170,974 results match your criteria insertion

Role of NSD1 as potential therapeutic targets in tumor.

Pharmacol Res 2021 Sep 15:105888. Epub 2021 Sep 15.

Macau Centre for Research and Development in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao SAR, 999078, China. Electronic address:

Nuclear receptor binding SET Domain Protein 1 (NSD1) is a bifunctional transcriptional regulatory protein that encodes histone methyltransferase. Mono- and di-methylation of H3K36 by NSD1 is mainly primarily involved in the regulation of gene expression, DNA repair, alternative splicing, and other important biological processes. Many types of cancers, including acute myelogenous leukemia (AML), liver cancer, lung cancer, endometrial carcinoma, colorectal cancer, and pancreatic cancer, are associated with NSD1 fusion, missense mutation, nonsense mutation, silent mutation, deletion, and insertion of frameshift, and deletion in a frame. Read More

View Article and Full-Text PDF
September 2021

Macrophages in the cochlea; an immunological link between risk factors and progressive hearing loss.

Glia 2021 Sep 18. Epub 2021 Sep 18.

Clinical and Experimental Sciences, Faculty of Medicine, IfLS, University of Southampton, Southampton, UK.

Macrophages are abundant in the cochlea; however, their role in hearing loss is not well understood. Insults to the cochlea, such as noise or insertion of a cochlear implant, cause an inflammatory response, which includes activation of tissue-resident macrophages. Activation is characterized by changes in macrophage morphology, mediator expression, and distribution. Read More

View Article and Full-Text PDF
September 2021

Fully Automated Measurement of Cochlear Duct Length From Clinical Temporal Bone Computed Tomography.

Laryngoscope 2021 Sep 18. Epub 2021 Sep 18.

Department of Otolaryngology-Head & Neck Surgery, Stanford University School of Medicine, Stanford, California, U.S.A.

Objectives/hypothesis: To present and validate a novel fully automated method to measure cochlear dimensions, including cochlear duct length (CDL).

Study Design: Cross-sectional study.

Methods: The computational method combined 1) a deep learning (DL) algorithm to segment the cochlea and otic capsule and 2) geometric analysis to measure anti-modiolar distances from the round window to the apex. Read More

View Article and Full-Text PDF
September 2021

A switch-on molecular biosensor for detection of caspase-3 and imaging of apoptosis of cells.

Sci China Life Sci 2021 Sep 9. Epub 2021 Sep 9.

National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China.

Apoptosis is a form of programmed cell death that is essential for maintaining internal environmental stability. Disordered apoptosis can cause a variety of diseases; therefore, sensing apoptosis can provide help in study of mechanism of the relevant diseases and drug development. It is known that caspase-3 is a key enzyme involved in apoptosis and the expression of its activity is an indication of apoptosis. Read More

View Article and Full-Text PDF
September 2021

Comparison of degree of medial rectus muscle misalignment after medial orbital wall decompression with or without periosteal flap.

Graefes Arch Clin Exp Ophthalmol 2021 Sep 18. Epub 2021 Sep 18.

Department of Oculoplastic, Orbital & Lacrimal Surgery, Aichi Medical University Hospital, 1-1 Yazako-Karimata, Nagakute, Aichi, 480-1195, Japan.

Purpose: To compare the degree of postoperative medial rectus (MR) muscle misalignment in patients who underwent medial orbital wall decompression with or without a periosteal flap along the MR muscle.

Methods: This retrospective, observational study included 40 sides from 26 patients. The following parameters were measured on axial computed tomographic images taken post- and/or preoperatively: the distance of the anteroposterior line between the posterior lacrimal crest and the junction of the ethmoid and sphenoid sinuses from the most medial point of the medial margin of the MR muscle; the angle created at the point of the MR globe insertion, the most medial point of the MR muscle, and the junction of the ethmoid and sphenoid sinuses; and the MR muscle cross-sectional area. Read More

View Article and Full-Text PDF
September 2021

Ultrasound of the symptomatic shoulder arthroplasty: Spectrum and prevalence of periarticular soft tissue pathology.

J Clin Ultrasound 2021 Sep 18. Epub 2021 Sep 18.

Department of Radiology, Langone Orthopedic Hospital, New York, New York, USA.

Purpose: To describe our experience using ultrasound (US) to evaluate postoperative complications in the presence of in situ shoulder arthroplasty.

