23,560 results match your criteria injury tbi


CCR2 deficiency alters activation of microglia subsets in traumatic brain injury.

Cell Rep 2021 Sep;36(12):109727

Department of Medicine, Division of Rheumatology, University of California, San Francisco (UCSF), San Francisco, CA, USA; San Francisco VA Health Care System, San Francisco, CA, USA. Electronic address:

In traumatic brain injury (TBI), a diversity of brain resident and peripherally derived myeloid cells have the potential to worsen damage and/or to assist in healing. We define the heterogeneity of microglia and macrophage phenotypes during TBI in wild-type (WT) mice and Ccr2 mice, which lack macrophage influx following TBI and are resistant to brain damage. We use unbiased single-cell RNA sequencing methods to uncover 25 microglia, monocyte/macrophage, and dendritic cell subsets in acute TBI and normal brains. Read More

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September 2021

Inclusion, delivery, assessment, and outcomes in longitudinal research on sleep disturbance and agitation in TBI-rehabilitation: lessons learned and future considerations.

Brain Inj 2021 Sep 22:1-8. Epub 2021 Sep 22.

Hammel Neurorehabilitation and Research Center, Hammel, Denmark.

Purpose: This article presents some issues for consideration before scaling from a pilot study to a larger investigation in longitudinal observational studies of traumatic brain injury (TBI) rehabilitation.

Materials And Methods: We present a case to discuss protocol improvements in longitudinal TBI-rehabilitation studies. The case was a pilot study conducted at two university hospitals in Denmark investigating 1-year outcomes related to sleep disturbance and agitation during neurointensive care. Read More

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September 2021

The role of Extracellular Vesicles in Traumatic Brain Injury-induced Acute Lung Injury.

Am J Physiol Lung Cell Mol Physiol 2021 Sep 22. Epub 2021 Sep 22.

Tianjin Institute of Neurology, Departments of Neurosurgery,, grid.412645.0Tianjin Medical University General Hospital, Tianjin, China.

Acute lung injury (ALI), a common complication after traumatic brain injury (TBI), can evolve into acute respiratory distress syndrome (ARDS) and has a mortality rate of 30-40%. Secondary ALI after TBI exhibits the following typical pathological features: infiltration of neutrophils into the alveolar and interstitial space, alveolar septal thickening, alveolar edema and hemorrhage. Extracellular vesicles (EVs) were recently identified as key mediators in TBI-induced ALI. Read More

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September 2021

Mannose-binding lectin promotes blood-brain barrier breakdown and exacerbates axonal damage after traumatic brain injury in mice.

Exp Neurol 2021 Sep 18:113865. Epub 2021 Sep 18.

Department of Neuroscience and Experimental Therapeutics, Institute for Biomedical Research of Barcelona (IIBB), Spanish National Research Council (CSIC), Barcelona, Spain; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain. Electronic address:

Leukocyte infiltration and blood-brain barrier breakdown contribute to secondary brain damage after traumatic brain injury (TBI). TBI induces neuroimmune responses triggering pathogenic complement activation through different pathways, including the lectin pathway. We investigated mechanisms underlying mannose-binding lectin (MBL)-mediated brain damage focusing on neutrophil infiltration and blood-brain barrier breakdown in a TBI mouse model. Read More

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September 2021

Reemergence of the language network during recovery from severe traumatic brain injury: A pilot functional MRI study.

Brain Inj 2021 Sep 21:1-11. Epub 2021 Sep 21.

Center for Neurotechnology and Neurorecovery, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.

Primary Objective: We hypothesized that, in patients with acute severe traumatic brain injury (TBI) who recover basic language function, speech-evoked blood-oxygen-level-dependent (BOLD) functional MRI (fMRI) responses within the canonical language network increase over the first 6 months post-injury.

Research Design: We conducted a prospective, longitudinal fMRI pilot study of adults with acute severe TBI admitted to the intensive care unit. We also enrolled age- and sex-matched healthy subjects. Read More

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September 2021

Early Intensified Rehabilitation Training with Hyperbaric Oxygen Therapy Improves Functional Disorders and Prognosis of Patients with Traumatic Brain Injury.

