722 results match your criteria injury pta

Bone-Patellar Tendon-Bone Autograft Thickness Is a Risk Factor for Graft Failure. A Case-Control Analysis.

Bull Hosp Jt Dis (2013) 2021 Jun;79(2):72-77

Background: Graft failure following anterior cruciate ligament reconstruction (ACLR) is a devastating complication. Risk factors such as patient characteristics and tunnel positions are well described. The relationship between graft dimension and failure rates has been investigated mainly in soft tissue grafts. Read More

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Population Pharmacokinetics and Probability of Target Attainment of Different Dosing Regimens of Ceftazidime in Critically Ill Patients with a Proven or Suspected Infection.

Antibiotics (Basel) 2021 May 21;10(6). Epub 2021 May 21.

Hospital Pharmacy and Clinical Pharmacology, Amsterdam University Medical Centre, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.

Altered pharmacokinetics (PK) of hydrophilic antibiotics in critically ill patients is common, with possible consequences for efficacy and resistance. We aimed to describe ceftazidime population PK in critically ill patients with a proven or suspected infection and to establish optimal dosing. Blood samples were collected for ceftazidime concentration measurement. Read More

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Aspects of Cognitive Impairment Associated with Agitated Behaviour during Post-traumatic Amnesia.

J Int Neuropsychol Soc 2021 May 17:1-9. Epub 2021 May 17.

Turner Institute for Brain and Mental Health, School of Psychological Sciences, Monash University, Clayton, Victoria, Australia.

Objectives: Post-traumatic amnesia (PTA) is a transient period of recovery following traumatic brain injury (TBI) characterised by disorientation, amnesia, and cognitive disturbance. Agitation is common during PTA and presents as a barrier to patient outcome. A relationship between cognitive impairment and agitation has been observed. Read More

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Effect of cilostazol on arteriovenous fistula in hemodialysis patients.

Nefrologia (Engl Ed) 2021 May 10. Epub 2021 May 10.

Department of Internal Medicine, Chungnam National University School of Medicine, Daejeon, Republic of Korea; Department of Nephrology, Chungnam National University Hospital, Daejeon, Republic of Korea. Electronic address:

Background: The maturation and patency of permanent vascular access are critical in patients requiring hemodialysis. Although numerus trials have been attempted to achieve permanently patent vascular access, little have been noticeable. Cilostazol, a phosphodiesterase-3 inhibitor, has been shown to be effective in peripheral arterial disease including vascular injury-induced intimal hyperplasia. Read More

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Assessing Sleep Architecture With Polysomnography During Posttraumatic Amnesia After Traumatic Brain Injury: A Pilot Study.

Neurorehabil Neural Repair 2021 May 12:15459683211011241. Epub 2021 May 12.

Epworth HealthCare, Melbourne, Victoria, Australia.

Background: Early-onset sleep disturbance is common following moderate to severe traumatic brain injury (TBI) and often emerges while patients are in posttraumatic amnesia (PTA). However, sleep disruptions during this subacute recovery phase are not well-defined, and research often utilizes indirect measures (actigraphy) that quantify sleep based on activity. This study aims to examine sleep macro-architecture and sleep quality directly with ambulatory polysomnography (PSG) and measure endogenous salivary melatonin levels for patients experiencing PTA following moderate to severe TBI. Read More

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Rates of false positive outcomes on the A-WPTAS picture items in a sample of non-concussed athletes.

Brain Inj 2021 Jun 10;35(7):783-787. Epub 2021 May 10.

Department of Cognitive Science, Macquarie University, Sydney, NSW, Australia.

Accurate diagnosis of sports related concussion ensures that athletes are removed from play if concussed and prevents incorrect removal when a concussion has not occurred. Although various screening tools are currently in use, there is no gold standard measure with which to diagnose sports related concussion.: The current study aimed to investigate the diagnostic accuracy of the Abbreviated Westmead Post Traumatic Amnesia Scale (A-WPTAS) picture task, a neurocognitive measure used to assess mild traumatic brain injury. Read More

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Population Pharmacokinetic Modeling and Simulations of Imipenem in Burn Patients With and Without Continuous Venovenous Hemofiltration in the Military Health System.

J Clin Pharmacol 2021 Apr 2. Epub 2021 Apr 2.

