68 results match your criteria interconnection clusters

HIV-1 molecular transmission network among sexually transmitted populations in Liaoning Province, China.

Medicine (Baltimore) 2021 Jul;100(28):e26640

Liaoning Provincial Center for Disease Control and Prevention, Shenyang, Liaoning, China.

Introduction: In recent years, with the development of molecular epidemiology, molecular transmission networks based on evolutionary theory and sequence analysis have been widely used in research on human immunodeficiency virus (HIV)-1 transmission dynamics and precise intervention for high-risk populations. The HIV-1 molecular transmission network is a new method to study the population's access to the network, the characteristics of clustering, and the characteristics of interconnection in the network. Here, we analyzed the characteristics of the HIV-1 molecular transmission network of sexually transmitted people in Liaoning Province. Read More

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A rapid density method for taxi passengers hot spot recognition and visualization based on DBSCAN.

Sci Rep 2021 May 3;11(1):9420. Epub 2021 May 3.

Faculty of Computer and Software Engineering, Huaiyin Institute of Technology, Huaian, 223003, People's Republic of China.

With the development of city size and vehicle interconnection, visual analysis technology is playing a very important role in the course of city calculation and city perception. A Reasonable visual model can effectively present the feature of city. In order to solve the problem of traditional density algorithm that cluster the large scale data slowly and cannot find cluster centers to adapt taxi track data. Read More

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Different Phenomena in Magnetic/Electrical Properties of Co(II) and Ni(II) Isomorphous MOFs.

ACS Omega 2021 Apr 26;6(13):9213-9221. Epub 2021 Mar 26.

Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education; Yunnan Research & Development Center for Natural Products; School of Chemical Science and Technology, Yunnan University, Kunming 650091, P. R. China.

Two unprecedented and stable metal-organic frameworks, {[Co(HO)(L)(OH)]·2.5HO·0.5DMF} () and {[Ni(HO)(L)(OH)]·1. Read More

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Nucleation of melt: From fundamentals to dispersed systems.

Adv Colloid Interface Sci 2021 Mar 29;289:102361. Epub 2021 Jan 29.

Birmingham Centre for Energy Storage & School of Chemical Engineering, Univ. of Birmingham, B15 2TT, UK.

The most evident aspects of a first order transition of a system from an old to a new phase, are the presence of a discontinuity at the interface between both phases and the thermal effects related to the latent heat exchanged with the surrounding environment. These effects are the result of a sequence of events promoted by thermodynamic conditions persisting over the equilibrium in a metastable state. The breakdown of metastability is promoted by infinitesimal energy fluctuations resulting in the germination of clusters of the new phase that can grow to a critical size (nucleus) and then develop or vanish. Read More

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An Integrative Transcriptomic Analysis of Systemic Juvenile Idiopathic Arthritis for Identifying Potential Genetic Markers and Drug Candidates.

Int J Mol Sci 2021 Jan 12;22(2). Epub 2021 Jan 12.

Department of Life Science, Dongguk University-Seoul, Seoul 04620, Korea.

Systemic juvenile idiopathic arthritis (sJIA) is a rare subtype of juvenile idiopathic arthritis, whose clinical features are systemic fever and rash accompanied by painful joints and inflammation. Even though sJIA has been reported to be an autoinflammatory disorder, its exact pathogenesis remains unclear. In this study, we integrated a meta-analysis with a weighted gene co-expression network analysis (WGCNA) using 5 microarray datasets and an RNA sequencing dataset to understand the interconnection of susceptibility genes for sJIA. Read More

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January 2021

Spatiotemporal Organization of Chemotaxis Pathways in Magnetospirillum gryphiswaldense.

Appl Environ Microbiol 2020 12 17;87(1). Epub 2020 Dec 17.

Department of Microbiology, University of Bayreuth, Bayreuth, Germany.

employs iron-rich nanoparticles for magnetic navigation within environmental redox gradients. This behavior termed magneto-aerotaxis was previously shown to rely on the sensory pathway CheOp1, but the precise localization of CheOp1-related chemoreceptor arrays during the cell cycle and its possible interconnection with three other chemotaxis pathways have remained unstudied. Here, we analyzed the localization of chemoreceptor-associated adaptor protein CheW and histidine kinase CheA by superresolution microscopy in a spatiotemporal manner. Read More

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December 2020

Cluster-Fault Tolerant Routing in a Torus.

Sensors (Basel) 2020 Jun 9;20(11). Epub 2020 Jun 9.

