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Larazotide Acetate for Treatment of Celiac Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Clin Res Hepatol Gastroenterol 2021 Jul 30:101782. Epub 2021 Jul 30.

College of Medicine, Alfaisal University, Riyadh, Saudi Arabia; College of Graduate Health Sciences, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America. Electronic address:

Purpose: The standard of care for treatment of celiac disease (CD) is a stringent lifetime gluten-free diet (GFD). Larazotide acetate (AT-1001) is an anti-zonulin which functions as a gut permeability regulator for treatment of CD. We endeavored to conduct a systematic review and meta-analysis of all randomized controlled trials (RCTs) which studied the efficacy and safety of AT-1001 in patients with CD. Read More

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Anti-Glomerular Basement Membrane Disease (Goodpasture Disease): From Pathogenesis to Plasma Exchange to IdeS.

Ther Apher Dial 2021 Aug 2. Epub 2021 Aug 2.

Department of Medicine, University of Cambridge, Cambridge, United Kingdom.

Anti-glomerular basement membrane (GBM) disease (Goodpasture disease) often presents with severe kidney failure and pulmonary hemorrhage. Anti-GBM antibodies are pathogenic, and other autoantibodies such as laminin-521 have been identified recently, potentially indicating a subset with a more severe disease phenotype and poor prognosis. Around 30-40% of patients are also anti-neutrophil cytoplasmatic antibody (ANCA)-positive and this subset combines features of anti-GBM disease and ANCA-associated vasculitis, with particular impact on long-term treatment. Read More

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Biventricular dysfunction and lung congestion in athletes on anabolic androgenic steroids: a speckle tracking and stress lung echocardiography analysis.

Eur J Prev Cardiol 2021 Aug 2. Epub 2021 Aug 2.

Institute of Clinical Physiology, CNR, Pisa, Via G. Moruzzi, Pisa 56121, Italy.

Aims: The real effects of the chronic consumption of anabolic-androgenic steroids (AASs) on cardiovascular structures are subjects of intense debate. The aim of the study was to detect by speckle tracking echocardiography (STE) right ventricular (RV) and left ventricular (LV) dysfunction at rest and during exercise stress echocardiography (ESE) in athletes abusing AAS.

Methods And Results: One hundred and fifteen top-level competitive bodybuilders were selected (70 males), including 65 athletes misusing AAS for at least 5 years (users), 50 anabolic-free bodybuilders (non-users), compared to 50 age- and sex-matched healthy sedentary controls. Read More

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Are Wearable Sensors Valid and Reliable for Studying the Baseball Pitching Motion? An Independent Comparison With Marker-Based Motion Capture.

Am J Sports Med 2021 Aug 2:3635465211029017. Epub 2021 Aug 2.

Motion Analysis Laboratory, Mayo Clinic, Rochester, Minnesota, USA.

Background: In recent years, the prevalence of medial ulnar collateral ligament injuries has increased in throwers of all ages and skill levels. The motusBASEBALL sensor possesses an inertial measurement unit (IMU) that has been developed and applied to the throwing arm to allow for measurements of several objective parameters, which may prove beneficial for monitoring, rehabilitation, and injury prevention in the throwing athlete. However, the reliability, consistency, and validity of the IMU have not been independently assessed. Read More

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Iodized oil computed tomography versus ultrasound-guided radiofrequency ablation for early hepatocellular carcinoma.

Hepatol Int 2021 Aug 2. Epub 2021 Aug 2.

Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan.

Background And Purpose: Radiofrequency ablation (RFA) is the standard of care for early stage hepatocellular carcinoma (HCC). However, the clinical outcomes of iodized oil computed tomography (IoCT) versus ultrasound (US)-guided RFA for HCC remain unclear.

Methods: We retrospectively analyzed consecutive treatment-naïve patients who received curative RFA for HCC within Milan criteria from January 2016 to December 2018. Read More

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Patient-Specific Coronary Artery Bypass Graft 3D Printing: Implications for Procedural Planning in Complex Percutaneous Coronary Interventions.

