542 results match your criteria integrated 3d-printed


High-Resolution 3D Printing for Electronics.

Adv Sci (Weinh) 2022 Jan 17:e2104623. Epub 2022 Jan 17.

Department of Materials Science and Engineering, Yonsei University, Seoul, 03722, Republic of Korea.

The ability to form arbitrary 3D structures provides the next level of complexity and a greater degree of freedom in the design of electronic devices. Since recent progress in electronics has expanded their applicability in various fields in which structural conformability and dynamic configuration are required, high-resolution 3D printing technologies can offer significant potential for freeform electronics. Here, the recent progress in novel 3D printing methods for freeform electronics is reviewed, with providing a comprehensive study on 3D-printable functional materials and processes for various device components. Read More

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January 2022

Zoomorphic Mobile Robot Development for Vertical Movement Based on the Geometrical Family Caterpillar.

Comput Intell Neurosci 2022 7;2022:3046116. Epub 2022 Jan 7.

The PNG University of Technology, Lae, Papua New Guinea.

Research in robotics is one of the promising areas in mobile robot development, which is planned to be implemented in extreme dangerous conditions of areas explored by humans. This article aims at developing and improving a prototype of zoomorphic mobile robots that are designed to repeat the existing biological objects in nature. The authors performed a detailed analysis on the structure and dynamics of the geometrical family caterpillar movement, which is passed on a practical design implemented to perform the dynamic movement on uneven vertical surfaces. Read More

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January 2022

A 3D-printed bioactive polycaprolactone scaffold assembled with core/shell microspheres as a sustained BMP2-releasing system for bone repair.

Mater Sci Eng C Mater Biol Appl 2022 Jan 5:112619. Epub 2022 Jan 5.

Department of Orthopedic Surgery, Shenzhen Hospital, Southern Medical University, Shenzhen 518000, PR China; The Third School of Clinical Medicine, Southern Medical University, Guangzhou 510500, PR China; Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering, School of Basic Medical Science, Southern Medical University, Guangzhou 510515, PR China. Electronic address:

Integration of biological factors and hierarchical rigid scaffolds is of great interest in bone tissue engineering for fabrication of biomimetic constructs with high physical and biological performance for enhanced bone repair. Core/shell microspheres (CSMs) delivering bone morphogenetic protein-2 (BMP-2) and a strategy to integrate CSMs with 3D-printed scaffolds were developed herein to form a hybrid 3D system for bone repair. The scaffold was printed with polycaprolactone (PCL) and then coated with polydopamine. Read More

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January 2022

Integrated 3D Printing-Based Framework-A Strategy to Fabricate Tubular Structures with Mechanocompromised Hydrogels.

ACS Appl Bio Mater 2021 Sep 26;4(9):6982-6992. Epub 2021 Aug 26.

Department of Biomedical Engineering, Indian Institute of Technology Hyderabad, Kandi, Sangareddy 502284, Telangana, India.

Several hollow organs perform various crucial functions in the body and must be replaced, repaired, or augmented in many disease conditions. Fabrication of tissue analogues to these hollow organs is incredibly challenging. Still, recent advancements in biofabrication have allowed researchers to pursue the development of several hollow organs such as blood vessels, esophagus, trachea, urethra, and others. Read More

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September 2021

Lab-In-A-Syringe: A Novel Electrochemical Biosensor for On-Site and Real-Time Monitoring of Dopamine in Freely Behaving Mice.

ACS Sens 2022 Jan 10. Epub 2022 Jan 10.

Department of Pharmaceutical Sciences, University of California, Irvine, California 92697-4625, United States.

There is a growing demand for real-time analysis and sampling of biofluids on a single low-cost platform in ultralow fluid volumes with robustness. In this study, a microfluidic sensor was developed, manufactured through an additive manufacturing technique, and used for dopamine (DA) measurements. We implemented a biosensing system using pencil graphites (PGEs) integrated into a three-dimensional (3D) printed microfluidic syringe-type device (μSyringe). Read More

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January 2022

NIR-II Ratiometric Lanthanide-Dye Hybrid Nanoprobes Doped Bioscaffolds for In Situ Bone Repair Monitoring.

