50 results match your criteria inter-organ crosstalk

Discovery of Thymosin Beta-4 as a Human Exerkine and Growth Factor.

Am J Physiol Cell Physiol 2021 09 8. Epub 2021 Sep 8.

Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.

Skeletal muscle is an endocrine organ secreting exercise-induced factors (exerkines), which play a pivotal role in inter-organ crosstalk. Using mass spectrometry (MS)-based proteomics, we characterized the secretome and identified thymosin beta-4 (TMSB4X) as the most upregulated secreted protein in the media of contracting C2C12 myotubes. TMSB4X was also acutely increased in plasma of exercising humans irrespective of the insulin resistance condition or exercise mode. Read More

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September 2021

Treatment with atrial natriuretic peptide induces adipose tissue browning and exerts thermogenic actions in vivo.

Sci Rep 2021 Aug 31;11(1):17466. Epub 2021 Aug 31.

Division of Cardiology, Department of Internal Medicine, The Jikei University School of Medicine, 3-25-8, Nishi-Shimbashi, Minato-ku, Tokyo, 105-8461, Japan.

Increasing evidence suggests natriuretic peptides (NPs) coordinate inter-organ metabolic crosstalk with adipose tissues and play a critical role in energy metabolism. We recently reported A-type NP (ANP) raises intracellular temperature in cultured adipocytes in a low-temperature-sensitive manner. We herein investigated whether exogenous ANP-treatment exerts a significant impact on adipose tissues in vivo. Read More

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Regulation of Adaptive Cell Proliferation by Vagal Nerve Signals for Maintenance of Whole-Body Homeostasis: Potential Therapeutic Target for Insulin-Deficient Diabetes.

Junta Imai

Tohoku J Exp Med 2021 08;254(4):245-252

Department of Metabolism and Diabetes, Tohoku University Graduate School of Medicine.

In insulin-resistant states such as obesity, pancreatic β-cells proliferate to prevent blood glucose elevations. Failure of this β-cells proliferative response leads to the development of diabetes. On the other hand, when organs are damaged, cells proliferate to repair the organs. Read More

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Organogenesis in vitro.

Curr Opin Cell Biol 2021 Aug 2;73:84-91. Epub 2021 Aug 2.

Division of Gastroenterology, Hepatology and Nutrition and Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, USA; Center for Stem Cell and Organoid Medicine (CuSTOM), Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA; Institute of Research, Tokyo Medical and Dental University, Japan. Electronic address:

Organoids are three-dimensional structures that self-organize from human pluripotent stem cells or primary tissue, potentially serving as a traceable and manipulatable platform to facilitate our understanding of organogenesis. Despite the ongoing advancement in generating organoids of diverse systems, biological applications of in vitro generated organoids remain as a major challenge in part due to a substantial lack of intricate complexity. The studies of development and regeneration enumerate the essential roles of highly diversified nonepithelial populations such as mesenchyme and endothelium in directing fate specification, morphogenesis, and maturation. Read More

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Enhanced Access to the Health-Related Skin Metabolome by Fast, Reproducible and Non-Invasive WET PREP Sampling.

Metabolites 2021 Jun 24;11(7). Epub 2021 Jun 24.

German Research Center for Environmental Health, Institute of Environmental Medicine, Helmholtz Zentrum München, D-85764 Neuherberg, Germany.

Our skin influences our physical and mental health, and its chemical composition can reflect environmental and disease conditions. Therefore, through sampling the skin metabolome, we can provide a promising window into the mechanisms of the body. However, the broad application of skin metabolomics has recently been hampered by a lack of easy and widely applicable sampling methods. Read More

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Intercellular and inter-organ crosstalk in browning of white adipose tissue: molecular mechanism and therapeutic complications.

J Mol Cell Biol 2021 Jun 29. Epub 2021 Jun 29.

The State Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong, Hong Kong, China.

Adipose tissue (AT) is highly plastic and heterogeneous in response to environmental and nutritional changes. The development of heat-dissipating beige adipocytes in white AT (WAT) through a process known as browning (or beiging) has garnered much attention as a promising therapeutic strategy for obesity and its related metabolic complications. This is due to its inducibility in response to thermogenic stimulation and its association with improved metabolic health. Read More

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Biglycan: A regulator of hepatorenal inflammation and autophagy.