J Invasive Cardiol 2021 Aug;33(8):E592-E603

Cardiac Catheterization Laboratory, Einstein Medical Center, 5501 Old York Road, Philadelphia, PA 19141 USA.

Background: Three-dimensional (3D) printing technology has seen tremendous growth in augmenting didactics, research, and preprocedural planning with structural heart procedures. Limited investigative efforts have been made in other areas of the cardiovascular spectrum. 3D-printed models (PMs) of anatomically complex coronary artery bypass graft (CABG) patients from coronary computed tomography angiography (CCTA) have implications for adaptive learning and preprocedural planning. Read More

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Virtual reality simulator metrics cannot be used to assess competence in ureteronephroscopy and stone removal - a validation study.

Scand J Urol 2021 Aug 2:1-5. Epub 2021 Aug 2.

Copenhagen Academy for Medical Education and Simulation (CAMES), Rigshospitalet, Copenhagen, Denmark.

Objective: The growing use of simulation-based training makes it necessary to develop efficient training programs in order to ensure optimal use of time and resources. Our aim was to develop and gather validity evidence for a simulation-based test in ureteronephroscopy and set a pass/fail standard for the test that will allow future mastery learning.

Design: This study is a validation study. Read More

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Biomarkers of Coronary Microvascular Dysfunction in Patients With Microvascular Angina: A Narrative Review.

Angiology 2021 Aug 2:33197211034267. Epub 2021 Aug 2.

Department of Excellence of Sciences for Health Promotion and Maternal-Child Care, Internal Medicine and Specialties (ProMISE), University of Palermo, Palermo, Italy.

The current gold standard for diagnosis of coronary microvascular dysfunction (CMD) in the absence of myocardial diseases, whose clinical manifestation is microvascular angina (MVA), is reactivity testing using adenosine or acetylcholine during coronary angiography. This invasive test can be difficult to perform, expensive, and harmful. The identification of easily obtainable blood biomarkers which reflect the pathophysiology of CMD, characterized by high reliability, precision, accuracy, and accessibility may reduce risks and costs related to invasive procedures and even facilitate the screening and diagnosis of CMD. Read More

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Payer perceptions of the use of real-world evidence in oncology-based decision making.

J Manag Care Spec Pharm 2021 Aug;27(8):1096-1105

Pfizer, Inc.

Randomized controlled trials (RCTs), the gold standard of safety and efficacy evidence, are conducted in select patients that may not mirror real-world populations. As a result, healthcare decision makers may have limited information when making formulary decisions, especially in oncology, given accelerated regulatory approvals and niche patient populations. Real-world evidence (RWE) studies may help address these knowledge gaps and help inform oncology formulary decision making. Read More

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Outcomes for Muscle-invasive Bladder Cancer with Radical Cystectomy or Trimodal Therapy in US Veterans.

Eur Urol Open Sci 2021 Aug 9;30:1-10. Epub 2021 Jun 9.

Division of Hematology-Oncology, Department of Internal Medicine, University of California San Diego, La Jolla, CA, USA.

Background: Muscle-invasive bladder cancer (MIBC) remains undertreated despite multiple potentially curative options. Both radical cystectomy (RC) with or without neoadjuvant chemotherapy and trimodal therapy (TMT), including transurethral resection of bladder tumor followed by chemoradiotherapy, are standard treatments.

Objective: To evaluate real-world clinical outcomes of RC with neoadjuvant chemotherapy (RC-NAC), RC without NAC, TMT with National Comprehensive Cancer Network guideline-preferred radiosensitizing chemotherapy including cisplatin or mitomycin-C and 5-fluorouracil (pTMT), and TMT with nonpreferred chemotherapy (npTMT). Read More

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Low PEEP Mechanical Ventilation and PaO/FiO Ratio Evolution in COVID-19 Patients.

SN Compr Clin Med 2021 Jul 24:1-8. Epub 2021 Jul 24.