Methods: Review of patients who underwent US evaluation following total shoulder arthroplasty (TSA), reverse total shoulder arthroplasty (RTSA) or hemiarthroplasty from 2007 to 2020. All studies were reviewed independently by two musculoskeletal radiologists to assess for joint effusion, periarticular collection, and characterization of associated rotator cuff tears. Read More

View Article and Full-Text PDF
September 2021

Prevalence of peripheral intravenous catheters and policy adherence: A point prevalence in a tertiary care university hospital.

J Clin Nurs 2021 Sep 17. Epub 2021 Sep 17.

Department of Nursing, Canterbury District Health Board, Christchurch, New Zealand.

Aims And Objectives: To determine prevalence and policy adherence for peripheral intravenous catheters (PIVC) in adult inpatients at a tertiary care university hospital (with about 83,000 inpatient admissions annually).

Background: Up to 80% of hospitalised patients receive intravenous therapy, most commonly via PIVCs. However, these devices are not risk-free. Read More

View Article and Full-Text PDF
September 2021

PIGG defines the Emm blood group system.

Sci Rep 2021 Sep 17;11(1):18545. Epub 2021 Sep 17.

Immunohematology and Genomics Laboratory, New York Blood Center, New York, NY, USA.

Emm is a high incidence red cell antigen with eight previously reported Emm- probands. Anti-Emm appears to be naturally occurring yet responsible for a clinically significant acute hemolytic transfusion reaction. Previous work suggests that Emm is located on a GPI-anchored protein, but the antigenic epitope and genetic basis have been elusive. Read More

View Article and Full-Text PDF
September 2021

Peptide Presentations of Marsupial MHC Class I Visualize Immune Features of Lower Mammals Paralleled with Bats.

J Immunol 2021 Sep 17. Epub 2021 Sep 17.

School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou, China;

Marsupials are one of three major mammalian lineages that include the placental eutherians and the egg-laying monotremes. The marsupial brushtail possum is an important protected species in the Australian forest ecosystem. Molecules encoded by the MHC genes are essential mediators of adaptive immune responses in virus-host interactions. Read More

View Article and Full-Text PDF
September 2021

Intraparenchymal hemorrhage after serial ventricular reservoir taps in neonates with hydrocephalus and association with neurodevelopmental outcome at 2 years of age.

J Neurosurg Pediatr 2021 Sep 17:1-8. Epub 2021 Sep 17.

7Division of Neuroscience, Department of Neurosurgery, University Medical Center Utrecht, and Utrecht University, Utrecht, The Netherlands.

Objective: Decompressing the ventricles with a temporary device is often the initial neurosurgical intervention for preterm infants with hydrocephalus. The authors observed a subgroup of infants who developed intraparenchymal hemorrhage (IPH) after serial ventricular reservoir taps and sought to describe the characteristics of IPH and its association with neurodevelopmental outcome.

Methods: In this multicenter, case-control study, for each neonate with periventricular and/or subcortical IPH, a gestational age-matched control with reservoir who did not develop IPH was selected. Read More

View Article and Full-Text PDF
September 2021

Placental apoptotic markers are associated with placental morphometry.

Placenta 2021 Aug 19;115:1-11. Epub 2021 Aug 19.

Department of Mother and Child Health, Interactive Research School for Health Affairs (IRSHA), Bharati Vidyapeeth (Deemed to Be University), Pune-Satara Road, Pune, 411043, India. Electronic address:

Introduction: Preeclampsia is a hypertensive disorder affecting both mother and the fetus and is a major cause of maternal and neonatal morbidity and mortality. Abnormal placentation is a common feature in preeclampsia that contributes to placental dysfunction. It is likely that increased homocysteine and oxidative stress influence apoptosis in preeclampsia. Read More

View Article and Full-Text PDF

Consecutive and Selective Double Methylene Insertion of Lithium Carbenoids to Isothiocyanates: A Direct Assembly of Four-membered Sulfur-Containing Cycles.

Angew Chem Int Ed Engl 2021 Sep 17. Epub 2021 Sep 17.

Universita degli Studi di Torino Dipartimento di Chimica, Department of Chemistry, Via P. Giuria 7, 1090, Torino, ITALY.