Nano Lett 2022 Jan 10. Epub 2022 Jan 10.

Department of Chemistry, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, State Key Laboratory of Molecular Engineering of Polymers and iChem, Fudan University, Shanghai 200433, China.

In situ monitoring of tissue regeneration progression is of primary importance to basic medical research and clinical transformation. Despite significant progress in the field of tissue engineering and regenerative medicine, few technologies have been established to in situ inspect the regenerative process. Here, we present an integrated second near-infrared (NIR-II, 1000-1700 nm) window in vivo imaging strategy based on 3D-printed bioactive glass scaffolds doped with NIR-II ratiometric lanthanide-dye hybrid nanoprobes, allowing for in situ monitoring of the early inflammation, angiogenesis, and implant degradation during mouse skull repair. Read More

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January 2022

On-board smartphone micromotor-based fluorescence assays.

Lab Chip 2022 Jan 7. Epub 2022 Jan 7.

Department of Analytical Chemistry, Physical Chemistry and Chemical Engineering, University of Alcala, Alcala de Henares E-28871, Madrid, Spain.

Herein, we describe the design of a portable device integrated with micromotors for real-time fluorescence sensing of (bio)markers. The system comprises a universal 3D printed platform to hold a commercial smartphone, which is equipped with an external magnification optical lens (20-400×) and tailor-made emission filters directly attached to the camera, an adjustable sample holder to accommodate a glass slide and laser excitation sources. On a first approach, we illustrate the suitability of the platform using magnetic Janus micromotors modified with fluorescent [email protected] quantum dots for real-time ON-OFF mercury detection. Read More

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January 2022

Microscale impeller pump for recirculating flow in organs-on-chip and microreactors.

Lab Chip 2022 Jan 6. Epub 2022 Jan 6.

Departments of Chemistry and Biomedical Engineering, University of Virginia, 248 McCormick Rd, Charlottesville, VA 22904, USA.

Fluid flow is an integral part of microfluidic and organ-on-chip technology, ideally providing biomimetic fluid, cell, and nutrient exchange as well as physiological or pathological shear stress. Currently, many of the pumps that actively perfuse fluid at biomimetic flow rates are incompatible with use inside cell culture incubators, require many tubing connections, or are too large to run many devices in a confined space. To address these issues, we developed a user-friendly impeller pump that uses a 3D-printed device and impeller to recirculate fluid and cells on-chip. Read More

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January 2022

3D printed transwell-integrated nose-on-chip model to evaluate effects of air flow-induced mechanical stresses on mucous secretion.

Biomed Microdevices 2022 Jan 4;24(1). Epub 2022 Jan 4.

Air Force Research Laboratory, 711Th Human Performance Wing, Wright-Patterson AFB, Dayton, OH, USA.

While there are many chip models that simulate the air-tissue interface of the respiratory system, only a few represent the upper respiratory system. These chips are restricted to unidirectional flow patterns that are not comparable to the highly dynamic and variable flow patterns found in the native nasal cavity. Here we describe the development of a tunable nose-on-chip device that mimics the air-mucosa interface and is coupled to an air delivery system that simulates natural breathing patterns through the generation of bi-directional air flow. Read More

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January 2022

Integrated Platform Addressing the Finger-Prick Blood Processing Challenges of Point-of-Care Electrical Biomarker Testing.

Anal Chem 2022 Jan 3. Epub 2022 Jan 3.

Future Industries Institute, University of South Australia, Mawson Lakes, South Australia 5095, Australia.

Continued advances in label-free electrical biosensors pave the way to simple, rapid, cost-effective, high-sensitivity, and quantitative biomarker testing at the point-of-care setting that would profoundly transform healthcare. However, implementation in routine diagnostics is faced with significant challenges associated with the inherent requirement for biofluid sample processing before and during testing. We present here a simple yet robust autonomous finger-prick blood sample processing platform integrated with nanoscale field-effect transistor biosensors and demonstrate the feasibility of measuring the SARS-CoV-2 nucleocapsid protein. Read More

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January 2022

Nanoengineered biomimetic hydrogels: A major advancement to fabricate 3D-printed constructs for regenerative medicine.

