118 results match your criteria inner superparamagnetic


Use of Super Paramagnetic Iron Oxide Nanoparticles as Drug Carriers in Brain and Ear: State of the Art and Challenges.

Brain Sci 2021 Mar 11;11(3). Epub 2021 Mar 11.

Department of Otolaryngology-Head and Neck Surgery, Dijon University Hospital, 21000 Dijon, France.

Drug delivery and distribution in the central nervous system (CNS) and the inner ear represent a challenge for the medical and scientific world, especially because of the blood-brain and the blood-perilymph barriers. Solutions are being studied to circumvent or to facilitate drug diffusion across these structures. Using superparamagnetic iron oxide nanoparticles (SPIONs), which can be coated to change their properties and ensure biocompatibility, represents a promising tool as a drug carrier. Read More

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Superparamagnetic behaviour of metallic Co nanoparticles according to variable temperature magnetic resonance.

Phys Chem Chem Phys 2021 Feb;23(4):2723-2730

SIMM, ESPCI Paris, Université PSL, CNRS UMR 7615, 10 Rue Vauquelin, 75005, Paris, France.

Investigating the size distributions of Co nanoparticle ensembles is an important problem, which has no straightforward solution. In this work, we use the combination of 59Co internal field nuclear magnetic resonance (59Co IF NMR) and ferromagnetic resonance (FMR) spectroscopies on a metallic Co nanoparticle sample with a narrow Co nanoparticle size distribution due to encapsulation within the inner channels of carbon nanotubes. High-resolution transmission electron microscopy (TEM) images showed that the nanoparticles can be represented as prolate spheroids, with the majority of particles having an aspect ratio between 1 and 2. Read More

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February 2021

Near real-time magnetic particle imaging for visual assessment of vascular stenosis in a phantom model.

Phys Med 2021 Jan 19;81:210-214. Epub 2021 Jan 19.

Department of Diagnostic and Interventional Radiology, University Hospital Würzburg, Würzburg, Germany. Electronic address:

Purpose: This study aimed to investigate the potential of magnetic particle imaging (MPI) to quantify artificial stenoses in vessel phantoms in near real-time.

Methods: Custom-made stenosis phantoms with different degrees of stenosis (0%, 25%, 50%, 75%, and 100%; length 40 mm, inner diameter 8 mm, Polyoxymethylene) were filled with diluted Ferucarbotran (superparamagnetic iron-oxide nanoparticle (SPION) tracer agent, 500 mmol (Fe)/l). A traveling wave MPI scanner (spatial resolution ~ 2 mm, gradient strength ~ 1. Read More

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January 2021

Production and Characterization of an Integrated Multi-Layer 3D Printed PLGA/GelMA Scaffold Aimed for Bile Duct Restoration and Detection.

Front Bioeng Biotechnol 2020 26;8:971. Epub 2020 Aug 26.

Department of Hepatobiliary Surgery, Affiliated Haikou Hospital of Xiangya Medical College, Central South University, Haikou, China.

We successfully fabricated artificial bile duct via 3D printing technique which was composed of poly (lactic-co-glycolic acid) (PLGA) and gelatin methacrylate (GelMA). The PLGA-inner layer provided sufficient strength to support the bile duct contraction, the GelMA-outer layer possessed good biocompatibility to provide a good living environment for the cells. Moreover, IKVAV laminin peptide (Ile-Lys-Val-Ala-Val) and ultrasmall superparamagnetic iron oxide (USPIO) were used to regulate scaffold cell adhesion and magnetic resonance imaging (MRI) detection, respectively. Read More

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An Approach for Magnetic Halloysite Nanocomposite with Selective Loading of Superparamagnetic Magnetite Nanoparticles in the Lumen.

Inorg Chem 2020 Sep 12;59(17):12086-12096. Epub 2020 Aug 12.

Dipartimento di Chimica, Università degli Studi di Milano, Via Golgi 19, 20133 Milano, Italy.