A formal CH 2 -CH 2 homologation conducted with C1 carbenoids on a carbon electrophile for the obtainment of a four-membered cycle is reported. The logic proposes the consecutive delivery of two single nucleophilic CH 2 units to an isothiocyanate - as competent electrophilic partner - resulting in the assembling of a rare imino-thietane cluster. The single synthetic operation procedure documents genuine chemocontrol, as indicated by the tolerance to various reactive elements decorating the starting materials. Read More

View Article and Full-Text PDF
September 2021

Characterizing Adverse Events Reporting for an Over-the-Counter Disposable Intravaginal Support Device for Stress Urinary Incontinence.

Female Pelvic Med Reconstr Surg 2021 Sep 15. Epub 2021 Sep 15.

From the Department of Urology Department of Obstetrics and Gynecology Department of Healthcare Policy and Research, Weill Cornell Medical College-New York Presbyterian, New York, NY.

Objectives: In recent years, new intravaginal support devices for stress urinary incontinence have been introduced to the market. Although studies have demonstrated their safety and efficacy, few studies have examined adverse events attributed to their use. The objective of this study was to characterize reported adverse events for an over-the-counter intravaginal support device and determine whether further medical treatment was necessary to manage the adverse event. Read More

View Article and Full-Text PDF
September 2021

Initial Clinical Experience with a Symmetric Tip Tunneled Hemodialysis Catheter Without Side Holes.

ASAIO J 2021 Sep 17. Epub 2021 Sep 17.

From the Division of Interventional Radiology, Hadassah Medical Center, Jerusalem, Israel Department of Medicine, University of Michigan, Ann Arbor, Michigan.

The purpose of this article is to assess the performance and safety of a novel tunneled symmetric, side-hole-free tunneled cuffed catheter hypothesized to sustain adequate flow without the need for side holes. Between November 2016 and January 2019, Pristine hemodialysis catheters were placed de novo in 45 end-stage renal disease patients (27 males and 18 females) at a single investigational site. Forty-one catheters were placed in the right and four in the left internal jugular vein. Read More

View Article and Full-Text PDF
September 2021

A systematic review of Sec24 cargo interactome.

Traffic 2021 Sep 17. Epub 2021 Sep 17.

MRC Centre for Molecular Bacteriology and Infection, Department of Life Sciences, Imperial College, London, UK.

Endoplasmic reticulum (ER)-to-Golgi trafficking is an essential and highly conserved cellular process. The coat protein complex-II (COPII) arm of the trafficking machinery incorporates a wide array of cargo proteins into vesicles through direct or indirect interactions with Sec24, the principal subunit of the COPII coat. Approximately one-third of all mammalian proteins rely on the COPII-mediated secretory pathway for membrane insertion or secretion. Read More

View Article and Full-Text PDF
September 2021

Comparison of Routine Replacement With Clinically Indicated Replacement of Peripheral Intravenous Catheters.

JAMA Intern Med 2021 Sep 17. Epub 2021 Sep 17.

Infection Control Program and World Health Organization Collaborating Centre on Patient Safety, University of Geneva Hospitals and Faculty of Medicine, Geneva, Switzerland.

Importance: Peripheral intravenous catheters (PVCs) are the most frequently used indwelling devices in hospitals worldwide. Peripheral intravenous catheter bloodstream infections (PVC-BSIs) are rare, but severe and preventable, adverse events.

Objective: To investigate the incidence of PVC-BSIs after changing the policy of routine PVC replacement every 96 hours to clinically indicated replacement. Read More

View Article and Full-Text PDF
September 2021

Evolution of over a 23-year period in France, 1996 to 2018.

Euro Surveill 2021 09;26(37)

Institut Pasteur, Biodiversity and Epidemiology of Bacterial Pathogens, Paris, France.

Background is the main agent of whooping cough. Vaccination with acellular pertussis vaccines has been largely implemented in high-income countries. These vaccines contain 1 to 5 antigens: pertussis toxin (PT), filamentous haemagglutinin (FHA), pertactin (PRN) and/or fimbrial proteins (FIM2 and FIM3). Read More

View Article and Full-Text PDF
September 2021

Real Time Prediction of Sclera Force with LSTM Neural Networks in Robot-Assisted Retinal Surgery.

Achiev Solut Mech Eng II (2019) 2020 Feb;896:183-194

LCSR at the Johns Hopkins University, Baltimore, MD, 21218, USA.

