362 results match your criteria insufficiency sri


Sheehan's syndrome as a mimic of premature ovarian insufficiency: need for advocacy.

Climacteric 2021 Apr 8. Epub 2021 Apr 8.

Department of Endocrinology, Max Superspeciality Hospital, New Delhi, India.

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Assessment of Vitamin D Levels and Its Correlation With Osteoporosis and Fracture Site Comminution in Osteoporotic Hip Fractures in Tertiary Care Hospital.

Cureus 2021 Jan 29;13(1):e12982. Epub 2021 Jan 29.

Department of Orthopaedics, Sri Devaraj Urs Medical College, Sri Devaraj Urs Academy of Higher Education and Research, Kolar, IND.

Introduction: A global concern is vitamin D deficiency and insufficiency. There is a particularly high risk for pregnant women, people of color (Blacks, Hispanics, and those with increased skin melanin pigmentation), obese children and adults, and children and adults who are abstinent from direct sun exposure. The goal of this study was to understand the incidence of vitamin D deficiency in patients with osteoporotic hip fractures in our rural population and also to know its association with osteoporosis and osteoporotic hip fractures in a tertiary care trauma center. Read More

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January 2021

The Severe Respiratory Insufficiency Application (SRI App): a pilot randomised controlled trial.

Thorax 2021 Mar 2. Epub 2021 Mar 2.

Lung Clinic, Kliniken der Stadt Köln gGmbH, Köln, Germany

An application (app) for the Severe Respiratory Insufficiency Questionnaire (SRI) has been designed and developed for mobile devices. In a randomised controlled trial comprising 60 patients with chronic respiratory failure, the app was compared with the classic paper SRI. Thereby, it was shown that the SRI app is a practical tool that is well accepted. Read More

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Isolated left subclavian with a compensatory ductus in a child with Tetralogy of Fallot.

Asian Cardiovasc Thorac Ann 2021 Feb 20:218492321997385. Epub 2021 Feb 20.

Department of Paediatric Cardiac Intensive Care, Sri Sathya Sai Sanjeevani International Centre for Child Heart Care and Research, Palwal, India.

Tetralogy of Fallot is a cyanotic heart disease wherein aortopulmonary collaterals serve as source of pulmonary blood flow to maintain oxygenation. We report an incidentally detected isolated left subclavian artery supplying a compensatory ductus in a child with Tetralogy of Fallot that effectively contributed as a de novo palliative systemic to pulmonary artery shunt. Clinically, the entity could not be suspected, as the child did not have symptoms suggestive of arterial insufficiency of the left arm or weak pulses or neurological symptoms. Read More

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February 2021

Improvement in quality of life with treatment of chronic venous disease: A longitudinal observational study in Kandy, Sri Lanka.

Phlebology 2021 Feb 16:268355521990972. Epub 2021 Feb 16.

Division of Surgery and Surgical Oncology, Singapore General Hospital and National Cancer Centre Singapore, Singapore.

Objective: This study assessed the improvement in Quality of Life (QoL) of Chronic Venous Disease (CVD) patients in Sri Lanka following treatment.

Methods: This was a prospective observational study of 58 newly or previously diagnosed CVD patients. QoL was assessed by the 14-item ChronIc Venous dIsease quality of life Questionnaire (CIVIQ-14) at 4 and 8 weeks after treatment. Read More

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February 2021

The Utility of Novel Renal Biomarkers in Assessment of Chronic Kidney Disease of Unknown Etiology (CKDu): A Review.

Int J Environ Res Public Health 2020 12 18;17(24). Epub 2020 Dec 18.

The Nicholas School of the Environment, Duke University, Durham, NC 27708, USA.

Chronic Kidney Disease (CKD) is a globally prevalent non-communicable disease with significant mortality and morbidity. It is typically associated with diabetes and hypertension; however, over the last two decades, an emergence of CKD of unknown etiology (CKDu) has claimed thousands of lives in several tropical agricultural communities. CKDu is associated with gradual loss of renal function without initial symptoms until reaching complete kidney failure and eventually death. Read More

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December 2020

Fertility Preservation: The Challenge of Freezing and Transplanting Ovarian Tissue.

Trends Mol Med 2020 Dec 9. Epub 2020 Dec 9.