Biotechnol Bioeng 2021 Dec 27. Epub 2021 Dec 27.

University Politehnica of Bucharest, Advanced Polymer Materials Group, Bucharest, Romania.

Nanostructured compounds already validated as performant reinforcements for biomedical applications together with different fabrication strategies have been often used to channel the biophysical and biochemical features of hydrogel networks. Ergo, a wide array of nanostructured compounds has been employed as additive materials integrated with hydrophilic networks based on naturally-derived polymers to produce promising scaffolding materials for specific fields of regenerative medicine. To date, nanoengineered hydrogels are extensively explored in (bio)printing formulations, representing the most advanced designs of hydrogel (bio)inks able to fabricate structures with improved mechanical properties and high print fidelity along with a cell-interactive environment. Read More

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December 2021

Integrating Real-time Video View with Pre-operative Models for Image-guided Renal Navigation: An in vitro Evaluation Study.

Annu Int Conf IEEE Eng Med Biol Soc 2021 11;2021:1366-1371

To provide a complete picture of a scene sufficient to conduct a minimally invasive, image-guided renal intervention, real-time laparoscopic video needs to be integrated with underlying anatomy information typically available from pre- or intra-operative images. Here we present a simple and efficient hand-eye calibration method for an optically tracked camera, which only requires the acquisition of several poses of a Polaris stylus featuring 4 markers automatically localized by both the camera and the optical tracker. We evaluate the calibration using both the Polaris stylus, as well as a patient-specific 3D printed kidney phantom in terms of the number of poses acquired, as well as the depth of the imaged scene into the field of view of the camera, by projecting the several landmarks on the imaged object at known location in the 3D world onto the camera image. Read More

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November 2021

3D Printing of Conductive Hydrogel-Elastomer Hybrids for Stretchable Electronics.

ACS Appl Mater Interfaces 2021 Dec 6;13(49):59243-59251. Epub 2021 Dec 6.

State Key Laboratory of Fluid Power & Mechatronic System, Key Laboratory of Soft Machines and Smart Devices of Zhejiang Province, Center for X-Mechanics, Department of Engineering Mechanics, Zhejiang University, Hangzhou 310027, China.

Electronically conductive hydrogels integrated with dielectric elastomers show great promise in a wide range of applications, such as biomedical devices, soft robotics, and stretchable electronics. However, one big conundrum that impedes the functionality and performance of hydrogel-elastomer-based devices lies in the strict demands of device integration and the requirements for devices with satisfactory mechanical and electrical properties. Herein, the digital light processing three-dimensional (3D) printing method is used to fabricate 3D functional devices that bridge submillimeter-scale device resolution to centimeter-scale object size and simultaneously realize complex hybrid structures with strong adhesion interfaces and desired functionalities. Read More

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December 2021

Dual-Material 3D-Printed Intestinal Model Devices with Integrated Villi-like Scaffolds.

ACS Appl Mater Interfaces 2021 Dec 6;13(49):58434-58446. Epub 2021 Dec 6.

Center for Intestinal Absorption and Transport of Biopharmaceuticals, Department of Health Technology, Technical University of Denmark, DK-2800 Kgs. Lyngby, Denmark.

small intestinal models aim to mimic the intestinal function and structure, including the villi architecture of the native tissue. Accurate models in a scalable format are in great demand to advance, for example, the development of orally administered pharmaceutical products. Widely used planar intestinal cell monolayers for compound screening applications fail to recapitulate the three-dimensional (3D) microstructural characteristics of the intestinal villi arrays. Read More

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December 2021

Silicon-Phosphorus-Nanosheets-Integrated 3D-Printable Hydrogel as a Bioactive and Biodegradable Scaffold for Vascularized Bone Regeneration.

