23,301 results match your criteria interstitial fibrosis

Impact of the immunotherapy induction on allograft outcome and survival in kidney transplant patients with donor-specific antibodies to HLA-DQB1.

Transpl Immunol 2021 Apr 7:101390. Epub 2021 Apr 7.

IMUNOLAB - Laboratory of Histocompatibility, Belo Horizonte, Minas Gerais State, Brazil; Institute of Research and Education of the Hospital Santa Casa, Belo Horizonte, Minas Gerais State, Brazil. Electronic address:

Background: The presence of donor-specific antibodies (DSAs) against HLA-DQB1 is considered a significant barrier to good outcome and allograft survival in kidney transplantation (KT). This study aimed to assess the impact of induction immunotherapy on the outcome and allograft survival in KT patients with HLA-DQB1-DSA.

Methodology: Thirty-two patients who had undergone KT and found to be positive for HLA-DQB1-DSA were monitored at least one to 10 years. Read More

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Isolation and culture of adult murine cardiac atrial and ventricular fibroblasts and myofibroblasts.

Methods 2021 Apr 7. Epub 2021 Apr 7.

Montreal Heart Institute, 5000 Belanger, Montréal, Québec, H1T 1C8, Canada; Departments of Biochemistry and Molecular Medicine, Université de Montréal, Montréal, Québec, H3C 3J7, Canada; Pharmacology and Physiology, Université de Montréal, Montréal, Québec, H3C 3J7, Canada; Université de Montréal, Montréal, Québec, H3C 3J7, Canada. Electronic address:

Cardiac fibroblasts play a critical role in extracellular matrix homeostasis, wound healing, and cardiac interstitial fibrosis: the latter being a pathophysiological response to a chronic increase in afterload. Using a standard protocol to isolate cardiac fibroblasts and maintain them in their quiescent phenotype in vitro will enable a better understanding of cardiac fibroblast biology and their role in the response to profibrotic stimuli. Here, we describe an enzymatic method for isolating cardiac fibroblasts. Read More

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Prednisone-induced sustained remission in a patient with familial fibronectin glomerulopathy (GFND).

CEN Case Rep 2021 Apr 10. Epub 2021 Apr 10.

Nephrology Division, Department of Medicine, University of Rochester, 601 Elmwood Avenue, Box 675, Rochester, NY, 14642, USA.

Glomerulopathy with Fibronectin Deposits (GFND) is a rare, autosomal dominant disease characterized by proteinuria, hematuria and progressive renal failure associated with glomerular deposition of fibronectin, frequently resulting in end-stage renal disease (ESRD). There is no established treatment for this condition beyond conservative measures such as blood pressure control and the use of angiotensin-converting enzyme (ACE) inhibitors. We present a case of GFND associated with progressive chronic kidney disease (CKD) and nephrotic range proteinuria showing a sustained response to prednisone treatment. Read More

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There is detectable variation in the lipidomic profile between stable and progressive patients with idiopathic pulmonary fibrosis (IPF).

Respir Res 2021 Apr 9;22(1):105. Epub 2021 Apr 9.

School of Biomedical Science, University of Western Australia, Crawley, WA, Australia.

Background: Idiopathic pulmonary fibrosis (IPF) is a chronic interstitial lung disease characterized by fibrosis and progressive loss of lung function. The pathophysiological pathways involved in IPF are not well understood. Abnormal lipid metabolism has been described in various other chronic lung diseases including asthma and chronic obstructive pulmonary disease (COPD). Read More

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Interstitial lung abnormalities and pulmonary fibrosis in COVID-19 patients: a short-term follow-up case series.

Clin Imaging 2021 Mar 29;77:180-186. Epub 2021 Mar 29.

Thomas Jefferson University Hospital, Department of Radiology, 132 S 10th St., Philadelphia, PA 19017, USA. Electronic address:

Fibrotic lung changes are well-known complications of SARS, MERS, and ARDS from other causes and are anticipated in recovered COVID patients. However, there is limited data so far showing a temporal relationship between lung changes on imaging in the acute phase and follow-up imaging after recovery from the infection. We present 12 patients who demonstrate the development of interstitial lung changes and pulmonary fibrosis in the same distribution and pattern as the acute phase findings, up to 6 months after the acute infection, demonstrating a direct relationship between these changes and COVID-19 pneumonia. Read More

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Nicotinamide Mononucleotide Attenuates Renal Interstitial Fibrosis After AKI by Suppressing Tubular DNA Damage and Senescence.