Pôle de Gynécologie, Institut de Recherche Expérimentale et Clinique, Université Catholique de Louvain, Brussels, Belgium.

Cancer treatments are increasingly effective, but can result in iatrogenic premature ovarian insufficiency. Ovarian tissue cryopreservation is the only option available to preserve fertility in prepubertal girls and young women who require immediate chemotherapy. Ovarian tissue transplantation has been shown to restore hormonal cycles and fertility, but a large proportion of the follicle reserve is lost as a consequence of exposure to hypoxia. Read More

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December 2020

The water chemistry and microbiome of household wells in Medawachchiya, Sri Lanka, an area with high prevalence of chronic kidney disease of unknown origin (CKDu).

Sci Rep 2020 10 26;10(1):18295. Epub 2020 Oct 26.

Australian Nuclear Science and Technology Organisation (ANSTO), New Illawarra Rd, Lucas Heights, NSW, 2234, Australia.

Chronic kidney disease (CKD) of unknown etiology (CKDu) mostly affects agricultural communities in Central America, South Asia, Africa, but likely also in North America and Australia. One such area with increased CKDu prevalence is the Medawachchiya District Secretariat Division of the Anuradhapura District in the North Central Province of Sri Lanka. Recent research has focused on the presence of various microbial pathogens in drinking water as potential causal or contributing factors to CKDu, yet no study to date has performed a more comprehensive microbial and water chemistry assessment of household wells used for domestic water supply in areas of high CKDu prevalence. Read More

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October 2020

A comparative review: Chronic Kidney Disease of unknown etiology (CKDu) research conducted in Latin America versus Asia.

Environ Res 2021 01 7;192:110270. Epub 2020 Oct 7.

RTI International, Research Triangle Park, NC, USA.

Introduction: The incidence of chronic kidney disease of unknown or uncertain etiology (CKDu) is recognized as a global non-communicable health crisis. The goal of this work is to compare the types of research studies in Latin America and Asia, two regions with increasing CKDu incidence.

Methods: A comparative literature review was conducted to evaluate the CKDu research design for peer-reviewed articles published from 2015 to 2019. Read More

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January 2021

Real-World Estimates of Adrenal Insufficiency-Related Adverse Events in Children With Congenital Adrenal Hyperplasia.

J Clin Endocrinol Metab 2021 Jan;106(1):e192-e203

Developmental Endocrinology Research Group, School of Medicine, Dentistry & Nursing, University of Glasgow, Glasgow, UK.

Background: Although congenital adrenal hyperplasia (CAH) is known to be associated with adrenal crises (AC), its association with patient- or clinician-reported sick day episodes (SDE) is less clear.

Methods: Data on children with classic 21-hydroxylase deficiency CAH from 34 centers in 18 countries, of which 7 were Low or Middle Income Countries (LMIC) and 11 were High Income (HIC), were collected from the International CAH Registry and analyzed to examine the clinical factors associated with SDE and AC.

Results: A total of 518 children-with a median of 11 children (range 1, 53) per center-had 5388 visits evaluated over a total of 2300 patient-years. Read More

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January 2021

Chronic interstitial nephritis of agricultural communities: continuing with the term CKDu (chronic kidney disease of unknown cause) is detrimental.

Authors:
Chula Herath

Kidney Int 2020 09;98(3):786

Department of Nephrology, Sri Jayewardenepura General Hospital, Nugegoda, Western Province, Sri Lanka. Electronic address:

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September 2020

Kidney developmental effects of metal-herbicide mixtures: Implications for chronic kidney disease of unknown etiology.

Environ Int 2020 11 17;144:106019. Epub 2020 Aug 17.

Department of Molecular and Biomedical Sciences, University of Maine, Orono, ME 04469, USA; Nicholas School of the Environment, Duke University, Durham, NC 27708, USA; School of Marine Sciences, University of Maine, Orono, ME 04469, USA.

Chronic kidney disease of unknown etiology (CKDu) is an emerging global concern affecting several agricultural communities in the Americas and South Asia. Environmental contaminants such as heavy metals (e.g. Read More

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November 2020

Fertility preservation in women for medical and social reasons: Oocytes vs ovarian tissue.