Institute of Engineering, Tokyo University of Agriculture and Technology, Tokyo 184-8588, Japan.

The number of Internet-connected devices grows very rapidly, with even fears of running out of available IP addresses. It is clear that the number of sensors follows this trend, thus inducing large sensor networks. It is insightful to make the comparison with the huge number of processors of modern supercomputers. Read More

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Non-conventional Hydrogen Bonding and Aromaticity: A Systematic Study on Model Nucleobases and Their Solvated Clusters.

Chemphyschem 2020 08 17;21(16):1826-1835. Epub 2020 Jul 17.

School of Chemical Sciences, National Institute of Science Education and Research (NISER), PO-Bhimpur-Padanpur, Via-Jatni, District-Khurda, PIN-752050, Bhubaneswar, INDIA.

The conceptual development of aromaticity is essential to rationalize and understand the structure and behavior of aromatic heterocycles. This work addresses for the first time, the interconnection between aromaticity and sulfur/selenium centered hydrogen bonds (S/SeCHBs) involved in representative heterocycle models of canonical nucleobases (2-Pyridone; 2PY) and its sulfur (2-Thiopyridone; 2TPY) and selenium (2-Selenopyridone; 2SePY) analogs. The nucleus-independent chemical shift (NICS) and gauge induced magnetic current density (GIMIC) values suggested significant reduction of aromaticity upon replacement of exocyclic carbonyl oxygen with sulfur and selenium. Read More

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Grounding evaluation design in the socio-ecological model of health: a logic framework for the assessment of a national routine immunization communication initiative in Kyrgyzstan.

Glob Health Promot 2020 12 13;27(4):59-68. Epub 2020 May 13.

UNICEF-Kyrgyzstan, Bishkek, Kyrgyzstan.

Childhood routine immunization (RI) is a highly effective public health intervention for the prevention of infectious diseases. Despite high immunization rates, a 2018 Knowledge, Attitudes, and Practices (KAP) study by the United Nations Children's Fund (UNICEF) noted a growing practice of vaccine refusal among parents and primary caregivers as well as clusters of significantly lower immunization coverage in some provinces. Moreover, a 2018 Joint Appraisal report by GAVI (Global Vaccine Alliance) has highlighted a decrease in immunization rates among children under 1 year of age from 96. Read More

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December 2020

Altered microtubule structure, hemichannel localization and beating activity in cardiomyocytes expressing pathologic nuclear lamin A/C.

Heliyon 2020 Jan 23;6(1):e03175. Epub 2020 Jan 23.

Department of Engineering and Architecture, University of Trieste, Trieste, Italy.

Given the clinical effect of laminopathies, understanding lamin mechanical properties will benefit the treatment of heart failure. Here we report a mechano-dynamic study of mutations in neonatal rat ventricular myocytes (NRVM) using single cell spectroscopy with Atomic Force Microscopy (AFM) and measured changes in beating force, frequency and contractile amplitude of selected mutant-expressing cells within cell clusters. Furthermore, since beat-to-beat variations can provide clues on the origin of arrhythmias, we analyzed the beating rate variability using a time-domain method which provides a Poincaré plot. Read More

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January 2020

Assessment of biomechanical properties of the extracellular and pericellular matrix and their interconnection throughout the course of osteoarthritis.

J Biomech 2019 Dec 10;97:109409. Epub 2019 Oct 10.

Laboratory of Cell Biology, Department of Orthopaedic Surgery, University Hospital of Tübingen, Waldhörnlestraße 22, D-72072 Tübingen, Germany; Department of Orthopaedic Surgery, University Hospital of Tübingen, Hoppe-Seyler-Straße 3, D-72076 Tübingen, Germany. Electronic address:

During osteoarthritis (OA)-triggered cartilage degeneration, the chondrocytes spatially rearrange from single to double strings, and then to small and finally big clusters. Both the extracellular matrix (ECM) and the pericellular matrix (PCM) progressively degrade in osteoarthritis, changing the overall mechanical properties of the cartilage. We investigated the mechanical properties particularly elasticity of the ECM and PCM and their interconnection as a function of chondrocyte spatial organisation. Read More

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December 2019

Reprogramming of gene expression in Escherichia coli cultured on pyruvate versus glucose.

Mol Genet Genomics 2019 Oct 30;294(5):1359-1371. Epub 2019 Jul 30.

Department of Immunology, Microbiology and Parasitology, University of the Basque Country UPV/EHU, Leioa, Spain.

