428,020 results match your criteria insulin

The Kidney-Heart Connection in Obesity.

Nephron 2021 Apr 13:1-5. Epub 2021 Apr 13.

Área de Bioquímica y Biología Molecular, Departamento de Ciencias Básicas de la Salud, Facultad de Ciencias de la Salud, Universidad Rey Juan Carlos, Madrid, Spain.

There is a strong relationship between the kidney and the heart, where if one of these organs fails, so does the other, in the so-called cardiorenal syndrome (CRS). Besides, there are also interactions with the rest of the body leading to a metabolic state that establishes a feedback loop that is perpetuated. The CRS is characterized by hemodynamic changes, activation of neuro-humoral systems, natriuretic peptides, and changes in mineral metabolism. Read More

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Innate Immune Cells in the Adipose Tissue in Health and Metabolic Disease.

J Innate Immun 2021 Apr 13:1-27. Epub 2021 Apr 13.

Institute for Clinical Chemistry and Laboratory Medicine, Medical Faculty, Technische Universität Dresden, Dresden, Germany.

Metabolic disorders, such as obesity, type 2 diabetes mellitus, and nonalcoholic fatty liver disease, are characterized by chronic low-grade tissue and systemic inflammation. During obesity, the adipose tissue undergoes immunometabolic and functional transformation. Adipose tissue inflammation is driven by innate and adaptive immune cells and instigates insulin resistance. Read More

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Physiological effects of intraperitoneal versus subcutaneous insulin infusion in patients with diabetes mellitus type 1: A systematic review and meta-analysis.

PLoS One 2021 13;16(4):e0249611. Epub 2021 Apr 13.

Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway.

The intraperitoneal route of administration accounts for less than 1% of insulin treatment regimes in patients with diabetes mellitus type 1 (DM1). Despite being used for decades, a systematic review of various physiological effects of this route of insulin administration is lacking. Thus, the aim of this systematic review was to identify the physiological effects of continuous intraperitoneal insulin infusion (CIPII) compared to those of continuous subcutaneous insulin infusion (CSII) in patients with DM1. Read More

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Systemic and adipocyte transcriptional and metabolic dysregulation in Idiopathic Intracranial Hypertension.

JCI Insight 2021 Apr 13. Epub 2021 Apr 13.

Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, United Kingdom.

Background: Idiopathic intracranial hypertension (IIH) is a condition predominantly affecting obese women of reproductive age. Recent evidence suggests that IIH is a disease of metabolic dysregulation, androgen excess and an increased risk of cardiovascular morbidity. Here we evaluate systemic and adipose specific metabolic determinants of the IIH phenotype. Read More

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Agreement of blood glucose measured with glucose meter in arterial, central venous, and capillary samples in adult critically ill patients.

Nurs Crit Care 2021 Apr 13. Epub 2021 Apr 13.

Intensive Care Unit, Hospital Universitario San Cecilio, Granada, Spain.

Background: The measurement of blood glucose in critically ill patients is still performed in many ICUs with glucose meters and capillary samples. Several prevalent factors in these patients affect the accuracy of the results and should be interpreted with caution. A weak recommendation from the Surviving Sepsis Campaign (SSC) suggests the use of arterial blood rather than capillary blood for point of care testing using glucose meters. Read More

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Systematic Review and Meta-Analysis of the Impact of Bariatric Surgery on Lower Urinary Tract Symptoms in Males.

Obes Surg 2021 Apr 13. Epub 2021 Apr 13.

Department of Bariatric Surgery, St Richard's Hospital, Chichester, UK.

Background: Obesity is a chronic disease with multisystem morbidity. There are multiple studies reporting the effect of bariatric surgery on cardiovascular and metabolic disease, but few examine its impact on lower urinary tract symptoms. This article aims to perform a systematic review with meta-analysis, to determine the effects of bariatric surgery on lower urinary tract symptoms in male patients. Read More

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Prevalence and risk factors for obesity among elderly patients living with HIV/AIDS in a low-resource setting.

Medicine (Baltimore) 2021 Apr;100(15):e25399

Institute of Human Virology, Federal Capital Territory, Abuja, Nigeria.