Matrix Biol 2021 06 10;100-101:150-161. Epub 2021 Jun 10.

Institute of Pharmacology and Toxicology, Goethe University, Frankfurt, Germany. Electronic address:

Soluble biglycan, a small leucine-rich proteoglycan, plays a significant role in several pathologies as it has emerged as an extracellular matrix-derived danger-associated molecular pattern. Biglycan is released from the extracellular matrix in response to tissue injury and, as a canonical danger signal, interacts with innate immune receptors, Toll-like receptors 2 and 4, thereby triggering a sustained inflammatory response. Recent evidence indicates that biglycan acts as a molecular switch between inflammation and autophagy by a specific interaction with the Toll-like co-receptor CD14 and CD44, respectively. Read More

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Dynamic adult tracheal plasticity drives stem cell adaptation to changes in intestinal homeostasis in Drosophila.

Nat Cell Biol 2021 05 10;23(5):485-496. Epub 2021 May 10.

Institute of Cancer Sciences-University of Glasgow, Wolfson Wohl Cancer Research Centre, Glasgow, UK.

Coordination of stem cell function by local and niche-derived signals is essential to preserve adult tissue homeostasis and organismal health. The vasculature is a prominent component of multiple stem cell niches. However, its role in adult intestinal homeostasis remains largely understudied. Read More

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Uremic Toxins in Organ Crosstalk.

Front Med (Lausanne) 2021 16;8:592602. Epub 2021 Apr 16.

Departments of Pediatrics and Medicine (Nephrology), San Diego School of Medicine, University of California, San Diego, La Jolla, CA, United States.

Many putative uremic toxins-like indoxyl sulfate, p-cresol sulfate, kynurenic acid, uric acid, and CMPF-are organic anions. Both inter-organ and inter-organismal communication are involved. For example, the gut microbiome is the main source of indole, which, after modification by liver drug metabolizing enzymes (DMEs), becomes indoxyl sulfate. Read More

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Weight-loss-independent benefits of exercise on liver steatosis and stiffness in Japanese men with NAFLD.

JHEP Rep 2021 Jun 10;3(3):100253. Epub 2021 Feb 10.

Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan.

Background & Aims: A weight-loss-independent beneficial effect of exercise on non-alcoholic fatty liver disease (NAFLD) management has been reported, but the underlying mechanism is unknown. To help determine this mechanism, the effects of exercise on individual tissues (liver, adipose tissue, and skeletal muscle) were retrospectively studied.

Methods: Data from Japanese obese men with NAFLD in a 3-month exercise regimen were analysed and compared with those in a 3-month dietary restriction program designed to achieve weight loss. Read More

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Hyperoxia-activated circulating extracellular vesicles induce lung and brain injury in neonatal rats.

Sci Rep 2021 Apr 22;11(1):8791. Epub 2021 Apr 22.

Division of Neonatology and Batchelor Children's Research Institute, Department of Pediatrics, University of Miami Miller School of Medicine, P. O. Box 016960, Miami, FL, 33101, USA.

Hyperoxia-induced lung injury plays a key role in the development of bronchopulmonary dysplasia (BPD), characterized by inflammatory injury and impaired lung development in preterm infants. Although BPD is a predictor of poor neurodevelopmental outcomes, currently it is uncertain how lung injury contributes to brain injury in preterm infants. Extracellular vesicles (EVs) are a heterogeneous group of cell-derived membranous structures that regulate intercellular and inter-organ communications. Read More

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Adipocyte PHLPP2 inhibition prevents obesity-induced fatty liver.

Nat Commun 2021 03 23;12(1):1822. Epub 2021 Mar 23.

Department of Medicine, Columbia University, New York, NY, USA.

Increased adiposity confers risk for systemic insulin resistance and type 2 diabetes (T2D), but mechanisms underlying this pathogenic inter-organ crosstalk are incompletely understood. We find PHLPP2 (PH domain and leucine rich repeat protein phosphatase 2), recently identified as the Akt Ser473 phosphatase, to be increased in adipocytes from obese mice. To identify the functional consequence of increased adipocyte PHLPP2 in obese mice, we generated adipocyte-specific PHLPP2 knockout (A-PHLPP2) mice. Read More

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Adipose Extracellular Vesicles in Intercellular and Inter-Organ Crosstalk in Metabolic Health and Diseases.

