1,299 results match your criteria integral proper

EXOC1 plays an integral role in spermatogonia pseudopod elongation and spermatocyte stable syncytium formation in mice.

Elife 2021 May 11;10. Epub 2021 May 11.

Laboratory Animal Resource Center, Trans-border Medical Research Center, University of Tsukuba, Tsukuba, Japan.

The male germ cells must adopt the correct morphology at each differentiation stage for proper spermatogenesis. The spermatogonia regulates its differentiation state by its own migration. The male germ cells differentiate and mature with the formation of syncytia, failure of forming the appropriate syncytia results in the arrest at the spermatocyte stage. Read More

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Perceived Barriers to Primary Care Services Utilization and its Associations with Overall Satisfaction of Patients in Saudi Arabia: A Cross-Sectional Questionnaire-Based Study.

J Prim Care Community Health 2021 Jan-Dec;12:21501327211014065

Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia.

Introduction: Primary care plays an integral role in modern healthcare systems. More so in a country that is currently undergoing a reform of its health system. Their remains barriers that hinder patients from seeking medical assistance from primary physicians. Read More

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TMEM41B and VMP1 are scramblases and regulate the distribution of cholesterol and phosphatidylserine.

J Cell Biol 2021 Jun;220(6)

School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, New South Wales, Australia.

TMEM41B and VMP1 are integral membrane proteins of the endoplasmic reticulum (ER) and regulate the formation of autophagosomes, lipid droplets (LDs), and lipoproteins. Recently, TMEM41B was identified as a crucial host factor for infection by all coronaviruses and flaviviruses. The molecular function of TMEM41B and VMP1, which belong to a large evolutionarily conserved family, remains elusive. Read More

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Fatigue Performance of Double-Layered Asphalt Concrete Beams Reinforced with New Type of Geocomposites.

Materials (Basel) 2021 Apr 24;14(9). Epub 2021 Apr 24.

Faculty of Civil Engineering, Silesian University of Technology, 44-100 Gliwice, Poland.

The reinforcement of asphalt layers with geosynthetics has been used for several decades, but proper evaluation of the influence of these materials on pavement fatigue life is still a challenging task. The presented study investigates a novel approach to the reinforcement of asphalt layers using a new type of geogrid composite, in which square or hexagonal polypropylene stiff monolithic paving grid with integral junctions is bonded to polypropylene non-woven paving fabric. The laboratory fatigue tests were performed on large asphalt concrete beams reinforced with the new type of geocomposite. Read More

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Bioinformatic strategies for the analysis of genomic aberrations detected by targeted NGS panels with clinical application.

PeerJ 2021 31;9:e10897. Epub 2021 Mar 31.

Center of Molecular Medicine, Central European Institute of Technology, Masaryk University, Brno, Czech Republic.

Molecular profiling of tumor samples has acquired importance in cancer research, but currently also plays an important role in the clinical management of cancer patients. Rapid identification of genomic aberrations improves diagnosis, prognosis and effective therapy selection. This can be attributed mainly to the development of next-generation sequencing (NGS) methods, especially targeted DNA panels. Read More

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Lipoprotein DolP supports proper folding of BamA in the bacterial outer membrane promoting fitness upon envelope stress.

Elife 2021 04 13;10. Epub 2021 Apr 13.

Laboratoire de Microbiologie et Génétique Moléculaires (LMGM), Centre de Biologie Intégrative (CBI), Université de Toulouse, CNRS, UPS, Toulouse, France.

In Proteobacteria, integral outer membrane proteins (OMPs) are crucial for the maintenance of the envelope permeability barrier to some antibiotics and detergents. In Enterobacteria, envelope stress caused by unfolded OMPs activates the sigmaE (σ) transcriptional response. σ upregulates OMP biogenesis factors, including the β-barrel assembly machinery (BAM) that catalyses OMP folding. Read More

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Percutaneous Transhepatic Vein Permcath: A Case Report.

Indian J Nephrol 2020 Nov-Dec;30(6):430-432. Epub 2020 Nov 19.

Interventional Radiology, Apollo Hospital, Jubillee Hills, Hyderabad, Telangana, India.

