6,370 results match your criteria insignificant difference

Disruption on right temporoparietal junction with transcranial magnetic stimulation affects moral judgment: no difference between first- and third-personal narration with TMS.

Neuropsychologia 2021 Apr 12:107858. Epub 2021 Apr 12.

Department of Human Development and Family Studies, National Taiwan Normal University, Taiwan.

Brain imaging studies have observed that the right temporoparietal junction (rTPJ) was involved in the information processing of moral judgments and in the understanding of the beliefs/intentions of other people. However, most of these studies used moral stories in the third-person point of view. This study aimed to investigate to what extent the disruption of rTPJ affected moral judgments with stories in first-person narration by non-invasive transcranial magnetic stimulation (TMS). Read More

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Topical ketorolac as an adjunctive treatment with intravitreal bevacizumab in the management of diabetic macular edema: A double-masked placebo-controlled randomized clinical trial.

Graefes Arch Clin Exp Ophthalmol 2021 Apr 15. Epub 2021 Apr 15.

Department of Epidemiology and Biostatistics, Tehran University of Medical Sciences, Tehran, Iran.

Purpose: To evaluate the additional effect of ketorolac eye drops on therapeutic effects of intravitreal Bevacizumab in patients with diabetic macular edema (DME) METHODS: In a randomized clinical trial, 50 patients with center involved DME (macular thickness ≥ 300 microns accompanied by decreased VA (24 < BCVA ≤ 70 ETDRS letters) were enrolled consecutively and randomized 1:1 to receive either bevacizumab plus topical ketorolac (25 patients) or bevacizumab plus artificial tears (25 patients). Patients with proliferative diabetic retinopathy, history of intraocular surgery, intravitreal injection in less than three months, macular photocoagulation less than 6 months and any other concomitant ocular pathologies were excluded from the study. All the patients received three consecutive monthly injections of intravitreal bevacizumab (IVB). Read More

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Reduced regulatory T lymphocytes in migraine patients.

Neurol Res 2021 Apr 14:1-6. Epub 2021 Apr 14.

Molecular and Medicine Research Center, Department of Microbiology and Immunology, School of Medicine, Arak University of Medical Sciences, Arak, Iran.

: Migraine is a primary headache disorder with unknown pathophysiology. Recently, many studies have suggested the role of immune dysfunction in the pathophysiology of this disorder. In this study, we investigated the percentage of regulatory T cells (Treg cells) in different migraine categories. Read More

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Awareness of dental practitioners and intern dental practitioners in Northern Cyprus towards pandemic of SARS-CoV-2.

O Onoral M G Caymaz

Niger J Clin Pract 2021 Apr;24(4):534-545

Department of Oral and Maxillofacial Surgery, Near East University Faculty of Dentistry, Nicosia, Mersin, Turkey.

Aims: This study aimed to evaluate the perception, attitude, and awareness of dental practitioners (DPs) and intern DPs towards SARS-COV-2 by comparing the awareness-attitude score (AAS).

Materials And Methods: An online survey was generated in Google Forms. An invitation email was sent to all DPs in Northern Cyprus (n = 270) and intern DPs at Near East University (n = 200). Read More

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Diagnostic nomogram based on intralesional and perilesional radiomics features and clinical factors of clinically significant prostate cancer.

J Magn Reson Imaging 2021 May;53(5):1550-1558

Department of Radiology, Yantai Yuhuangding Hospital, Qingdao University, Yantai, China.

Previous studies on the value of radiomics for diagnosing clinically significant prostate cancer (csPCa) only utilized intralesional features. However, the role of tumor microenvironment is important in tumor generation and progression. The aim of this study is to build and validate a nomogram based on perilesional and intralesional radiomics features and clinical factors for csPCa. Read More

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Clinicopathological Implications of RHOA Mutations in Angioimmunoblastic T-Cell Lymphoma: A Meta-analysis: RHOA mutations in AITL.

Clin Lymphoma Myeloma Leuk 2021 Mar 19. Epub 2021 Mar 19.

Department of Pathology, Oklahoma University Health Sciences Center, Oklahoma City, OK; Stephenson Cancer Center, Oklahoma University Health Sciences Center, Oklahoma City, OK. Electronic address:

Background: Studies have recently shown that RHOA mutations play a crucial role in angioimmunoblastic T-cell lymphoma (AITL) pathogenesis. We aimed to pool data from these studies to provide a comparison of clinicopathological features between the RHOA mutant and RHOA wild-type groups in the AITL population.

