133,147 results match your criteria insulin resistance


The Impact of Telmisartan on Cardiometabolic Risk Factors in Hypertensive Male Siblings of Women with Polycystic Ovary Syndrome.

J Clin Pharmacol 2021 Apr 10. Epub 2021 Apr 10.

Department of Internal Medicine and Clinical Pharmacology, Medical University of Silesia, Katowice, Poland.

Brothers of women with polycystic ovary syndrome (PCOS) were found to be at increased risk for cardiometabolic disorders. This risk may be exacerbated by concurrent poorly-controlled hypertension. Angiotensin II receptor blockers are the most frequently used anti-hypertensive drugs. Read More

View Article and Full-Text PDF

Insulin resistance and bone health in adolescents.

Arch Osteoporos 2021 Apr 10;16(1):66. Epub 2021 Apr 10.

Endocrinology and Metabolism Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

Insulin resistance may be linked to bone health in young people. This study is the first on adolescents that jointly examined the association of bone health with insulin resistance and body composition. Our results revealed significant negative association between bone parameters and insulin resistance, even after adjustment for confounding factors. Read More

View Article and Full-Text PDF

Atherogenic Dyslipidemia After Liver Transplantation: Mechanisms and Clinical Implications.

Liver Transpl 2021 Apr 10. Epub 2021 Apr 10.

Department of Gastroenterology, Nutrition and Hepatology, Virginia Commonwealth University, Richmond, VA, United States.

Cardiovascular disease (CVD), particularly atherosclerosis-associated CVD, is a major cause of long-term mortality after liver transplantation (LT). The liver is central in lipid homeostasis and changes associated with insulin resistance, weight gain, adipose tissue inflammation, and development of nonalcoholic fatty liver disease after LT promote atherogenesis. These factors synergistically alter lipid homeostasis, thereby leading to production of pro-atherogenic lipoproteins, which contribute to heighted risk of CVD associated events observed in LT recipients. Read More

View Article and Full-Text PDF

Insights into intrauterine growth restriction based on maternal and umbilical cord blood metabolomics.

Sci Rep 2021 Apr 9;11(1):7824. Epub 2021 Apr 9.

Institute of Chemical Biology, National Hellenic Research Foundation, Athens, Greece.

Intrauterine growth restriction (IUGR) is a fetal adverse condition, ascribed by limited oxygen and nutrient supply from the mother to the fetus. Management of IUGR is an ongoing challenge because of its connection with increased fetal mortality, preterm delivery and postnatal pathologies. Untargeted nuclear magnetic resonance (H NMR) metabolomics was applied in 84 umbilical cord blood and maternal blood samples obtained from 48 IUGR and 36 appropriate for gestational age (AGA) deliveries. Read More

View Article and Full-Text PDF

[A new hypothesis on vascular calcifi cation: the exhausting buff er syndrome (EBS)].

Neuropsychopharmacol Hung 2021 Mar;23(1):215-220

Municipal Clinic of Szentendre, Internal Medicine Szentendre,

Here we propose that the Western world lifestyle disrupts phosphate metabolism and homeostasis due to caloric or acidic hyperphagia. Psychic factors such as social defeat due to stressed social coexistence characterized by reduced activity and chronic hypoventilation (hypercapnia) also play a role. At least two mechanisms mediate the harmful vascular eff ects of phosphates with intracellular acidosis being a feature in both of them. Read More

View Article and Full-Text PDF

Cell-autonomous defects contribute to insulin resistance in skeletal muscle.

J Diabetes Investig 2021 Apr 9. Epub 2021 Apr 9.

Department of Diabetes, Endocrinology and Nutrition, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

Insulin resistance is a major factor in the development of type 2 diabetes. Skeletal muscle is the first organ to exhibit insulin resistance, which precedes onset of type 2 diabetes and may be predictive of the disease (1). Despite the fact that skeletal muscle insulin resistance is clearly involved in the pathogenesis of type 2 diabetes, it has been unclear whether the underlying mechanism crucially involves defects in cell-autonomous signaling or alterations in blood lipids, hormones, and other systemic changes that modulate insulin action in type 2 diabetes. Read More

View Article and Full-Text PDF

Pro- and anti-inflammatory adipokines are associated with cardiometabolic risk markers in Brazilian schoolchildren.