Zhe Huang Aimin Xu

Front Immunol 2021 25;12:608680. Epub 2021 Feb 25.

The State Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong, Hong Kong, China.

Adipose tissue (AT) is a highly heterogeneous and dynamic organ that plays important roles in regulating energy metabolism and insulin sensitivity. In addition to its classical roles in nutrient sensing and energy storage/dissipation, AT secretes a large number of bioactive molecules (termed adipokines) participating in immune responses and metabolic regulation through their paracrine and/or endocrine actions. Adipose-derived extracellular vesicles (ADEVs), including exosomes, microvesicles (MVs), and apoptotic bodies, have recently emerged as a novel class of signal messengers, mediating intercellular communications and inter-organ crosstalk. Read More

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Multiple organs involved in the pathogenesis of non-alcoholic fatty liver disease.

Xiaoyan Li Hua Wang

Cell Biosci 2020 Dec 7;10(1):140. Epub 2020 Dec 7.

Department of Oncology, the First Affiliated Hospital of Anhui Medical University, Hefei, 230022, China.

Non-alcoholic fatty liver disease (NAFLD) represents the leading cause of chronic liver disease worldwide and the anticipated health burden is huge. There are limited therapeutic approaches for NAFLD now. It's imperative to get a better understanding of the disease pathogenesis if new treatments are to be discovered. Read More

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December 2020

Hepatokines and metabolism: Deciphering communication from the liver.

Mol Metab 2021 02 4;44:101138. Epub 2020 Dec 4.

Department of Neuroscience and Pharmacology, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA; Fraternal Order of Eagles Diabetes Research Center, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA; Iowa Neuroscience Institute, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA; Department of Veterans Affairs Medical Center, Iowa City, IA 52242, USA. Electronic address:

Background: The liver is a key regulator of systemic energy homeostasis and can sense and respond to nutrient excess and deficiency through crosstalk with multiple tissues. Regulation of systemic energy homeostasis by the liver is mediated in part through regulation of glucose and lipid metabolism. Dysregulation of either process may result in metabolic dysfunction and contribute to the development of insulin resistance or fatty liver disease. Read More

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February 2021

Interorgan communication in the control of metamorphosis.

Curr Opin Insect Sci 2021 02 23;43:54-62. Epub 2020 Oct 23.

Department of Biology, University of Copenhagen, 2100 Copenhagen, Denmark. Electronic address:

Steroid hormones control major developmental transitions such as metamorphosis in insects and puberty in mammals. The juvenile must attain a sufficient size before it begins maturation in order to give rise to a properly sized and reproductively fit adult. Studies in the insect Drosophila have begun to reveal a remarkable example of the complex interplay between different organs and the neuroendocrine system that controls the production of the steroid ecdysone, which triggers metamorphosis. Read More

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February 2021

The Evolving Role of Caveolin-1: A Critical Regulator of Extracellular Vesicles.

Med Sci (Basel) 2020 Nov 4;8(4). Epub 2020 Nov 4.

Division of Pulmonary and Critical Care Medicine, Department of Medicine, Boston University Medical Campus, 72 E Concord St. R304. Boston, MA 02118, USA.

Emerging evidence suggests that extracellular vesicles (EVs) play an essential role in mediating intercellular communication and inter-organ crosstalk both at normal physiological conditions and in the pathogenesis of human diseases. EV cargos are made up of a broad spectrum of molecules including lipids, proteins, and nucleic acids such as DNA, RNA, and microRNAs. The complex EV cargo composition is cell type-specific. Read More

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November 2020

Investigation of the relationship between sensorineural hearing loss and associated comorbidities in patients with chronic kidney disease: A nationwide, population-based cohort study.

PLoS One 2020 11;15(9):e0238913. Epub 2020 Sep 11.

Division of Nephrology, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, Republic of China.

Hearing impairment was observed in patients with chronic kidney disease (CKD). Our purpose was to investigate the relationship between sensorineural hearing loss (SNHL) and associated comorbidities in the CKD population. We conducted a retrospective, population-based study to examine the risk of developing SNHL in patients with CKD. Read More

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November 2020

The Role of Exercise in the Interplay between Myokines, Hepatokines, Osteokines, Adipokines, and Modulation of Inflammation for Energy Substrate Redistribution and Fat Mass Loss: A Review.