Adv Wound Care (New Rochelle) 2021 Dec 15;10(12):663-670. Epub 2019 Mar 15.

College of Biology and Environmental Engineering, Zhejiang Shuren University, Hangzhou, China.

Traumatic brain injury (TBI) is a global public health problem. Hyperbaric oxygen (HBO) therapy may be beneficial for TBI because it improves cerebral blood flow into tissues exhibiting low blood flow. This was done to observe the clinical therapeutic effect of different intensities of rehabilitation training and HBO therapy in early stages of TBI. Read More

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December 2021

Modafinil attenuates the neuroinflammatory response after experimental traumatic brain injury.

J Neurosurg Sci 2021 Sep 21. Epub 2021 Sep 21.

Department of Neurosurgery, Gazi University Hospital, Ankara, Turkey.

Background: Modafinil has been proven to exert anti-inflammatory, anti-oxidative and neuroprotective effects on numerous neurological disorders. However, its effects after traumatic brain injury (TBI) has not been yet explore. This study aimed to explore if Modafinil can attenuate the neuroinflammatory phase of TBI and clarify the possible underlying mechanisms. Read More

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September 2021

Paroxysmal Sympathetic Hyperactivity in Moderate-to-Severe Traumatic Brain Injury and the Role of Beta-Blockers: A Scoping Review.

Emerg Med Int 2021 11;2021:5589239. Epub 2021 Sep 11.

Research Department, Association of Future African Neurosurgeons, Yaounde, Cameroon.

Introduction: Most cases of paroxysmal sympathetic hyperactivity (PSH) result from traumatic brain injury (TBI). Little is known about its pathophysiology and treatment, and several neuroprotective drugs are used including beta-blockers. The aim of our study is to collate existing evidence of the role of beta-blockers in the treatment of PSH. Read More

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September 2021

Current practices and beliefs regarding supporting dating skills in rehabilitation for traumatic brain injury: a survey study.

Brain Inj 2021 Sep 20:1-14. Epub 2021 Sep 20.

School of Health Sciences, City, University of London, London, UK.

Background: Relationships are important to quality of life after traumatic brain injury (TBI). However, there has been limited research into how to support dating skills or how professionals view this area.

Method: An online 52-item survey was developed and sent to professionals in the UK involved in rehabilitation after TBI. Read More

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September 2021

Health symptoms after war zone deployment-related mild traumatic brain injury: contributions of mental disorders and lifetime brain injuries.

Brain Inj 2021 Sep 20:1-11. Epub 2021 Sep 20.

Va Mid-Atlantic Mental Illness, Research, And Clinical Center, Durham, NC, USA.

Primary Objective: To gain a better understanding of the complex relationship between combat deployment-related mild traumatic brain injury (mTBI) and persistent post-concussive symptoms (PPCSs), taking into consideration a wide range of potentially mediating and confounding factors.

Research Design: Cross-sectional.

Methods And Procedures: Subjects were 613 U. Read More

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September 2021

Age- and sex-specific predictors of inpatient rehabilitation facility discharge destination for adult patients with traumatic brain injury.

Brain Inj 2021 Sep 20:1-13. Epub 2021 Sep 20.

School of Nursing, Duke University, Durham, NC, USA.

Objective: : To determine age- and sex-specific predictors of discharge destination among patients with traumatic brain injury (TBI) receiving inpatient rehabilitation facility (IRF) care.

Design: : Secondary analysis of Uniform Data System for Medical Rehabilitation data.

Methods: : Logistic regression of patients (N = 221,961) age ≥18, TBI diagnosis, admitted to IRF between 2002 and 2018. Read More

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September 2021

Pre-injury chronic alcohol abuse predicts intracranial hemorrhagic progression, unfavorable clinical outcome, and mortality in severe traumatic brain injury.

Brain Inj 2021 Sep 20:1-8. Epub 2021 Sep 20.

Department of Neuroscience, Section of Neurosurgery, Uppsala University, Uppsala, Sweden.

Objective: We aimed to determine the incidence of pre-injury alcohol abuse in TBI at our neurointensive care unit (NICU), the relation to intracranial hemorrhage evolution, and clinical outcome.

