Food Chem Toxicol 2022 Aug 5:113332. Epub 2022 Aug 5.
Department of Environmental and Global Health, College of Public Health and Health Professions, University of Florida, Gainesville, FL, United States; Center for Environmental and Human Toxicology, University of Florida, Gainesville, FL, United States. Electronic address:
Meloxicam is a non-steroidal anti-inflammatory drug (NSAID) commonly used in food-producing animals, including chickens in an extralabel manner. This study aimed to develop a physiologically based pharmacokinetic (PBPK) model for meloxicam in broiler chickens and laying hens to facilitate withdrawal interval (WDI) estimations. The model structure for broiler chickens contained six compartments including plasma, muscle, liver, kidney, fat and rest of body, while an additional compartment of ovary was included for laying hens. Read More