Nutrients 2020 Jun 26;12(6). Epub 2020 Jun 26.

Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Ave. Morones Prieto 3000, Monterrey N.L. 64710, Mexico.

Exercise is an effective strategy for preventing and treating obesity and its related cardiometabolic disorders, resulting in significant loss of body fat mass, white adipose tissue browning, redistribution of energy substrates, optimization of global energy expenditure, enhancement of hypothalamic circuits that control appetite-satiety and energy expenditure, and decreased systemic inflammation and insulin resistance. Novel exercise-inducible soluble factors, including myokines, hepatokines, and osteokines, and immune cytokines and adipokines are hypothesized to play an important role in the body's response to exercise. To our knowledge, no review has provided a comprehensive integrative overview of these novel molecular players and the mechanisms involved in the redistribution of metabolic fuel during and after exercise, the loss of weight and fat mass, and reduced inflammation. Read More

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Implications of the Adiponectin System in Non-Small Cell Lung Cancer Patients: A Case-Control Study.

Biomolecules 2020 06 18;10(6). Epub 2020 Jun 18.

Department of Translational Medical Sciences, University of Campania "L. Vanvitelli", 80131 Naples, Italy.

Alterations of adipose tissue occurring in obesity have been recognized as a major risk factor for several cancers. The relationship between adipose tissue and lung cancer, which is the main cancer-related cause of death worldwide, still requires investigation. Perturbations in the adipokine system are likely to interfere with inter-organ crosstalk in lung cancer, which may influence the lung tumor microenvironment. Read More

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Modulation of inter-organ signalling in obese mice by spontaneous physical activity during mammary cancer development.

Sci Rep 2020 05 29;10(1):8794. Epub 2020 May 29.

Université Clermont Auvergne, INRAE, UNH, F-63000, Clermont-Ferrand, France.

Accumulative evidence links breast cancer development to excess weight and obesity. During obesity, dysregulations of adipose tissue induce an increase in pro-inflammatory adipokine secretions, such as leptin and oestrogen secretions. Furthermore, a raise in oxidative stress, along with a decrease in antioxidant capacity, induces and maintains chronic inflammation, which creates a permissive environment for cancer development. Read More

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Osteoimmunology - Bidirectional dialogue and inevitable union of the fields of bone and immunity.

Proc Jpn Acad Ser B Phys Biol Sci 2020 ;96(4):159-169

Department of Immunology, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo.

Bone is a critically important part of the skeletal system that is essential for body support and locomotion. The immune system protects against pathogens and is active in host defense. These two seemingly distinct systems in fact interact with each other, share molecules and create a collaborative regulatory system called the "osteoimmune system". Read More

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December 2020

Exercise-Released Myokines in the Control of Energy Metabolism.

Front Physiol 2020 13;11:91. Epub 2020 Feb 13.

INSERM, UMR 1048, Obesity Research Laboratory, Institute of Metabolic and Cardiovascular Diseases, Toulouse, France.

Physical activity reduces cardiometabolic risk, while physical inactivity increases chronic diseases risk. This led to the idea that exercise-induced muscle contraction contributes to metabolic regulation and health. It is now well established that skeletal muscle, through the release of endocrine factors, i. Read More

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February 2020

Coordinated alteration of mRNA-microRNA transcriptomes associated with exosomes and fatty acid metabolism in adipose tissue and skeletal muscle in grazing cattle.

Asian-Australas J Anim Sci 2020 Nov 24;33(11):1824-1836. Epub 2019 Dec 24.

Field Science Center, School of Veterinary Medicine, Kitasato University, Yakumo, Hokkaido 049-3121, Japan.

Objective: On the hypothesis that grazing of cattle prompts organs to secrete or internalize circulating microRNAs (c-miRNAs) in parallel with changes in energy metabolism, we aimed to clarify biological events in adipose, skeletal muscle, and liver tissues in grazing Japanese Shorthorn (JSH) steers by a transcriptomic approach.

Methods: The subcutaneous fat (SCF), biceps femoris muscle (BFM), and liver in JSH steers after three months of grazing or housing were analyzed using microarray and quantitative polymerase chain reaction (qPCR), followed by gene ontology (GO) and functional annotation analyses.