Previous studies revealed important roles of small RNAs (sRNAs) in regulation of bacterial metabolism, stress responses and virulence. However, only a minor fraction of sRNAs is well characterized with respect to the spectra of their targets, conditional expression profiles and actual mechanisms they use to regulate gene expression to control particular biological pathways. To learn more about the specific contribution of sRNAs to the global regulatory network controlling the Escherichia coli central carbon metabolism (CCM), we employed microarray analysis and compared transcriptome profiles of E. Read More

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October 2019

Weighted gene co-expression network analysis to explain the relationship between plasma total carotenoids and lipid profile.

Genes Nutr 2019 8;14:16. Epub 2019 May 8.

1Institute of Nutrition and Functional Foods (INAF), Laval University, 2440 Hochelaga Blvd, Quebec City, QC G1V 0A6 Canada.

Background: Variability in circulating carotenoids may be attributable to several factors including, among others, genetic variants and lipid profile. However, relatively few studies have considered the impact of gene expression in the inter-individual variability in circulating carotenoids. Most studies considered expression of genes individually and ignored their high degree of interconnection. Read More

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Formation Mechanism of a Polyanonic Framework from Layer to Chain Explored by Adjusting Time, Temperature, and pH: Preparation and Characterization of Metal-Complex-Templated 1D Borate and 2D Nickel Borate.

Inorg Chem 2019 Feb 18;58(3):2012-2019. Epub 2019 Jan 18.

School of Light Industry and Chemical Engineering , Guangdong University of Technology , Guangzhou , Guangdong 510006 , People's Republic of China.

The first column of two-dimensional (2D)-layered metal-complex-templated nickel borate was obtained by using a solvothermal synthesis method. The 2D nickel borate [Ni(en)]·[NiBO(OH)]·Cl (1; en = ethylenediamine) contains [Ni(en)], Cl, and the first reported inorganic nickel borate layer [NiBO(OH)], which is formed by the interconnection of Ni and O atoms in the B-O cluster. By increasing the reaction temperature during the synthesis process of compound 1, the one-dimensional (1D) chain nickel borate [Ni(en)]·[BO(OH)]·Cl (2) was obtained, wherein the [BO(OH)] cluster was connected through an O atom to form a 1D chain structure. Read More

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February 2019

Dimerization interface of osteoprotegerin revealed by hydrogen-deuterium exchange mass spectrometry.

J Biol Chem 2018 11 25;293(45):17523-17535. Epub 2018 Sep 25.

the Department of Oral Biology, University of Buffalo, Buffalo, New York 14214, and

Previous structural studies of osteoprotegerin (OPG), a crucial negative regulator of bone remodeling and osteoclastogenesis, were mostly limited to the N-terminal ligand-binding domains. It is now known that the three C-terminal domains of OPG also play essential roles in its function by mediating OPG dimerization, OPG-heparan sulfate (HS) interactions, and formation of the OPG-HS-receptor activator of nuclear factor κB ligand (RANKL) ternary complex. Employing hydrogen-deuterium exchange MS methods, here we investigated the structure of full-length OPG in complex with HS or RANKL in solution. Read More

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November 2018

Mating-type factor-specific regulation of the fumagillin/pseurotin secondary metabolite supercluster in Aspergillus fumigatus.

Mol Microbiol 2018 12 23;110(6):1045-1065. Epub 2018 Oct 23.

Mikrobiologisches Institut - Klinische Mikrobiologie, Immunologie und Hygiene, Universitätsklinikum Erlangen and Friedrich-Alexander-Universität Erlangen-Nürnberg, Germany.

In the human pathogenic mold Aspergillus fumigatus, sexual identity is determined by the mating-type idiomorphs MAT1-1 and MAT1-2 residing at the MAT locus. Upon crossing of compatible partners, a heterothallic mating is executed to eventually form cleistothecia that contain recombinant ascospores. Given that the MAT1 gene products are DNA binding master regulators that govern this complex developmental process, we monitored the MAT1-driven transcriptomes of A. Read More

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December 2018

Controllable Gaussian-shaped soliton clusters in strongly nonlocal media.