Anaesthesiology Division, Balgrist University Hospital, Zürich, Switzerland.

Invasive mechanical ventilation (IMV) is the standard treatment in critically ill COVID-19 patients with acute severe respiratory distress syndrome (ARDS). When IMV setting is extremely aggressive, especially through the application of high positive-end-expiratory respiration (PEEP) values, lung damage can occur. Until today, in COVID-19 patients, two types of ARDS were identified (L- and H-type); for the L-type, a was supposed to be preferred, but data are still missing. Read More

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Microbiological and Clinicoepidemiological Profile of a Series of Patients with Infective Endocarditis at a Center in Eastern Nepal.

Can J Infect Dis Med Microbiol 2021 22;2021:9980465. Epub 2021 Jul 22.

Department of Internal Medicine, B. P. Koirala Institute of Health Sciences (BPKIHS), Dharan 56700, Sunsari, Nepal.

Background: The microbiological and clinicoepidemiological profile of infective endocarditis (IE) has undergone significant change over time. The pattern of IE studied at local level provides broader vision in understanding the current scenario of this disease. This study aimed to depict the overall picture of IE and its changing profile by evaluating the microbiological and clinicoepidemiological features in the context of a tertiary care center of eastern Nepal. Read More

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The Multivariable Multiaxial Suggestibility Inventory-2 (MMSI-2): A Psychometric Alternative to Measure and Explain Supernatural Experiences.

Front Psychol 2021 16;12:692194. Epub 2021 Jul 16.

School of Psychology, Education and Sport Sciences, Blanquerna, Ramon Llull University, Barcelona, Spain.

This paper presents the English adaptation of the (MMSI-2), a questionnaire developed specifically for psychological assessment and prediction of anomalous phenomena. The sample consisted of 613 respondents from England (47.6% were women and 52. Read More

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In a simulated adult trauma patient, can pelvic binders be applied accurately by paramedics and HEMS paramedics? A pilot observational study.

Samuel McCreesh

Br Paramed J 2021 May;6(1):23-29

Yorkshire Ambulance Service NHS Trust.

Background: Pre-hospital treatment of suspected haemorrhagic pelvic fractures includes application of a purpose-made pelvic binder. Recent hospital studies identified poor accuracy of pelvic binder application, but there is little pre-hospital research to date.

Methods: A pilot observational study was conducted in an NHS ambulance service to examine the accuracy of landmark identification and pelvic binder application. Read More

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Cancer-Associated Thrombosis: A Clinical Scoping Review of the Risk Assessment Models Across Solid Tumours and Haematological Malignancies.

Int J Gen Med 2021 24;14:3881-3897. Epub 2021 Jul 24.

Department of Internal Medicine, Faculty of Medicine, International Islamic University Malaysia, Kuantan, Pahang, Malaysia.

Cancer-associated thrombosis (CAT) is a leading cause of death in cancer patients receiving outpatient chemotherapy. The latest guidelines emphasize stratifying the patients in terms of CAT risks periodically. Multiple risk assessment models (RAMs) were developed to classify patients and guide thromboprophylaxis to high-risk patients. Read More

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Determination of Guanfacine in Oral Fluid and Serum of Children and Adolescents With Attention-Deficit/Hyperactivity Disorder: A Short Communication.

Ther Drug Monit 2021 Jul 30. Epub 2021 Jul 30.

Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Center of Mental Health, University Hospital Würzburg, Würzburg, Germany Institute for Pharmacy and Food Chemistry, University of Würzburg, Würzburg, Germany.

Background: Guanfacine, a selective α2A-adrenoreceptor agonist, is a second-line medication for treating children and adolescents with attention-deficit/hyperkinetic disorder (ADHD). The dosage administered as milligram per body weight to balance the potential benefits and risks of treatment. Therapeutic drug monitoring (TDM) is useful for identifying a patient's therapeutic window to optimize individual drug dosing and reduce the risk of adverse drug reactions. Read More

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Neoadjuvant Therapy for Resectable Pancreatic Cancer: A New Standard of Care. Pooled Data from Three Randomized Controlled Trials.