Adv Healthc Mater 2021 Dec 5:e2101911. Epub 2021 Dec 5.

College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, China.

Natural bone is a highly vascularized tissue that relies on the vasculature for blood and nutrients supply to maintain skeletal integrity. Bioactive nanomaterials with the capability of improving vascularized bone regeneration are highly demanded for bone tissue engineering. In this work, 2D silicon phosphorus (SiP) is explored as a new kind of bioactive and biodegradable nanomaterial with excellent angiogenesis and osteogenesis, and a 3D printed biohybrid hydrogel of GelMA-PEGDA incorporated with photocrosslinkable SiP-nanosheet (GelMA-PEGDA/SiPAC) is developed to apply on bone tissue engineering. Read More

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December 2021

Precision 3D printed meniscus scaffolds to facilitate hMSCs proliferation and chondrogenic differentiation for tissue regeneration.

J Nanobiotechnology 2021 Dec 2;19(1):400. Epub 2021 Dec 2.

Medtronic Technology Center, Shanghai, 201114, China.

Background: The poor regenerative capability and structural complexity make the reconstruction of meniscus particularly challenging in clinic. 3D printing of polymer scaffolds holds the promise of precisely constructing complex tissue architecture, however the resultant scaffolds usually lack of sufficient bioactivity to effectively generate new tissue.

Results: Herein, 3D printing-based strategy via the cryo-printing technology was employed to fabricate customized polyurethane (PU) porous scaffolds that mimic native meniscus. Read More

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December 2021

Portable on-chip colorimetric biosensing platform integrated with a smartphone for label/PCR-free detection of Cryptosporidium RNA.

Sci Rep 2021 12 1;11(1):23192. Epub 2021 Dec 1.

School of Engineering, Faculty of Applied Science, The University of British Columbia, Kelowna, BC, V1V 1V7, Canada.

Cryptosporidium, a protozoan pathogen, is a leading threat to public health and the economy. Herein, we report the development of a portable, colorimetric biosensing platform for the sensitive, selective and label/PCR-free detection of Cryptosporidium RNA using oligonucleotides modified gold nanoparticles (AuNPs). A pair of specific thiolated oligonucleotides, complementary to adjacent sequences on Cryptosporidium RNA, were attached to AuNPs. Read More

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December 2021

Manufacturing of Microfluidic Devices with Interchangeable Commercial Fiber Optic Sensors.

Sensors (Basel) 2021 Nov 11;21(22). Epub 2021 Nov 11.

Research Centre for Carbon Solutions (RCCS), School of Engineering and Physical Sciences, Heriot-Watt University, Edinburgh EH14 4AS, UK.

In situ measurements are highly desirable in many microfluidic applications because they enable real-time, local monitoring of physical and chemical parameters, providing valuable insight into microscopic events and processes that occur in microfluidic devices. Unfortunately, the manufacturing of microfluidic devices with integrated sensors can be time-consuming, expensive, and "know-how" demanding. In this article, we describe an easy-to-implement method developed to integrate various "off-the-shelf" fiber optic sensors within microfluidic devices. Read More

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November 2021

A 3D-Printed Microfluidic Device for qPCR Detection of Macrolide-Resistant Mutations of .

Biosensors (Basel) 2021 Oct 29;11(11). Epub 2021 Oct 29.

State Key Laboratory of Transducer Technology, Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences, Shanghai 200050, China.

Mycoplasma pneumonia (MP) is a common respiratory infection generally treated with macrolides, but resistance mutations against macrolides are often detected in in China. Rapid and accurate identification of and its mutant type is necessary for precise medication. This paper presents a 3D-printed microfluidic device to achieve this. Read More

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October 2021

Framework for automated sorting of neural spikes from Neuralynx-acquired tetrode recordings in freely-moving mice.

Bioelectron Med 2021 Nov 23;7(1):17. Epub 2021 Nov 23.

