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The Pattern of Superficial Lymphadenopathy on Fine Needle Aspiration Cytology in Clinical Practice in Islamabad.

Cureus 2021 Aug 10;13(8):e17075. Epub 2021 Aug 10.

Medical Affairs and Clinical Research, Hilton Pharma Pvt. Ltd., Karachi, PAK.

Background:  In adults, lymph nodes are not normally palpable. A number of patients with asymptomatic lymphadenopathy never visit physicians for the condition, and thus, this important sign is often missed by the medical practitioner if it is not the presenting complaint. The incidence of lymphadenopathy is suggested to be increasing. Read More

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Homeopathic Treatment for COVID-19-Related Symptoms: A Case Series.

Complement Med Res 2021 Sep 14:1-6. Epub 2021 Sep 14.

Center for Integrative Complementary Medicine, Shaare Zedek Medical Center, Jerusalem, Israel.

Background: Severe acute respiratory syndrome due to coronavirus 2 (SARS CoV-2) is a novel infectious disease, which has quickly developed into a pandemic. The spectrum of COVID-19 symptoms is broad, ranging from a mild, self-limiting respiratory tract illness to severe progressive pneumonia, multi-organ failure and possible death. Despite much effort and multiple clinical trials, there are, to date, no specific therapeutic agents to treat or cure the coronavirus infection. Read More

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September 2021

Development of Inspired Therapeutics Pediatric VAD: Benchtop Evaluation of Impeller Performance and Torques for MagLev Motor Design.

Cardiovasc Eng Technol 2021 Sep 13. Epub 2021 Sep 13.

Inspired Therapeutics LLC, 125 E. Merritt Island Cswy, #107-341, Merritt Island, FL, 32925, USA.

Purpose: Despite the availability of first-generation extracorporeal mechanical circulatory support (MCS) systems that are widely used throughout the world, there is a need for the next generation of smaller, more portable devices (designed without cables and a minimal number of connectors) that can be used in all in-hospital and transport settings to support patients in heart failure. Moreover, a system that can be universally used for all indications for use including cardiopulmonary bypass (CPB), uni- or biventricular support (VAD), extracorporeal membrane oxygenation (ECMO) and respiratory assist that is suitable for use for adult, neonate, and pediatric patients is desirable. Providing a single, well designed, universal technology could reduce the incidence of human errors by limiting the need for training of hospital staff on a single system for a variety of indications throughout the hospital rather than having to train on multiple complex systems. Read More

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September 2021

A Phase 1 Study of an MPS1 Inhibitor (BAY 1217389) in Combination with Paclitaxel using a novel Randomized Continual Reassessment Method for Dose Escalation.

Clin Cancer Res 2021 Sep 13. Epub 2021 Sep 13.

Department of Medical Oncology, Erasmus MC Cancer Institute

Purpose: MPS1 kinase inhibitor, BAY 1217389 (BAY) synergizes with paclitaxel. This phase 1 study assessed the combination of BAY with paclitaxel using a novel randomized continuous reassessment method (rCRM) to improve dose determination.

Experimental Design: Patients with solid tumors were randomized to receive oral BAY (BID 2‑days‑on/5‑days‑off) with weekly paclitaxel (90 mg/m) or paclitaxel monotherapy in cycle 1. Read More

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September 2021

Two years outcomes of treating full-thickness macula hole associated with idiopathic macular telangiectasia type 2 by internal limiting membrane inverted flap technique: Case reports.

Medicine (Baltimore) 2021 Sep;100(36):e27078

Department of Ophthalmology, Akita University Graduate School of Medicine, Akita, Japan.

Rational: Macular telangiectasia (MacTel) is an uncommon ocular disorder that can lead to legal blindness. MacTel type 2 is characterized by a bilateral loss of macular transparency, the presence of white crystals on the retina, aberrant blood vessel growth, and neurodegeneration of the macula. Full-thickness macular holes (FTMHs) are a prominent cause of vision reduction in MacTel type 2, and the standard care for an FTMH is pars plana vitrectomy (PPV) to restore the FTMH and best-corrected visual acuity (BCVA). Read More

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September 2021

A Review of Four Practice Guidelines of Inflammatory Bowel Disease.

Cureus 2021 Aug 3;13(8):e16859. Epub 2021 Aug 3.

Clinical Research, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, USA.

Inflammatory bowel disease (IBD) is a term that encompasses conditions characterized by chronic inflammation of the gastrointestinal tract (GIT). It includes Crohn's disease and ulcerative colitis. Major scientific organizations interested in gastrointestinal systems or GIT-focused organizations worldwide release guidelines for diagnosing, classifying, managing, and treating IBD. Read More

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Portal Vein Thrombosis and Splenic Infarction in a COVID-19 Patient.