In patients with end-stage renal disease (ESRD), functional vascular access is like a lifeline. Among the patients undergoing hemodialysis, arteriovenous fistulas are done in most of them. However, in approximately 15% of these patients with multiple access failures, the use of tunneled dialysis catheters (TDC) for hemodialysis has become an integral component of treatment plans. Read More

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November 2020

Differences in the properties of porcine cortical and nuclear fiber cell plasma membranes revealed by saturation recovery EPR spin labeling measurements.

Exp Eye Res 2021 May 12;206:108536. Epub 2021 Mar 12.

Department of Biophysics, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI, 53226, USA. Electronic address:

Eye lens membranes are complex biological samples. They consist of a variety of lipids that form the lipid bilayer matrix, integral proteins embedded into the lipid bilayer, and peripheral proteins. This molecular diversity in membrane composition induces formation of lipid domains with particular physical properties that are responsible for the maintenance of proper membrane functions. Read More

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Bicaudal C is required for the function of the follicular epithelium during oogenesis in Rhodnius prolixus.

Dev Genes Evol 2021 Mar 11;231(1-2):33-45. Epub 2021 Mar 11.

Centro de Bioinvestigaciones (UNNOBA-CICBA), CITNOBA (UNNOBA-CONICET), 2700, Pergamino, Buenos Aires, Argentina.

The morphology and physiology of the oogenesis have been well studied in the vector of Chagas disease Rhodnius prolixus. However, the molecular interactions that regulate the process of egg formation, key for the reproductive cycle of the vector, is still largely unknown. In order to understand the molecular and cellular basis of the oogenesis, we examined the function of the gene Bicaudal C (BicC) during oogenesis and early development of R. Read More

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Assignment of vibrational states within configuration interaction calculations.

J Chem Phys 2020 May;152(19):194112

Institut für Theoretische Chemie, Universität Stuttgart, Pfaffenwaldring 55, 70569 Stuttgart, Germany.

The assignment of vibrational states is an integral part of quantum chemical calculations, which supports the analysis of experimental infrared spectra. In variational calculations, usually, it is the leading coefficient of the configuration interaction vector, which provides the state identity. However, this concept will possibly fail in case of special coordinate systems, such as, for example, localized normal coordinates, or within calculations for overtones of non-Abelian molecules, when a real valued configuration basis has been employed. Read More

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Proper CycE-Cdk2 activity in endocycling tissues requires regulation of the cyclin-dependent kinase inhibitor Dacapo by dE2F1b in Drosophila.

Genetics 2021 Mar;217(1):1-15

Department of Biology, Developmental Biology Research Initiative, McGill University, Montreal, Quebec H3A 1B1 Canada.

Polyploidy is an integral part of development and is associated with cellular stress, aging, and pathological conditions. The endocycle, comprised of successive rounds of G and S phases without mitosis, is widely employed to produce polyploid cells in plants and animals. In Drosophila, maintenance of the endocycle is dependent on E2F-governed oscillations of Cyclin E (CycE)-Cdk2 activity, which is known to be largely regulated at the level of transcription. Read More

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Selection of Embedding Dimension and Delay Time in Phase Space Reconstruction via Symbolic Dynamics.

Entropy (Basel) 2021 Feb 11;23(2). Epub 2021 Feb 11.

Departamento Metodos Cuantitativos, Ciencias Juridicas y Lenguas Modernas, Universidad Politecnica de Cartagena, 30201 Cartagena, Spain.

The modeling and prediction of chaotic time series require proper reconstruction of the state space from the available data in order to successfully estimate invariant properties of the embedded attractor. Thus, one must choose appropriate time delay τ∗ and embedding dimension for phase space reconstruction. The value of τ∗ can be estimated from the Mutual Information, but this method is rather cumbersome computationally. Read More

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February 2021

Expression of a membrane-targeted fluorescent reporter disrupts auditory hair cell mechanoelectrical transduction and causes profound deafness.

Hear Res 2021 May 18;404:108212. Epub 2021 Feb 18.