Laboratory of Immune & Neural Networks, Institute of Molecular Medicine, Feinstein Institutes for Medical Research, Northwell Health, Manhasset, New York, USA, 350 Community Drive, Manhasset, NY, 11030, USA.

Background: Extracellular recording represents a crucial electrophysiological technique in neuroscience for studying the activity of single neurons and neuronal populations. The electrodes capture voltage traces that, with the help of analytical tools, reveal action potentials ('spikes') as well as local field potentials. The process of spike sorting is used for the extraction of action potentials generated by individual neurons. Read More

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November 2021

Optical module for single-shot quantitative phase imaging based on the transport of intensity equation with field of view multiplexing.

Opt Express 2021 Nov;29(24):39904-39919

We present a cost-effective, simple, and robust method that enables single-shot quantitative phase imaging (QPI) based on the transport of intensity equation (TIE) using an add-on optical module that can be assembled into the exit port of any regular microscope. The module integrates a beamsplitter (BS) cube (placed in a non-conventional way) for duplicating the output image onto the digital sensor (field of view - FOV - multiplexing), a Stokes lens (SL) for astigmatism compensation (introduced by the BS cube), and an optical quality glass plate over one of the FOV halves for defocusing generation (needed for single-shot TIE algorithm). Altogether, the system provides two laterally separated intensity images that are simultaneously recorded and slightly defocused one to each other, thus enabling accurate QPI by conventional TIE-based algorithms in a single snapshot. Read More

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November 2021

Using Spheroids as Building Blocks Towards 3D Bioprinting of Tumor Microenvironment.

Int J Bioprint 2021 21;7(4):444. Epub 2021 Oct 21.

Department of Pharmaceutics, University of Florida, Gainesville, Florida, 32610, USA.

Cancer still ranks as a leading cause of mortality worldwide. Although considerable efforts have been dedicated to anticancer therapeutics, progress is still slow, partially due to the absence of robust prediction models. Multicellular tumor spheroids, as a major three-dimensional (3D) culture model exhibiting features of avascular tumors, gained great popularity in pathophysiological studies and high throughput drug screening. Read More

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October 2021

Valvular regurgitation flow jet assessment using in vitro 4D flow MRI: Implication for mitral regurgitation.

Magn Reson Med 2021 Nov 16. Epub 2021 Nov 16.

Department of Radiology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, USA.

Purpose: The purpose of this study was to evaluate the accuracy of four-dimensional (4D) flow MRI for direct assessment of peak velocity, flow volume, and momentum of a mitral regurgitation (MR) flow jets using an in vitro pulsatile jet flow phantom. We systematically investigated the impact of spatial resolution and quantification location along the jet on flow quantities with Doppler ultrasound as a reference for peak velocity.

Methods: Four-dimensional flow MRI data of a pulsatile jet through a circular, elliptical, and 3D-printed patient-specific MR orifice model was acquired with varying spatial resolution (1. Read More

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November 2021

The effect of 3-D printed polylactic acid scaffold with and without hyaluronic acid on bone regeneration.

J Periodontol 2021 Nov 13. Epub 2021 Nov 13.

Department of Periodontology, School of Dentistry and Dental Research Institute, Seoul National University, 101, Daehak-ro, Jongno-gu, Seoul, 03080, Republic of Korea.

Background: Three- dimensional (3D) technology has been suggested to overcome several limitations in guided bone regeneration (GBR) procedures because 3D-printed scaffolds can be easily molded to patient-specific bone defect site. This study aimed to investigate the effect of 3-D printed polylactic acid (PLA) scaffolds with or without hyaluronic acid (HA) in a rabbit calvaria model.

Methods: A calvaria defect with a diameter of 15 mm was created in 30 New Zealand white rabbits. Read More

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November 2021

Improved Motion Classification With an Integrated Multimodal Exoskeleton Interface.

Front Neurorobot 2021 25;15:693110. Epub 2021 Oct 25.

Robotics & Multibody Mechanics Research Group, MECH Department, Vrije Universiteit Brussel, Brussel, Belgium.