Cureus 2021 Aug 2;13(8):e16843. Epub 2021 Aug 2.

Internal Medicine, Jersey Shore University Medical Center/Saint Francis Medical Center Program, Trenton, USA.

COVID-19 is a novel viral infection that primarily affects the lungs and runs the gamut from a mild, self-limiting, febrile illness to respiratory failure and death. It manifested as a global pandemic in 2020 and has since claimed millions of lives. Only a few months into this pandemic, it became evident that the viral infection leads to a hypercoagulable state. Read More

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Surgical Treatment of Epiretinal Membrane.

Acta Med Okayama 2021 Aug;75(4):403-413

Department of Ophthalmology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences.

Epiretinal membrane (ERM) is a common retinal disease characterized by cellular proliferation and metaplasia that lead to the formation of a pathological fibrocellular membrane immediately superjacent to the inner retinal surface. The vast majority of ERMs are considered idiopathic. However, ERM formation can result from various primary intraocular diseases, including retinal breaks and detachment, retinal vascular diseases, and vitreoretinal inflammatory conditions. Read More

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Single-layer Inverted Internal Limiting Membrane Flap Versus Conventional Peel for Small- or Medium-sized Full-thickness Macular Holes.

Am J Ophthalmol 2021 Sep 9. Epub 2021 Sep 9.

Department of Ophthalmology, Chang Gung Memorial Hospital, Linkou Medical Center, Taiwan; College of Medicine, Chang Gung University, Taoyuan, Taiwan; Department of Ophthalmology, Chang Gung Memorial Hospital, Keelung, Taiwan. Electronic address:

Purpose: To compare the outcomes of using an internal limiting membrane (ILM) flap and the conventional ILM peel technique for small- or medium-sized full-thickness macular hole (FTMH) repair.

Design: Retrospective, interventional case series.

Methods: Eyes with an FTMH ≤ 400 µm that underwent vitrectomy with either a single-layer inverted ILM flap (flap group, 55 eyes) or an ILM peel (peel group, 62 eyes) were enrolled. Read More

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September 2021

Long COVID Patient Symptoms and its Evaluation and Management.

JNMA J Nepal Med Assoc 2021 Aug 12;59(240):823-831. Epub 2021 Aug 12.

Department of Computer Science, Marquette University, Milwaukee, Wisconsin, United States of America.

While the acute case burdens and deaths from the COVID-19 pandemic (in Nepal approaching 700,000 and 10,000 respectively) have been costly, the characteristics and potentially huge dimensions of the chronic disease sequelae of this infectious disease are only slowly becoming apparent. We reviewed Pub Med, major medical meeting and medical journal, and investigative journalist materials seeking to frame and describe COVID-19 chronic disease. The consequences of COVID-19 infections follow major organ damage, and induction of immunological and hormonal systems dysfunction. Read More

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Risk factors for failure of resolving optic disc pit maculopathy after primary vitrectomy without laser photocoagulation.

Jpn J Ophthalmol 2021 Sep 9. Epub 2021 Sep 9.

Department of Ophthalmology, Kyorin University School of Medicine, 6-20-2, Shinkawa, Mitaka, Tokyo, 181-8611, Japan.

Purpose: To determine factors significantly correlated with the failure of macular reattachment by pars plana vitrectomy (PPV) without laser photocoagulation of the optic disc margin to treat optic disc pit (ODP) maculopathy.

Design: Retrospective, interventional case series.

Methods: We reviewed the medical records of 35 consecutive patients with ODP maculopathy who underwent PPV without laser photocoagulation. Read More

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September 2021

Irinotecan and its metabolite SN38 inhibits procollagen I production of dermal fibroblasts from Systemic Sclerosis patients.

Sci Rep 2021 Sep 9;11(1):18011. Epub 2021 Sep 9.

Service de Médecine Interne et Maladies Infectieuses, Hôpital Saint-André, CHU de Bordeaux, 1 rue Jean Burguet, 33000, Bordeaux, France.

Systemic sclerosis (SSc) is a rare autoimmune connective tissue disease characterized by a microangiopathy and fibrosis of the skin and internal organs. No treatment has been proved to be efficient in case of early or advanced SSc to prevent or reduce fibrosis. There are strong arguments for a key role of topo-I in the pathogenesis of diffuse SSc. Read More

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September 2021

Anthracyclines Strike Back: Rediscovering Non-Pegylated Liposomal Doxorubicin in Current Therapeutic Scenarios of Breast Cancer.