We present for the first time a method for the preparation of magnetic halloysite nanotubes (HNT) by loading of preformed superparamagnetic magnetite nanoparticles (SPION) of diameter size ∼6 nm with a hydrodynamic diameter of ∼10 nm into HNT. We found that the most effective route to reach this goal relies on the modification of the inner lumen of HNT by tetradecylphosphonic acid (TDP) to give HNT-TDP, followed by the loading with preformed oleic acid (OA)-stabilized SPION. Transmission electron microscopy evidenced the presence of highly crystalline magnetic nanoparticles only in the lumen, partially ordered in chainlike structures. Read More

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September 2020

Transplantation and Tracking of the Human Umbilical Cord Mesenchymal Stem Cell Labeled with Superparamagnetic Iron Oxide in Deaf Pigs.

Anat Rec (Hoboken) 2020 03 14;303(3):494-505. Epub 2020 Jan 14.

School of Medicine, Nankai University, Tianjin, China.

The purpose of this study was to establish a safe and effective approach to label the human umbilical cord mesenchymal stem cells (UC-MSCs) derived from the Wharton's Jelly with superparamagnetic iron oxide (SPIO) nanoparticles as a cell tracer. The cytotoxicity of the SPIO was screened in vitro by cytochemical experiments. The results showed the new infection protocol of SPIO-Lip2000 mixture had high efficiency and the optimal labeling concentration was a 50 μg/ml SPIO suspension. Read More

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Red-blood-cell-membrane-enveloped magnetic nanoclusters as a biomimetic theranostic nanoplatform for bimodal imaging-guided cancer photothermal therapy.

J Mater Chem B 2020 01 6;8(4):803-812. Epub 2020 Jan 6.

Jiangsu Key Laboratory for Carbon-based Functional Materials & Devices, Institute of Functional Nano & Soft Materials (FUNSOM), Soochow University, Suzhou, 215123, Jiangsu, P. R. China.

The use of red blood cell (RBC) membrane coatings has recently been found to be a biomimetic strategy to confer inner core nanomaterials with improved pharmacokinetic profiles by utilizing the intrinsic long blood circulation time of RBCs. Here, we envelope superparamagnetic nanoclusters (MNCs) with RBC membrane ghosts to obtain MNC@RBCs with significantly improved physiological stability compared to that of bare MNCs. After being loaded with near-infrared (NIR) cypate molecules, the as-prepared Cyp-MNC@RBCs show remarkably increased NIR absorbance and resultant efficient photothermal conversion efficacy. Read More

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January 2020

Systematic Intracellular Biocompatibility Assessments of Superparamagnetic Iron Oxide Nanoparticles in Human Umbilical Cord Mesenchyme Stem Cells in Testifying Its Reusability for Inner Cell Tracking by MRI.

J Biomed Nanotechnol 2019 Nov;15(11):2179-2192

Until now, there is no effective method for tracking transplanted stem cells in human. Ruicun (RC) is a new ultra-small SPIONs agent that has been approved by China Food and Drug Administration for iron supplementation but not as a stem cell tracer in clinic. In this study, we demonstrated magnetic resonance imaging-based tracking of RC-labeled human umbilical cord derived mesenchymal stem cells (MSCs) transplanted to locally injured site of rat spinal cords. Read More

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November 2019

A fast nucleic acid extraction system for point-of-care and integration of digital PCR.

Analyst 2019 Nov;144(23):7032-7040

Research Centre for Analytical Instrumentation, Institute of Cyber-Systems and Control, State Key Laboratory of Industrial Control Technology, Zhejiang University, Hangzhou, Zhejiang Province 310023, P. R. China.

Digital PCR is a powerful amplification method for absolute quantification of nucleic acids. The systems that integrated the nucleic acid extraction and amplification can reduce detection time, improve accuracy, and reduce labor costs. However, current nucleic acid extraction systems cannot be integrated well with integrated fluidic circuit (IFC) dPCR or droplet digital PCR chips perfectly and limit the application of digital PCR. Read More

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November 2019

Organophilic, Superparamagnetic, and Reversibly Thermoresponsive Silica-Polypeptide Core-Shell Particles.

Langmuir 2019 11 23;35(44):14248-14257. Epub 2019 Oct 23.