Abstract: Obesity is associated with detrimental changes in cardiovascular and metabolic parameters, including blood pressure, dyslipidemia, markers of systemic inflammation, and insulin resistance. In the elderly living with the human immunodeficiency virus (EPLHIV), and being treated with antiretroviral medications, the obesity complications escalate and expose the elderly to the risk of noncommunicable diseases. Given that over 3 million EPLHIV in sub-Sahara Africa, we assessed the prevalence of obesity and its associated factors among EPLHIV in a low-resource setting. Read More

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Increasing selenium supply during the close-up dry period improves nutrient metabolism and attenuates inflammatory response after calving in dairy cows.

Jian Gong Min Xiao

Anim Sci J 2021 Jan;92(1):e13551

College of Life Science and Technology, Inner Mongolia Normal University, Hohhot, China.

The objective of this study was to investigate whether feeding selenium (Se)-replete cows a Se-yeast supplement in late pregnancy affects nutrient metabolism and inflammatory response during the periparturient period. Twenty cows were randomly assigned to two groups with 10 cows each. Cows in one group received Se-yeast at 0. Read More

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January 2021

Astragaloside IV alleviates liver injury in type 2 diabetes due to promotion of AMPK/mTOR‑mediated autophagy.

Mol Med Rep 2021 Jun 13;23(6). Epub 2021 Apr 13.

Key Laboratory of Anti‑Inflammatory and Immunopharmacology, Ministry of Education, Department of Pharmacology, Basic Medicine College, Anhui Medical University, Hefei, Anhui 230032, P.R. China.

Diabetic liver injury is a serious complication of type 2 diabetes mellitus (T2DM), which is often irreversible in the later stage, and affects the quality of life. Autophagy serves an important role in the occurrence and development of diabetic liver injury. For example, it can improve insulin resistance (IR), dyslipidaemia, oxidative stress and inflammation. Read More

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Control of IFN-I responses by the aminopeptidase IRAP in neonatal C57BL/6 alveolar macrophages during RSV infection.

Mucosal Immunol 2021 Apr 12. Epub 2021 Apr 12.

INRAE, UVSQ, VIM, Université Paris-Saclay, Jouy-en-Josas, France.

Respiratory Syncytial Virus (RSV) is the major cause of lower respiratory tract infection in infants, in whom, the sensing of RSV by innate immune receptors and its regulation are still poorly described. However, the severe bronchiolitis following RSV infection in neonates has been associated with a defect in type I interferons (IFN-I) production, a cytokine produced mainly by alveolar macrophages (AMs) upon RSV infection in adults. In the present study, neonatal C57BL/6 AMs mobilized very weakly the IFN-I pathway upon RSV infection in vitro and failed to restrain virus replication. Read More

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The relationship between plasma taurine levels in early pregnancy and later gestational diabetes mellitus risk in Chinese pregnant women.

Sci Rep 2021 Apr 12;11(1):7993. Epub 2021 Apr 12.

Department of Clinical Laboratory, Peking Union Medical College Hospital, Peking Union Medical College Hospital, China Academic Medical Science and Peking Union Medical College, Beijing, 100730, People's Republic of China.

Taurine is a sulfur-containing amino acid that plays an important role in glucose homeostasis. However, it remains unknown whether the plasma concentration of taurine affects the risk of later gestational diabetes mellitus (GDM) development. We recruited 398 singleton-pregnancy women and followed up them during the course of pregnancy. Read More

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Regulation of plasma triglyceride partitioning by adipose-derived ANGPTL4 in mice.

Sci Rep 2021 Apr 12;11(1):7873. Epub 2021 Apr 12.

Department of Biochemistry, Fraternal Order of Eagles Diabetes Research Center, and Obesity Research and Education Initiative, University of Iowa, 169 Newton Rd., PBDB 3326, Iowa City, IA, 52242, USA.

Elevated plasma triglyceride levels are associated with metabolic disease. Angiopoietin-like protein 4 (ANGPTL4) regulates plasma triglyceride levels by inhibiting lipoprotein lipase (LPL). Our aim was to investigate the role of adipocyte-specific deficiency of ANGPTL4 in mice during high fat diet feeding. Read More

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Prevention of atherosclerotic cardiovascular disease in South Asians in the US: A clinical perspective from the National Lipid Association.

J Clin Lipidol 2021 Mar 29. Epub 2021 Mar 29.

Advocate Lutheran General Hospital, Park Ridge, IL, United States.