Eur J Pediatr 2021 Apr 9. Epub 2021 Apr 9.

Department of Nutrition and Health, Universidade Federal de Viçosa, Av. P.H. Rolfs s/n, Centro de Ciências Biológicas II, Campus Universitário, Viçosa, Minas Gerais, 36570-900, Brazil.

Pro- and anti-inflammatory adipokines have been regarded as potential markers of obesity and cardiometabolic comorbidities. However, few studies have evaluated this association in children. We aimed to evaluate the relationship between adipokine concentrations and cardiometabolic risk markers in Brazilian schoolchildren. Read More

View Article and Full-Text PDF

Potential Alteration of Statin-Related Pharmacological Features in Diabetes Mellitus.

Biomed Res Int 2021 26;2021:6698743. Epub 2021 Mar 26.

Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.

Objective: Type 2 diabetes mellitus is a chronic metabolic disease caused by insulin resistance or insulin deficiency resulting in elevated blood glucose levels. Poorly controlled diabetes is associated with the development of cardiovascular disease and dyslipidemia. 3-Hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statin) are an important class of therapeutic agents used to control hyperlipidemia and prevent cardiovascular disease in diabetic and nondiabetic patients. Read More

View Article and Full-Text PDF

Psoriasis and Diabetes, a Dangerous Association: Evaluation of Insulin Resistance, Lipid Abnormalities, and Cardiovascular Risk Biomarkers.

Front Med (Lausanne) 2021 23;8:605691. Epub 2021 Mar 23.

Department of Internal Medicine and Therapeutics, Centre of Diabetes and Metabolic Diseases, University of Pavia and Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo, Pavia, Italy.

Psoriasis is an immune-mediated dermatosis with cardio-metabolic comorbidities. The aim of this study was to assess insulin-resistance, lipid abnormalities, and cardiovascular risk biomarkers in psoriatic patients with or without type 2 diabetes mellitus (T2DM). We enrolled 425 patients: 86 psoriatics, 69 psoriatics with T2DM, 120 T2DM patients, and 150 healthy subjects. Read More

View Article and Full-Text PDF

Vitamin D Effect on Ultrasonography and Laboratory Indices and Biochemical Indicators in the Blood: an Interventional Study on 12 to 18-Year-Old Children with Fatty Liver.

Pediatr Gastroenterol Hepatol Nutr 2021 Mar 4;24(2):187-196. Epub 2021 Mar 4.

Fellowship of Interventional Radiology, Birjand University of Medical Sciences, Birjand, Iran.

Purpose: The rising prevalence of childhood obesity in the past decades has caused non-alcoholic fatty liver disease (NAFLD) to become the most common cause of pediatric chronic liver disease worldwide. This study was aimed at determining the effect of vitamin D (Vit D) on ultrasonography and laboratory indices of NAFLD and some blood biochemical indicators in children.

Methods: In this interventional study liver ultrasonography was performed in 200 children with overweight and obesity. Read More

View Article and Full-Text PDF

Insulin Resistance Indexes as Biomarkers of Lifetime Cardiovascular Risk among Adults from Peru.

J Nutr Metab 2021 25;2021:6633700. Epub 2021 Mar 25.

Department of Basic Sciences, Human Medicine School, Peruvian Union University (UPeU), Lima 15, Peru.

Background: Cardiovascular disease (CVD) is the most prevalent cause of death from disease and disability in the world. Reliable markers are needed to assess and reduce cardiovascular risk. This study aimed to determine if insulin resistance indexes, triglycerides to HDL-cholesterol ratio (TG/HDL-C), and triglyceride glucose index (TyG) are biomarkers for lifetime cardiovascular risk (CVR). Read More

View Article and Full-Text PDF

Early Predictors in the Onset of Type 2 Diabetes at Different Fasting Blood Glucose Levels.