Methods: We searched PubMed and Web of Science for the keywords "RHOA AND lymphoma" and selected only studies reporting the clinical significance of RHOA mutations in AITL. Read More

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Mineral and Technological Features of Magnetite-Hematite Ores and Their Influence on the Choice of Processing Technology.

ACS Omega 2021 Apr 24;6(13):9077-9085. Epub 2021 Mar 24.

Saint Petersburg Mining University, St. Petersburg 199106, Russia.

Analysis of the current technical solutions for the processing of iron ores showed that the high-grade ores are directly exposed to metallurgical processing; by comparison, low-grade ores, depending on the mineralogical and material composition, are directed to beneficiation including gravitational, magnetic, and flotation processes or their combination. Obtaining high-quality concentrates with high iron content and low content of impurities from low-grade iron ores requires the maximum possible liberation of valuable minerals and a high accuracy of separating features (difference in density, magnetic susceptibility, wettability, etc.). Read More

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Carboxymethyl Cellulose versus Hydroxypropyl Methylcellulose Tear Substitutes for Dry Eye Due to Computer Vision Syndrome: Comparison of Efficacy and Safety.

Int J Appl Basic Med Res 2021 Jan-Mar;11(1):4-8. Epub 2021 Jan 26.

Department of Ophthalmology, Christian Medical College and Hospital, Ludhiana, Punjab, India.

Background: Prolonged use of visual display terminal images on electronic devices such as computers frequently leads to symptoms of dry eye. Tear substitutes form the mainstay of treatment for mild-to-moderate dry eye.

Aim: The study aimed to evaluate the efficacy and safety of carboxymethyl cellulose (CMC) versus hydroxypropyl methylcellulose (HPMC) tear substitutes for dry eye due to computer vision syndrome (CVS). Read More

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January 2021

Prevalence of Vitamin D Deficiency in a Young Adult With Acute Spinal Cord Injury.

Cureus 2021 Mar 9;13(3):e13791. Epub 2021 Mar 9.

Department of Orthopaedic Surgery, King George's Medical University, Lucknow, IND.

Introduction: Vitamin D deficiency has been implicated as an etiologic factor responsible for osteoporosis and various skeletal and extra-skeletal issues in spinal cord injury patients. There is a dearth of publications regarding the prevalence of vitamin D deficiency in acute spinal cord injury (ASCI) patients, thus it becomes imperative to study the status of vitamin D in ASCI cases to make an early diagnosis and start treatment for osteoporosis. Apart from this, we also planned to evaluate other factors associated with vitamin D deficiency in our subset of patients. Read More

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Randomized double-blind trial comparing effects of low-flow vs high-flow anesthesia on postoperative lung functions using respirometer.

J Anaesthesiol Clin Pharmacol 2020 Oct-Dec;36(4):535-540. Epub 2021 Jan 18.

Department of Anesthesiology, Shri Sathya Sai Medical College and Research Institute, (Sri Balaji Vidyapeeth, Deemed to be University), Kancheepuram, Tamil Nadu, India.

Background And Aims: Modern anesthetic practice utilizes low-flow anesthesia with evolving evidence on its pulmonary effects. Studies comparing measurement of vital capacity and inspiratory reserve volume using respirometer in both low-flow and high-flow anesthesia are sparse. We evaluated the effects of low-flow and high-flow anesthesia on postoperative pulmonary functions using respirometer. Read More

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January 2021

Gametocyte carriage of Plasmodium falciparum (pfs25) and Plasmodium vivax (pvs25) during mass screening and treatment in West Timor, Indonesia: a longitudinal prospective study.

Malar J 2021 Apr 9;20(1):177. Epub 2021 Apr 9.

Indonesian Medical Education and Research Institute, Jakarta, Indonesia.

Background: A goal of malaria epidemiological interventions is the detection and treatment of parasite reservoirs in endemic areas-an activity that is expected to reduce local transmission. Since the gametocyte is the only transmissible stage from human host to mosquito vector, this study evaluated the pre and post presence of gametocytes during a mass screening and treatment (MST) intervention conducted during 2013 in East Nusa Tenggara, Indonesia.

Methods: RT-qPCR targeting pfs25 and pvs25 transcripts-gametocyte molecular markers for Plasmodium falciparum and Plasmodium vivax, respectively, was performed to detect and quantify gametocytes in blood samples of P. Read More

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Macular vascular changes in pregnant women with gestational diabetes mellitus by optical coherence tomography angiography.

BMC Ophthalmol 2021 Apr 9;21(1):170. Epub 2021 Apr 9.

Department of Ophthalmology, Shanghai Tenth People's Hospital affiliated with Tongji University, 301 Middle Yan Chang Road, Shanghai, 200072, People's Republic of China.