It is now well recognized that South Asians living in the US (SAUS) have a higher prevalence of atherosclerotic cardiovascular disease (ASCVD) that begins earlier and is more aggressive than age-matched people of other ethnicities. SA ancestry is now recognized as a risk enhancer in the US cholesterol treatment guidelines. The pathophysiology of this is not fully understood but may relate to insulin resistance, genetic and dietary factors, lack of physical exercise, visceral adiposity and other, yet undiscovered biologic mechanisms. Read More

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Simplified glycaemic management for patients with type 2 diabetes admitted for acute decompensated heart failure using linagliptin.

Med Clin (Barc) 2021 Apr 9. Epub 2021 Apr 9.

Servicio de Medicina Interna, Hospital Regional Universitario de Málaga, Instituto de Investigación Biomédica de Málaga (IBIMA), Universidad de Málaga (UMA), Málaga, Spain; Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y Nutrición (CIBERobn), Instituto de Salud Carlos III, Madrid, Spain.

Introduction And Objectives: Hyperglycaemia in hospitalized patients with type 2 diabetes is preferably managed with insulin. We aimed to analyse the glycaemic efficacy, treatment simplicity, and safety of our hospital's antihyperglycemic regimens (linagliptin-basal insulin versus basal-bolus insulin) in patients with type 2 diabetes admitted for heart failure decompensation.

Patients And Methods: In this real-world study, we included patients with mild-to-moderate hyperglycaemia managed with our antihyperglycemic regimens between 2016 and 2018. Read More

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Thirst for Information and Needs Reflections of Type 2 Diabetes Patients Receiving Insulin Treatment in North-East Ethiopia: A Qualitative Exploration.

J Prev Med Public Health 2021 Mar 1;54(2):119-128. Epub 2021 Mar 1.

Department of Pharmacy, College of Medicine and Health Sciences (CMHS), Wollo University, Dessie, Ethiopia.

Objectives: Ongoing, proactive, planned, and patient-centered diabetes education is the cornerstone of care for all persons with diabetes. Thus, the aim of this study was to explore the information needs of type 2 diabetes mellitus patients receiving insulin treatment in North-East Ethiopia.

Methods: The study was conducted from July 2019 to January 2020 using a qualitative enquiry (phenomenological approach) with purposive sampling. Read More

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Painless foot drop: an unusual acute presentation of new onset type 1 diabetes mellitus.

Endocrinol Diabetes Metab Case Rep 2021 Mar 16;2021. Epub 2021 Mar 16.

Department of Diabetes and Endocrinology, Guy's and St Thomas' NHS Foundation trust, London, UK and School of Cardiovascular Medicine and Sciences, King's College London UK.

Summary: A 26-year-old Caucasian female with no past medical history or family history of auto-immune disease presented to the emergency department with new onset painless left foot drop. A panel of blood tests revealed blood glucose of 49.9 mmol/L and raised blood ketone levels. Read More

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Hypoglycemia after bariatric surgery: importance of exhaustive hormonal study.

Endocrinol Diabetes Metab Case Rep 2021 Mar 20;2021. Epub 2021 Mar 20.

Endocrinology and Nutrition, Hospital Universitari Germans Trias I Pujol, Badalona, Spain.

Summary: Hypoglycemia is an uncommon clinical problem in non-diabetic patients or patients not being treated for diabetes mellitus. It is a rare, but well-established complication of bariatric surgery and, in some cases, it can be the only symptom of another medical problem. A 50-year-old woman with a history of partially recovered hypopituitarism after transsphenoidal surgery for a non-functioning pituitary macroadenoma complained about symptomatic hypoglycemia after sleeve gastrectomy surgery. Read More

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Islet-on-a-chip: Biomimetic micropillar-based microfluidic system for three-dimensional pancreatic islet cell culture.

Biosens Bioelectron 2021 Apr 2;183:113215. Epub 2021 Apr 2.

Medical Biotechnology, Faculty of Chemistry, Warsaw University of Technology, Poland. Electronic address:

Type 2 diabetes is currently one of the most common metabolic diseases, affecting all ages worldwide. As the incidence of type 2 diabetes increases, a growing number of studies focus on islets of Langerhans. A three-dimensional research model that maps islet morphology and maintains hormonal balance in vivo is still needed. Read More

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The brain as an insulin-sensitive metabolic organ.

