589,112 results match your criteria intensive care


Effectiveness of pentoxifylline in severe early-onset fetal growth restriction: A randomized double-blinded clinical trial.

Taiwan J Obstet Gynecol 2022 Jul;61(4):612-619

Hafez Hospital, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address:

Objective: Management of pregnancy complicated by severe early-onset fetal growth restriction (FGR) is one of the most challenging obstetrical issues. So far, there has not been a proven option for the treatment or improvement of this condition. Improper immune response during placentation leads to inadequate trophoblast invasion and impaired utero-placental perfusion. Read More

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Chemotherapy induced gastrointestinal toxicities.

Adv Cancer Res 2022 21;155:131-166. Epub 2022 Mar 21.

Department of Pharmacology and Toxicology, School of Medicine, Virginia Commonwealth University, Richmond, VA, United States.

Chemotherapy-induced gastrointestinal dysfunction is a common occurrence associated with many different classes of chemotherapeutic agents. Gastrointestinal toxicity includes mucositis, diarrhea, and constipation, and can often be a dose-limiting complication, induce cessation of treatment and could be life threatening. The gastrointestinal epithelium is rich in rapidly dividing cells and hence is a prime target for chemotherapeutic drugs. Read More

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Organ donation and COVID-19: Should precautionary principle still apply?

Anaesth Crit Care Pain Med 2022 Jun 29:101120. Epub 2022 Jun 29.

Neuro-Intensive Care Unit, Fondation Ophtalmologique de Rothschild, Paris, France.

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Implementation of ReSPECT in acute hospitals: a retrospective observational study.

Resuscitation 2022 Jun 29. Epub 2022 Jun 29.

Warwick Clinical Trials Unit, Warwick Medical School, University of Warwick, Coventry, CV4 7AL, UK.

Aims: To evaluate, in UK acute hospitals, the early implementation of Recommended Summary Plan for Emergency Care and Treatment (ReSPECT), which embeds cardiopulmonary resuscitation (CPR) recommendations within wider emergency treatment plans To understand for whom and how the process was being used and the quality of form completion.

Methods: A retrospective observational study evaluating emergency care and treatment planning approaches used in acute UK hospitals (2015-2019), and in six English hospital trusts the extent of ReSPECT use, patient characteristics and completion quality in a sample 3000 patient case notes.

Results: The use of stand-alone Do Not Attempt Cardiopulmonary Resuscitation forms fell from 133/186 hospitals in 2015 to 64/186 in 2019 (a 38% absolute reduction). Read More

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Impact of vaccination on the symptoms of hospitalised patients with SARS-CoV-2 delta variant (B.1.617.1) infection.

Clin Microbiol Infect 2022 Jun 29. Epub 2022 Jun 29.

Department of Internal Medicine and Infectious Diseases, University Hospital of Poitiers; Poitiers, France; Groupe Vaccination-Prévention de la Société de Pathologie Infectieuse de Langue Française (SPILF).

Objectives: The diffusion of the SARS-CoV-2 delta (B.1.617. Read More

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Chlorine exposure and intensive exercise induces airway hyperreactivity in a 3-week murine exercise model.

Sci Total Environ 2022 Jun 29:157046. Epub 2022 Jun 29.

KU Leuven, Department of Public Health and Primary Care, Centre for Environment and Health, Herestraat 49 box 952, 3000 Leuven, Belgium. Electronic address:

Rationale: Exercise-induced bronchoconstriction (EIB) is defined as acute narrowing of the airways during or immediately after exercise. EIB has a high prevalence in elite swimmers probably due to the high ventilation rate and exposure to the chlorine by-products. It is still puzzling which pathophysiological mechanisms drive EIB. Read More

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oReduced astrocytic mGluR5 in the hippocampus is associated with stress-induced depressive-like behaviors in mice.

Neurosci Lett 2022 Jun 29:136766. Epub 2022 Jun 29.