Ann Surg 2021 Jul 29. Epub 2021 Jul 29.

Department of Surgery and Transplantation, University Hospital Zurich, Zurich, Switzerland Department of Surgery, University Hospital Erlangen, Erlangen, Germany Division of Pancreatic Surgery, IRCCS, Azienda Ospedaliero Universitaria di Bologna, Bologna, Italy Department of Internal Medicine and Surgery (DIMEC), Alma Mater Studiorum, University of Bologna, S.Orsola-Malpighi Hospital, Bologna, Italy Epidemiology, Biostatistics and Prevention Institute, University of Zurich, Zurich, Switzerland Department of Oncology, University Hospital Zurich, Zurich, Switzerland Department of Radiation Oncology, University Hospital Magdeburg, Magdeburg, Germany Department of Radiation Oncology, University Hospital Erlangen, Erlangen, Germany Department of Surgery, Hospital Ansbach, Ansbach, Germany Department of Experimental, Diagnostic and Specialty Medicine, S. Orsola-Malpighi University Hospital, Bologna, Italy Medical Oncology, IRCCS Azienda Ospedaliero, University of Bologna, Bologna, Italy Department of General, Visceral- and Transplantation Surgery, University Hospital Frankfurt am Main, Frankfurt, Germany Department of General and Transplantation Surgery, University Hospital Cologne, Köln, Germany Department of Digestive Surgery and Liver Transplantation, Croix Rousse University Hospital, University Lyon, Lyon, France Department of General, Visceral and Transplantation Surgery, University Hospital of Mainz, Mainz, Germany.

Objective: The aim of this study was to pool data from randomized controlled trials (RCT) limited to resectable pancreatic ductal adenocarcinoma (PDAC) to determine whether a neoadjuvant therapy impacts on disease-free survival (DFS) and surgical outcome.Summary Background Data: Few underpowered studies have suggested benefits from neoadjuvant chemo (± radiation) for strictly resectable PDAC without offering conclusive recommendations.

Methods: Three RCTs were identified comparing neoadjuvant chemo (± radio) therapy vs. Read More

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[Examination of Analytical Method for Mothproofing Agents to Revise the Official Methods Based on "Act on the Control of Household Products Containing Harmful Substances"].

Yakugaku Zasshi 2021 ;141(8):1031-1040

National Institute of Health Sciences.

In Japan, the use of mothproofing agents [dieldrin and 4,6-dichloro-7-(2,4,5-trichlorophenoxy)-2-trifluoromethylbenzimidazole; DTTB] in textiles is regulated by the Act on the Control of Household Products Containing Harmful Substances. Since official analytical methods for these agents have been in place for approximately 40 years, we developed an improved method in a previous study. In the present study, we validated this method. Read More

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January 2021

Application of Quantitative NMR Spectroscopy to the Quality Evaluation of Diclofenac Gargles as Hospital Preparations.

Chem Pharm Bull (Tokyo) 2021 ;69(8):721-726

Division of Pharmacy, Ehime University Hospital.

Hospital preparations are frequently prepared in Japanese hospitals when ready-made formulations to meet patients' needs are unavailable. Although the quality of hospital preparations have to be ensured for efficacy and safety, such quality evaluation tends to be insufficient mainly due to lack of manpower and experimental environments in hospitals. In this paper, we investigated the applicability of quantitative (q)NMR spectroscopy to the quality control of diclofenac gargles as examples of hospital preparations, as it has various merits for the quantitative analysis of mixtures in solutions. Read More

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January 2021

Sumac fruit supplementation improve glycemic parameters in patients with metabolic syndrome and related disorders: A systematic review and meta-analysis.

Phytomedicine 2021 Jul 21:153661. Epub 2021 Jul 21.

Songhor Healthcare Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.