Diabetes Metab Syndr Obes 2021 31;14:1485-1492. Epub 2021 Mar 31.

Department of Endocrinology, The First People's Hospital of Yinchuan, Yinchuan, 750001, People's Republic of China.

Purpose: This study investigates the possible roles and potential prediction ability of metabolic parameters in the early development of T2D by detecting their serum levels at different fasting blood glucose (FBG) levels.

Methods: The subjects were included and divided into normal glucose tolerance (NGT), prediabetes (PD), and T2Dsubgroups. Apart from detecting the levels of routine biochemical parameters, fasting serum insulin (FINS), 25(OH)D, thioredoxin-interacting protein (TXNIP), thioredoxin (TRX), and NOD-like receptor family, pyrin domain-containing 3 (NLRP3) were detected. Read More

View Article and Full-Text PDF

Metabolic complications of hepatitis C virus infection.

World J Gastroenterol 2021 Apr;27(13):1267-1282

Department of Endocrinology and Metabolism, Lancashire Teaching Hospitals NHS Trust, Preston PR2 9HT, United Kingdom.

Hepatitis C virus (HCV) infection is a systemic disease that is implicated in multiple extrahepatic organ dysfunction contributing to its protean manifestations. HCV is associated with diverse extrahepatic disorders including atherosclerosis, glucose and lipid metabolic disturbances, alterations in the iron metabolic pathways, and lymphoproliferative diseases over and above the traditional liver manifestations of cirrhosis and hepatocellular carcinoma. The orchestration between HCV major proteins and the liver-muscle-adipose axis, poses a major burden on the global health of human body organs, if not adequately addressed. Read More

View Article and Full-Text PDF

Autocrine IGF2 programmes β-cell plasticity under conditions of increased metabolic demand.

Sci Rep 2021 Apr 8;11(1):7717. Epub 2021 Apr 8.

Metabolic Research Laboratories and MRC Metabolic Diseases Unit, Institute of Metabolic Science, Addenbrookes Hospital, University of Cambridge, Cambridge, CB2 0QQ, UK.

When exposed to nutrient excess and insulin resistance, pancreatic β-cells undergo adaptive changes in order to maintain glucose homeostasis. The role that growth control genes, highly expressed in early pancreas development, might exert in programming β-cell plasticity in later life is a poorly studied area. The imprinted Igf2 (insulin-like growth factor 2) gene is highly transcribed during early life and has been identified in recent genome-wide association studies as a type 2 diabetes susceptibility gene in humans. Read More

View Article and Full-Text PDF

Carbohydrates: Separating fact from fiction.

Atherosclerosis 2021 Mar 28. Epub 2021 Mar 28.

Department of Cardiovascular Medicine, Heart, Vascular, Thoracic Institute, Cleveland Clinic, Cleveland, OH, USA. Electronic address:

The role of carbohydrate in a healthy diet has been controversial. The confusion over carbohydrate has come from the long standing limitation of dietary recall studies as well as inability in many of these studies to delineate between the different types of carbohydrates. It is the aim of this paper, to understand and review the data on the role of carbohydrate as pertaining to weight, insulin resistance, diabetes, inflammation, lipids, as well as epidemiological data on long-term cardiovascular outcome and all-cause mortality. Read More

View Article and Full-Text PDF

Molecular mechanisms of lipotoxicity-induced pancreatic β-cell dysfunction.

Int Rev Cell Mol Biol 2021 12;359:357-402. Epub 2021 Mar 12.

Department of Molecular Biophysics, Biofisika Institute (University of Basque Country and Consejo Superior de Investigaciones Científicas (UPV/EHU, CSIC)), Leioa, Spain; Department of Biochemistry and Molecular Biology, University of the Basque Country (UPV/EHU), Leioa, Spain. Electronic address:

Type 2 diabetes (T2D), a heterogeneous disorder derived from metabolic dysfunctions, leads to a glucose overflow in the circulation due to both defective insulin secretion and peripheral insulin resistance. One of the critical risk factor for T2D is obesity, which represents a global epidemic that has nearly tripled since 1975. Obesity is characterized by chronically elevated free fatty acid (FFA) levels, which cause deleterious effects on glucose homeostasis referred to as lipotoxicity. Read More

View Article and Full-Text PDF

Mixed pathologies in pancreatic β cells from subjects with neurodegenerative diseases and their interaction with prion protein.