Particles with a superparamagnetic cobalt inner core, silica outer core, and covalently bound homopolypeptide shell were investigated under thermal and magnetic stimuli. The homopolypeptide was poly(ε-carbobenzyloxy-l-lysine), PCBL, which is known to exhibit a thermoreversible coil ⇔ helix transition when dissolved as a pure polymer in cresol. Tethering to a core particle did not prevent PCBL from undergoing this conformational transition, as confirmed by dynamic light scattering and optical rotation, but the transition was broadened compared to that of the untethered polymer. Read More

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November 2019

A biodegradable multifunctional porous microsphere composed of carrageenan for promoting imageable trans-arterial chemoembolization.

Int J Biol Macromol 2020 Jan 14;142:866-878. Epub 2019 Oct 14.

State Key Laboratory of Bioelectronics, Jiangsu Key Laboratory for Biomaterials and Devices, School of Biological Sciences & Medical Engineering, Southeast University, Nanjing 210096, China. Electronic address:

Trans-arterial chemoembolization (TACE) has been a mainstream treatment for hepatocellular carcinoma (HCC), accordingly there are more requirements for embolic agents' properties, mainly concentrated on biodegradability and imaging function. A new kind of biodegradable multifunctional porous microspheres (BMPMs) with internal coarse plications are ingeniously designed and manufactured, consisting of carrageenan, inhexol and superparamagnetic iron oxide nanoparticle (SPIO). BMPMs' sound roundness and excellent swelling behavior guarantee them to be smoothly transported into appointed arteries' ends and achieve satisfactory embolization effect. Read More

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January 2020

Experimental Evaluation on the Heating Efficiency of Magnetoferritin Nanoparticles in an Alternating Magnetic Field.

Nanomaterials (Basel) 2019 Oct 14;9(10). Epub 2019 Oct 14.

Biogeomagnetism Group, Paleomagnetism and Geochronology Laboratory, Key Laboratory of Earth and Planetary Physics, Institute of Geology and Geophysics, Chinese Academy of Sciences, Beijing 100029, China.

The superparamagnetic substance magnetoferritin is a potential bio-nanomaterial for tumor magnetic hyperthermia because of its active tumor-targeting outer protein shell, uniform and tunable nanosized inner mineral core, monodispersity and good biocompatibility. Here, we evaluated the heating efficiency of magnetoferritin nanoparticles in an alternating magnetic field (AMF). The effects of core-size, Fe concentration, viscosity, and field frequency and amplitude were investigated. Read More

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October 2019

Superparamagnetic Nanoparticle Delivery to the Cochlea Through Round Window by External Magnetic Field: Feasibility and Toxicity.

Surg Innov 2019 Dec 3;26(6):646-655. Epub 2019 Sep 3.

Otolaryngology Department, Dijon University Hospital, Dijon, France.

. The objective of this study was to evaluate the feasibility and toxicity of superparamagnetic iron oxide nanoparticles (SPIONs) administered into the cochlea through the round window (RW) by an external magnetic field. . Read More

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December 2019

Fabrication of Magnetic Pd/MOF Hollow Nanospheres with Double-Shell Structure: Toward Highly Efficient and Recyclable Nanocatalysts for Hydrogenation Reaction.

ACS Appl Mater Interfaces 2019 Sep 22;11(35):32251-32260. Epub 2019 Aug 22.

Key Laboratory of Jiangxi Province for Environment and Energy, College of Chemistry , Nanchang University , Nanchang , Jiangxi 330031 , P. R. China.

MNPs@MOF catalysts obtained by encapsulating metal nanoparticles (NPs) into metal-organic frameworks (MOFs) show fascinating performance in heterogeneous catalysis. The improvement of catalytic activity and reusability of MNPs@MOF catalysts has been a great challenge for a long time. Herein, we demonstrate well-designed Pd/MOFs, featuring hollow double-shell structure and magnetic property, exhibiting high reusability, efficient catalytic activity, and size selectivity for hydrogenation reaction. Read More

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September 2019

Intelligent nanoflowers: a full tumor microenvironment-responsive multimodal cancer theranostic nanoplatform.

Nanoscale 2019 Sep 8;11(33):15508-15518. Epub 2019 Aug 8.

School of Science, MOE Key Laboratory for Nonequilibrium Synthesis and Modulation of Condensed Matter, Xi'an Key Laboratory of Sustainable Energy Material Chemistry, Xi'an Jiaotong University, Xi'an 710049, P. R. China. and Instrumental Analysis Center of Xi'an Jiaotong University, Xi'an 710049, P. R. China.

