited. Read More

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Text message reminders and peer education increase HIV and Syphilis testing among female sex workers: a pilot quasi-experimental study in Uganda.

BMC Health Serv Res 2021 May 7;21(1):436. Epub 2021 May 7.

School of Public Health, College of Health Sciences, Makerere University, Kampala, Uganda.

Background: Globally, female sex workers (FSW) are disproportionately affected by HIV and other sexually transmitted infections (STIs). However, uptake of STI and HIV testing services among FSW in sub-Saharan Africa remains low. We aimed to assess the effect of FSW-led peer education and text message reminders on 3-monthly syphilis and HIV testing among FSW in Uganda. Read More

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