Cancers (Basel) 2021 Sep 1;13(17). Epub 2021 Sep 1.

Department of Medicine, Surgery and Health Sciences, University of Trieste, 34127 Trieste, Italy.

Anthracyclines are among the most active chemotherapies (CT) in breast cancer (BC). However, cardiotoxicity is a risk and peculiar side effect that has been limiting their use in clinical practice, especially after the introduction of taxanes. Non-pegylated liposomal doxorubicin (NPLD) has been developed to optimize the toxicity profile induced by anthracyclines, while maintaining its unquestionable therapeutic index, thanks to its delivering characteristics that increase its diffusion in tumor tissues and reduce it in normal tissues. Read More

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September 2021

Internal Limiting Membrane Peeling versus Nonpeeling to Prevent Epiretinal Membrane Formation following Vitrectomy for Posterior Segment Open-Globe Injury.

J Ophthalmol 2021 28;2021:3152728. Epub 2021 Aug 28.

The Eye Hospital, School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, Zhejiang, China.

Purpose: Approximately 30% of patients with an open-globe injury (OGI) develop a secondary epiretinal membrane (ERM). This study was performed to assess whether internal limiting membrane (ILM) peeling in the treatment of posterior segment OGI prevents ERM formation.

Methods: The medical records of 33 patients who underwent vitrectomy for posterior segment OGI from 2016 to 2019 were retrospectively analyzed. Read More

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Insulin-like growth factor 2 and incidence of liver cancer in a nested case-control study.

Cancer Epidemiol Biomarkers Prev 2021 Sep 8. Epub 2021 Sep 8.

Department of Public Health, Hokkaido University Faculty of Medicine.

Background: Insulin-like growth factor (IGF)2 is a potent mitogen. To elucidate the relationship between IGF2 and risk of tumorigenesis, we analyzed associations between serum levels of IGF2 and incidence of liver cancer in a prospective case-control study nested in the Japan Collaborative Cohort study.

Methods: A baseline survey was conducted from 1988 using blood samples from 39,242 subjects. Read More

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September 2021

Improving Chemotherapy-Induced Peripheral Neuropathy in Patients with Breast or Colon Cancer after End of (Neo)adjuvant Therapy: Results from the Observational Study STEFANO.

Oncol Res Treat 2021 Sep 8:1-9. Epub 2021 Sep 8.

Medical Department, iOMEDICO, Freiburg im Breisgau, Germany.

Introduction: Chemotherapy-induced peripheral neuropathy (CIPN) is a common side effect persisting after completion of neurotoxic chemotherapies. This observational study was designed to evaluate the effectiveness of the dietary supplement OnLife® (patented mixture of specific fatty acids and palmitoylethanolamide) in improving symptoms of CIPN in breast and colon cancer patients.

Methods: Improvement of CIPN was evaluated in adult patients, previously treated with (neo)adjuvant paclitaxel- (breast cancer) or oxaliplatin-based (colon cancer) therapies, receiving OnLife® for 3 months after completion of chemotherapy. Read More

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September 2021

Surgical Management of Recurrent and Persistent Macular Holes: A Practical Approach.

Ophthalmol Ther 2021 Sep 7. Epub 2021 Sep 7.

Cole Eye Institute, Cleveland Clinic, 9500 Euclid Ave, i-32, Cleveland, OH, 44195, USA.

Primary surgery for macular hole (MH) closure has a high success rate with current methods of pars plana vitrectomy and internal limiting membrane (ILM) peeling. When primary surgery fails, there are several options available for secondary repair, including extension of the ILM peel, creation of an ILM flap, pedunculated ILM flap, lens capsule flap transplantation, autologous retinal transplantation, use of a human amniotic membrane plug, adjuvant autologous platelet concentrate, induction of macular detachments with subretinal blebs, and creation of retinal incisions. In this review, we discuss the practical approach to each of these surgical techniques for the management of recurrent or persistent MHs. Read More

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September 2021

Values and preferences towards medical cannabis among people living with chronic pain: a mixed-methods systematic review.

BMJ Open 2021 09 7;11(9):e050831. Epub 2021 Sep 7.

Department of Health Research Methods, Evidence & Impact, McMaster University, Hamilton, Ontario, Canada

Objective: To explore values and preferences towards medical cannabis among people living with chronic pain.

Design: Mixed-methods systematic review.

Data Sources: We searched MEDLINE, EMBASE and PsycINFO from inception to 17 March 2020. Read More

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September 2021

Flap technique-assisted surgeries for advanced retinitis pigmentosa complicated with macular hole: a case report and literature review.