Department of Neurobiology and Department of General Intensive Care Unit of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China; NHC and CAMS Key Laboratory of Medical Neurobiology, MOE Frontier Science Center for Brain Research and Brain-Machine Integration, School of Brain Science and Brain Medicine, Zhejiang University, Hangzhou 310058, China; National Health and Disease Human Brain Tissue Resource Center, Hangzhou 310058, China. Electronic address:

Major depressive disorder (MDD) is one of the most common and disabling mental disorders that characterized by profound disturbances in emotional regulation, motivation, cognition, and the physiology of affected individuals. Although MDD was initially thought to be primarily triggered through neuronal dysfunction, the pathological alterations in astrocytic function have been previously reported in MDD. We report that chronic restraint stress (CRS) induces astrocyte activation and decreases expression of astrocytic mGluR5 in the hippocampal CA1 of susceptible mice exhibited depressive-like behaviors. Read More

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Caribbean Latinx with moderate-severe asthma bear greater asthma morbidity than other Latinx.

J Allergy Clin Immunol 2022 Jun 29. Epub 2022 Jun 29.

Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, Massachusetts, United States of America.

Background: Hispanic/Latinx (HL) ethnicity encompasses racially and culturally diverse subgroups. Studies suggest that Puerto Ricans (PR) may bear greater asthma-related morbidity than Mexicans, but these were conducted in children or had limited clinical characterization.

Objective: To determine whether disparities in asthma morbidity exist among HL adult subgroups METHODS: Adults with moderate-severe asthma were recruited from US clinics, including Puerto Rico, for the PREPARE trial. Read More

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Evaluation of high speed centrifugation for routine biochemistry.

Clin Chim Acta 2022 Jun 29. Epub 2022 Jun 29.

Department of Biochemistry, indexes Lapeyronie University Hospital, Montpellier, France; PhyMedExp, INSERM U1046, CNRS UMR 9214, University of Montpellier, Montpellier, France Intensive Care Medicine Department, Lapeyronie University Hospital. Electronic address:

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Aortic Valve Repair in Pediatric Patients - 30 Years Single Center Experience.

Ann Thorac Surg 2022 Jun 29. Epub 2022 Jun 29.

Department of Cardiac Surgery, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria. Electronic address:

Background: Valve repair is the procedure of choice for congenital aortic valve disease. With increasing experience, the surgical armamentarium broadened from simple commissurotomy to more complex techniques. We report our 30-year experience with pediatric aortic valve repair. Read More

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Enoxaparin for primary thromboprophylaxis in symptomatic outpatients with COVID-19 (OVID): a randomised, open-label, parallel-group, multicentre, phase 3 trial.

Lancet Haematol 2022 Jun 29. Epub 2022 Jun 29.

Department of Angiology, University Hospital Zurich, Zurich, Switzerland; University of Zurich, Zurich, Switzerland.

Background: COVID-19 is a viral prothrombotic respiratory infection. Heparins exert antithrombotic and anti-inflammatory effects, and might have antiviral properties. We aimed to investigate whether thromboprophylaxis with enoxaparin would prevent untoward hospitalisation and death in symptomatic, but clinically stable outpatients with COVID-19. Read More

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The effectiveness of intensive home treatment as a substitute for hospital admission in acute psychiatric crisis resolution in the Netherlands: a two-centre Zelen double-consent randomised controlled trial.

Lancet Psychiatry 2022 Jun 29. Epub 2022 Jun 29.

Department of Research, Arkin, Amsterdam, Netherlands; Vrije Universiteit Department Clinical Psychology, Amsterdam, The Netherlands.

Background: Although de-institutionalisation has been underway for decades, admission to hospital followed by low-intensity outpatient care remains the usual treatment for patients with an acute psychiatric crisis. Intensive home treatment has been developed for patients in a severe psychiatric crisis as an alternative to inpatient care. This study aimed to evaluate the potential of intensive home treatment to reduce bed-days and its clinical effectiveness compared with treatment as usual. Read More

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Mass cytometry reveals a conserved immune trajectory of recovery in hospitalized COVID-19 patients.

Immunity 2022 Jun 7. Epub 2022 Jun 7.