Background: Retinal capillary is vulnerable to diabetes, whether gestational diabetes mellitus (GDM) eyes without clinical retinopathy have capillary abnormalities has not been well studied. To observe the microvasculature changes in eyes of GDM women compared with normoglycemic pregnant women and non-pregnant women by optical coherence tomography-angiography (OCT-A).

Methods: GDM women, age-matched normoglycemic pregnant women and non-pregnant women were included in this study. Read More

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Properties of degradable polyhydroxyalkanoates with different monomer compositions.

Int J Biol Macromol 2021 Apr 6;182:98-114. Epub 2021 Apr 6.

Siberian Federal University, 79 Svobodnyi av., Krasnoyarsk 660041, Russia; Institute of Biophysics SB RAS, Federal Research Center "Krasnoyarsk Science Center SB RAS", 50/50 Akademgorodok, Krasnoyarsk 660036, Russia.

Purpose: To synthesize and investigate polyhydroxyalkanoates (PHAs) with different monomer composition and percentages and polymer films prepared from them.

Results: Various PHAs: homopolymer poly-3-hydroxybutyrate P(3HB) and 2-, 3-, and 4-component copolymers comprising various combinations of 3-hydroxybutyrate (3HB), 3-hydroxyvalerate (3HV), 4-hydroxybutyrate (4HB), and 3-hydroxyhexanoate (3HHx) monomers were synthesized under specialized conditions. Relationships were found between the monomer composition of PHAs and their molecular-weight and thermal properties and degree of crystallinity. Read More

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Comparative evaluation of microleakage of metallic copings luted with three different commercially available luting cements: An study.

J Indian Prosthodont Soc 2021 Jan-Mar;21(1):57-65

Department of Prosthodontics, Genesis Institute of Dental Sciences and Research, Ferozepur, Punjab, India.

Aim: To evaluate the microleakage of metallic copings luted with three different commercially available luting cements.

Setting And Design: Comparative evaluation in vitro study.

Materials And Methods: Thirty replicas of abutment analog were milled and divided into 3 groups. Read More

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Infrared thermographic evaluation of rise in temperature with conventional versus trephine drills.

J Indian Prosthodont Soc 2021 Jan-Mar;21(1):45-49

Department of Prosthodontics, College of Dental Sciences and Hospital, Indore, Madhya Pradesh, India.

Aim: To compare the rise in temperature using trephines over conventional ones during bone site preparation.

Setting And Design: An-vitro, evaluative study.

Materials And Methods: Twenty implant sites were prepared using pilot drill up to depth of 10 mm on bovine femoral bone. Read More

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Birth-related subdural hemorrhage: prevalence and imaging morphology.

Pediatr Radiol 2021 Apr 8. Epub 2021 Apr 8.

Department of Radiology, University of Arkansas for Medical Sciences (UAMS), Little Rock, AR, USA.

Background: Birth trauma accounts for 1-2% of the mortality in newborns with significant intracranial injuries presenting in the immediate postnatal period. However, a significant number of asymptomatic neonates harbor birth-related intracranial hemorrhage (ICH), with birth-related subdural hemorrhage (SDH) being a common occurrence on infant brain CT and MRI studies performed as a standard of care for a variety of reasons. Although clinically insignificant, birth-related SDH is frequently brought up in courts as an alternative explanation for SDH in suspected abusive head trauma. Read More

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Sarcopenia in patients undergoing lower limb bypass surgery is associated with higher mortality and major amputation rates.

Ann Vasc Surg 2021 Apr 2. Epub 2021 Apr 2.

Population Health Sciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle, UK.

Background: Sarcopenia is adversely associated with survival in several diseases. Vasculopathy is often associated with multimorbidity and consequent deconditioning with poor long-term outcomes. This study examined the impact of sarcopenia on clinical outcome in patients with and without critical limb-threatening ischaemia who underwent infrainguinal bypass surgery. Read More

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Effect of Dipeptidyl peptidase-4 inhibitors on the progression of atherosclerosis in patients with type 2 diabetes mellitus: a meta-analysis of randomized controlled trials.

Int J Clin Pract 2021 Apr 5:e14213. Epub 2021 Apr 5.

Department of Traditional Chinese Medicine, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250021, Shandong, China.

Objectives: Type 2 diabetes mellitus(T2DM) can accelerate the clinical process of atherosclerosis(AS). Dipeptidyl peptidase-4 inhibitors(DPP-4Is) have potential anti-AS effects. And, we completed a meta-analysis of the changes in carotid intima-media thickness(CIMT), flow-mediated dilation(FMD), and pulse wave velocity(PWV) of DPP-4Is to research the effect of DPP-4Is in the progression of AS in T2DM patients. Read More

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Hypocalcemia: A possible risk factor for anastomotic leak in digestive surgery.