Human motion intention detection is an essential part of the control of upper-body exoskeletons. While surface electromyography (sEMG)-based systems may be able to provide anticipatory control, they typically require exact placement of the electrodes on the muscle bodies which limits the practical use and donning of the technology. In this study, we propose a novel physical interface for exoskeletons with integrated sEMG- and pressure sensors. Read More

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October 2021

3D printed enzymatic microchip for multiplexed electrochemical biosensing.

Anal Chim Acta 2021 Nov 28;1186:339114. Epub 2021 Sep 28.

Laboratory of Analytical Chemistry, Department of Chemistry, National and Kapodistrian University of Athens, Athens, 157 71, Greece. Electronic address:

The low-cost e-fabrication of specialized multianalyte biosensors within the point-of-care (POC) settings in a few minutes remains a great challenge. Unlike prefabricated biosensors, 3D printing seems to be able to meet this challenge, empowering the end user with the freedom to create on-demand devices adapted to immediate bioanalytical need. Here, we describe a novel miniature all-3D-printed 4-electrode biochip, capable of the simultaneous determination of different biomarkers in a single assay. Read More

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November 2021

3D ultrasound navigation system for screw insertion in posterior spine surgery: a phantom study.

Int J Comput Assist Radiol Surg 2021 Nov 2. Epub 2021 Nov 2.

Department of Biomedical Engineering, University of Alberta, 1098 Research Transition Facility, 8308-114 Street, Edmonton, AB, T6G 2V2, Canada.

Purpose: Posterior spinal fusion surgery is required to correct severe idiopathic scoliosis. The surgery involves insertion of screws which requires high accuracy to prevent neurologic damage to the spinal cord. Although conventional CT navigation can reduce this risk, 3D-ultrasound-based navigation could achieve this without added ionizing radiation and usage of expensive and bulky equipment. Read More

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November 2021

3D printed and spiral lithographically patterned erbium-doped polymer micro-waveguide amplifiers.

Sci Rep 2021 Oct 28;11(1):21292. Epub 2021 Oct 28.

Photonics Devices and System Group, Singapore University of Technology and Design, 8 Somapah Rd, Singapore, 487372, Singapore.

Infrared (IR)-emitting RE doped materials have been extensively used to fabricate active components of integrated optical devices in various fields, such as fiber amplifiers, telecommunications, optoelectronics, and waveguides. Among various RE elements, trivalent erbium ions (Er 3+) are of great interest since their emissive behavior span the low loss telecommunication window of 1300-1650 nm. In this paper, we report two types of polymeric waveguide amplifiers. Read More

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October 2021

3D printing for the integration of porous materials into miniaturised fluidic devices: A review.

Anal Chim Acta 2021 Nov 14;1185:338796. Epub 2021 Jul 14.

Deakin University, Centre for Rural and Regional Futures, Locked Bag 20000, Geelong, VIC 3320, Australia. Electronic address:

Porous materials facilitate the efficient separation of chemicals and particulate matter by providing selectivity through structural and surface properties and are attractive as sorbent owing to their large surface area. This broad applicability of porous materials makes the integration of porous materials and microfluidic devices important in the development of more efficient, advanced separation platforms. Additive manufacturing approaches are fundamentally different to traditional manufacturing methods, providing unique opportunities in the fabrication of fluidic devices. Read More

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November 2021

3D Printed Integrated Multi-Layer Microfluidic Chips for Ultra-High Volumetric Throughput Nanoliposome Preparation.

Front Bioeng Biotechnol 2021 11;9:773705. Epub 2021 Oct 11.

School of Mechanical and Electrical Engineering, Central South University, Changsha, China.

Although microfluidic approaches for liposomes preparation have been developed, fabricating microfluidic devices remains expensive and time-consuming. Also, owing to the traditional layout of microchannels, the volumetric throughput of microfluidics has been greatly limited. Herein an ultra-high volumetric throughput nanoliposome preparation method using 3D printed microfluidic chips is presented. Read More

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October 2021