Retinal microsurgery is one of the most technically demanding surgeries, during which the surgical tool needs to be inserted into the eyeball and is constantly constrained by the sclerotomy port. During the surgery, any unexpected manipulation could cause extreme tool-sclera contact force leading to sclera damage. Although, a robot assistant could reduce hand tremor and improve the tool positioning accuracy, it cannot prevent or alarm the surgeon about the upcoming danger caused by surgeon's misoperations, i. Read More

View Article and Full-Text PDF
February 2020

The mitogenome of common snipe, Linnaeus, 1758 and evolutionary implications for the family Scolopacidae.

Mitochondrial DNA B Resour 2021 9;6(10):2886-2889. Epub 2021 Sep 9.

Shaanxi Institute of Zoology, Xi'an, China.

The mitochondrial genome (mitogenome) of Linnaeus, 1758 was determined by the high-throughput data. The assembled mitogenome was 16,919 bp in length, with a 58.7% A + T content and GC skew of -0. Read More

View Article and Full-Text PDF
September 2021

Identification and Characterization of a Novel Aminoglycoside 3''-Nucleotidyltransferase, ANT(3'')-IId, From .

Front Microbiol 2021 31;12:728216. Epub 2021 Aug 31.

Key Laboratory of Medical Genetics of Zhejiang Province, Key Laboratory of Laboratory Medicine, Ministry of Education, School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou, China.

A novel plasmid-encoded aminoglycoside 3''-nucleotidyltransferase ANT(3")-IId, was discovered in strain H7 isolated from a chick on an animal farm in Wenzhou, China. The whole-genome of H7 consisted of one chromosome and five plasmids (pH7-250, pH7-108, pH7-68, pH7-48, and pH7-11). was identified as being encoded on pH7-250, sharing the highest amino acid identity of 50. Read More

View Article and Full-Text PDF

Effects of Patent Ductus Arteriosus on the Hemodynamics of Modified Blalock-Taussig Shunt Based on Patient-Specific Simulation.

Front Physiol 2021 31;12:707128. Epub 2021 Aug 31.

Department of Cardiothoracic Surgery, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

The question of preserving the patent ductus arteriosus (PDA) during the modified Blalock-Taussig shunt (MBTS) procedure remains controversial. The goal of this study was to investigate the effects of the PDA on the flow features of the MBTS to help with preoperative surgery design and postoperative prediction. In this study, a patient with pulmonary atresia and PDA was included. Read More

View Article and Full-Text PDF

Analysis and synthesis of assistive tools for insertion tasks.

Proc Inst Mech Eng B J Eng Manuf 2021 Nov 21;235(13):2066-2080. Epub 2021 May 21.

Manufacturing Systems Research Lab, General Motors R&D, Warren, MI, USA.

This article studies two types of assembly tasks, namely snap-fit insertions and press-fit hose insertions. Experimental data and theoretical modelling of a snap-fit assembly are used to design a tool that can perform the snap-fit task effectively. The design process of the tool is presented and experimental tests developed to validate its effectiveness are described. Read More

View Article and Full-Text PDF
November 2021

The Th1 cell regulatory circuitry is largely conserved between human and mouse.

Life Sci Alliance 2021 Nov 16;4(11). Epub 2021 Sep 16.

Regulatory Genomics Group, UCL Cancer Institute and CRUK UCL Centre, University College London, London, UK

Gene expression programs controlled by lineage-determining transcription factors are often conserved between species. However, infectious diseases have exerted profound evolutionary pressure, and therefore the genes regulated by immune-specific transcription factors might be expected to exhibit greater divergence. T-bet (Tbx21) is the immune-specific, lineage-specifying transcription factor for T helper type I (Th1) immunity, which is fundamental for the immune response to intracellular pathogens but also underlies inflammatory diseases. Read More

View Article and Full-Text PDF
November 2021

Urology residency training in Greece. Results from the first national resident survey.

Actas Urol Esp (Engl Ed) 2021 Sep 13. Epub 2021 Sep 13.

Department of Urology «Agios Savvas», Anti-Cancer Oncologic Hospital of Athens, Atenas, Greece.