Methods: Patients with TBI treated at our NICU at Uppsala university hospital, Sweden, 2008-2018, were included. Clinical, radiological, and outcome variables were evaluated. Read More

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September 2021

Impact of diabetic hyperglycemia on clinical outcomes in patients with diabetes mellitus following traumatic brain injury.

Turk Neurosurg 2021 Mar 29. Epub 2021 Mar 29.

Chang Gung Medical College and University, Chang Gung Memorial Hospital at Linkou, Department of Neurosurgery, Taiwan.

Aim: Diabetes mellitus (DM) is known to induce negative systemic effects in patients with trauma. However, data on the association between DM and isolated traumatic brain injury (TBI) is limited, especially in the Asian population. This study aimed to identify the effect of patients with DM with TBI in Taiwan. Read More

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Compound 21, a Direct AT2R Agonist, Induces IL-10 and Inhibits Inflammation in Mice Following Traumatic Brain Injury.

Neuromolecular Med 2021 Sep 20. Epub 2021 Sep 20.

Department of Anatomy and Neurobiology, University of Tennessee Health Science Center, Memphis, TN, 38163, USA.

Recent studies demonstrated that the angiotensin type 2 receptor (AT2R) agonist, compound 21 (C21), provides neuroprotection and enhances recovery in experimental stroke. However, C21 has never been tested in traumatic brain injury (TBI). Here, we aim to examine whether C21 confers protection after TBI. Read More

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September 2021

Elevation of Pro-inflammatory and Anti-inflammatory Cytokines in Rat Serum after Acute Methamphetamine Treatment and Traumatic Brain Injury.

J Mol Neurosci 2021 Sep 20. Epub 2021 Sep 20.

Program for Neurotrauma, Neuroproteomics, and Biomarkers Research, Gainesville, FL, USA.

The use of methamphetamine (METH) is a growing worldwide epidemic that bears grave societal implications. METH is known to exert its neurotoxic effects on the dopaminergic and serotonergic systems of the brain. In addition to this classical studied mechanism of damage, findings from our laboratory and others have shown that acute METH treatment and mechanical injury, i. Read More

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September 2021

Cytotoxic edema associated with hemorrhage predicts poor outcome after traumatic brain injury.

J Neurotrauma 2021 Sep 19. Epub 2021 Sep 19.

National Institute of Neurological Disorders and Stroke, Section on Stroke Diagnostics and Therapeutics, Building 10, B1D733, NIH, Bethesda, Maryland, United States, 20892;

Magnetic resonance imaging (MRI) is rarely used in the acute evaluation of traumatic brain injury (TBI), but may identify findings of clinical importance not detected by computed tomography (CT). We aimed to characterize the association of cytotoxic edema and hemorrhage, including traumatic microbleeds, on MRI obtained within hours of acute head trauma and investigated the relationship to clinical outcomes. Patients prospectively enrolled in the Traumatic Head Injury Neuroimaging Classification study (NCT01132937) with evidence of diffusion-related findings or hemorrhage on neuroimaging were included. Read More

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September 2021

Traumatic Brain Injury Accelerates the Onset of Cognitive Dysfunction and Aggravates Alzheimer's-Like Pathology in the Hippocampus by Altering the Phenotype of Microglia in the APP/PS1 Mouse Model.

Front Neurol 2021 1;12:666430. Epub 2021 Sep 1.

Department of Human Anatomy, Harbin Medical University, Harbin, China.

An increasing number of studies have suggested that traumatic brain injury (TBI) is associated with some neurodegenerative diseases, including Alzheimer's disease (AD). Various aspects of the mechanism of TBI-induced AD have been elucidated. However, there are also studies opposing the view that TBI is one of the causes of AD. Read More

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September 2021

NLRP3 Inflammasome-Dependent Increases in High Mobility Group Box 1 Involved in the Cognitive Dysfunction Caused by Tau-Overexpression.

Front Aging Neurosci 2021 3;13:721474. Epub 2021 Sep 3.

Department of Army Occupational Disease, State Key Laboratory of Trauma, Burns and Combined Injury, Research Institute of Surgery, Daping Hospital, Army Medical University, Chongqing, China.