Best Pract Res Clin Obstet Gynaecol 2021 Jan 21;70:63-80. Epub 2020 Jul 21.

Université Catholique de Louvain, Belgium; Société de Recherche pour l'Infertilité (SRI), 143 Avenue Grandchamp, 1150, Brussels, Belgium. Electronic address:

Approximately 10% of cancers occur in women under 45 years of age. Chemotherapy, radiotherapy, and bone marrow transplantation cure more than 90% of cancer in women, but can result in premature ovarian insufficiency depending on follicular reserve, age, and drugs used. Some benign diseases are also indications for fertility preservation, particularly those requiring chemotherapy (like thalassemia and lupus), recurrent endometriosis, and family history of premature menopause. Read More

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January 2021

Using water quality and isotope studies to inform research in chronic kidney disease of unknown aetiology endemic areas in Sri Lanka.

Sci Total Environ 2020 Nov 16;745:140896. Epub 2020 Jul 16.

School of Mechanical, Biomedical and Process Engineering, Science and Engineering Faculty, Queensland University of Technology, Brisbane, Queensland 4000, Australia.

Chronic Kidney Disease of unknown aetiology (CKDu) is a major public health concern in dry climatic, agricultural regions of Sri Lanka. The chemistry of groundwater (the main source of drinking water) in the area has been studied extensively, in relation to the occurrence of CKDu. This paper investigates water quality studies published in CKDu affected areas of Sri Lanka and also presents a new data set of 27 hydrochemical and isotopic samples collected from groundwater wells in selected CKDu endemic areas in Sri Lanka. Read More

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November 2020

Evaluation of groundwater quality and reverse osmosis water treatment plants in the endemic areas of Chronic Kidney Disease of Unknown Etiology (CKDu) in Sri Lanka.

Sci Total Environ 2020 Nov 8;745:140716. Epub 2020 Jul 8.

Department of Urban Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan.

Community-based reverse osmosis (RO) water treatment plants are employed as an interim solution for producing safe drinking water for the endemic areas of Chronic Kidney Disease of Unknown Etiology (CKDu) in the rural dry zone of Sri Lanka. It is recognized that RO-treated groundwater diminishes the progression of CKDu; thus, proper maintenance of these RO plants would be indispensable to protect public health. The present study broadly investigated the quality of groundwater in CKDu-endemic areas, and the performance, operations, and maintenance of the RO plants which purified this groundwater. Read More

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November 2020

The Impact of SARS-Cov-2 Virus Infection on the Endocrine System.

J Endocr Soc 2020 Aug 2;4(8):bvaa082. Epub 2020 Jul 2.

Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, University of Oxford, London, UK.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus has spread across the globe rapidly causing an unprecedented pandemic. Because of the novelty of the disease, the possible impact on the endocrine system is not clear. To compile a mini-review describing possible endocrine consequences of SARS-CoV-2 infection, we performed a literature survey using the key words Covid-19, Coronavirus, SARS CoV-1, SARS Cov-2, Endocrine, and related terms in medical databases including PubMed, Google Scholar, and MedARXiv from the year 2000. Read More

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The Effect of Bariatric Surgery on Patients with Chronic Kidney Disease.

Obes Surg 2020 Nov 6;30(11):4665-4668. Epub 2020 Jul 6.

Department of Minimal Access, Metabolic and Bariatric Surgery, Max Super Speciality Hospital, Press Enclave Road, Saket, New Delhi, 110017, India.

The effect of bariatric surgery on renal functions of patients with chronic kidney disease (CKD) is not well characterized. This prospective study included 13 adult patients having chronic kidney disease who underwent bariatric surgery. The primary objective was to examine the change in glomerular filtration rate (GFR) at 6 months post-bariatric surgery. Read More

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November 2020

The authors reply.

Kidney Int 2020 09 2;98(3):787-789. Epub 2020 Jul 2.

Laboratory of Pathophysiology, University Antwerp, Antwerp, Belgium. Electronic address:

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September 2020

Diamond Blackfan anemia is mediated by hyperactive Nemo-like kinase.

Nat Commun 2020 07 3;11(1):3344. Epub 2020 Jul 3.

Division of Hematology/Oncology, Department of Pediatrics, Stanford University, Stanford, CA, 94305, USA.

