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Early Results of Popliteal Vein External Banding for Treatment of Chronic Venous Insufficiency.

Ann Vasc Surg 2021 Jun 18. Epub 2021 Jun 18.

Emory University Hospital, Department of Surgery, Division of Vascular Surgery, 1364 Clifton Rd, NE, Atlanta, GA, USA, 30322; Grady Health, Department of Surgery, Division of Vascular Surgery, 80 Jesse Hill Jr Dr SE, Atlanta, GA, USA, 30303. Electronic address:

Introduction: Chronic venous insufficiency (CVI) encompasses a myriad of clinical manifestations including lower extremity swelling and pain, ulcerations and chronic skin changes such as stasis dermatitis, and lipodermatosclerosis. CVI effects greater than 25 million Americans and has a significant socioeconomic and psychosocial impact. Treatment of CVI varies depending on the etiology. Read More

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Registry to investigate the efficacy and safety of the VenaBlock VeIn SEaling system for VaRicose veins in SingApore - Six months results of the RIVIERA trial.

Phlebology 2021 Jun 21:2683555211025181. Epub 2021 Jun 21.

Department of Vascular Surgery, Singapore General Hospital, Singapore, Singapore.

Background: The Venablock Venous Closure System (Invamed, Ankara, Turkey) is a novel cyanoacrylate-based non-thermal non-tumescent embolization device to block refluxing truncal veins for chronic venous insufficiency and varicose veins. The aim was to prospectively evaluate the safety and 6 months efficacy of Venablock for the treatment of primary great saphenous vein (GSV) and small saphenous vein (SSV) incompetency in a multi-ethnic cohort from Singapore.

Methods: This was a single arm, single investigator prospective study of 29 patients (39 limbs, 39 truncal veins) recruited over a 5-month period (August 2019 to February 2020), who were treated with the Venablock device at a tertiary vascular unit in Singapore. Read More

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Hydroxyfluorooxoborate Na[B3O3F2(OH)2][B(OH)3]: Optimizing the Optical Anisotropy with Heteroanionic Units for Deep Ultraviolet Birefringent Crystals.

Angew Chem Int Ed Engl 2021 Jun 21. Epub 2021 Jun 21.

Chinese Academy of Sciences, Xinjiang technical of physics and chemistry, 40-1 South Beijing Road Urumqi 830011 China, 830011, Urumqi, CHINA.

Maximizing the optical anisotropy in birefringent materials has emerged as an efficient route for modulating the polarization-dependent light propagation. Currently, the generation of deep-ultraviolet (deep-UV) polarized light below 200 nm is essential but challenging due to the interdisciplinary significance and insufficiency of high-performing birefringent crystals. Herein, by introducing multiple heteroanionic units, the first sodium hydroxyfluorooxoborate Na[B3O3F2(OH)2][B(OH)3] has been characterized as a novel deep-UV birefringent crystal. Read More

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Association of advanced glycation end-products levels with vascular events in postmenopausal women.

Geriatr Gerontol Int 2021 Jun 20. Epub 2021 Jun 20.

Department of Orthopedic Surgery, Jikei University School of Medicine, Tokyo, Japan.

Aim: Advanced glycation end-products (AGEs) are a known factor that accelerates vascular complications. AGEs (e.g. Read More

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Role of Daratumumab in Combination With Standard Therapies in Patients With Relapsed and Refractory Multiple Myeloma.

Cureus 2021 Jun 4;13(6):e15440. Epub 2021 Jun 4.

Internal Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA.

Multiple myeloma (MM) is a hematological malignancy characterized by renal insufficiency, bone lesions, anemia, and hypercalcemia. In this modern era of medicine, even with the development of drugs like immunomodulatory agents (IMiDs) and proteasome inhibitors (PI), the treatment of MM prevails as a challenge. However, even after the attainment of total remission, relapse of MM and disease progression is frequent. Read More

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Staged Total Hip Arthroplasty: A Novel Technique in Managing Native and Periprosthetic Acetabular Insufficiency.

Arthroplast Today 2021 Jun 31;9:78-82. Epub 2021 May 31.

Division of Orthopaedic Surgery, Southern Illinois University School of Medicine, Springfield, IL, USA.