Molecular Physiology and Biophysics Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, United States. Electronic address:

The reporter mT/mG mice expressing a membrane-targeted fluorescent protein are becoming widely used to study the auditory and vestibular system due to its versatility. Here we show that high expression levels of the fluorescent mtdTomato reporter affect the function of the sensory hair cells and the auditory performance of mT/mG transgenic mice. Auditory brainstem responses and distortion product otoacoustic emissions revealed that adult mT/mG homozygous mice are profoundly deaf, whereas heterozygous mice present high frequency loss. Read More

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Loss of mature D1 leads to compromised CP43 assembly in Arabidopsis thaliana.

BMC Plant Biol 2021 Feb 20;21(1):106. Epub 2021 Feb 20.

State Key Laboratory of Hybrid Rice, College of Life Sciences, Wuhan University, Wuhan, 430072, China.

Background: Photosystem II (PSII) is a highly conserved integral-membrane multi-subunit pigment-protein complex. The proteins, pigments, lipids, and ions in PSII need to be assembled precisely to ensure a proper PSII biogenesis. D1 is the main subunit of PSII core reaction center (RC), and is usually synthesized as a precursor D1. Read More

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February 2021

Biomechanical Response to External Biofeedback During Functional Tasks in Individuals With Chronic Ankle Instability.

J Athl Train 2021 Feb 18. Epub 2021 Feb 18.

Department of Kinesiology, University of North Carolina at Charlotte.

Context: Altered biomechanics displayed by individuals with chronic ankle instability (CAI) is a possible cause of recurring injuries and posttraumatic osteoarthritis. Current interventions are unable to modify aberrant biomechanics, leading to research efforts to determine if real-time external biofeedback can result in changes.

Objective: To determine the real-time effects of visual and auditory biofeedback on functional-task biomechanics in individuals with CAI. Read More

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February 2021

External Quality Assessment Practices in Clinical Biochemistry Laboratory: What is the need ?

A Niraula M Bataju

Kathmandu Univ Med J (KUMJ) 2020 Jan.-Mar;18(69):86-92

Department of Biochemistry, KIST Medical College and Teaching Hospital, Lalitpur, Nepal.

Health Care services is considered as an amalgamation between the doctor undergoing the examination and laboratory personnel behind the proper diagnosis of the patient. It has evolved to a large extent from a simple process of examination to handling the prescription to the patient. During this evolution, there has been a remarkable development in the field of laboratory diagnosis. Read More

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February 2021

Thoracic Endemic Fungi in the United States: Importance of Patient Location.

Radiographics 2021 Mar-Apr;41(2):380-398. Epub 2021 Feb 5.

From the Department of Clinical Radiology, University of Missouri-Columbia, 1 Hospital Dr, Columbia, MO 65212 (J.R.K., A.H.); Department of Radiology, University of Southern California, Los Angeles, Calif (L.F.B.); Departments of Diagnostic Radiology (C.F.) and Pathology (D.S.), Oregon Health Sciences & University, Portland, Ore; and Department of Diagnostic Radiology, University of Kansas Medical Center, Kansas City, Kan (C.M.W.).

The digitization of radiographic studies along with high-speed transmission of images has formed the basis of teleradiology, which has become an integral component in the workflow of a contemporary radiology practice. It is with this advent and growing utilization of teleradiology that the significance of the source location of images has gained importance. Specifically, the importance of where the patient resides and what endemic fungi occur in that location cannot be underestimated. Read More

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February 2021

Recognizing the value of software: a software citation guide.

F1000Res 2020 19;9:1257. Epub 2020 Oct 19.

AAAS, Washington, DC, USA.

Software is as integral as a research paper, monograph, or dataset in terms of facilitating the full understanding and dissemination of research. This article provides broadly applicable guidance on software citation for the communities and institutions publishing academic journals and conference proceedings. We expect those communities and institutions to produce versions of this document with software examples and citation styles that are appropriate for their intended audience. Read More

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Hypoxia-inducible factor (HIF): fuel for cancer progression.

Curr Mol Pharmacol 2021 Jan 20. Epub 2021 Jan 20.

School of Pharmaceutical Sciences, Lovely Professional University, Phagwara-144411, Punjab. India.