Although the collaborative therapy of chemotherapy (CT) and photodynamic therapy (PDT) is much more efficient for tumor treatment than monotherapies, premature leakage of drugs from nanocarriers and hypoxia in the tumor microenvironment (TME) result in systemic toxicity and suboptimal therapy efficiency. To overcome these limitations, we developed an intelligent nanoflower composite (termed FHCPC@MnO) by coating functionalized polyphosphazene on superparamagnetic FeO nanoclusters and then growing MnO nanosheets as an outer shell. The FHCPC@MnO nanoflowers with multistage HO/pH/GSH-responsive properties could fully exploit TME characteristics, including supernormal glutathione (GSH) levels, low pH and high HO, to realize the specific release of drugs in tumors and maximum synergetic therapeutic effects. Read More

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September 2019

Urethroplasty with a bilayered poly-D,L-lactide-co-ε-caprolactone scaffold seeded with allogenic mesenchymal stem cells.

J Biomed Mater Res B Appl Biomater 2020 04 1;108(3):1010-1021. Epub 2019 Aug 1.

Institute of Cytology of the Russian Academy of Sciences (RAS), St. Petersburg, Russia.

Reconstructive surgery for urethral defects employing tissue-engineered scaffolds represents an alternative treatment for urethroplasty. The aim of this study was to compare the therapeutic efficacy of the bilayer poly-D,L-lactide/poly-ε-caprolactone (PL-PC) scaffold seeded with allogenic mesenchymal stem cells (MSCs) for urethra reconstruction in a rabbit model with conventional urethroplasty employing an autologous buccal mucosa graft (BG). The inner layer of the scaffold based on poly-D,L-lactic acid (PL) was seeded with MSCs, while the outer layer, prepared from poly-ε-caprolactone, protected the surrounding tissues from urine. Read More

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Magnetic Particle Imaging-Guided Stenting.

J Endovasc Ther 2019 08 27;26(4):512-519. Epub 2019 May 27.

1 Department of Diagnostic and Interventional Radiology, Würzburg, Germany.

To assess the feasibility of magnetic particle imaging (MPI) to guide stenting in a phantom model. MPI is a new tomographic imaging method based on the background-free magnetic field detection of a tracer agent composed of superparamagnetic iron oxide nanoparticles (SPIOs). All experiments were conducted on a custom-built MPI scanner (field of view: 29-mm diameter, 65-mm length; isotropic spatial resolution 1-1. Read More

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Creating a synthetic platform for the encapsulation of nanocrystals with covalently bound polymer shells.

Nanoscale 2019 Mar 13;11(9):3847-3854. Epub 2019 Feb 13.

Institute of Physical Chemistry, Fraunhofer CAN, Grindelallee 117, 20146 Hamburg, Germany.

We present a platform for the encapsulation of superparamagnetic iron oxide nanocrystals (SPIONs) with a highly stable diblock copolymer shell allowing a homogeneous dispersion of the nanocrystals into a polymer matrix in the resulting nanocomposites. High polymer shell stability was achieved by crosslinking the inner polydiene shell for example in a persulfate based redox process. The advantage of this crosslinking reaction is the avoidance of heat and UV light for the initiation, making it suitable for heat or UV sensitive systems. Read More

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3D-Printed Biodegradable Microswimmer for Theranostic Cargo Delivery and Release.

ACS Nano 2019 03 25;13(3):3353-3362. Epub 2019 Feb 25.

Physical Intelligence Department , Max Planck Institute for Intelligent Systems , 70569 Stuttgart , Germany.

Untethered mobile microrobots have the potential to leverage minimally invasive theranostic functions precisely and efficiently in hard-to-reach, confined, and delicate inner body sites. However, such a complex task requires an integrated design and engineering, where powering, control, environmental sensing, medical functionality, and biodegradability need to be considered altogether. The present study reports a hydrogel-based, magnetically powered and controlled, enzymatically degradable microswimmer, which is responsive to the pathological markers in its microenvironment for theranostic cargo delivery and release tasks. Read More

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Copper Ferrite Magnetic Nanoparticles for the Immobilization of Enzyme.