Background: There is no consensus on how to best address acetabular insufficiency. Several described techniques have a high rate of loosening and most rely on fixation to intact innominate bones. They also require extensive exposure and expensive implants. Read More

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Vitamin C Inhibits the Metabolic Changes Induced by Tet1 Insufficiency Under High Fat Diet Stress.

Mol Nutr Food Res 2021 Jun 15:e2100417. Epub 2021 Jun 15.

Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan, 430072, China.

Scope: DNA methylation contributes to obesity, but the role of the DNA demethylase ten-eleven translocation protein 1 (Tet1) in obesity remains unclear. Vitamin C is a cofactor for the Tet family of proteins, but whether vitamin C can be used to treat obesity via Tet1 awaits clarification.

Methods And Results: Tet1 and Tet1 mice are fed a high fat diet (HFD). Read More

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A novel homozygous missense variant in the NAXE gene in an Iranian family with progressive encephalopathy with brain edema and leukoencephalopathy.

Acta Neurol Belg 2021 Jun 13. Epub 2021 Jun 13.

Department of Medical Genetics, Faculty of Medical Sciences, Tarbiat Modares University, Jalah-Al Ahmad Hwy, 14117-1316, Tehran, Iran.

Homozygous or compound heterozygous mutations in the NAD(P)HX epimerase (NAXE) gene, cause early-onset progressive encephalopathy with brain edema and/or leukoencephalopathy 1. This disorder is characterized by psychomotor regression, hypotonia, ataxia, respiratory insufficiency, tetraparesis, and seizures, leading to coma and death in early childhood. In this study, whole-exome sequencing was used to identify the pathogenic variant, followed by confirmation of identified variant in the proband and segregation analysis in the family by Sanger sequencing. Read More

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Respiratory Failure in Noonan Syndrome Treated by Microsurgical Thoracic Duct-Venous Anastomosis.

Ann Thorac Surg 2021 Jun 8. Epub 2021 Jun 8.

Division of Plastic Surgery, Department of Surgery, University of Pennsylvania. Electronic address:

Noonan Syndrome is a disorder characterized by central and peripheral lymphatic conducting anomalies, leading to chylothorax, chylous ascites, and metabolic derangement. Novel imaging modalities including dynamic contrast magnetic resonance lymphangiography (DCMRL) and intranodal lymphangiography have allowed for increased visualization of lymphatic pathology. We describe the first study of a 61-year-old male with Noonan syndrome who developed severe pulmonary insufficiency and chylothoraces. Read More

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Pancreas morphogenesis and homeostasis depends on tightly regulated Zeb1 levels in epithelial cells.

Cell Death Discov 2021 Jun 11;7(1):138. Epub 2021 Jun 11.

Department of Experimental Medicine 1, Nikolaus-Fiebiger Center for Molecular Medicine, Friedrich-Alexander University of Erlangen-Nürnberg, Erlangen, Germany.

The pancreas is comprised of exocrine and endocrine compartments releasing digestive enzymes into the duodenum and regulating blood glucose levels by insulin and glucagon release. Tissue homeostasis is depending on transcription factor networks, involving Ptf1α, Ngn3, Nkx6.1, and Sox9, which are already activated during organogenesis. Read More

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Medical recommender systems based on continuous-valued logic and multi-criteria decision operators, using interpretable neural networks.

BMC Med Inform Decis Mak 2021 06 11;21(1):186. Epub 2021 Jun 11.

Knowledgepark GmbH, Leonrodstr. 68, 80636, Munich, Germany.

Background: Out of the pressure of Digital Transformation, the major industrial domains are using advanced and efficient digital technologies to implement processes that are applied on a daily basis. Unfortunately, this still does not happen in the same way in the medical domain. For this reason, doctors usually do not have the time or knowledge to evaluate all alternative treatment options for each patient accurately and individually. Read More

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A Novel L1 Linker Mutation in DES Resulted in Total Absence of Protein.

J Mol Neurosci 2021 Jun 9. Epub 2021 Jun 9.

Department of Neuropathology, National Institute of Mental Health and Neuro Sciences, Bengaluru, Karnataka, 560 029, India.

Desminopathies (MIM*601419) are clinically heterogeneous, manifesting with myopathy and/or cardiomyopathy and with intra-sarcoplasmic desmin-positive deposits. They have either an autosomal dominant (AD) or recessive (AR) pattern of inheritance. Desmin is a crucial intermediate filament protein regulating various cellular functions in muscle cells. Read More

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[Current aspects of heart-kidney interactions : Summary of important clinical studies from 2020].