BMC Ophthalmol 2021 Sep 6;21(1):322. Epub 2021 Sep 6.

Department of Ophthalmology, National Taiwan University Hospital, Medical College, National Taiwan University, 7 Chung-Shan S. Road, Taipei, Taiwan.

Background: Full-thickness macular hole (FTMH) is a rare complication in retinitis pigmentosa (RP) patients and may increase intraoperative challenges. Furthermore, lens capsular flap transplantation and inverted internal limiting membrane (ILM) flap were reported to close complicated FTMH successfully. Here, we present a case of bilateral advanced RP complicated by a FTMH treated with a novel lens capsular flap transplantation and inverted internal limiting membrane flap. Read More

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September 2021

The Spectrum of Internal Limiting Membrane Disease in Alport Syndrome: a Multimodal Imaging Study.

Retina 2021 Sep 1. Epub 2021 Sep 1.

Department of Ophthalmology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA School of Medicine, Vita-Salute San Raffaele University, Milan, Italy Department of Ophthalmology, IRCCS San Raffaele Scientific Institute, Milan, Italy Department of Ophthalmology, Medical University of Vienna, Vienna, Austria Division of Nephrology and Hypertension, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL Division of Nephrology and Dialysis, Department of Medicine III, Medical University of Vienna, Vienna, Austria Institute of Medical Genetics, Medical University of Vienna, Vienna, Austria Centre for Nephrology and Metabolic Medicine, Weisswasser, Germany.

Purpose: To characterize the spectrum of internal limiting membrane (ILM) disease in Alport syndrome (AS) using multimodal imaging, including widefield (WF) and ultra-widefield (UWF) modalities, and to report their relative prevalence according to the genetic pattern of inheritance.

Methods: Cross-sectional clinical study of patients diagnosed with AS. All patients underwent UWF color photography and autofluorescence, WF-optical coherence tomography angiography (OCTA), and spectral-domain OCT (SD-OCT). Read More

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September 2021

Effects of the COVID-19 Pandemic on Solid Organ Transplantation During 2020 in Poland Compared with Countries in Western Europe, Asia, and North America: A Review.

Med Sci Monit 2021 Sep 4;27:e932025. Epub 2021 Sep 4.

Department of General and Transplantation Surgery, Medical University of Warsaw, Warsaw, Poland.

The coronavirus disease 2019 (COVID-19) pandemic, due to infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which began in March 2020, affected organ donor acceptance and rates of heart, lung, kidney, and liver transplants worldwide. According to data reported to POLTRANSPLANT, the number of solid organ transplants decreased by over 35% and the number of patients enlisted de novo for organ transplantation was reduced to 70% of its pre-COVID-19 volume in Poland. Most transplant centers in Western Europe and the USA have also drastically reduced their activity when compared to the pre-pandemic era. Read More

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September 2021

Internal limiting membrane detachment in acute central retinal artery occlusion: a novel prognostic sign seen on OCT.

Int J Retina Vitreous 2021 Sep 3;7(1):51. Epub 2021 Sep 3.

Medical Retina and Vitreoretinal Surgery, University of Pittsburgh School of Medicine, 203 Lothrop Street, Suite 800, Pittsburg, PA, 15213, USA.

Background: To present a series of acute central retinal artery occlusion (CRAO) cases showing internal limiting membrane detachment (ILMD) on optical coherence tomography (OCT) and to describe the possible etiopathogenesis and outcomes associated with it.

Methods: Demographic and OCT features of patients with acute CRAO were analysed retrospectively. OCT parameters noted were posterior vitreous opacities, ILMD, inner retinal layer stratification, hyperreflectivity and thickening, cystoid macular edema, neurosensory detachment. Read More

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September 2021

Combined fovea-sparing internal limiting membrane peeling with internal limiting membrane flap technique for progressive myopic traction maculopathy.

Graefes Arch Clin Exp Ophthalmol 2021 Sep 3. Epub 2021 Sep 3.

Department of Ophthalmology, National Taiwan University Hospital, Taipei, Taiwan.

Background: To present the anatomical and functional outcomes of combined fovea-sparing internal limiting membrane peeling (FSIP) with internal limiting membrane flap (ILMF) for myopic traction maculopathy (MTM).

Methods: This is a retrospective, observational study. Included were 66 eyes of 62 patients who underwent vitrectomy with combined FSIP and ILMF (or modified ILMF) for MTM with a minimal follow-up of 6 months. Read More

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September 2021

A Rare Case of Rapidly Transforming Pancreatitis With Life-Threatening Complications and Multi-Organ Failure.