Hypoxia is an integral part of tumor microenvironment, caused primarily due to rapidly multiplying tumor cells and a lack of proper blood supply. Among the major hypoxic pathways, HIF-1 transcription factor activation is one of the widely investigated pathways in the hypoxic tumor microenvironment (TME). HIF-1 is known to activate several adaptive reactions in response to oxygen deficiency in tumor cells. Read More

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January 2021

Quantum-Classical Path Integral Simulation of Excess Proton Dynamics in a Water Dimer Embedded in the Gramicidin Channel.

J Chem Theory Comput 2021 Feb 25;17(2):627-638. Epub 2021 Jan 25.

Department of Chemistry, University of Illinois, 505 South Mathews Avenue, Urbana, Illinois 61801, United States.

We use the quantum-classical path integral (QCPI) methodology to investigate the relaxation dynamics of an excess proton that has been inserted in a water dimer embedded in the gramicidin A channel at room temperature. We obtain one-dimensional potential slices for the quantum degree of freedom through a proper transformation to internal coordinates. Our results indicate that the proton transfer is driven by the oscillation of the oxygen pair, and that the transfer occurs primarily at single-well or nearby low-barrier configurations. Read More

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February 2021

Association Between Formative Assessment and Academic Performance for Undergraduate Medical Students in a Chinese Clinical Skills Training Course.

Med Sci Monit 2021 Jan 23;27:e929068. Epub 2021 Jan 23.

Department of Simulation Center, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong, China (mainland).

BACKGROUND Previous research suggests that formative assessment (FA) enhances learning outcomes, but few studies have evaluated its impact on clinical skills training in China. We conducted this study in a clinical skills integral curriculum to further explore the educational value of FA. MATERIAL AND METHODS Sixty undergraduates from the Second Clinical Medical School of the Southern Medical University in 2016 were selected as the experimental group (consecutive FA), and 50 undergraduates in 2015 were selected as the control term (only final summative assessment, SA). Read More

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January 2021

Clinical and Epidemiological Characteristics of Postdischarge Patients With COVID-19 in Tehran, Iran: Protocol for a Prospective Cohort Study (Tele-COVID-19 Study).

JMIR Res Protoc 2021 Feb 2;10(2):e23316. Epub 2021 Feb 2.

HIV/Sexually Transmitted Infection Surveillance Research Center, and World Health Organization Collaborating Center for HIV Surveillance, Institute for Futures Studies in Health, Kerman University of Medical Sciences, Kerman, Iran.

Background: COVID-19 was declared a pandemic on March 11, 2020. Given that the severe shortage of hospital beds has led to early discharge and insufficient patient education on home care routines and isolation protocols, the close follow-up of patients and their immediate relatives is an integral part of transitioning from hospital care to home care for patients with COVID-19.

Objective: We designed the Tele-COVID-19 prospective cohort to follow-up with COVID-19 patients in Tehran, Iran, and improve health care delivery and the recording of postdischarge patients' clinical profiles. Read More

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February 2021

Investigating the malleable socioeconomic resilience pathway to urban cohesion: a case of Taipei metropolitan area.

Tzen-Ying Ling

Environ Dev Sustain 2021 Jan 10:1-26. Epub 2021 Jan 10.

Department of Architecture, Tamkang University, No. 151, Yingzhuan Rd, Tamsui District, New Taipei City, 251 Taiwan.

It is known that globalization has led first- and second-tier cities' urban restructuring trajectories, excreted pressures, and caused tremendous socioeconomic volatility. This resulted in marginalized communities in dire of social empowerment, employment structure variance, and industry sectoral adjustment. Moreover, recent successive climate and health crisis unfolded and affirmed the state of our urban incompetence to sustain socioeconomic resilience or otherwise; lacking swift responses in providing critical management and services, cites are facing multifaceted challenges. Read More

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January 2021

Treatment of COVID-19 pneumonia with glucocorticoids (CORTIVID): a structured summary of a study protocol for a randomised controlled trial.

Trials 2021 Jan 11;22(1):43. Epub 2021 Jan 11.

Internal Medicine Department, Complejo Hospitalario de Navarra, Pamplona, Spain.

Objectives: The aim of this study is to assess the effectiveness and safety of glucocorticoid infusion pulse therapy to improve the clinical outcomes of patients with COVID-19 pneumonia with elevated inflammatory biomarkers.