Mol Metab 2021 Apr 9:101234. Epub 2021 Apr 9.

Center for Brain Immunology and Glia, University of Virginia, Charlottesville, VA, USA; Department of Neuroscience, University of Virginia, Charlottesville, VA, USA; Division of Endocrinology and Metabolism, University of Virginia, Charlottesville, VA, USA. Electronic address:

Background: The brain was once thought of as an insulin-insensitive organ. We now know that the insulin receptor is present throughout the brain and serves important functions in whole body metabolism and brain function. Brain insulin signaling is involved in not only brain homeostatic processes, but also neuropathological processes such as cognitive decline and Alzheimer's disease. Read More

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A step towards glucose control with a novel nanomagnetic-insulin fordiabetes care.

Int J Pharm 2021 Apr 9:120587. Epub 2021 Apr 9.

Division of Biomedical Engineering, University of Saskatchewan, Saskatoon, Canada; School of Mechatronic Engineering and Automation, Shanghai University, Shanghai, 200436, PR China. Electronic address:

Massive efforts have been devoted to insulin delivery for diabetes care. Achieving a long-term tight-regulated blood glucose level with a low risk of hypoglycemia remains a great challenge. In this study we propose a novel strategy to efficiently regulate insulin action after insulin is injected or released into patient body aiming to achieve better glycemic control, which is achieved by the administration of insulin-conjugated magnetic nanoparticles (MNPs-Ins). Read More

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Integrated metabolomics and network pharmacology approach to exploring the potential mechanism of Tianxiang Capsule for treating motion sickness.

J Ethnopharmacol 2021 Apr 9:114107. Epub 2021 Apr 9.

School of Pharmacy, Second Military Medical University, Shanghai, 200433, China. Electronic address:

Ethnopharmacological Relevance: Motion sickness is a multi-system syndrome caused by abnormal spatial environmental sensory conflicts. Tianxiang Capsule (TXC) is a traditional Chinese medicine (TCM) formula for the prevention and treatment of motion sickness for years. However, the main active components of TXC and mechanism of its therapeutic effects on motion sickness are still unclear. Read More

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Nano-based drug delivery systems used as vehicles to enhance polyphenols therapeutic effect for diabetes mellitus treatment.

Pharmacol Res 2021 Apr 9:105604. Epub 2021 Apr 9.

LAQV, REQUIMTE, Laboratory of Applied Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal. Electronic address:

Diabetes mellitus is one of the biggest health emergencies of the 21 century worldwide, characterized by deficiency in insulin secretion and/or action, leading to hyperglycemia. Despite the currently available antidiabetic therapeutic options, 4.2 million people died in 2019 due to diabetes. Read More

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Morphologic design of sugar-based polymer nanoparticles for delivery of antidiabetic peptides.

J Control Release 2021 Apr 9. Epub 2021 Apr 9.

Departments of Chemistry, Chemical Engineering, and Materials Science & Engineering, Texas A&M University, College Station, TX 77842, USA. Electronic address:

Zwitterionic polymer nanoparticles of diverse morphologies (spherical, cylindrical, and platelet-like) constructed from biocompatible sugar-based polymers are designed to extend the pharmacological activities of short- and long-acting insulin peptides, thereby providing potential for therapeutic systems capable of reducing the frequency of administration and improving patient compliance. Amphiphilic block copolymers composed of zwitterionic poly(d-glucose carbonate) and semicrystalline polylactide segments were synthesized, and the respective block length ratios were tuned to allow formation of nanoscopic assemblies having different morphologies. Insulin-loaded nanoparticles had similar sizes and morphologies to the unloaded nanoparticle counterparts. Read More

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Sodium glucose transporter inhibition in heart failure From an unexpected side effect to a novel treatment possibility.

Diabetes Res Clin Pract 2021 Apr 9:108796. Epub 2021 Apr 9.

Department of Medicine K2, Karolinska Institutet 171 76 Stockholm, Sweden. Electronic address:

Sodium-glucose transporter-2 inhibitors (SGLT2i), originally launched as glucose-lowering drugs, have been studied in large cardiovascular outcome trials to ascertain safety. Surprisingly, these compounds reduced the risk of cardiovascular events (cardiovascular death, non-fatal myocardial and non-fatal stroke) and total mortality. The mechanisms behind this benefit are only partly understood, but a major contributor is the reduction of heart failure hospitalisations, evident already within weeks after the initiation of the SGLT2i. Read More

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Novel compound heterozygous LRBA deletionsin a 6-month old with neonatal diabetes.

