J Biomech 2019 Dec 10;97:109409. Epub 2019 Oct 10.
Laboratory of Cell Biology, Department of Orthopaedic Surgery, University Hospital of Tübingen, Waldhörnlestraße 22, D-72072 Tübingen, Germany; Department of Orthopaedic Surgery, University Hospital of Tübingen, Hoppe-Seyler-Straße 3, D-72076 Tübingen, Germany. Electronic address:
During osteoarthritis (OA)-triggered cartilage degeneration, the chondrocytes spatially rearrange from single to double strings, and then to small and finally big clusters. Both the extracellular matrix (ECM) and the pericellular matrix (PCM) progressively degrade in osteoarthritis, changing the overall mechanical properties of the cartilage. We investigated the mechanical properties particularly elasticity of the ECM and PCM and their interconnection as a function of chondrocyte spatial organisation. Read More