Herz 2021 Jun 9. Epub 2021 Jun 9.

Klinik für Innere Medizin III, Klinik für Kardiologie, Angiologie und Internistische Intensivmedizin, IMED, Universitätsklinikum des Saarlandes, Homburg, Deutschland.

Patients with chronic kidney diseases show an increased cardiovascular morbidity and mortality. Last year a number of important studies on heart-kidney interaction were published, which are summarized and discussed in this article. In the DAPA-CKD study and the SCORED study two different sodium-glucose linked transporter 2 (SGLT2) inhibitors (dapagliflozin and sotagliflozin) were found to improve the prognosis of patients with chronic kidney diseases with and without diabetes. Read More

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Maternal circulating SPINT1 is reduced in small-for-gestational age pregnancies at 26 weeks: Growing up in Singapore towards health outcomes (GUSTO) cohort study.

Placenta 2021 Jul 1;110:24-28. Epub 2021 Jun 1.

The Department of Obstetrics and Gynaecology, Mercy Hospital for Women, University of Melbourne, Victoria, Australia; Singapore Institute of Clinical Sciences, Agency for Science, Technology and Research (A*STAR), Singapore; Department of Obstetrics and Gynaecology and Human Potential Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.

Fetal growth restriction arising from placental insufficiency is a leading cause of stillbirth. We recently identified low maternal circulating SPINT1 concentrations as a novel biomarker of poor fetal growth. Here we measured SPINT1 in a prospective cohort in Singapore. Read More

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Impaired humoral and cellular immunity after SARS-CoV2 BNT162b2 (Tozinameran) prime-boost vaccination in kidney transplant recipients.

J Clin Invest 2021 Jun 8. Epub 2021 Jun 8.

Department for General and Visceral Surgery, Charité-Universitätsmedizin Berlin, Berlin, Germany.

Novel mRNA-based vaccines have been proven powerful tools to combat the global pandemic caused by SARS-CoV2 with BNT162b2 (trade name: Comirnaty) efficiently protecting individuals from COVID-19 across a broad age range. Still, it remains largely unknown how renal insufficiency and immunosuppressive medication affect development of vaccine induced immunity. We therefore comprehensively analyzed humoral and cellular responses in kidney transplant recipients after the standard second vaccination dose. Read More

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The Molecular Regulation in the Pathophysiology in Ovarian Aging.

Aging Dis 2021 Jun 1;12(3):934-949. Epub 2021 Jun 1.

1Department of Obstetrics and Gynaecology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.

The female reproductive system is of great significance to women's health. Aging of the female reproductive system occurs approximately 10 years prior to the natural age-associated functional decline of other organ systems. With an increase in life expectancy worldwide, reproductive aging has gradually become a key health issue among women. Read More

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Diarrhea due to SARS-CoV-2-Related Exocrine Pancreatic Insufficiency.

Case Rep Gastrointest Med 2021 21;2021:9920981. Epub 2021 May 21.

Division of Gastroenterology, BronxCare Hospital Center a Clinical Affiliate of Mt Sinai Health Systems and Academic Affiliate of Icahn School of Medicine, Bronx, NY 10457, USA.

Gastrointestinal symptoms, especially diarrhea, are common with novel coronavirus SARS-CoV-2 infection. Angiotensin-converting enzyme-2 (ACE-2) receptors are heavily expressed in enterocytes and serve as entry receptors for SARS-CoV-2. ACE-2 receptors may also be responsible for pancreatic injury in patients infected with SARS-CoV-2. Read More

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A Novel UPLC-MS/MS Assay for the Measurement of Linezolid and its Metabolite PNU-142300 in Human Serum and its Application to Patients With Renal Insufficiency.

Front Pharmacol 2021 20;12:641872. Epub 2021 May 20.

Department of pharmacy, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.

The contribution of the metabolites of linezolid to the associated myelosuppression is unknown in patients who are renal impairment. In this research, the purpose of our experiment was to explore and develop a quick and robust ultra performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) assay for the determination of linezolid and its metabolite PNU-142300 in human serum simultaneously. The analytes were prepared using a simple and convenient approach with acetonitrile for protein crash, and then separated from the matrix on a Waters Acquity Ultra performance liquid chromatography (UPLC) BEH C18 (2. Read More

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When a Ciliate Meets a Flagellate: A Rare Case of spp. and spp. Isolated from the Urine of a Human Patient. Case Report and Brief Review of Literature.