Cureus 2021 Jul 30;13(7):e16766. Epub 2021 Jul 30.

Internal Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, USA.

Acute pancreatitis affects approximately 50,000-80,000 Americans each year. Eighty percent of those cases are related to alcohol use or biliary stones. It has traditionally been thought of as a self-limiting disease, in which the pancreas fully recovers with little or no intervention. Read More

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Theory and simulations of homonuclear three-spin systems in rotating solids.

J Chem Phys 2021 Aug;155(8):084201

Institut des Sciences et Ingénierie Chimiques, Ecole Polytechnique Fédérale de Lausanne (EPFL), CH-1015 Lausanne, Switzerland.

The homonuclear dipolar coupling is the internal spin interaction that contributes the most to the line shapes in magic-angle-spinning (MAS) H NMR spectra of solids, and linewidths typically extend over several hundred Hertz, limiting the H resolution. Understanding and reducing this contribution could provide rich structural information for organic solids. Here, we use average Hamiltonian theory to study two- and three-spin systems in the fast MAS regime. Read More

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A randomized pilot study of Rhythms And You (RAY): An internet-based program for bipolar disorder administered with and without clinical helper support in primary care.

J Affect Disord 2021 Aug 24;295:183-191. Epub 2021 Aug 24.

University of Pittsburgh School of Medicine, Department of Psychiatry, Pittsburgh, PA, United States.

Background: Rhythms And You (RAY) is an online intervention for bipolar disorders (BD) based on Interpersonal and Social Rhythm Therapy. We examined RAY's feasibility and acceptability for individuals with BD recruited from primary care. Because online interventions may be more effective when paired with human support, we evaluated RAY with and without weekly brief (∼5 min) calls from clinical helpers (CH). Read More

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Proteomics of Shell Matrix Proteins from the Cuttlefish Bone Reveals Unique Evolution for Cephalopod Biomineralization.

ACS Biomater Sci Eng 2021 Sep 1. Epub 2021 Sep 1.

Department of Innovation in Medical Education, and Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa K1H8M5, Ontario, Canada.

In contrast to the external shells in bivalves and gastropods, most cephalopods are missing this external protection. The cuttlefish, belonging to class cephalopod, has an internal biomineralized structure made of mainly calcium carbonate for controlling buoyancy. However, the macromolecules, especially proteins that control cuttlebone mineral formation, are not sufficiently understood, limiting our understanding of the evolution of this internal shell. Read More

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September 2021

Inferior Vena Cava Tumor Thrombus Secondary to Mucinous Adenocarcinoma of the Stomach.

Cureus 2021 Jul 21;13(7):e16543. Epub 2021 Jul 21.

Internal Medicine, University of Kansas School of Medicine, Wichita, USA.

The expansion of a tumor into a blood vessel is known as a tumor thrombus. Tumor thrombi are caused by many types of cancers and commonly confer a poor prognosis. Tumor thrombus secondary to non-hepatic gastrointestinal cancers are rare and when reported is typically seen in the portal vein rather than the inferior vena cava (IVC). Read More

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Mycotic infection prevalence among patients undergoing bronchoalveolar lavage with search of SARS-CoV-2 after two negative nasopharyngeal swabs.

J Breath Res 2021 09 13;15(4). Epub 2021 Sep 13.

Department of Translational Medicine, University of Piemonte Orientale, Novara, Italy.

The evidence that severe coronavirus disease 2019 (COVID-19) is a risk factor for development of mycotic respiratory infection with an increased mortality is rising. Immunosuppressed are among the most susceptible patients andspecies is the most feared superinfection. In this study we evaluated mycotic isolation prevalence on bronchoalveolar lavage (BAL) of patients who underwent bronchoscopy in search of severe acute respiratory coronavirus 2 (SARS-CoV-2) RNA. Read More

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September 2021

Marked self-limiting sinus bradycardia in COVID-19 patients not requiring therapy in the intensive care unit - case series report.

Pol Merkur Lekarski 2021 Aug;49(292):295-302

Department of Internal Medicine, Józef Struś Hospital, temporarily: COVID-19-dedicated Hospital, Poznań, Poland.

Cardiovascular complications of the COVID-19 comprise cardiac arrhythmias, including sinus bradycardia (SB).

Case Reports: The authors present clinical data of 19 hospitalized patients (12 males), aged 20-73 years, with marked (less than 45/min during daily hours) self-limiting SB. None of them had SB at admission or earlier, none had used cardiovascular medications potentially decreasing the heart rate. Read More

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