Exp Ther Med 2021 May 22;21(5):523. Epub 2021 Mar 22.

Department of Diabetes, Nutrition and Metabolic Diseases, Prof. N.C. Paulescu National Institute of Diabetes, Nutrition and Metabolic Disease, 020021 Bucharest, Romania.

Anastomotic leaks (ALs) remain the most severe complication in digestive surgery, as well as the most consumptive in terms of human and financial resources. There is an abundance of international research which has focused on identifying and correcting risk factors, and on individualized surgical management as well. The most frequent risk factors are male sex, obesity, diabetes, advanced malignant disease, ASA score, perioperative blood loss or perioperative transfusion, long operation time, emergency operation and altered nutritional status. Read More

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Predictors and Outcomes of Pancreatic Fistula Following Pancreaticoduodenectomy: a Dual Center Experience.

Indian J Surg Oncol 2021 Mar 27;12(1):22-30. Epub 2020 Aug 27.

Department of Surgical Gastroenterology, Dr. Ram Manohar Lohia Institute of Medical Sciences, Vibhuti Khand, Gomti Nagar, Lucknow, Uttar Pradesh 226010 India.

Fistula following leaked pancreatico-enteric anastomosis is a common, potentially lethal complication of pancreaticoduodenectomy (PD). Early assessment and prediction of its occurrence can improve postoperative outcomes. Various perioperative factors were analyzed for its contribution to clinically relevant postoperative pancreatic fistula (crPOPF). Read More

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Testosterone in Female Depression: A Meta-Analysis and Mendelian Randomization Study.

Biomolecules 2021 Mar 10;11(3). Epub 2021 Mar 10.

Med-X Research Institute and School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200030, China.

Testosterone's role in female depression is not well understood, with studies reporting conflicting results. Here, we use meta-analytical and Mendelian randomization techniques to determine whether serum testosterone levels differ between depressed and healthy women and whether such a relationship is casual. Our meta-analysis shows a significant association between absolute serum testosterone levels and female depression, which remains true for the premenopausal group while achieving borderline significance in the postmenopausal group. Read More

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Tenofovir Disoproxil Fumarate Is Superior to Entecavir in Reducing Hepatitis B Surface Antigen for Chronic Hepatitis B in China: 2-Year Comprehensive Comparative Result of a Matched Comparative Study.

Front Med (Lausanne) 2021 15;8:637126. Epub 2021 Mar 15.

State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Tenofovir disoproxil fumarate (TDF) and entecavir (ETV) are equally recommended as the first-line antiviral treatments for chronic hepatitis B (CHB) at present. We aimed to compare the long-term efficacy and safety between ETV and TDF therapy in CHB patients who had not received nucleoside analog treatment. In this single-center retrospective study, 414 patients who received ETV (290 patients) or TDF (124 patients) therapy at our center from January 2017 to May 2019 were included. Read More

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Hemodialysis Clearance of Enarodustat (JTZ-951), an Oral Erythropoiesis Stimulating Agent, in Patients with End-Stage Renal Disease.

Clin Pharmacol Drug Dev 2021 Mar 31. Epub 2021 Mar 31.

Clinical Pharmacology, Pharmaceutical Division, Japan Tobacco Inc., Tokyo, Japan.

The dialysis clearance of enarodustat (JTZ-951) was determined in patients (N = 6) with end-stage renal disease on hemodialysis. Enarodustat (5 mg PO) was administered before (day 1) and after hemodialysis (day 8) with pharmacokinetic assessments on the 2 occasions. Dialysis clearance was based on plasma and dialysate enarodustat concentrations. Read More

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Measurement of Left Ventricular Dimensions and Ejection Fraction in Neonates by Three-Dimensional Echocardiography: A Comparative Study Between Philips QLAB and TOMTEC Software-Are the Values Interchangeable?

Pediatr Cardiol 2021 Mar 31. Epub 2021 Mar 31.

Royal Brompton Hospital, London, UK.

Three-dimensional echocardiography is being used to evaluate left ventricular dimensions and ejection fraction in clinical practice. The validity and normal values have been established in a large group of normal adults, children and neonates. The aim of this study was to compare left ventricular dimensions and ejection fraction obtained from the same 3-dimensional echocardiography datasets using 2 commercially available applications: Philips QLAB and Tomtec 4D LEFT VENTRICLE-ANALYSIS. Read More

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Repeated measurements of ERGs and VEPs using chloral hydrate sedation and propofol anesthesia in young children.