Results: The results of transcriptomics indicated that SCF was highly responsive to grazing compared to BFM and liver tissues. Read More

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November 2020

Insights on the Role of Putative Muscle-Derived Factors on Pancreatic Beta Cell Function.

Front Physiol 2019 8;10:1024. Epub 2019 Aug 8.

Departamento de Ciencias de la Salud, Nutrición y Dietética, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.

Skeletal muscle is a main target of insulin action that plays a pivotal role in postprandial glucose disposal. Importantly, skeletal muscle insulin sensitivity relates inversely with pancreatic insulin secretion, which prompted the hypothesis of the existence of a skeletal muscle-pancreas crosstalk mediated through an endocrine factor. The observation that changes in skeletal muscle glucose metabolism are accompanied by altered insulin secretion supports this hypothesis. Read More

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Inter-organ communication: a gatekeeper for metabolic health.

EMBO Rep 2019 09 19;20(9):e47903. Epub 2019 Aug 19.

Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland.

Multidirectional interactions between metabolic organs in the periphery and the central nervous system have evolved concomitantly with multicellular organisms to maintain whole-body energy homeostasis and ensure the organism's adaptation to external cues. These interactions are altered in pathological conditions such as obesity and type 2 diabetes. Bioactive peptides and proteins, such as hormones and cytokines, produced by both peripheral organs and the central nervous system, are key messengers in this inter-organ communication. Read More

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September 2019

Double bond configuration of palmitoleate is critical for atheroprotection.

Mol Metab 2019 10 7;28:58-72. Epub 2019 Aug 7.

Department of Molecular Biology and Genetics, Bilkent University, Ankara, 06800, Turkey; National Nanotechnology Center, Bilkent University, Ankara, 06800, Turkey; Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA; Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA; David Geffen School of Medicine, University of California, Los Angeles, CA, 90095, USA. Electronic address:

Objective: Saturated and trans fat consumption is associated with increased cardiovascular disease (CVD) risk. Current dietary guidelines recommend low fat and significantly reduced trans fat intake. Full fat dairy can worsen dyslipidemia, but recent epidemiological studies show full-fat dairy consumption may reduce diabetes and CVD risk. Read More

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October 2019

Intestinal lysozyme liberates Nod1 ligands from microbes to direct insulin trafficking in pancreatic beta cells.

Cell Res 2019 07 14;29(7):516-532. Epub 2019 Jun 14.

Key Laboratory of Infection and Immunity, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China.

Long-range communication between intestinal symbiotic bacteria and extra-intestinal organs can occur through circulating bacterial signal molecules, through neural circuits, or through cytokines or hormones from host cells. Here we report that Nod1 ligands derived from intestinal bacteria act as signal molecules and directly modulate insulin trafficking in pancreatic beta cells. The cytosolic peptidoglycan receptor Nod1 and its downstream adapter Rip2 are required for insulin trafficking in beta cells in a cell-autonomous manner. Read More

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Mouse Models for Atherosclerosis Research-Which Is My Line?

Front Cardiovasc Med 2019 12;6:46. Epub 2019 Apr 12.

Center for Molecular Cardiology, University of Zurich, Zurich, Switzerland.

Atherosclerosis is one of the primary causes of cardiovascular disease and mortality. This chronic immunometabolic disease evolves during decades in humans and encompasses different organs and immune cell types, as well as local and systemic processes that promote the progression of the disease. The most frequently used animal model to study these atherogenic processes and inter-organ crosstalk in a short time frame are genetically modified mouse models. Read More

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Inflammatory pathways in alcoholic steatohepatitis.

J Hepatol 2019 02;70(2):249-259

Southern California Research Center for ALPD and Cirrhosis, Department of Pathology, University of Southern California, Greater Los Angeles VA Healthcare System, Los Angeles, CA, United States. Electronic address:

Inflammatory processes are primary contributors to the development and progression of alcoholic steatohepatitis (ASH), with severe alcoholic hepatitis characterised by non-resolving inflammation. Inflammation in the progression of ASH is a complex response to microbial dysbiosis, loss of barrier integrity in the intestine, hepatocellular stress and death, as well as inter-organ crosstalk. Herein, we review the roles of multiple cell types that are involved in inflammation in ASH, including resident macrophages and infiltrating monocytes, as well as other cell types in the innate and adaptive immune system. Read More

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February 2019