Background And Objectives: This is the first national survey assessing Greek Urology residency programs. The main objective of this study is to assess the level of confidence and perception of Greek Urology residents regarding their educational program and detect areas of improvement.

Material And Methods: A 51-question survey was developed via an electronic platform and answered by 91 out of 104 Greek residents from March 2019 until May 2019. Read More

View Article and Full-Text PDF
September 2021

Radiological comparison of penetrating endplate trajectory versus anterior bicortical trajectory for sacral pedicle screw insertion in posterior lumbosacral interbody fusion.

J Orthop Sci 2021 Sep 13. Epub 2021 Sep 13.

Department of Orthopaedic Surgery, National Hospital Organization, Murayama Medical Center, Musashimurayama, Tokyo, Japan.

Background: The bicortical or tricortical fixation technique with purchase into the anterior sacral wall or promontory has been recommended to achieve rigid sacral pedicle screw fixation, which carries the potential risk of neurovascular injuries. The penetrating endplate screw (PES) technique was proposed as an alternative screw trajectory to facilitate both strong fixation and safety. However, there has been no report on the practical significance of using the PES technique. Read More

View Article and Full-Text PDF
September 2021

Efficacy of additional periprostatic apex nerve block on pain in each of 12 transrectal prostate core biopsies: a retrospective study.

BMC Urol 2021 Sep 16;21(1):132. Epub 2021 Sep 16.

Department of Urology, Gangnam Severance Hospital, Yonsei University College of Medicine, 211 Eonju-ro, Gangnam-gu, Seoul, 06273, Republic of Korea.

Background: We identified pain variation according to prostate biopsy sites and compared differences in pain relief according to the site of periprostatic nerve block (PNB).

Methods: This retrospective study collected data from 312 patients who underwent transrectal prostate biopsies between January 2019 and August 2020. Patients were stratified into two groups according to the site of local anesthesia (base vs. Read More

View Article and Full-Text PDF
September 2021

Revisiting the CooJ family, a potential chaperone for nickel delivery to [NiFe]‑carbon monoxide dehydrogenase.

J Inorg Biochem 2021 Aug 23;225:111588. Epub 2021 Aug 23.

University of Grenoble Alpes, CEA, CNRS, IRIG, CBM, F-38000 Grenoble, France. Electronic address:

Nickel insertion into nickel-dependent carbon monoxide dehydrogenase (CODH) represents a key step in the enzyme activation. This is the last step of the biosynthesis of the active site, which contains an atypical heteronuclear NiFeS cluster known as the C-cluster. The enzyme maturation is performed by three accessory proteins, namely CooC, CooT and CooJ. Read More

View Article and Full-Text PDF

Inactivation of CbrAB two-component system hampers root colonization in rhizospheric strain of Pseudomonas aeruginosa PGPR2.

Biochim Biophys Acta Gene Regul Mech 2021 Sep 13:194763. Epub 2021 Sep 13.

Department of Genetics, School of Biological Sciences, Madurai Kamaraj University, Madurai, India. Electronic address:

Two-component systems (TCS) are one of the signal transduction mechanisms, which sense physiological/biological restraints and respond to changing environmental conditions by regulating the gene expression. Previously, by employing a forward genetic screen (INSeq), we identified that cbrA gene is essential for the fitness of Pseudomonas aeruginosa PGPR2 during root colonization. Here, we report the functional characterization of cbrAB TCS in PGPR2 during root colonization. Read More

View Article and Full-Text PDF
September 2021

Interactions of chlorogenic acid and isochlorogenic acid A with model lipid bilayer membranes: Insights from molecular dynamics simulations.

Chem Phys Lipids 2021 Sep 13:105136. Epub 2021 Sep 13.

School of Food Science and Technology · School of Chemical Engineering, Hubei University of Arts and Science, Xiangyang, 441053, China; Food Ingredients Engineering Technology Research Center of Hubei, Xiangyang, 441053, China. Electronic address:

Because of the negative side-effects of synthetic preservatives, the naturally-occurring polyphenols aroused intense interest of researchers. It has been suggested that chlorogenic acid (CA) and isochlorogenic acid A (iso-CAA) were good candidates to replace the synthetic preservatives. Moreover, the bactericidal activity of iso-CAA was stronger than CA, and the anti-bacterial activities of iso-CAA and CA were highly membrane-dependent. Read More

View Article and Full-Text PDF
September 2021