Doc Ophthalmol 2021 Mar 29. Epub 2021 Mar 29.

Department of Ophthalmology, Children's Hospital Los Angeles, Los Angeles, CA, USA.

Purpose: Sedation with chloral hydrate or anesthesia using propofol allow ocular examination and testing in young children, but these drugs may affect electrophysiologic recordings. We compared the flash and pattern ERGs and VEPs recorded with each drug in a cohort of young children enrolled in a prospective study of optic nerve hypoplasia (ONH) syndrome.

Methods: ERGs and VEPs to light-adapted, standard, full-field flashes, to standard and steady-state pattern-reversal (PR) were recorded with cycloplegia in 9 participants. Read More

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Changes in pro-environmental behaviour and its determinants during long-term period in a transition country as Lithuania.

Environ Dev Sustain 2021 Mar 22:1-17. Epub 2021 Mar 22.

Department of Environmental Sciences, Vytautas Magnus University, Donelaičio str. 28, 44404 Kaunas, Lithuania.

The changes in pro-environmental behaviour, whether people become more environmentally friendly or not, have been analysed very scarcely. Therefore, the aim of this paper was to analyse the changes in pro-environmental behaviour and its determinants in Lithuania as a transition European Union country comparing years 2011 and 2020. Applying Chi-Square and t test statistics, the results showed a significant increase in performance of pro-environmental behaviour in 2020. Read More

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Comparative evaluation of the wear resistance of two different implant abutment materials after cyclic loading - An in vitro study.

Contemp Clin Dent 2020 Jul-Sep;11(3):229-236. Epub 2020 Nov 26.

Department of Prosthodontics and Implantology, The Tamilnadu Dr MGR Medical University, Chennai, Tamil Nadu, India.

Purpose: To comparatively evaluate the wear resistance of two different implant abutment materials with titanium implants after cyclic loading.

Methodology: Two groups utilizing 20 titanium implants secured in resin blocks, in which 10 titanium implants are connected with titanium abutments (Group I, = 10) and the other 10 titanium implants are connected with Polyether ether Ketone (PEEK) abutments (Group II, = 10). Abutments are cyclically loaded for 550,000 cycles. Read More

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November 2020

Synthesis and evaluation of magnesium/co-precipitated hydroxyapatite based composite for biomedical application.

J Mech Behav Biomed Mater 2021 Mar 17;118:104460. Epub 2021 Mar 17.

Biomaterials and Multiscale Mechanics Laboratory, Department of Metallurgical and Materials Engineering, Indian Institute of Technology Roorkee, Uttarakhand, 247667, India. Electronic address:

Owing to its inductive attributes, hydroxyapatite is an ideal reinforcement to tailor the degradation kinetics of magnesium-based temporary orthopedic implants. However, the large difference in the melting temperature of hydroxyapatite and magnesium lead to an insignificant interaction between them during the sintering process, which has been a major limitation in their consolidation. Doping of pure HA with Mg and Zn ions could be a viable solution by making it coherent with the Mg matrix. Read More

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Reduction of structural hierarchy translates into variable influence on the performance of boron nitride aerogel.

iScience 2021 Mar 1;24(3):102251. Epub 2021 Mar 1.

Shenyang National Laboratory for Materials Science, Institute of Metal Research, Chinese Academy of Sciences, Shenyang 110016, China.

The rise of ceramic aerogel offers traditional ceramics a new window. Alongside the emerging prospects, what is open to explore includes the elegant design of a ceramic aerogel with tailorable inner organizations, what would occur when complex hierarchy exists in such an already intricate system, and how the properties get influenced as the complexity fades. Borrowing the wisdom from supramolecular world, we exquisitely transform BN aerogel from a complex hierarchy to a flatten microstructure based on solvent-induced morphology switch of its supramolecular precursor gel. Read More

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Clinical Features and Prognoses of IgG4-Positive and IgG4-Negative Lacrimal Lymphomas.

Front Oncol 2021 8;11:622847. Epub 2021 Mar 8.

Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China.

The clinical characteristics and prognoses of immunoglobulin G4-positive (IgG4+) and IgG4-negative (IgG4-) lacrimal lymphomas were comparatively analyzed to screen for clinical indicators with differential diagnostic significance. This was a retrospective and single-center clinical study. From June 2011 to June 2018, clinical data of 39 patients with lacrimal lymphoma, diagnosed by histopathology were collected from the Department of Ophthalmology, Beijing Tongren Hospital, Capital Medical University. Read More

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