Front Physiol 2021 23;12:649547. Epub 2021 Mar 23.

Key Laboratory of Renal Disease, Renal Division, Department of Medicine, Peking University First Hospital, Peking University Institute of Nephrology, Ministry of Health of China, Beijing, China.

Acute kidney injury (AKI) is a worldwide health problem currently lacking therapeutics that directly promote renal repair or prevent the occurrence of chronic fibrosis. DNA damage is a feature of many forms of kidney injury, and targeting DNA damage and repair might be effective strategies for kidney protection in AKI. Boosting nicotinamide adenine dinucleotide (NAD) levels is thought to have beneficial effects on DNA damage repair and fibrosis in other organs. Read More

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Action plans in idiopathic pulmonary fibrosis: a qualitative study-'I do what I can do'.

BMJ Support Palliat Care 2021 Apr 8. Epub 2021 Apr 8.

Palliative/End of Life Care, Continuing Care, Alberta Health Services, Edmonton, Alberta, Canada.

Background: Idiopathic pulmonary fibrosis (IPF) is a progressive, incurable fibrotic lung disease in which patients and caregivers report a high symptom burden. Symptoms are often poorly managed and patients and caregivers struggle to alleviate their distress in the absence of self-management support.

Aim: To explore perceptions of symptoms, symptom management strategies and self-efficacy for patients with IPF and caregivers who received self-management education and action plans created and provided in a Multidisciplinary Collaborative Interstitial Lung Disease (MDC-ILD) Clinic. Read More

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Prognostic role of Krebs von den Lungen-6 (KL-6) measurement in idiopathic pulmonary fibrosis: a systematic review and meta-analysis.

Clin Chem Lab Med 2021 Apr 9. Epub 2021 Apr 9.

Research Centre for Metrological Traceability in Laboratory Medicine (CIRME), University of Milan, Milan, Italy.

Objectives: Idiopathic pulmonary fibrosis (IPF) is a progressive interstitial disease with limited therapeutic options. The measurement of Krebs von den Lungen-6 (KL-6) glycoprotein has been proposed for evaluating the risk of IPF progression and predicting patient prognosis, but the robustness of available evidence is unclear.

Methods: We searched Medline and Embase databases for peer-reviewed literature from inception to April 2020. Read More

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Tumor necrosis factor alpha and interleukin 1 beta suppress myofibroblast activation via nuclear factor kappa B signaling in 3D-cultured mitral valve interstitial cells.

Acta Biomater 2021 Apr 5. Epub 2021 Apr 5.

Department of Bioengineering, Rice University, 6500 Main St, Houston TX 77030. Electronic address:

Mitral valve disease is a major cause of cardiovascular morbidity throughout the world. Many different mitral valve pathologies feature fibrotic remodeling, often accompanied by an inflammatory state. Mitral valve fibrosis is mediated by valvular interstitial cells (VICs), which reside in the valve leaflets and often differentiate into myofibroblast-like cells during disease conditions. Read More

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Long term outcome of immunoglobulin A (IgA) nephropathy: A single center experience.

PLoS One 2021 8;16(4):e0249592. Epub 2021 Apr 8.

Department of Pathology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.

Introduction: IgA nephropathy (IgAN) has a heterogeneous presentation and the progression to end stage renal disease (ESRD) is often influenced by demographics, ethnicity, as well as choice of treatment regimen. In this study, we investigated the long term survival of IgAN patients in our center and the factors affecting it.

Methods: This study included all biopsy-proven IgAN patients with ≥ 1year follow-up. Read More

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Increased Levels of ER Stress and Apoptosis in a Sheep Model for Pulmonary Fibrosis Are Alleviated by Blockade of the KCa3.1 Ion Channel.

Can Respir J 2021 19;2021:6683195. Epub 2021 Mar 19.

School of Veterinary Science, The University of Melbourne, Parkville, VIC, Australia.