Walter Reed Army Institute of Research, Experimental Therapeutics, Silver Spring, Maryland, USA.

Continuous venovenous hemofiltration (CVVH) is a life-sustaining procedure in patients with severe burns and acute kidney injury. Physiologic changes from burn injury and use of CVVH may alter imipenem pharmacokinetics (PK). We aimed to compare imipenem clearance (CL) in burn patients with and without CVVH, determine the effect of burn on imipenem volume of distribution (CVVH, n = 12; no CVVH, n = 11), in combination with previously published models. Read More

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What a headache! Reviewing mild traumatic brain injury management in a new trauma service.

N Z Med J 2021 03 26;134(1531):59-66. Epub 2021 Mar 26.

Consultant General and Colorectal Surgeon, Christchurch Hospital, Canterbury District Health Board, New Zealand.

Aim: Mild traumatic brain injury (mild TBI) is a common, poorly managed condition with an underestimated impact and inadequate follow-up. This study aimed to assess local practice in terms of assessment and follow-up.

Methods: A retrospective review of all patients presenting to Christchurch Hospital between 1 August 2019 and 30 September 2019 with ICD-10 coded diagnosis of head trauma was conducted. Read More

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Relationship between post-traumatic amnesia and white matter integrity in traumatic brain injury using tract-based spatial statistics.

Sci Rep 2021 Mar 25;11(1):6898. Epub 2021 Mar 25.

Department of Physical Medicine and Rehabilitation, College of Medicine, Yeungnam University, 317-1, Daemyungdong, Namku, Daegu, 705-717, Republic of Korea.

This study used tract-based spatial statistics to examine the relationship between post-traumatic amnesia (PTA) and white matter integrity in patients with a traumatic brain injury (TBI). Forty-seven patients with TBI in the chronic stage and 47 age- and sex-matched normal control subjects were recruited to the study. Correlation coefficients were calculated to observe the relationships among the PTA duration, white matter fractional anisotropy (FA) values, and mini-mental state examination (MMSE) results in the patient group. Read More

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Network Pharmacology-Based Study on the Molecular Biological Mechanism of Action for Qingdu Decoction against Chronic Liver Injury.

Evid Based Complement Alternat Med 2021 3;2021:6661667. Epub 2021 Mar 3.

School of Traditional Chinese Medicine, Capital Medical University, Beijing 10069, China.

Background: Qingdu Decoction (QDD) is a traditional Chinese medicine formula for treating chronic liver injury (CLI). . A network pharmacology combining experimental validation was used to investigate potential mechanisms of QDD against CLI. Read More

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Feasibility of modifying the hospital environment to reduce the length of amnesia after traumatic brain injury: a pilot randomized controlled trial.

Int J Qual Health Care 2021 Mar;33(1)

Department of Neuroscience, Monash University, Melbourne, VIC, Australia.

Background: Reorientation programmes have been an important component of neurotrauma rehabilitation for adults who suffer from post-traumatic amnesia (PTA) after traumatic brain injury (TBI); however, research testing the efficacy of acute programmes is limited.

Objective: This study aimed to determine if it is feasible to provide a standardized environmental reorientation programme to adults suffering from PTA after TBI in an acute care hospital setting, and whether it is likely to be beneficial.

Methods: We conducted a randomized controlled trial with concealed allocation and intention-to-treat analysis. Read More

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Immune cell profiling in the joint following human and murine articular fracture.

Osteoarthritis Cartilage 2021 06 25;29(6):915-923. Epub 2021 Feb 25.

Department of Orthopaedic Surgery, Duke University Medical Center, Durham, NC, 27710, USA. Electronic address:

Objective: Human and in vivo animal research implicates inflammation following articular fracture as contributing to post-traumatic arthritis. However, relevant immune cell subsets present following injury are currently undefined. Immunophenotyping human and murine synovial fluid may help to identify immune cell populations that play key roles in the response to articular fracture. Read More

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Audiometric Outcomes Following Transmastoid and Middle Cranial Fossa Approaches for Repair of Cerebrospinal Fluid Otorrhea.

Otol Neurotol 2021 03;42(3):424-430

Department of Head and Neck Surgery, Kaiser Permanente San Diego, California.

Objective: Describe audiometric outcomes following transmastoid and middle cranial fossa (MCF) approaches for repair of cerebrospinal fluid (CSF) otorhinorrhea.