Background: Metabolic syndrome (MetS) is the one of the main causes of mortality worldwide. Several randomized controlled trials (RCTs) have revealed the beneficial effects of sumac (Rhus coriaria) on cardiometabolic risk factors. However, the entirety of the evidence has yet to be summarized in a systematic review. Read More

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Internal limiting membrane graft in full-thickness macular hole secondary to macular telangiectasia type 2.

J Fr Ophtalmol 2021 Jul 29. Epub 2021 Jul 29.

Department of Ophthalmology, Antalya Education and Research Hospital, University of Health Sciences, Antalya, Turkey. Electronic address:

We present a case report of an autologous internal limiting membrane (ILM) graft transposition technique in a 60-years-old female patient who with a full-thickness macular hole (FTMH) secondary to idiopathic macular telangiectasia type 2 (MacTel type 2). To our knowledge, our case is the first report of ILM graft transposition to treat persistent FTMH secondary to MacTel type 2. MacTel type 2 is an acquired disease characterized by macular capillary abnormalities and retinal neurodegeneration. Read More

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Current knowledge about biomarkers of acute kidney injury in liver cirrhosis.

Clin Mol Hepatol 2021 Aug 2. Epub 2021 Aug 2.

Departments of Internal Medicine, Korea University College of Medicine, Seoul, Korea.

Acute kidney injury (AKI) is common in advanced cirrhosis. Prerenal azotemia, hepatorenal syndrome, and acute tubular necrosis are the main causes of AKI in patients with cirrhosis. Evaluation of renal function and differentiation between functional and structural kidney injury are important issues in the management of cirrhosis. Read More

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Phase II clinical trial of personalized VCD-VTD sequential therapy using the Vulnerable Elders Survey-13 (VES-13) for transplant-ineligible patients with newly diagnosed multiple myeloma.

Ann Hematol 2021 Jul 31. Epub 2021 Jul 31.

Department of Hematology, Kitasato University School of Medicine, Sagamihara, Japan.

The Vulnerable Elders Survey-13 (VES-13) is a well-studied simplified frailty screening tool for elderly patients in the oncology setting. We conducted a prospective clinical trial to evaluate the efficacy and safety of dose-adjusted treatment based on the VES-13 in transplant-ineligible patients with newly diagnosed multiple myeloma (MM). In the Fit group (VES-13 <3), patients were treated with 4 cycles of standard-dose VCD (bortezomib, cyclophosphamide, and dexamethasone) followed by 4 cycles of standard-dose VTD (bortezomib, thalidomide, and dexamethasone). Read More

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Meta-analysis of controlled studies on minimally interrupted vs. continuous use of non-vitamin K antagonist oral anticoagulants in catheter ablation for atrial fibrillation.

Europace 2021 Aug 1. Epub 2021 Aug 1.

Department of Cardiology, Radboud Institute for Health Sciences, Radboud University Medical Center, PO Box 6101, 6500 HB Nijmegen, the Netherlands.

Aims: At present, there are no guideline recommendations for minimally interrupted use of non-vitamin K antagonist oral anticoagulants (mi-NOAC) during catheter ablation (CA) for atrial fibrillation (AF). Current evidence is predominantly based on observational studies, with continuous use of vitamin K antagonist in the control arm. This quantitative summary reflects the first high-level evidence on contemporary regimens, with continuous NOAC use (c-NOAC) as the current gold standard. Read More

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A liquid chromatography-tandem mass spectrometry method for the determination of apixaban in human plasma and its application to pharmacokinetics studies in the Indian population.

Anal Methods 2021 Aug 1. Epub 2021 Aug 1.

Department of Chemistry, Sunandan Divatia School of Science, NMIMS University, Mumbai 400056, India.

Apixaban is a novel oral anticoagulant intended to treat and prevent blood clots and to prevent strokes in patients with nonvalvular atrial fibrillation. The development and validation of a fast, selective, accurate, and precise method using high-performance liquid chromatography tandem mass spectrometry is described for the estimation of apixaban in human plasma, with apixaban 13CD3 as an internal standard (IS). Using a reverse phase Gemini C18 column (50 mm × 4. Read More

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Impact of compression stockings on wound healing and complications in ankle fractures: A retrospective cohort study.