Opt Express 2018 Jul;26(15):19182-19198

In this paper, we discuss the evolution of the Gaussian-shaped soliton clusters in strongly nonlocal nonlinear media, which is modeled by the nonlinear Schrödinger equation. The influences of three initial incident parameters (the initial transverse velocity, the initial position, the input power) on propagation dynamics of the soliton clusters are all discussed in detail. The results show that the intensity distribution, the trajectory, the center distance, and the angular velocity of the clusters can be controlled by adjusting the initial incident parameters. Read More

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Organization of projection from brainstem auditory nuclei to the inferior colliculus of Japanese house bat (Pipistrellus abramus).

Brain Behav 2018 08 12;8(8):e01059. Epub 2018 Jul 12.

Neuroethology and Bioengineering Laboratory, Faculty of Life and Medical Sciences, Doshisha University, Kyotanabe, Japan.

Objectives: Echolocating bats show remarkable specialization which is related to analysis of echoes of biosonars in subcortical auditory brainstem pathways. The inferior colliculus (IC) receives inputs from all lower brainstem auditory nuclei, i.e. Read More

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Analysis of Research on Nurses' Job Stress Using Network Analysis.

West J Nurs Res 2019 03 15;41(3):338-354. Epub 2018 Jun 15.

Keimyung University, Daegu, South Korea.

This study established a network related to nurses' job stress by conducting a social network analysis of titles, keywords, and abstracts, and it identified emerging topics of research. NetMiner 4.0 visualized an interconnection between critical keywords and investigated their frequency of appearance to construe the trends in nurses' job stress measures used in studies conducted over 55 years (1960-2015). Read More

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Regulation of plant cell wall degradation by light in .

Monika Schmoll

Fungal Biol Biotechnol 2018 24;5:10. Epub 2018 Apr 24.

Center for Health and Bioresources, AIT Austrian Institute of Technology GmbH, Konrad Lorenz Straße 24, 3430 Tulln, Austria.

(syn. ) is the model organism for industrial production of plant cell wall degradating enzymes. The integration of light and nutrient signals for adaptation of enzyme production in emerged as an important regulatory mechanism to be tackled for strain improvement. Read More

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Detangling PPI networks to uncover functionally meaningful clusters.

BMC Syst Biol 2018 03 21;12(Suppl 3):24. Epub 2018 Mar 21.

Department of Computer Science, Tufts University, Medford, 02155, MA, USA.

Background: Decomposing a protein-protein interaction network (PPI network) into non-overlapping clusters or communities, sometimes called "network modules," is an important way to explore functional roles of sets of genes. When the method to accomplish this decomposition is solely based on purely graph-theoretic measures of the interconnection structure of the network, this is often called unsupervised clustering or community detection. In this study, we compare unsupervised computational methods for decomposing a PPI network into non-overlapping modules. Read More

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Two new 3-D cadmium bromoplumbates: the only example of heterometallic bromoplumbate based on crown [Cd(PbO)Br] clusters.

Dalton Trans 2018 Apr;47(14):4833-4839

Chongqing Key Laboratory of Inorganic Functional Materials, College of Chemistry, Chongqing Normal University, Chongqing, 401331, P. R. China.

Two new cadmium bromoplumbates [CdPb2Br2L2]n (1, L = ethylene glycol) and [CdPb6Br6L4]n (2) have been solvothermally synthesized and structurally characterized. 1 contains 1-D neutral heterometallic chains [CdPb2Br2L2]n, which are further connected via weak Pb-Br bonds, resulting in a 3-D network structure. The 3-D framework of 2 is constructed by the interconnection of a 2-D neutral layer [CdPb6Br6L4]nvia weak Pb-Br bonds. Read More

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K Li Gd (BO ) : A New Gadolinium-Rich Orthoborate for Cryogenic Magnetic Cooling.

Chemistry 2018 Mar 1;24(13):3147-3150. Epub 2018 Feb 1.

Beijing Center for Crystal Research and Development, Key Laboratory of Functional Crystals and Laser Technology, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing, 100190, China.

Magnetic cooling technology based on magnetocaloric effect (MCE) has attracted great interest in obtaining extremely low temperatures, for example, for space exploration. Here, we grew a new gadolinium-rich orthoborate K Li Gd (BO ) (1) as a promising cryogenic magnetic coolant. It exhibits a complicated three dimensional framework constructed from BO groups and gadolinium-oxygen chains. Read More

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Targeted attachment of functional groups at Ge clusters via silylation reactions.

Chem Commun (Camb) 2017 Aug;53(86):11798-11801

Department Chemie, Technische Universität München, Lichtenbergstraße 4, 85747 Garching, Germany.