Department of Otolaryngology-Head and Neck Cancer, University of California, San Francisco, San Francisco, CA 94143, USA; Department of Immunology & Immunology and Sandler Asthma Basic Research Center, University of California, San Francisco, San Francisco, CA 94143, USA; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94158, USA; Chan Zuckerberg Biohub, San Francisco, CA 94158, USA; Parker Institute for Cancer Immunotherapy, San Francisco, CA 94129, USA; Department of Pathology, University of California, San Francisco, San Francisco, CA 94115, USA. Electronic address:

While studies have elucidated many pathophysiological elements of COVID-19, little is known about immunological changes during COVID-19 resolution. We analyzed immune cells and phosphorylated signaling states at single-cell resolution from longitudinal blood samples of patients hospitalized with COVID-19, pneumonia and/or sepsis, and healthy individuals by mass cytometry. COVID-19 patients showed distinct immune compositions and an early, coordinated, and elevated immune cell signaling profile associated with early hospital discharge. Read More

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Using a mediating model of death attitude and meaning in life to understand nursing students attitude about hospice care.

Nurse Educ Today 2022 Jun 24;116:105448. Epub 2022 Jun 24.

School of Nursing, Massachusetts College of Pharmacy and Health Sciences, Boston, MA 02115, USA.

Background: Nurse-led hospice teams are an emerging trend in contemporary health care practice in China. However, Chinese nursing students are often ill-prepared to work in hospice care. Study findings on the attitude of nursing students toward the care of people who are dying and death varied among different countries and regions. Read More

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Comparing pregnancy outcomes between symptomatic and asymptomatic COVID-19 positive unvaccinated women: Multicenter study in Saudi Arabia.

J Infect Public Health 2022 Jun 24;15(8):845-852. Epub 2022 Jun 24.

Department of Obstetrics and Gynecology, Ministry of National Health Affairs, Riyadh, Saudi Arabia.

Introduction: COVID-19 infection in pregnancy ranges from asymptomatic infection to severe disease. However, the maternal and pregnancy outcomes are primarily favorable. Acute Respiratory Illness (ARI) score is a Visual Triage Checklist for Acute Respiratory symptoms created by the ministry of health of Saudi Arabia to screen the patient for acute respiratory infection with MERS-CoV. Read More

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Association of triglyceride-glucose index with prognosis of COVID-19: A population-based study.

J Infect Public Health 2022 Jun 24;15(8):837-844. Epub 2022 Jun 24.

Department of Neurology, Yongin Severance Hospital, Yonsei University College of Medicine, Yongin-si, Republic of Korea. Electronic address:

Background: Triglyceride-glucose (TyG) index is a simple and reliable surrogate marker for insulin resistance. Epidemiology studies have shown that insulin resistance is a risk factor for various infectious diseases. We evaluated the prognostic value of TyG index measured before the COVID-19 infection in COVID-19 infected patients. Read More

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Outcomes After Transfer of Pediatric Trauma Patients: Does Everyone Need to Visit the Trauma Bay?

J Surg Res 2022 Jun 29;279:164-169. Epub 2022 Jun 29.

Department of Surgery, Valley Children's Hospital, Madera, California. Electronic address:

Introduction: Critically injured children and teens often present to adult trauma centers or nontrauma facilities prior to transfer to a pediatric trauma center. For pediatric patients wanting transfer to the intensive care unit (ICU), there is little data to guide which can be safely transferred directly to the unit, and which should be evaluated first in the trauma bay.

Methods: We used our institutional trauma registry to evaluate transferred trauma patients over a three year period. Read More

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In-hospital mortality of critically Ill patients with interactions of acute kidney injury and acute respiratory failure in the resource-limited settings: Results from SEA-AKI study.

J Crit Care 2022 Jun 28;71:154103. Epub 2022 Jun 28.

Division of Nephrology, Department of Medicine, Faculty of Medicine, Chulalongkorn University, and King Chulalongkorn Memorial Hospital, Bangkok, Thailand; Center for Critical Care Nephrology, The CRISMA Center, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States; Excellence Center for Critical Care Nephrology, King Chulalongkorn Memorial Hospital, Bangkok, Thailand; Center of Excellence in Critical Care Nephrology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand; Academy of Science, Royal Society of Thailand, Bangkok, Thailand. Electronic address:

Purpose: Our goal was to describe clinical outcomes and explore the physiological interactions between acute kidney injury (AKI) and acute respiratory failure (ARF) in critically ill patients.