Acta Neuropathol Commun 2021 Apr 8;9(1):64. Epub 2021 Apr 8.

Neurosciences Division, Center for Applied Medical Research (CIMA), Universidad de Navarra, Pamplona, Spain.

Protein misfolding diseases refer to a variety of disorders that develop as a consequence of the misfolding of proteins in various organs. The etiologies of Parkinson's and Alzheimer's disease remain unclear, but it seems that type two diabetes and other prediabetic states could contribute to the appearance of the sporadic forms of these diseases. In addition to amylin deposition, other amyloidogenic proteins implicated in the pathophysiology of neurodegenerative diseases could have important roles in the pathogenesis of this disease. Read More

View Article and Full-Text PDF

Comparison of changes in lipid metabolism disorder, insulin resistance, inflammation and intestinal flora in patients in different stages of uremia.

Minerva Med 2021 Apr 9. Epub 2021 Apr 9.

Department of Nephrology, The Second Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Guiyang, China -

View Article and Full-Text PDF

Metabolic syndrome in Zambian adults with human immunodeficiency virus on antiretroviral therapy: Prevalence and associated factors.

Medicine (Baltimore) 2021 Apr;100(14):e25236

University of Zambia School of Public Health.

Abstract: Metabolic syndrome (MetS) is a constellation of factors including hypertension, abdominal obesity, dyslipidemia, and insulin resistance that separately and together significantly increase risk for cardiovascular disease (CVD) and diabetes. In sub-Saharan Africa, with a substantial burden of human immunodeficiency virus (HIV) and increasing prevalence of CVD and diabetes, there is a paucity of epidemiological data on demographic, laboratory, and clinical characteristics associated with MetS among people with HIV (people with human [PWH]). Therefore, this study aimed to determine the burden and factors influencing MetS in antiretroviral therapy (ART)-experienced individuals in Zambia. Read More

View Article and Full-Text PDF

Altered subcutaneous adipose tissue parameters after switching ART-controlled HIV+ patients to raltegravir/maraviroc.

AIDS 2021 Apr 6. Epub 2021 Apr 6.

Sorbonne Université, Inserm, Faculty of Medicine, Centre de Recherche Saint-Antoine (CRSA), ICAN, Paris, France Department of Biochemistry-Pharmacology-Molecular Biology, APHP, Henri-Mondor Hospital, Université Paris Est Créteil, France Sorbonne Université, Inserm, Faculty of Medicine, Nutrition and obesities: systemic approaches (NutriOmics), Paris, France Assistance Publique Hôpitaux de Paris, Sorbonne Université, Nutrition department, Pitié-Salpétrière hospital, CRNH Ile-de-France, GH APHP-Sorbonne Université, Paris, France Department of Endocrinology, CRMR Prisis, Saint-Antoine Hospital, GH APHP-Sorbonne Université, Paris France Sorbonne Université, Inserm, Faculty of Medicine, Institut Pierre Louis d'Epidémiologie et de Santé Publique (IPLESP), Paris, France IRD, Sorbonne University, UMMISCO, Bondy, France Department of Infectious Diseases, Pitié-Salpétrière hospital, GH APHP-Sorbonne Université, Paris France.

Objective: To evaluate the effect on anthropometric, metabolic and adipose tissue parameters of switching ART-controlled persons living with HIV (PLWH) from a protease-inhibitor regimen to raltegravir/maraviroc.

Design: Substudy of ROCnRAL-ANRS157 with investigation of subcutaneous abdominal adipose tissue (SCAT) biopsy at inclusion and study end.