Idiopathic pulmonary fibrosis (IPF) is a fatal interstitial lung disease, characterized by progressive damage to the lung tissues. Apoptosis and endoplasmic reticulum stress (ER stress) in type II alveolar epithelial cells (AECs) and lung macrophages have been linked with the development of IPF. Therefore, apoptosis- and ER stress-targeted therapies have drawn attention as potential avenues for treatment of IPF. Read More

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Elastography: a surrogate marker of renal allograft fibrosis - quantification by shear-wave technique.

Pol J Radiol 2021 7;86:e151-e156. Epub 2021 Mar 7.

Kovai Medical Center and Hospital, Coimbatore, India.

Purpose: Renal fibrosis is the most common cause of allograft failure in kidney transplantations. Evaluation of renal abnormalities has progressed considerably over the past years. Currently, the diagnosis of intrarenal fibrosis and quantification of its development with non-invasive assessment tools is possible. Read More

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Assessment of chronic allograft injury in renal transplantation using diffusional kurtosis imaging.

BMC Med Imaging 2021 Apr 7;21(1):63. Epub 2021 Apr 7.

Institute of Urology, Capital Medical University, 8 Gongren Tiyuchang Nanlu, Chaoyang District, Beijing, 200020, People's Republic of China.

Background: Chronic allograft injury (CAI) is a significant reason for which many grafts were lost. The study was conducted to assess the usefulness of diffusional kurtosis imaging (DKI) technology in the non-invasive assessment of CAI.

Methods: Between February 2019 and October 2019, 110 renal allograft recipients were included to analyze relevant DKI parameters. Read More

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Fibrotic expression profile analysis reveals repurposed drugs with potential anti-fibrotic mode of action.

PLoS One 2021 7;16(4):e0249687. Epub 2021 Apr 7.

Department of Bioinformatics, The Cyprus Institute of Neurology and Genetics, Nicosia, Cyprus.

Fibrotic diseases cover a spectrum of systemic and organ-specific maladies that affect a large portion of the population, currently without cure. The shared characteristic these diseases feature is their uncontrollable fibrogenesis deemed responsible for the accumulated damage in the susceptible tissues. Idiopathic Pulmonary Fibrosis, an interstitial lung disease, is one of the most common and studied fibrotic diseases and still remains an active research target. Read More

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Use of GLP1RAs and occurrence of respiratory disorders: a meta-analysis of large randomized trials of GLP1RAs.

Clin Respir J 2021 Apr 7. Epub 2021 Apr 7.

Department of Respiratory Medicine, Second Affiliated Hospital of KunMing Medical University, KunMing, 650101, China.

Objectives: No large sample studies have been designed to evaluate the efficacy of glucagon-like peptide-1 receptor agonists (GLP1RAs) in the primary and secondary prevention of respiratory disorders. We aimed at evaluating the relationship between use of GLP1RAs and occurrence of 12 kinds of respiratory disorders.

Methods: Large randomized placebo-controlled trials of GLP1RAs were included. Read More

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Evaluation of Renal Fibrosis by Mapping Histology and Magnetic Resonance Imaging.

Kidney Dis (Basel) 2021 Mar 12;7(2):131-142. Epub 2021 Feb 12.

National Clinical Research Center of Kidney Diseases, Jinling Hospital, Second Military Medical University, Nanjing, China.

Background: Renal fibrosis is a key driver of progression in chronic kidney disease (CKD). Recent advances in diagnostic imaging techniques have shown promising results for the noninvasive assessment of renal fibrosis. However, the specificity and accuracy of these techniques are controversial because they indirectly assess renal fibrosis. Read More

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Effect of combined pulmonary fibrosis and emphysema on patients with connective tissue diseases and systemic sclerosis: a systematic review and meta-analysis.

Arthritis Res Ther 2021 04 6;23(1):100. Epub 2021 Apr 6.

Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea.

Background: This study aimed to analyze the literature systematically to determine the clinical characteristics and prognosis of patients with connective tissue disease (CTD) with combined pulmonary fibrosis and emphysema (CPFE) compared to those of patients with CTD-interstitial lung disease (CTD-ILD) without emphysema.