Materials And Methods: Data were retrieved from the SEA-AKI study, a multinational multicenter database of adult ICUs from Thailand, Laos, and Indonesia. AKI was defined using KDIGO criteria stage 2-3. Read More

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COVID-19 and stroke recurrence by subtypes: A propensity-score matched analyses of stroke subtypes in 44,994 patients.

J Stroke Cerebrovasc Dis 2022 Jun 3;31(8):106591. Epub 2022 Jun 3.

Department of Neurosurgery, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555, USA.

Background: Cerebrovascular diseases (CVDs), including varying strokes, can recur in patients upon coronavirus disease 2019 (COVID-19) diagnosis, but risk factor stratification based on stroke subtypes and outcomes is not well studied in large studies using propensity-score matching. We identified risk factors and stroke recurrence based on varying subtypes in patients with a prior CVD and COVID-19.

Methods: We analyzed data from 45 health care organizations and created cohorts based on ICDs for varying stroke subtypes utilizing the TriNetX Analytics Network. Read More

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Antibiotic Resistant Infections among COVID-19 Inpatients in U.S. Hospitals.

Clin Infect Dis 2022 Jul 2. Epub 2022 Jul 2.

Division of Healthcare Quality Promotion, Centers for Disease Control and Prevention, Atlanta, GA, United States.

We described bacterial/fungal co-infections and antibiotic resistant infections among inpatients diagnosed with COVID-19 and compared findings with inpatients diagnosed with influenza-like-illness. Less than 10% of COVID-19 inpatients had bacterial/fungal co-infection. Longer lengths of stay, critical care stay, and mechanical ventilation contribute to increased incidence of hospital-onset infections among COVID-19 inpatients. Read More

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Progressive multifocal leukoencephalopathy: epidemiology and spectrum of predisposing conditions.

Brain 2022 Jul 2. Epub 2022 Jul 2.

Department of Infectious and Tropical Diseases, Toulouse University Hospital Center, Toulouse 31300, France.

Population-based data on the epidemiology of progressive multifocal leukoencephalopathy, its predisposing conditions and mortality rate are lacking, although such data are crucial to raise awareness among clinicians and to lay foundations for future therapeutic trials in immunomodulating therapies. In our study, patients were identified by interrogating the French national healthcare reimbursement database from January 1st, 2008 to December 31st, 2017, using progressive multifocal leukoencephalopathy International Classification of Diseases code and a patient's selection algorithm. Overall incidence rate, one-year all-cause mortality rate and survival patterns were calculated, and factors associated with death were identified using a multivariate Cox proportional hazards regression model. Read More

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P311 knockdown alleviates hyperoxia-induced injury by inactivating the Smad3 signaling pathway in type II alveolar epithelial cells.

Mol Cell Biochem 2022 Jul 2. Epub 2022 Jul 2.

Department of Pediatric Intensive Care Unit, Guizhou Provincial People's Hospital, 83 Zhongshan East Road, Guiyang, 550002, Guizhou, China.

P311 is associated with alveolar formation and development. However, the role and possible mechanism of P311 in hyperoxia-induced injury in type II alveolar epithelial cells (AEC II) need to be elucidated. In our study, rat AEC II (RLE-6TN) were exposure to normoxia (21% O and 5% CO) or hyperoxia (95% O and 5% CO) for 24 h, followed by determination of P311 expression. Read More

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Patient-Physician Relationships and Mammography Use in Korean American Women.

J Immigr Minor Health 2022 Jul 2. Epub 2022 Jul 2.

Department of Social Work and Sociology, North Carolina Agricultural & Technical State University, Greensboro, NC, USA.

Breast cancer is prevalent and fatal in Korean American women (KAW) and KAW report low screening rates. This study examined the impact of patient-physician relationships on mammography use in KAW, focusing on patient-physician ethnic and gender concordance, distrust in health professionals, and accessibility to health care. Cross-sectional survey data were collected from 340 KAW in North Carolina, and logistic regression was conducted to identify factors associated with mammography use. Read More

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Intensive care unit-to-unit capacity transfers are associated with increased mortality: no hasty conclusions in the event of a crisis.

