Biochem Biophys Res Commun 2021 May 1;555:109-114. Epub 2021 Apr 1.
Department of Bio-Systems Engineering, Graduate School of Science and Engineering, Yamagata University, 4-3-16 Jyonan, Yonezawa, 992-8510, Japan. Electronic address:
Desmin, an intermediate filament protein expressed in muscle cells, plays a key role in the integrity and regulation of the contractile system. Furthermore, the distribution of desmin in cells and its interplay with plasma and organelle membranes are crucial for cell functions; however, the fundamental properties of lipid-desmin interactions remain unknown. Using a water-in-oil method for a limited space system in vitro, we examined the distribution of desmin in three types of phospholipid droplets: 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC), 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE), and 1,2-dioleoyl-sn-glycero-3-phosphoserine (DOPS). Read More