Front Immunol 2021 7;12:728848. Epub 2021 Sep 7.
Snyder Institute for Chronic Diseases, Departments of Microbiology, Immunology and Infectious Diseases, Cumming School of Medicine and Comparative Biology and Experimental Medicine, Faculty of Veterinary Medicine, University of Calgary, Calgary, AB, Canada.
Intracellular phagosomal pathogens represent a formidable challenge for innate immune cells, as, paradoxically, these phagocytic cells can act as both host cells that support pathogen replication and, when properly activated, are the critical cells that mediate pathogen elimination. Infection by parasites of the genus provides an excellent model organism to investigate this complex host-pathogen interaction. In this review we focus on the dynamics of infection and the host innate immune response, including the impact of the adaptive immune response on phagocytic host cell recruitment and activation. Read More