Diamond Blackfan Anemia (DBA) is a congenital bone marrow failure syndrome associated with ribosomal gene mutations that lead to ribosomal insufficiency. DBA is characterized by anemia, congenital anomalies, and cancer predisposition. Treatment for DBA is associated with significant morbidity. Read More

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4th A in a triple A syndrome - A rare case report.

J Basic Clin Physiol Pharmacol 2020 Jun 24;31(6). Epub 2020 Jun 24.

Department of Physiology, Sri Ramachandra Medical College and Research Institute, Sri Ramachandra Institute of Higher Education and Research (SRIHER), Chennai, Tamil Nadu, India.

Objectives AAA (Allgrove) syndrome is a rare genetic disorder characterized by cardinal features of adrenal insufficiency, achalasia, and alacrimia. Case presentation A 21 year girl of known case of Triple A syndrome was referred for the evaluation of autonomic function. She was born full term with developmental delay and abnormal gait. Read More

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Clinical outcomes and hemodynamic performance of Dafodil™ aortic and mitral pericardial bioprosthesis: 1-year results from Dafodil-1 first-in-human trial.

J Cardiothorac Surg 2020 Jun 15;15(1):140. Epub 2020 Jun 15.

Department of Anaesthesia and Intensive Care, Epic Hospital, Sola, Sarkhej - Gandhinagar Highway, Opp. Kargil Petrol Pump, Ahmedabad, Gujarat, 380081, India.

Background: Bioprosthesis has been increasingly implanted for the treatment of transvalvular disease across the world. A new Dafodil™ pericardial bioprosthesis (Meril Life Sciences Pvt. Ltd. Read More

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Quality of Life and Symptom Burden among Chronic Kidney Disease of Uncertain Etiology (CKDu) Patients in Girandurukotte, Sri Lanka.

Int J Environ Res Public Health 2020 06 5;17(11). Epub 2020 Jun 5.

Transplant and Dialysis Unit, Teaching Hospital, Kandy 20000, Sri Lanka.

Symptom burden and health-related quality of life (HRQOL) are important predictors of how a disease affects patients' lives, especially for endemic health problems such as chronic kidney disease of uncertain etiology (CKDu). Our study describes symptom burden, HRQOL, and associated demographic and clinical variables in CKDu patients in the Girandurukotte area, Sri Lanka. A cross-sectional study included 120 CKDu patients attending the renal clinic in the endemic area. Read More

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The Influence of fluoride on chronic kidney disease of uncertain aetiology (CKDu) in Sri Lanka.

Chemosphere 2020 Oct 27;257:127186. Epub 2020 May 27.

Institute of Public Health and Welfare Research, Nakagyoku, Kyoto, Japan.

Fluoride is an element that is widely distributed in the environment. The involvement of fluoride in pathogenesis of Chronic Kidney Disease of uncertain aetiology (CKDu) in Sri Lanka is a much-debated topic. This study aimed to investigate the fluoride concentration in drinking water in CKDu affected areas in Sri Lanka and to evaluate the possible effect of renal impairment on serum fluoride levels in CKDu patients. Read More

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October 2020

Long-term outcome with focus on pulmonary hypertension in Obesity Hypoventilation Syndrome.

Clin Respir J 2020 Oct 3;14(10):940-947. Epub 2020 Jul 3.

Centre for Pneumology, Donaustauf Hospital, Donaustauf, Germany.

Introduction: Pulmonary Hypertension (PH) is a frequent comorbidity in Obesity Hypoventilation Syndrome (OHS).

Objective: We investigated long-term outcome of OHS with a particular emphasis on PH.

Methods: In a prospective design, 64 patients with OHS and established noninvasive positive pressure ventilation (NPPV), were assessed by serum biomarkers, right heart catheterization, blood gases analysis, lung function, Epworth-Sleepiness Scale (ESS), Pittsburgh Sleep Quality Index (PSQI), World Health Organization-functional class (WHO-FC) and health-related quality of life (HRQL) via the Severe Respiratory Insufficiency (SRI) questionnaire. Read More

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October 2020

The effects of home noninvasive ventilation on the quality of life and physiological parameters of patients with chronic respiratory failure.

Clin Respir J 2020 Sep 17;14(9):880-888. Epub 2020 Jun 17.