Tau hyperphosphorylation is a characteristic alteration present in a range of neurological conditions, such as traumatic brain injury (TBI) and neurodegenerative diseases. Treatments targeting high-mobility group box protein 1 (HMGB1) induce neuroprotective effects in these neuropathologic conditions. However, little is known about the interactions between hyperphosphorylated tau and HMGB1 in neuroinflammation. Read More

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September 2021

[Experience with 4 clinical cases. Traumatic encephalopathy may be associated with a single traumatic brain injury?]

Rehabilitacion (Madr) 2021 Sep 16. Epub 2021 Sep 16.

Hospital Clínic, Barcelona, España.

Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease that affects people who had repetitive head trauma. Also, in single traumatic brain injury (TBI), changes may be found during the follow-up visits. We present four clinical cases of patients visited at the Institut Guttmann clinic between 2017 and 2019. Read More

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September 2021

Traumatic Brain Injury in Children and Adolescents: Psychiatric Disorders 24 Years Later.

J Neuropsychiatry Clin Neurosci 2021 Sep 20:appineuropsych20050104. Epub 2021 Sep 20.

Department of Psychiatry, University of California, San Diego (Max, Troyer, Arif).

Objective: The investigators aimed to extend findings regarding predictive factors of psychiatric outcomes among children and adolescents with traumatic brain injury (TBI) from 2 to 24 years postinjury.

Methods: Youths aged 6-14 years who were hospitalized following TBI from 1992 to 1994 were assessed at baseline for TBI severity and for preinjury psychiatric, adaptive, and behavioral functioning; family functioning; family psychiatric history; socioeconomic status; and intelligence within weeks of injury. Predictors of psychiatric outcomes following pediatric TBI at 3, 6, 12, and 24 months postinjury have previously been reported. Read More

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September 2021

Neuroimaging Correlates of Syndromal Anxiety Following Traumatic Brain Injury: A Systematic Review of the Literature.

J Acad Consult Liaison Psychiatry 2021 Sep 14. Epub 2021 Sep 14.

Johns Hopkins University School of Medicine, Department of Psychiatry and Behavioral Sciences. Electronic address:

Background: Traumatic brain injury (TBI) can precipitate new-onset psychiatric symptoms or worsen existing psychiatric conditions. To elucidate specific mechanisms for this interaction, neuroimaging is often used to study both psychiatric conditions and TBI. This systematic review aims to synthesize the existing literature of neuroimaging findings among patients with anxiety after TBI. Read More

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September 2021

Differences in outcomes of mandatory motorcycle helmet legislation by country income level: A systematic review and meta-analysis.

PLoS Med 2021 Sep 17;18(9):e1003795. Epub 2021 Sep 17.

Program in Global Surgery and Social Change, Department of Global Health and Social Medicine, Harvard Medical School, Boston, Massachusetts, United States of America.

Background: The recent Lancet Commission on Legal Determinants of Global Health argues that governance can provide the framework for achieving sustainable development goals. Even though over 90% of fatal road traffic injuries occur in low- and middle-income countries (LMICs) primarily affecting motorcyclists, the utility of helmet laws outside of high-income settings has not been well characterized. We sought to evaluate the differences in outcomes of mandatory motorcycle helmet legislation and determine whether these varied across country income levels. Read More

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September 2021

Risk Factors and Neurologic Outcomes in Patients with Traumatic Brain Injury and Coagulopathy Within 72 h After Surgery.

Neuropsychiatr Dis Treat 2021 10;17:2905-2913. Epub 2021 Sep 10.

Department of Neurosurgery, The Second Affiliated Hospital of Air Force Medical University, Xi'an, 710038, Shaanxi Province, People's Republic of China.

Objective: The purpose of this study was to explore the effect of coagulopathy in patients with traumatic brain injury (TBI) during the early postoperative period.

Methods: The baseline characteristics, intraoperative management, and follow-up data of 462 patients with TBI between January 2015 and June 2019 were collected and retrospectively analyzed by multivariate logistic regression. Coagulopathy was defined as activated partial thromboplastin time > 40 s, international normalized ratio > 1. Read More

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September 2021

Blood biomarkers for mild traumatic brain injury: a selective review of unresolved issues.

