Encephale 2021 Apr 1. Epub 2021 Apr 1.
Faculté de biologie et de médecine, université de Lausanne, rue du Bugnon 21, 1005 Lausanne, Suisse; Institut humanités, sciences et société, université de Paris, 5, rue Thomas-Mann, 75013 Paris, France; Fondation Agalma, campus biotech, chemin des Mines 9, 1202 Genève, Suisse. Electronic address:
Objectives: The present study focuses on a review of scientific literature upon structural and functional abnormalities of the insular cortex found in schizophrenic patients in order to emphasize links between the pathophysiology of this brain region and the symptomatology of schizophrenia.
Methods: From a review based upon journal articles published since 2002 and indexed into the Pubmed data base, we first studied the main findings on the function of the insular cortex and its involvement in the perception and representation of the body states, as it is one of the main neural substrates for the interoception sense. Then, we highlighted various structural abnormalities found in schizophrenic patients in order to study links existing between dysfunctions in the insular cortex and an altered perception of body states and of self-awareness in schizophrenia. Read More