Trial Design: A parallel-group quadruple-blind (participant, intervention provider, outcome assessor and data manager), randomised controlled trial.

Participants: All patients admitted to hospital due to COVID-19 pneumonia will be considered eligible. Read More

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January 2021

An Improved Calibration Method for Photonic Mixer Device Solid-State Array Lidars Based on Electrical Analog Delay.

Sensors (Basel) 2020 Dec 20;20(24). Epub 2020 Dec 20.

Key Laboratory of Biomimetic Robots and Systems (Ministry of Education), Beijing Institute of Technology, Beijing 100081, China.

As a typical application of indirect-time-of-flight (ToF) technology, photonic mixer device (PMD) solid-state array Lidar has gained rapid development in recent years. With the advantages of high resolution, frame rate and accuracy, the equipment is widely used in target recognition, simultaneous localization and mapping (SLAM), industrial inspection, etc. The PMD Lidar is vulnerable to several factors such as ambient light, temperature and the target feature. Read More

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December 2020

Heat stress management in poultry.

Akshat Goel

J Anim Physiol Anim Nutr (Berl) 2021 Jan 8. Epub 2021 Jan 8.

Department of Animal Science, Gyeongsang National University, Jinju, Korea.

High ambient temperature is one of the major causes of economic losses in the livestock industry. The poultry industry is an integral part of the livestock industry. It faces severe losses due to heat stress (HS). Read More

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January 2021

Signal Recognition Particle RNA Contributes to Oxidative Stress Response in by Modulating Catalase Localization.

Front Microbiol 2020 18;11:613571. Epub 2020 Dec 18.

McKetta Department of Chemical Engineering, The University of Texas at Austin, Austin, TX, United States.

The proper functioning of many proteins requires their transport to the correct cellular compartment or their secretion. Signal recognition particle (SRP) is a major protein transport pathway responsible for the co-translational movement of integral membrane proteins as well as periplasmic proteins. is a ubiquitous bacterium that expresses a complex phenotype of extreme oxidative stress resistance, which depends on proteins involved in DNA repair, metabolism, gene regulation, and antioxidant defense. Read More

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December 2020

Valuableness of introduction of laryngeal abductor reflex intraoperative neuromonitoring technique in lower brainstem lesion.

Surg Neurol Int 2020 11;11:425. Epub 2020 Dec 11.

Department of Neurology, Lozano Blesa University Clinical Hospital, Zaragoza, Spain.

Background: Our aim is to evaluate the use of laryngeal adductor reflex (LAR) for posterior fossa and brainstem surgeries in conjunction with current intraoperative neuromonitoring (IONM) techniques.

Case Description: The patient is a 62-year-old woman who complained of decreased hearing on her left side, dizziness, and left facial palsy. After proper investigation, she was found to have a left vestibular schwannoma. Read More

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December 2020

The conserved translation factor LepA is required for optimal synthesis of a porin family in .

J Bacteriol 2020 Dec 23. Epub 2020 Dec 23.

Department of Immunology and Infectious Disease, Harvard TH Chan School of Public Health, Boston, Massachusetts, 02115, United States

The recalcitrance of mycobacteria to antibiotic therapy is in part due to its ability to build proteins into a multi-layer cell wall. Proper synthesis of both cell wall constituents and associated proteins is crucial to maintaining cell integrity, and intimately tied to antibiotic susceptibility. How mycobacteria properly synthesize the membrane-associated proteome, however, remains poorly understood. Read More

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December 2020

Clinical utility of a personalized and long-term monitoring device for Parkinson's disease in a real clinical practice setting: An expert opinion survey on STAT-ON™.

Neurologia 2020 Dec 24. Epub 2020 Dec 24.

Hospital Fundación Jiménez Díaz, Madrid, Spain.

Background: STAT-ON™ is an objective tool that registers ON-OFF fluctuations making possible to know the state of the patient at every moment of the day in normal life. Our aim was to analyze the opinion of different Parkinson's disease experts about the STAT-ON™ tool after using the device in a real clinical practice setting (RCPS).

Methods: STAT-ON™ was provided by the Company Sense4Care to Spanish neurologists for using it in a RCPS. Read More

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December 2020