Methods: We searched MEDLINE, EMBASE, Cochrane Library, and KoreaMed for relevant articles published before July 2019. Studies meeting all the following criteria were included: (1) original research studies evaluating the effect of CPFE on CTD, (2) studies that compared patients with CTD-CPFE to those with CTD-ILD without emphysema, and (3) studies providing data on physical capacity, pulmonary function, or death in patients with CTD. Read More

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LRG1 Mitigates Renal Interstitial Fibrosis through Alleviating Capillary Rarefaction and Inhibiting Inflammatory and Pro-Fibrotic Cytokines.

Am J Nephrol 2021 Apr 6:1-11. Epub 2021 Apr 6.

Division of Internal Medicine, Department of Nephrology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Introduction: Increasing evidence has demonstrated that loss of peritubular capillaries plays a critical role in renal interstitial fibrosis. Leucine-rich α2-glycoprotein-1 (LRG1) has been observed promoting angiogenesis in the ocular disease mouse model and myocardial infarction model. We aimed to explore the role of LRG1 in renal interstitial fibrosis. Read More

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All-trans retinoic acid regulating angiopoietins-1 and alleviating extracellular matrix accumulation in interstitial fibrosis rats.

Ren Fail 2021 Dec;43(1):658-663

Department of Nephrology, the Second Affiliated Hospital, Shantou University Medical College, Shantou, China.

All-trans retinoic acid (ATRA) is one of essentially active metabolite of vitamin A, and plays an important role in diverse physiological processes, such as cellular growth and function. Renal interstitial fibrosis (RIF) is a common pathological characteristic of chronic renal disease causing end-stage renal disease currently lacking effective treatment. Low level of Angiopoietins-1 (Angpt-1) is associated with extracellular matrix accumulation and fibrosis diseases. Read More

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December 2021

[A total replacement of the both ureters and urinary bladder by ileal conduit in a woman with contracted bladder and Ormonds disease].

Urologiia 2021 Mar(1):107-111

Department of urology of North-Western State Medical University named after I.I. Mechnikov, Saint Petersburg, Russia.

A description of the successful surgical treatment of a patient with irreversible changes in both ureters and bladder resulting from a severe form of Ormond's disease and interstitial cystitis, resulting in contracted bladder, is presented. For the first time in clinical practice, a one-stage cystectomy, a bilateral ureterectomy with complete replacement of both ureters and the bladder with two isoperistaltic small bowel segment was performed. The postoperative course was uneventful. Read More

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[Morphological analysis of the structure of parafistulous tissues in patients with vesicovaginal fistulas by the local interstitial application of platelet-rich plasma].

Urologiia 2021 Mar(1):21-26

Kuban State Medical University, Krasnodar, Russia.

The issue of complications of fistuloplasty of vesicovaginal fistulas (VVF) remains extremely relevant both for modern surgeons and for patients. Optimization of morphological characteristics by local interstitial application of Platelet-Rich Plasma (PRP) can positively affect the results of surgical treatment of VVF.

Purpose Of The Study: to conduct a comparative assessment of the morphological parameters of parafistulous tissues before and after local interstitial application of PRP. Read More

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Microbiota, renal disease and renal transplantation.

World J Transplant 2021 Mar;11(3):16-36

Nephrology and Dialysis Unit, Saints Cosmas and Damian Hospital, Pescia 51017, Italy.

Aim of this frontier review has been to highlight the role of microbiota in healthy subjects and in patients affected by renal diseases with particular reference to renal transplantation. The microbiota has a relevant role in conditioning the healthy status and the diseases. In particular gut microbiota is essential in the metabolism of food and has a relevant role for its relationship with the immune system. Read More

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Extract Attenuates Kidney Fibrosis Through Reducing Mesenchymal Transition and Inflammation in Ureteral Ligation Model in Mice.

Front Pharmacol 2021 17;12:621894. Epub 2021 Mar 17.

Department of Anatomy, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia.

Kidney fibrosis is the common final pathway of chronic kidney disease (CKD) and is characterized by inflammation, mesenchymal transition with myofibroblast formation and epithelial to mesenchymal transition (EMT). (CeA) is an herb that has a reno-protective effect. However, its mechanism of action in kidney fibrosis has not been elucidated. Read More

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Anti-TWEAK Antibody Alleviates Renal Interstitial Fibrosis by Increasing PGC-1α Expression in Lupus Nephritis.

J Inflamm Res 2021 26;14:1173-1184. Epub 2021 Mar 26.