Faculty of Medicine, Department of Chest Diseases, Ankara University, Ankara, Turkey.

Introduction: Home noninvasive mechanical ventilation (HNIV) in patients with chronic hypercapnic respiratory failure (CHRF) may improve the health-related quality of life (HRQoL) and reduce hospitalizations.

Objective: To determine the effects of HNIV on HRQoL, sleep quality and hospitalization rates in restrictive thoracic diseases (RTD) and chronic obstructive pulmonary disease (COPD) patients with CHRF.

Methods: In this prospective, single center study patients divided into two groups; the COPD and the RTD groups. Read More

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September 2020

Assessment of functional outcome of patients undergoing surgery for chronic pancreatitis: A prospective study.

Ann Hepatobiliary Pancreat Surg 2020 May;24(2):162-167

Department of Surgical Gastroenterology, Sri Venkateswara Institute of Medical Sciences (SVIMS), Tirupati, India.

Backgrounds/aims: This study was done with the aim of assessing impact of surgery for chronic pancreatitis on exocrine and endocrine functions, quality of life and pain relief of patients.

Methods: 35 patients of chronic pancreatitis who underwent surgery were included. Exocrine function assessed with fecal fat globule estimation and endocrine function assessed with glycated haemoglobin (HbA1C), fasting plasma glucose (FPG), Insulin and C-peptide levels. Read More

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Pulmonary hypertension - prevalence, risk factors, and its association with vascular calcification in chronic kidney disease and hemodialysis patients.

Saudi J Kidney Dis Transpl 2020 Mar-Apr;31(2):380-387

Department of Nephrology, Sri Ramachandra Institute of Higher Education and Research (Deemed to be University), Chennai, Tamil Nadu, India.

Pulmonary hypertension (PHTN) is a recently recognized complication in dialysis and it is associated with a poor outcome. We estimated the prevalence of PHTN and its association with vascular calcification in chronic kidney disease (CKD) and hemodialysis (HD) patients. One hundred and thirteen adult CKD patients were included in this study, of which 56 (49. Read More

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Validation of the Hungarian version of the SRI Questionnaire.

BMC Pulm Med 2020 May 7;20(1):130. Epub 2020 May 7.

Department of Pneumology, Cologne Merheim Hospital, Kliniken der Stadt Köln gGmbH, Witten/Herdecke University, Ostmerheimer Strasse 200, 51109, Cologne, Germany.

Background: Home mechanical ventilation is a reliable treatment for patients suffering from chronic respiratory failure, improving survival and quality of life. Prevalence has been increasing worldwide as a result of evolving technical possibilities, telemedicine and improving national guidelines. Projects to establish a national guideline and registry for patients treated with home mechanical ventilation are currently under way in Hungary and our aim was to validate a quality of life questionnaire suited for evaluation and follow up in this specific patient group. Read More

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Evaluation of biochemical profile of Chronic Kidney Disease of uncertain etiology in Sri Lanka.

PLoS One 2020 4;15(5):e0232522. Epub 2020 May 4.

Transplant and Dialysis Unit, Teaching Hospital, Kandy, Sri Lanka.

Chronic Kidney Disease of uncertain etiology (CKDu) is an endemic, disease that mostly affects young agricultural workers in the rural dry zone of Sri Lanka. This study was designed to identify specific biochemical manifestations of CKDu cases. All (119) non-dialysis definite CKDu patients in Girandurukotte and Wilgamuwa were selected. Read More

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Health related quality of life in chronic kidney disease; a descriptive study in a rural Sri Lankan community affected by chronic kidney disease.

Health Qual Life Outcomes 2020 Apr 23;18(1):106. Epub 2020 Apr 23.

Australian Centre for Health Service Innovation, Queensland University of Technology, Brisbane, Australia.

Introduction: The current epidemic of chronic kidney disease (CKD) in Sri Lanka is ascribed to the exponential increase in the number of CKD patients, which cannot be attributed to any known etiology (CKDu). The aim of this study is to describe the health related quality of life (HRQOL) and the associated factors among CKD/CKDu patients in a rural district in Sri Lanka.

Methods: A community based cross-sectional study included 1174 CKD/CKDu patients. Read More

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