Ann Intensive Care 2022 Jul 2;12(1):60. Epub 2022 Jul 2.

Service des Maladies Infectieuses et de Réanimation Médicale, Centre Hospitalier Universitaire de Rennes, Hôpital Pontchaillou, 2 rue Henri le Guilloux, 35033, Rennes, France.

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Chronic critical illness and post-intensive care syndrome: from pathophysiology to clinical challenges.

Ann Intensive Care 2022 Jul 2;12(1):58. Epub 2022 Jul 2.

Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA, 94143, USA.

Background: Post-intensive care syndrome (PICS) encompasses physical, cognition, and mental impairments persisting after intensive care unit (ICU) discharge. Ultimately it significantly impacts the long-term prognosis, both in functional outcomes and survival. Thus, survivors often develop permanent disabilities, consume a lot of healthcare resources, and may experience prolonged suffering. Read More

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Prognostic factors for renal function deterioration during palliative first-line chemotherapy for metastatic colorectal cancer: a retrospective study.

Support Care Cancer 2022 Jul 2. Epub 2022 Jul 2.

Division of Medical Oncology, Department of Internal Medicine, Korea University Anam Hospital, Korea University College of Medicine, 73, Goryeodae-ro, Seongbuk-gu, Seoul, 02841, Korea.

Purpose: First-line choice of therapy is critical as it affects treatment decisions in later lines in patients with metastatic colorectal cancer (mCRC). We assessed changes in renal function for 1 year among patients diagnosed with mCRC who received first-line chemotherapy. We aimed to analyze the prognostic factors and effect of each chemotherapy regimen on the renal function of the patients. Read More

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Ten actions to achieve gender equity among intensivists: the French Society of Intensive Care (FICS) model.

Ann Intensive Care 2022 Jul 2;12(1):59. Epub 2022 Jul 2.

Médecine Intensive Réanimation, APHP Centre, Cochin et Université de Paris, INSERM Unit 970, Cardiovascular Research Center (PARCC), Paris, France.

In our recent survey, we aimed to collect information on perceived inequity as well as professional and personal fulfillment among women intensivists in France. For the 371 respondents out of the 732 persons who received the survey, the findings were unequivocal: for one-third of the respondents, being a woman was considered as an obstacle to careers or academic advancement, and for two thirds, pregnancy was viewed as a barrier to their career advancement. Gender discrimination had been experienced by 55% of the respondents. Read More

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Clinical burden associated with therapies for cardio-pulmonary critical decompensation in preterm neonates across Canadian neonatal intensive care units.

Eur J Pediatr 2022 Jul 2. Epub 2022 Jul 2.

Department of Paediatrics, Mount Sinai Hospital, 600 University Avenue, Toronto, ON, M5G 1X5, Canada.

The aim of this retrospective cohort study was to study the clinical burden associated with cardio-pulmonary critical decompensations (CPCDs) in preterm neonates and factors associated with mortality. Through the Canadian Neonatal Network (30 tertiary NICUs, 2010-2017), we identified infants < 32-week gestational age with CPCDs, defined by "significant exposure" to cardiotropes and/or inhaled nitric oxide (iNO): (1) either therapy for ≥ 3 consecutive days, (2) both for ≥ 2 consecutive days, or (3) any exposure within 2 days of death. Early CPCDs (≤ 3 days of age) and late CPCDs (> 3 days) were examined separately. Read More

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Multi-center validation of an artificial intelligence system for detection of COVID-19 on chest radiographs in symptomatic patients.

Eur Radiol 2022 Jul 2. Epub 2022 Jul 2.

Radiology Department, Mayo Clinic, Rochester, MN, USA.

Objectives: While chest radiograph (CXR) is the first-line imaging investigation in patients with respiratory symptoms, differentiating COVID-19 from other respiratory infections on CXR remains challenging. We developed and validated an AI system for COVID-19 detection on presenting CXR.

Methods: A deep learning model (RadGenX), trained on 168,850 CXRs, was validated on a large international test set of presenting CXRs of symptomatic patients from 9 study sites (US, Italy, and Hong Kong SAR) and 2 public datasets from the US and Europe. Read More

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