Department of Rheumatology and Immunology, The Second Affiliated Hospital of Soochow University, Suzhou, People's Republic of China.

Purpose: Current studies on the mechanism of tumor necrosis factor-like weak inducer of apoptosis (TWEAK) in lupus nephritis (LN) mainly focus on the inflammatory pathway. Herein, we aimed to determine whether TWEAK could promote the progression of renal interstitial fibrosis by regulating peroxisome proliferator-activated receptor-gamma coactivator-1α (PGC-1α) expression and intervening in lipid metabolism in LN.

Materials And Methods: MRL/lpr mice, an animal model of lupus, were treated with the anti-TWEAK antibody or co-treated with adeno-associated virus-mediated PGC-1α short hairpin RNA (shRNA). Read More

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Change of the microvascularization in systemic sclerosis, a matter of air.

Best Pract Res Clin Rheumatol 2021 Apr 1:101683. Epub 2021 Apr 1.

Department of Rheumatology, Radboud University Medical Center, Nijmegen, the Netherlands. Electronic address:

Systemic sclerosis (SSc) is a rare complex disease, characterized by microvascular damage, auto-immunity, and fibrosis. Nailfold capillary microscopy (NCM), a safe and noninvasive imaging technique, can be used to visualize specific microvascular alterations in SSc. In this review, we discuss an interesting case of a patient with changes in microvascular pattern on NCM after pulmonary transplantation. Read More

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Current trends and future perspectives for heart failure treatment leveraging cGMP modifiers and the practical effector PKG.

J Cardiol 2021 Apr 1. Epub 2021 Apr 1.

Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.

Cyclic guanosine monophosphate (cGMP), an intracellular second messenger molecule synthesized by guanylated cyclases (GCs), controls various myocardial properties, including cell growth and survival, interstitial fibrosis, endothelial permeability, cardiac contractility, and cardiovascular remodeling. These processes are mediated by the main cGMP effector protein kinase G (PKG) activation of which exerts intrinsic protective responses against the adverse effects of neurohormonal stimulation and pathological cardiac stress. Therapeutic strategies that enhance cGMP levels and PKG activation have been used for heart failure, which can be executed by reducing natriuretic peptide (NP) proteolysis, enhancing cGMP synthesis, or blocking cGMP hydrolysis. Read More

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Collagen vitrigel membrane-coated nylon line prevents stenosis after conization of the cervix uteri.

Tissue Eng Part A 2021 Apr 3. Epub 2021 Apr 3.

Saga University Faculty of Medicine Graduate School of Medical Sciences, 38309, Pathology & Microbiology, Saga, Saga, Japan;

Cervical stenosis is a postoperative complication of conization for uterine cervical malignancy, but a standard method of preventing this complication has yet to be established. Collagen vitrigel is a collagen-based biomaterial that has anti-fibrotic and epithelization promoting actions. We evaluated the anti-stenotic effect of an indwelling collagen vitrigel membrane-coated nylon line (CVNL) following cervical conization in rabbits. Read More

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Effect of 3D printed polycaprolactone scaffold with a bionic structure on the early stage of fat grafting.

Mater Sci Eng C Mater Biol Appl 2021 Apr 16;123:111973. Epub 2021 Feb 16.

Department of General Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address:

Mature adipocytes are sensitive to stress and hypoxia, which are the two major obstacles in large-volume fat grafting. Bionic scaffolds are considered beneficial for fat grafting; however, their mechanism is still unclear. In this study, polycaprolactone scaffolds were fabricated by a 3D-printing technique and compounded with liposuction fat. Read More

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Association between pre-existing respiratory disease and its treatment, and severe COVID-19: a population cohort study.

Lancet Respir Med 2021 Apr 1. Epub 2021 Apr 1.

Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.

Background: Previous studies suggested that the prevalence of chronic respiratory disease in patients hospitalised with COVID-19 was lower than its prevalence in the general population. The aim of this study was to assess whether chronic lung disease or use of inhaled corticosteroids (ICS) affects the risk of contracting severe COVID-19.

Methods: In this population cohort study, records from 1205 general practices in England that contribute to the QResearch database were linked to Public Health England's database of SARS-CoV-2 testing and English hospital admissions, intensive care unit (ICU) admissions, and deaths for COVID-19. Read More

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