Methods: We performed lipoaspiration of paired SCAT samples, histology on fresh/fixed samples and examined the transcriptomic profile analyzed using Illumina microarrays after RNA extraction. Read More

View Article and Full-Text PDF

Association between Toxoplasma gondii infection and metabolic syndrome in obese adolescents: A possible immune-metabolic link.

Parasitol Int 2021 Apr 5:102343. Epub 2021 Apr 5.

Department of Clinical Pathology, Faculty of Medicine, Mansoura University, Egypt.

Background Toxoplasmosis as a global disease is considered as a triggering factor responsible for development of several clinical diseases. However, Toxoplasma gondii (T. gondii) is an understudied parasite of potential interest in obesity research. Read More

View Article and Full-Text PDF

Lipid based Nanocarriers for effective Drug Delivery and Treatment of Diabetes Associated Liver Fibrosis.

Adv Drug Deliv Rev 2021 Apr 5. Epub 2021 Apr 5.

Department of Pharmacy, Birla Institute of Technology and Science (BITS PILANI), Pilani, Rajasthan, INDIA-333031. Electronic address:

Non-alcoholic fatty liver disease (NAFLD) is a cluster of several liver diseases like hepatic steatosis, non-alcoholic steatohepatitis (NASH), non-alcoholic fatty liver (NAFL), liver fibrosis, and cirrhosis which may eventually progress to liver carcinoma. One of the primary key factors associated with the development and pathogenesis of NAFLD is Diabetes mellitus. The present review emphasizes on diabetes-associated development of liver fibrosis and its treatment using different lipid nanoparticles such as stable nucleic acid lipid nanoparticles, liposomes, solid lipid nanoparticles, nanostructured lipid nanocarriers, self-nanoemulsifying drug delivery systems, and conjugates including phospholipid, fatty acid and steroid-based. Read More

View Article and Full-Text PDF

Sex Differences in miRNA Expression and Cardiometabolic Risk Factors in Hispanic Adolescents With Obesity.

J Pediatr 2021 Apr 5. Epub 2021 Apr 5.

Department of Pediatrics, Baylor College of Medicine, Children's Hospital of San Antonio, San Antonio, Texas.

Objective: To evaluate sex differences in microRNA (miRNA) expression, anthropometric measures and cardiometabolic risk factors in Hispanic adolescents with obesity.

Study Design: Cross-sectional study of 68 (60% male) Hispanic adolescents with obesity, aged 13-17 years, recruited from a pediatric weight management clinic. We used small RNA sequencing to identify differentially expressed circulating miRNAs. Read More

View Article and Full-Text PDF

Whole genome variation in 27 Mexican indigenous populations, demographic and biomedical insights.

PLoS One 2021 8;16(4):e0249773. Epub 2021 Apr 8.

Instituto de Biotecnología, Universidad Nacional Autónoma de México (UNAM), Cuernavaca, Morelos, México.

There has been limited study of Native American whole genome diversity to date, which impairs effective implementation of personalized medicine and a detailed description of its demographic history. Here we report high coverage whole genome sequencing of 76 unrelated individuals, from 27 indigenous groups across Mexico, with more than 97% average Native American ancestry. On average, each individual has 3. Read More

View Article and Full-Text PDF

Oral intake of Lactobacillus plantarum L-14 extract alleviates TLR2- and AMPK-mediated obesity-associated disorders in high-fat-diet-induced obese C57BL/6J mice.

Cell Prolif 2021 Apr 8:e13039. Epub 2021 Apr 8.

Cellular Reprogramming and Embryo Biotechnology Laboratory, Dental Research Institute, Seoul National University School of Dentistry, Seoul, Korea.

Objectives: Whether periodic oral intake of postbiotics positively affects weight regulation and prevents obesity-associated diseases in vivo is unclear. This study evaluated the action mechanism of Lactobacillus plantarum L-14 (KTCT13497BP) extract and the effects of its periodic oral intake in a high-fat-diet (HFD) mouse model.