Biomark Res 2021 Sep 16;9(1):70. Epub 2021 Sep 16.

Department of Electrical and Computer Engineering, Missouri University of Science and Technology, Rolla, MO 65401, USA.

Background: The use of blood biomarkers after mild traumatic brain injury (mTBI) has been widely studied. We have identified eight unresolved issues related to the use of five commonly investigated blood biomarkers: neurofilament light chain, ubiquitin carboxy-terminal hydrolase-L1, tau, S100B, and glial acidic fibrillary protein. We conducted a focused literature review of unresolved issues in three areas: mode of entry into and exit from the blood, kinetics of blood biomarkers in the blood, and predictive capacity of the blood biomarkers after mTBI. Read More

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September 2021

Mental and physical health, and long-term quality of life among service members injured on deployment.

Health Qual Life Outcomes 2021 Sep 16;19(1):220. Epub 2021 Sep 16.

Operational Readiness Directorate, Naval Health Research Center, 140 Sylvester Road, San Diego, CA, 92106, USA.

Background: More than 52,000 casualties have been documented in post-9/11 conflicts. Service members with extremity injuries (EIs) or traumatic brain injury (TBI) may be at particular risk for long-term deficits in mental and physical health functioning compared with service members with other injuries.

Methods: The present study combined medical records with patient reports of mental health and health-related quality of life (HRQOL) for 2,537 service members injured in overseas contingency operations who participated in the Wounded Warrior Recovery Project. Read More

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September 2021

Pharmacotherapy to prevent the onset of depression following traumatic brain injury.

Expert Opin Pharmacother 2021 Sep 22:1-8. Epub 2021 Sep 22.

Section of Psychiatry, Department of Neuroscience, Reproductive Science, and Odontostomatology, Federico Ii University of Naples, Naples, Italy.

Introduction: Depressive symptoms may follow traumatic brain injury (TBI), affecting cognition, apathy, and overall general functioning. Pharmacotherapy to prevent the onset of depression following TBI is, therefore, crucial.

Areas Covered: The present report critically appraises current pharmacotherapy to prevent the onset of depression following TBI as well as novel potential pharmacological avenues on the matter. Read More

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September 2021

The Impact of the COVID-19 pandemic on traumatic brain injury management: Lessons learned over the first year.

World Neurosurg 2021 Sep 13. Epub 2021 Sep 13.

Department of Neurosurgery, University Hospital of Wales, Cardiff, United Kingdom; Neuroscience and Mental Health Research Institute, School of Medicine, Cardiff University, United Kingdom.

The COVID-19 pandemic has had widespread consequences on healthcare systems around the world. It resulted in extensive changes to the referral patterns, management and rehabilitation of surgical conditions. We aimed to evaluate the effect the COVID-19 pandemic has had on traumatic brain injury (TBI) specifically. Read More

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September 2021

Lessons Learned From a Traumatic Brain Injury Mass Casualty Incident.

J Spec Oper Med 2021 ;21(3):123-125

In January 2020, an American base was attacked by the largest theater ballistic missile strike in history. This case report covers the resulting mass casualty (MASCAL) incident. In this case, we defined this incident as a MASCAL due to a lack of medical personnel available to properly and timely evaluate the patients. Read More

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September 2021

Improvement in Memory Deficits With Memantine in Mania Secondary to Traumatic Brain Injury and Preexisting Perinatal Birth Injury.

J Psychiatr Pract 2021 Sep 16;27(5):390-394. Epub 2021 Sep 16.

Cognitive deficits are known to occur after brain injury, be it perinatal injury, traumatic brain injury (TBI), or any other type of insult to the brain. The problem may be compounded if psychiatric illness is present in addition to the brain injury because the illness itself or the psychotropic medications used in its management may lead to worsening of cognitive functioning. We present the case of a patient who presented to the hospital with symptoms suggestive of mania with psychotic features that had started after a recent TBI, with the brain scan also revealing the presence of a preexisting perinatal birth injury. Read More

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September 2021