Molecules with low-valent Ge atoms are generally synthesized from organohalogen germanes as precursors. The Zintl phase KGe provides reactive building blocks for a targeted synthesis of germanium-rich molecules. The silylation of Ge9 clusters with chlorosilanes ClSiRR', that carry unsaturated olefin groups R' leads to the introduction of olefinic side chains of variable lengths allowing for further reactions. Read More

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Interfacially-Located Nanoparticles Anticipate the Onset of Co-Continuity in Immiscible Polymer Blends.

Polymers (Basel) 2017 Aug 25;9(9). Epub 2017 Aug 25.

Dipartimento di Ingegneria Chimica, dei Materiali e della Produzione Industriale (INSTM Consortium-UdR Naples), University of Naples Federico II, P.le Tecchio 80, 80125 Naples, Italy.

The addition of nanoparticles has recently emerged as a clever tool to manipulate the microstructure and, through it, the macroscopic properties of immiscible polymer blends. Despite the huge number of studies in this field, the underlying mechanisms of most of the nanoparticle-induced effects on the blend microstructure remain poorly understood. Among others, the origin of effect of nanoparticles on the transition from distributed (drop-in-matrix) to co-continuous morphology is still controversial. Read More

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Hypersensitive dual-function luminescence switching of a silver-chalcogenolate cluster-based metal-organic framework.

Nat Chem 2017 07 13;9(7):689-697. Epub 2017 Feb 13.

College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou 450001, China.

Silver(i) chalcogenide/chalcogenolate clusters are promising photofunctional materials for sensing, optoelectronics and solar energy harvesting applications. However, their instability and poor room-temperature luminescent quantum yields have hampered more extensive study. Here, we graft such clusters to adaptable bridging ligands, enabling their interconnection and the formation of rigid metal-organic frameworks. Read More

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GeNICE: A Novel Framework for Gene Network Inference by Clustering, Exhaustive Search, and Multivariate Analysis.

J Comput Biol 2017 08 21;24(8):809-830. Epub 2017 Jun 21.

1 Escola Politécnica da Universidade de São Paulo , São Paulo, Brazil .

Gene network (GN) inference from temporal gene expression data is a crucial and challenging problem in systems biology. Expression data sets usually consist of dozens of temporal samples, while networks consist of thousands of genes, thus rendering many inference methods unfeasible in practice. To improve the scalability of GN inference methods, we propose a novel framework called GeNICE, based on probabilistic GNs; the main novelty is the introduction of a clustering procedure to group genes with related expression profiles and to provide an approximate solution with reduced computational complexity. Read More

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Thalamic reticular nucleus in Caiman crocodilus: Relationship with the dorsal thalamus.

M B Pritz

Neuroscience 2016 May 3;322:430-51. Epub 2016 Mar 3.

Molecular Neurosciences Department and the Krasnow Institute for Advanced Study, George Mason University, Fairfax, VA 22030, United States. Electronic address:

The thalamic reticular nucleus was investigated in one group of crocodilians, Caiman crocodilus. This neuronal aggregate is composed of two parts: a compact portion and a diffuse region made up of scattered cells within the forebrain bundles. In Caiman, both the lateral and medial forebrain bundles project to the telencephalon and the thalamic reticular nucleus is associated with each fiber tract. Read More

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A Graph-Based Interface for Visual Analytics of 3D Streamlines and Pathlines.

IEEE Trans Vis Comput Graph 2014 Aug;20(8):1127-40

Visual exploration of large and complex 3D steady and unsteady flow fields is critically important in many areas of science and engineering. In this paper, we introduce FlowGraph, a novel compound graph representation that organizes field line clusters and spatiotemporal regions hierarchically for occlusion-free and controllable visual exploration. It works with any seeding strategy as long as the domain is well covered and important flow features are captured. Read More

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Non-canonical ribosomal DNA segments in the human genome, and nucleoli functioning.

Gene 2015 Nov 9;572(2):237-42. Epub 2015 Jul 9.

The Institute of Gene Biology, RAS, 34/5, Vavilov St., Moscow, Russian Federation. Electronic address:

Ribosomal DNA (rDNA) in the human genome is represented by tandem repeats of 43 kb nucleotide sequences that form nucleoli organizers (NORs) on each of five pairs of acrocentric chromosomes. RDNA-similar segments of different lengths are also present on (NOR)(-) chromosomes. Many of these segments contain nucleotide substitutions, supplementary microsatellite clusters, and extended deletions. Read More

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November 2015