Biology (Basel) 2021 May 27;10(6). Epub 2021 May 27.

Department of Microbiology, Iuliu Hațieganu University of Medicine and Pharmacy, 400349 Cluj-Napoca, Romania.

An often-overlooked side of the population aging process and the steady rise of non-communicable diseases reflects the emergence of novel infectious pathogens on the background of an altered host immune response. The aim of this article was to present the first record of a ciliate and flagellate protozoa recovered from the urine of an elderly patient and to review the existing medical literature involving these parasites. A 70-year-old female patient was admitted for breathing difficulties on the basis of an acute exacerbation of COPD (Chronic obstructive pulmonary disease) with respiratory insufficiency. Read More

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Extracellular Vesicles as a Therapeutic Tool for Kidney Disease: Current Advances and Perspectives.

Int J Mol Sci 2021 May 28;22(11). Epub 2021 May 28.

Institute of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro 21941-902, Brazil.

Extracellular vesicles (EVs) have been described as important mediators of cell communication, regulating several physiological processes, including tissue recovery and regeneration. In the kidneys, EVs derived from stem cells have been shown to support tissue recovery in diverse disease models and have been considered an interesting alternative to cell therapy. For this purpose, however, several challenges remain to be overcome, such as the requirement of a high number of EVs for human therapy and the need for optimization of techniques for their isolation and characterization. Read More

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Modelling Hydrocortisone Pharmacokinetics on a Subcutaneous Pulsatile Infusion Replacement Strategy in Patients with Adrenocortical Insufficiency.

Pharmaceutics 2021 May 21;13(6). Epub 2021 May 21.

Laboratories of Integrative Neuroscience and Endocrinology, School of Clinical Sciences, University of Bristol, Bristol BS1 3NY, UK.

In the context of glucocorticoid (GC) therapeutics, recent studies have utilised a subcutaneous hydrocortisone (HC) infusion pump programmed to deliver multiple HC pulses throughout the day, with the purpose of restoring normal circadian and ultradian GC rhythmicity. A key challenge for the advancement of novel HC replacement therapies is the calibration of infusion pumps against cortisol levels measured in blood. However, repeated blood sampling sessions are enormously labour-intensive for both examiners and examinees. Read More

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Ellagic acid prevents 3-nitropropionic acid induced symptoms of Huntington's disease.

Naunyn Schmiedebergs Arch Pharmacol 2021 Jun 1. Epub 2021 Jun 1.

Department of Pharmacology, Amar Shaheed Baba Ajit Singh Jujhar Singh Memorial College of Pharmacy, Bela (Ropar), 140111, India.

Mitochondrial abnormalities and redox imbalance are major pathogenic factors in progression of Huntington's disease (HD), manifested clinically by affective, motor, cognitive, and psychiatric incompetence. Antioxidants behold much promise in mitigation of several pathological facets in HD. Ellagic acid (EA) is a naturally derived polyphenol acknowledged for potent neuroprotective abilities that enabled its significance amongst popular brain tonics. Read More

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Arteriovenous supercharging: A novel approach to improve reliability of the distally based sural flap.

Trop Doct 2021 May 31:494755211020854. Epub 2021 May 31.

Assistant Professor, Department of Surgery, NSCB Government Medical College, Jabalpur, Madhya Pradesh, India.

Complex soft-tissue defects of the distal third of the leg, foot and ankle with exposed bones/joints, tendons and implants need a flap for their closure. Distally based sural flap is commonly used, but it has a high partial necrosis rate due to venous insufficiency. We addressed this issue with AV supercharging by dorsalis pedis artery with short saphenous vein. Read More

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Choriocapillaris flow loss in center-involving retinitis pigmentosa: a quantitative optical coherence tomography angiography study using a novel classification system.

Graefes Arch Clin Exp Ophthalmol 2021 May 31. Epub 2021 May 31.

Wilmer Eye Institute, Johns Hopkins Hospital, Johns Hopkins University School of Medicine, 600 N Wolfe St, Baltimore, MD, 21287, USA.