Materials And Methods: Mouse pre-adipocyte 3T3-L1 cells and human bone marrow mesenchymal stem cells (hBM-MSC) were treated with L-14 extract every 2 days during adipogenic differentiation, and the mechanism underlying anti-adipogenic effects was analysed at cellular and molecular levels. Read More

View Article and Full-Text PDF

Fertility-Sparing Treatment for Atypical Endometrial Hyperplasia and Endometrial Cancer: A Cochrane Systematic Review Protocol.

Adv Ther 2021 Apr 8. Epub 2021 Apr 8.

Gynecology Department, Hospital El Pilar, Barcelona, Spain.

Introduction: Endometrial cancer is the fifth most common cancer in women and atypical endometrial hyperplasia is a precancerous lesion. Obesity is an important risk factor for endometrioid endometrial adenocarcinoma and endometrial hyperplasia. Progesterone is recommended as first-line treatment in endometrial cancer or atypical endometrial hyperplasia in women who wish to preserve fertility, but optimal treatment schedules have not been defined. Read More

View Article and Full-Text PDF

Metformin in non-diabetic patients with metabolic syndrome and diastolic dysfunction: the MET-DIME randomized trial.

Endocrine 2021 Apr 8. Epub 2021 Apr 8.

Cardiology Department, Gaia Hospital Centre, Vila Nova de Gaia, Portugal.

Purpose: Metabolic syndrome (MetS) affects one out of 3 adults in the western world and is associated with preclinical diastolic dysfunction that impairs functional capacity and quality of life (QoL). This randomized trial was designed to evaluate if the addition of metformin to the standard treatment of non-diabetic patients with MetS improves diastolic dysfunction.

Methods: Prospective, randomized, open-label, blinded-endpoint trial. Read More

View Article and Full-Text PDF

Dietary Selenium Requirement for the Prevention of Glucose Intolerance and Insulin Resistance in Middle-Aged Mice.

J Nutr 2021 Apr 8. Epub 2021 Apr 8.

Department of Food Science, Nutrition, and Health Promotion, Mississippi State University, Mississippi State, MS, USA.

Background: Although dietary selenium (Se) deficiency or excess induces type 2 diabetes-like symptoms in mice, suboptimal body Se status usually causes no symptoms but may promote age-related decline in overall health.

Objectives: We sought to determine the dietary Se requirement for protection against type 2 diabetes-like symptoms in mice.

Methods: Thirty mature (aged 4 mo) male C57BL/6J mice were fed a Se-deficient torula yeast AIN-93M diet supplemented with Na2SeO4 in graded concentrations totaling 0. Read More

View Article and Full-Text PDF

Dietary Supplementation with Glycine Enhances Intestinal Mucosal Integrity and Ameliorates Inflammation in C57BL/6J Mice with High-Fat Diet-Induced Obesity.

J Nutr 2021 Apr 8. Epub 2021 Apr 8.

Beijing Advanced Innovation Center for Food Nutrition and Human Health, China Agricultural University, Beijing, China.

Background: Obesity, a major public health problem worldwide, is associated with dysfunction of the intestinal barrier. Glycine (Gly) has been reported to enhance the expression of tight-junction proteins in porcine enterocytes. It is unknown whether Gly can improve intestinal barrier integrity in obese mice. Read More

View Article and Full-Text PDF

Study on Alanine Aminotransferase in Patients of Type 2 Diabetes Mellitus.

Mymensingh Med J 2021 Apr;30(2):343-350

Dr Foysal Ahamed, Assistant Professor, Department of Medicine, Mymensingh Medical College (MMC), Mymensingh, Bangladesh; E-mail:

Type 2 Diabetes mellitus (DM) is associated with various types of liver disorders including elevated liver enzymes. This study was carried out to observe hepatocellular injury in type 2 Diabetes mellitus as evidenced by raised Alanine aminotransferase (ALT) among the type 2 Diabetes mellitus patients and to find out association between elevated ALT and glycaemic control. This was a descriptive cross-sectional comparative study carried out in Department of Medicine, Rajshahi Medical College Hospital and Rajshahi Diabetic Association Hospital, Rajshahi, Bangladesh from July 2009 to June 2010. Read More

View Article and Full-Text PDF