Int J Orthop Trauma Nurs 2021 May 5;43:100866. Epub 2021 May 5.

Department of Orthopaedic Surgery and Traumatology, Kolding Hospital - part of Hospital Lillebaelt, Denmark; Department for Regional Health Research, University of Southern Denmark, Denmark. Electronic address:

Introduction: Ankle fractures treated with open reduction and internal fixation (ORIF) have a high incidence of wound complications. By reducing oedema, wound complications can, in theory, be minimized. This study investigates the impact of compression stocking (CS) on such complications after treatment with ORIF. Read More

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Appraisal of multivariable prognostic models for post-operative liver decompensation following partial hepatectomy: a systematic review.

HPB (Oxford) 2021 Jul 6. Epub 2021 Jul 6.

Department of Public Health Sciences, Queen's University, Kingston, ON, Canada; Division of Cancer Care and Epidemiology, Queen's Cancer Research Institute, Kingston, ON, Canada.

Background: Few reports have evaluated prognostic modelling studies of tools used for surgical decision-making. This systematic review aimed to describe and critically appraise studies that have developed or validated multivariable prognostic models for post-operative liver decompensation following partial hepatectomy.

Methods: This study was designed using the CHARMS checklist. Read More

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Mechanical Thrombectomy of Carotid Terminus Occlusion Using Direct Aspiration Technique-Video Illustration: 2-Dimensional Operative Video.

Oper Neurosurg (Hagerstown) 2021 Jul 31. Epub 2021 Jul 31.

Department of Neurosurgery, Medical University of South Carolina, Charleston, South Carolina, USA.

Acute carotid terminus occlusion (CTO) is responsible for up to 5% of acute ischemic strokes secondary to emergent large vessel occlusion (ELVO) and up to 20% of acute internal carotid artery (ICA) occlusions.1 The term "CTO" has also been used to describe occlusions in the supra-clinoid segment or at the bifurcation of the ICA. Compared to other ELVOs, patients with CTO present with higher stroke severity and larger infarct volume, likely to be a result of disruption of direct Circle of Willis collaterals across the anterior communicating artery (AComA) and posterior communicating artery (PComA). Read More

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Reliable SERS detection of pesticides with a large-scale self-assembled [email protected]@Ag nanoparticle array.

Spectrochim Acta A Mol Biomol Spectrosc 2021 Jul 21;263:120218. Epub 2021 Jul 21.

Institute of Quartermaster Engineering and Technology, Academy of Military Sciences PLA China, Beijing 100010, China.

The fabrication of sensitive and reliable interfacial plasmonic platform for measuring chemical contaminants in various phases is an exciting topic in the food industry and for environment monitoring. In this study, a high-performance surface-enhanced Raman spectroscopy (SERS) analytic platform was developed through self-assembly of the [email protected] [email protected] nanoparticles ([email protected]@Ag NPs) at the cyclohexane/water interface. By addition of the inducer ethanol, the [email protected]@Ag NPs in aqueous phase was effectively migrated to the biphasic interface, forming a large-scale close-packed nanoparticle array. Read More

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Application of ultra-sensitive GC-QqQ-MS/MS (MRM) method for the determination of diclofenac in whole blood samples without derivatization.

J Chromatogr B Analyt Technol Biomed Life Sci 2021 Jul 23;1179:122860. Epub 2021 Jul 23.

Wroclaw Medical University Department of Forensic Medicine, 4 J. Mikulicza-Radeckiego Street, Wroclaw 50345, Poland.

Diclofenac is one of the most frequently prescribed nonsteroidal anti-inflammatory drugs (NSAID) worldwide. Although it is considered a relatively safe drug, it exhibits high toxicity to some animal populations (e.g. Read More

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