Indian J Microbiol 2019 Mar 30;59(1):105-108. Epub 2018 Nov 30.

1Division of Chemical Engineering, Konkuk University, Seoul, 05029 Republic of Korea.

In this study, novel, hollow superparamagnetic copper ferrite (CuFeO) nanoparticles (NPs) were synthesized by a low-temperature hydrothermal method. The hollow magnetic spheres were characterized by field emission scanning electron microscopy and high resolution transmission electron microscopy to confirm their morphology and size. The hollow NPs were demonstrated as the support for biological materials by the immobilization of lipase on the inner and outer surfaces of the hollow spheres. Read More

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Macrophages hold the key to cancer's inner sanctum.

Authors:
Gerald L Wolf

Med Hypotheses 2019 Jan 30;122:111-114. Epub 2018 Oct 30.

Harvard Medical School, 250 Longwood Ave, Boston, MA 02115, United States. Electronic address:

All malignancies contain tumor-associated macrophages (TAMs) that facilitate cancer growth by secreting chemicals to elicit angiogenesis and shield the cancer from the immune system. The abundance of TAMs is a reflection of invasiveness and metastatic potential. TAMs will actively ingest ultrasmall superparamagnetic iron oxide (USPIO) nanoparticles following intravenous administration and will store them as large lysosomal aggregates which can be imaged with MRI and ultrasound and visualized or quantitated in tissue biopsies. Read More

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January 2019

Toxicology study for magnetic injection of prednisolone into the rat cochlea.

Eur J Pharm Sci 2019 Jan 19;126:33-48. Epub 2018 Jun 19.

Otomagnetics, Inc., Rockville, MD 20852, United States of America; Fischell Department of Bioengineering, University of Maryland, College Park, MD 20742, United States of America; Institute for Systems Research (ISR), University of Maryland, College Park, MD 20742, United States of America.

This paper investigates the safety of a novel 'magnetic injection' method of delivering therapy to the cochlea, in a rodent model. In this method of administration, a magnetic field is employed to actively transport drug-eluting superparamagnetic iron-oxide core nanoparticles into the cochlea, where they then release their drug payload (we delivered the steroid prednisolone). Our study design and selection of control groups was based on published regulatory guidance for safety studies that involve local drug delivery. Read More

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January 2019

Magnetic Particle Imaging Guided Real-Time Percutaneous Transluminal Angioplasty in a Phantom Model.

Cardiovasc Intervent Radiol 2018 Jul 16;41(7):1100-1105. Epub 2018 Apr 16.

Department of Diagnostic and Interventional Radiology, University Hospital Würzburg, Oberdürrbacherstrasse 6, 97080, Würzburg, Germany.

Purpose: To investigate the potential of real-time magnetic particle imaging (MPI) to guide percutaneous transluminal angioplasty (PTA) of vascular stenoses in a phantom model.

Materials And Methods: Experiments were conducted on a custom-built MPI scanner. Vascular stenosis phantoms consisted of polyvinyl chloride tubes (inner diameter 8 mm) prepared with a centrally aligned cable tie to form ~ 50% stenoses. Read More

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Development of a Coflowing Device for the Size-Controlled Preparation of Magnetic-Polymeric Microspheres as Embolization Agents in Magnetic Resonance Navigation Technology.

ACS Biomater Sci Eng 2018 Mar 21;4(3):1092-1102. Epub 2018 Feb 21.

Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada.

Droplet microfluidics technology has recently been introduced to generate particles for many biomedical applications that include therapeutic embolizing agents in hepatic, uterine or bronchial arteries. Embolic agents are available in a variety of shapes and sizes that are adjusted according to the target vessel characteristics. Magnetic embolic agents can additionally be navigated to the target location (e. Read More

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The Development of a Nano-based Approach to Alleviate Cisplatin-Induced Ototoxicity.

J Assoc Res Otolaryngol 2018 04 18;19(2):123-132. Epub 2018 Jan 18.

Department of Otolaryngology - Head & Neck Surgery, University of Pennsylvania Health System, BRB 1220, 421 Curie Blvd, Philadelphia, PA, 19104, USA.