Diabetes Res Clin Pract 2021 Apr 9:108798. Epub 2021 Apr 9.

Department of Human Genetics, The University of Chicago, 5841 S. Maryland Ave., G701, Chicago, IL 60637. Electronic address:

We report a 6-month-old boy with antibody-positive insulin-dependent diabetes mellitus. Sequencing identified compound heterozygous deletions of exon 5 and exons 36-37 in LRBA. At three years, he has yet to exhibit any other immune symptoms. Read More

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Diabetes, insulin and new therapeutic strategies for Parkinson's disease: focus on glucagon-like peptide-1 receptor agonists.

Front Neuroendocrinol 2021 Apr 9:100914. Epub 2021 Apr 9.

Laboratory of Cellular and Molecular Neurobiology of Parkinson's disease, Research Center for Molecular Medicine and Chronic Diseases (CIMUS), IDIS, University of Santiago de Compostela, Santiago de Compostela, Spain; Networking Research Center on Neurodegenerative Diseases (CiberNed), Spain.

Parkinson's disease and diabetes mellitus are two chronic disorders associated with aging that are becoming increasingly prevalent worldwide. Parkinson is a multifactorial progressive condition with no available disease modifying treatments at the moment. Over the last few years there is growing interest in the relationship between diabetes (and impaired insulin signaling) and neurodegenerative diseases, as well as the possible benefit of antidiabetic treatments as neuroprotectors, even in non-diabetic patients. Read More

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Valdecoxib improves lipid-induced skeletal muscle insulin resistance via simultaneous suppression of inflammation and endoplasmic reticulum stress.

Biochem Pharmacol 2021 Apr 9:114557. Epub 2021 Apr 9.

Department of Pharmacology, College of Medicine, Chung-Ang University, Seoul, Republic of Korea. Electronic address:

Valdecoxib (VAL), a non-steroidal anti-inflammatory drug, has been widely used for treatment of rheumatoid arthritis, osteoarthritis, and menstrual pain. It is a selective cyclooxygenase-2 inhibitor. The suppressive effects of VAL on cardiovascular diseases and neuroinflammation have been documented; however, its impact on insulin signaling in skeletal muscle has not been studied in detail. Read More

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The Human Islet: Mini-organ with Mega-impact.

Endocr Rev 2021 Apr 12. Epub 2021 Apr 12.

Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee.

This review focuses on the human pancreatic islet - including its structure, cell composition, development, function, and dysfunction. After providing a historical timeline of key discoveries about human islets over the past century, we describe new research approaches and technologies that are being used to study human islets and how these are providing insight into human islet physiology and pathophysiology. We also describe changes or adaptations in human islets in response to physiologic challenges such as pregnancy, aging, and insulin resistance and discuss islet changes in human diabetes of many forms. Read More

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[The impact on metabolic and reproductive diseases of low-carbohydrate and ketogenic diets].

Rev Med Chil 2020 Nov;148(11):1630-1639

Unidad de Endocrinología, Fundación Neuropsiquiátrica de Santiago, Santiago, Chile.

With low carbohydrate diets glucose becomes unavailable as a source of energy for our body, leading to the production of ketones from fatty acids in the liver. The increase in plasma ketones is known as nutritional ketosis. The available evidence from basic and clinical studies indicates that both low carbohydrate and high fat low carbohydrate diets are effective for weight loss and are better than non-intervention. Read More

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November 2020

Analysis of astaxanthin molecular targets based on network pharmacological strategies.

J Food Biochem 2021 Apr 12:e13717. Epub 2021 Apr 12.

College of Chemistry & Environmental Science, Guangdong Ocean University, Zhanjiang, China.

In order to further explore the potential pharmacological activity of astaxanthin (AST), network pharmacological approaches were employed in this work to systematically investigate its affinity targets, perturbed signaling pathways, and related disease applications. First, potential targets were captured based on AST chemical structure information. Enrichment analysis was then performed using bioinformatics tools to predict the biological processes and diseases in which AST targets are involved. Read More

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