Purpose: Choriocapillaris insufficiency may play a role in centripetal retinitis pigmentosa (RP) progression involving the fovea. However, the relationship between choriocapillaris integrity and foveal damage in RP is unclear. We examined the relationship between choriocapillaris flow and the presence of foveal photoreceptor involvement in RP. Read More

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OFx: A method of 4D image construction from free-breathing non-gated MRI slice acquisitions of the thorax via optical flux.

Med Image Anal 2021 Apr 25;72:102088. Epub 2021 Apr 25.

Center for Thoracic Insufficiency Syndrome, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.

Purpose: Since real-time 4D dynamic magnetic resonance imaging (dMRI) methods with adequate spatial and temporal resolution for imaging the pediatric thorax are currently not available, free-breathing slice acquisitions followed by appropriate 4D construction methods are currently employed. Self-gating methods, which extract breathing signals only from image information without any external gating technology, have much potential for this purpose, such as for use in studying pediatric thoracic insufficiency syndrome (TIS). Patients with TIS frequently suffer from extreme malformations of the chest wall, diaphragm, and spine, leading to breathing that is very complex, including deep or shallow respiratory cycles. Read More

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Renal Health: Providing Information and Technological Tools to Empower Patients to Live Better with Kidney Disease.

Stud Health Technol Inform 2021 May;281:674-678

Applied Informatics Graduate Program, Technology Sciences Center, University of Fortaleza, Fortaleza, Ceará, Brazil.

Chronic kidney disease (CKD) is a growing Public Health problem. Recent evidence points that low education and poor socio-economic conditions are associated with higher risk of developing CKD and progressing to dialysis or transplantation need. Hence patient empowerment through health education and qualification with technological tools that allows better treatment adherence may play an important role in the achievement of optimal clinical outcomes. Read More

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Transapical off-pump mitral valve repair following prior mitral valve surgery: A case report.

Medicine (Baltimore) 2021 May;100(21):e26148

Department of Cardiothoracic and Vascular Surgery, Kepler University Hospital, Medical Faculty, Johannes Kepler University, Linz, Austria.

Rationale: Redo surgeries after mitral valve repair are technically demanding. Procedures applying the NeoChord device (NeoChord Inc, St. Louis Park, MN) have proven to be safe and feasible in selected patients requiring mitral valve repair due to a leaflet prolapse or flail. Read More

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Effectiveness and safety profiling of zolpidem and acupressure in CKD associated pruritus: An interventional study.

Medicine (Baltimore) 2021 May;100(21):e25995

School of Pharmacy, Monash University, Jalan Lagoon Selatan, Bandar Sunway, Selangor Darul Ehsan, Malaysia.

Background: Chronic kidney disease (CKD)-associated pruritus (CKD-aP) contributes to poor quality of life, including reduced sleep quality and poor sleep quality is a source of patient stress and is linked to lower health-related quality of life. This study aimed to investigate the effectiveness of zolpidem 10 mg and acupressure therapy on foot acupoints to improve the sleep quality and overall quality of life among hemodialysis patients suffering from CKD-aP.

Method: A multicenter, prospective, randomized, parallel-design, open label interventional study to estimate the effectiveness of zolpidem (10 mg) oral tablets versus acupressure on sleep quality and quality of life in patients with CKD-aP on hemodialysis. Read More

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Cerebrovascular insufficiency and amyloidogenic signaling in Ossabaw swine with cardiometabolic heart failure.

JCI Insight 2021 May 24;6(10). Epub 2021 May 24.

Department of Biomedical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.

Individuals with heart failure (HF) frequently present with comorbidities, including obesity, insulin resistance, hypertension, and dyslipidemia. Many patients with HF experience cardiogenic dementia, yet the pathophysiology of this disease remains poorly understood. Using a swine model of cardiometabolic HF (Western diet+aortic banding; WD-AB), we tested the hypothesis that WD-AB would promote a multidementia phenotype involving cerebrovascular dysfunction alongside evidence of Alzheimer's disease (AD) pathology. Read More

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Pseudoaneurysm of Ascending Aorta induced by Brucella Endocarditis In bicuspid Aortic Valve.

Echocardiography 2021 Jun 20;38(6):1017-1020. Epub 2021 May 20.

Department of Cardiology, Peking University People's Hospital, Beijing, China.

Brucellosis is endemic in the Mediterranean region, South American countries, and Asia. In China, it is frequently diagnosed in herdsmen who often have contact with livestock. Brucella endocarditis (BE) is a rare complication, but it is the leading reason for mortality. Read More

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