Cisplatin-induced hearing loss is experienced by a high percentage of patients with squamous cell carcinoma undergoing cisplatin chemotherapy. A novel nano-construct capable of sequestering extracellular cisplatin was developed to combat this problem. The nano-construct consisted of superparamagnetic iron oxide nanoparticles (SPIONs) entrapped within polymeric micelles, which were formed from a glutathione diethyl ester-conjugated amphiphilic diblock copolymer. Read More

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Influence of Grafted Block Copolymer Structure on Thermoresponsiveness of Superparamagnetic Core-Shell Nanoparticles.

Biomacromolecules 2018 05 6;19(5):1435-1444. Epub 2017 Dec 6.

Institute for Biologically Inspired Materials, Department of Nanobiotechnology , University of Natural Resources and Life Sciences, Vienna , Muthgasse 11 , 1190 Vienna , Austria.

The morphology and topology of thermoresponsive polymers have a strong impact on their responsive properties. Grafting onto spherical particles has been shown to reduce responsiveness and transition temperatures; grafting of block copolymers has shown that switchable or retained wettability of a surface or particle during desolvation of one block can take place. Here, doubly thermoresponsive block copolymers were grafted onto spherical, monodisperse, and superparamagnetic iron oxide nanoparticles to investigate the effect of thermal desolvation on spherical brushes of block copolymers. Read More

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Enhanced magnetostriction derived from magnetic single domain structures in cluster-assembled SmCo films.

Nanotechnology 2017 Nov;28(45):455705

School of Physical Science and Technology, & Inner Mongolia Key Lab of Nanoscience and Nanotechnology, Inner Mongolia University, Hohhot 010021, People's Republic of China.

Cluster-assembled SmCo alloy films were prepared by low energy cluster beam deposition. The structure, magnetic domain, magnetization, and magnetostriction of the films were characterized. It is shown that the as-prepared films are assembled in compact and uniformly distributed spherical cluster nanoparticles, most of which, after vacuum in situ annealing at 700 K, aggregated to form cluster islands. Read More

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November 2017

Magnetic Particle Imaging for Quantification of Vascular Stenoses: A Phantom Study.

IEEE Trans Med Imaging 2018 01 21;37(1):61-67. Epub 2017 Jun 21.

Magnetic particle imaging (MPI) is a promising new tomographic imaging method to detect the spatial distribution of superparamagnetic iron-oxide nanoparticles (SPIOs). The aim of this paper was to investigate the potential of MPI to quantify artificial stenoses in vessel phantoms. Custom-made stenosis phantoms (length 40 mm; inner diameter 8 mm) with different degrees of stenosis (0%, 25%, 50%, 75%, and 100%) were scanned in a custom-built MPI scanner (in-plane resolution: ~1-1. Read More

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January 2018

On the injectability of free-standing magnetic nanofilms.

Biomed Microdevices 2017 Sep;19(3):51

Center for MicroBioRobotics IIT@SSSA, Istituto Italiano di Tecnologia, Viale Rinaldo Piaggio 34, 56025, Pontedera, Italy.

Free-standing films with sub-micrometric thickness, composed of soft polymers and functional nanostructures are promising candidates for many potential applications in the biomedical field, such as reduced port abdominal surgery. In this work, freely suspended poly(L-lactic acid) nanofilms with controlled morphology embedding superparamagnetic iron oxide nanoparticles were fabricated by spin-coating deposition. The mechanical properties of magnetic nanofilms were investigated by Strain-Induced Elastic Buckling Instability for Mechanical Measurements (SIEBIMM) test. Read More

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September 2017

pH-responsive pHLIP (pH low insertion peptide) nanoclusters of superparamagnetic iron oxide nanoparticles as a tumor-selective MRI contrast agent.

Acta Biomater 2017 06 29;55:194-203. Epub 2017 Mar 29.

Department of Nanomedicine & Biopharmaceuticals, National Engineering Research Center for Nanomedicine, Huazhong University of Science and Technology, Wuhan 430074, China. Electronic address:

Superparamagnetic iron oxide nanoparticles (SPION) are contrast agents used for noninvasive tumor magnetic resonance imaging (MRI). SPION with active targeting by tumor-specific ligands can effectively enhance the MRI sensitivity and specificity of tumors. However, the challenge remains when the tumor specific markers are yet to be determined, especially in the case of early tumor detection. Read More

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