Study Design: Retrospective case series.

Setting: Tertiary skull base referral center. Read More

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Early intravenous tranexamic acid intervention reduces post-traumatic hidden blood loss in elderly patients with intertrochanteric fracture: a randomized controlled trial.

J Orthop Surg Res 2021 Feb 3;16(1):106. Epub 2021 Feb 3.

Department of Radiology, Chongqing Traditional Chinese Medicine Hospital, Chongqing, 400022, People's Republic of China.

Purpose: Elderly patients with intertrochanteric fractures exhibit post-traumatic hidden blood loss (HBL). This study aimed to evaluate the efficacy and safety of reducing post-traumatic HBL via early intravenous (IV) tranexamic acid (TXA) intervention in elderly patients with intertrochanteric fracture.

Methods: A prospective randomized controlled study was conducted with 125 patients (age ≥ 65 years, injury time ≤ 6 h) who presented with intertrochanteric fracture from September 2018 and September 2019. Read More

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February 2021

Butylphthalide enhances recovery from sudden deafness.

Am J Otolaryngol 2021 Mar-Apr;42(2):102891. Epub 2021 Jan 4.

Department of Otolaryngology Head and Neck Surgery, General Hospital of Southern Theater Command of PLA (Guangzhou Liuhuaqiao Hospital), Liuhua road 111, Guangzhou 510010, Guangdong, China.

Objectives: Cochlear microcirculation disturbance caused by vasculopathy is a common cause of sudden deafness (SD). Reactive oxygen species (ROS) plays an important role in cochlear injury during ischemia-reperfusion. Butylphthalide can improve microcirculation, reduce ROS formation and inhibit apoptosis. Read More

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January 2021

Popliteal artery: Anatomical study and review of the literature.

Ann Anat 2021 Mar 2;234:151654. Epub 2020 Dec 2.

Department of Human Anatomy and Embryology, Facultad de Medicina, Universidad Complutense de Madrid, Spain. Electronic address:

Background: The frequency of appearance of anatomical variability in the terminal division of the popliteal artery (PA) is different according to the type of sample used, and ranges from 2% to 21%. The PA locates 1,01 cm behind to the lateral meniscus, which makes it vulnerable during surgical procedures. Iatrogenic injury of the PA or its terminal branches increases if anatomical variables are present. Read More

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Late-gestation heat stress abatement in dairy heifers promotes thermoregulation and improves productivity.

J Dairy Sci 2021 Feb 25;104(2):2357-2368. Epub 2020 Nov 25.

Department of Animal Sciences, University of Florida, Gainesville, 32608. Electronic address:

Multiparous, nonlactating pregnant cows are negatively affected by heat stress, but the effect of heat stress on more thermotolerant pregnant heifers has received less attention. Our objective was to characterize the effect of late-gestation heat abatement on thermoregulatory responses and subsequent milk production of nulliparous Holstein heifers. Pregnant heifers, blocked by body condition score (BCS) and predicted transmitting ability (PTA) for milk, were enrolled in either heat stress (HT, shade of freestall barn; n = 16) or cooling (CL, shade of freestall barn, water soakers, and fans; n = 15) environments during the last 60 d of pregnancy (~8 weeks). Read More

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February 2021

Factors influencing functional outcomes following open reduction internal fixation of acetabular fractures.

Injury 2021 Jun 16;52(6):1396-1402. Epub 2020 Nov 16.

Study performed at MetroHealth Medical Center, an affiliate of Case Western Reserve University School of Medicine, Cleveland, Ohio, USA. Electronic address:

Introduction: Recent large series of patient-reported outcomes after acetabulum fracture are limited, and potentially modifiable risk factors may be unidentified. The goal of this study was to describe patient and injury factors which negatively influence functional outcomes following operative management of acetabular fractures.

Methods: 699 patients with acetabular fractures were treated with open reduction and internal fixation (ORIF). Read More

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The accuracy of a novel pedicle screw insertion technique assisted by a special angular scale in the subaxial cervical spine using lateral mass as a reference marker.

J Orthop Surg Res 2020 Nov 23;15(1):551. Epub 2020 Nov 23.

Department of Spine Surgery, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, 210009, Jiangsu, China.

Background: Posterior cervical pedicle screw (CPS) internal fixation has better biomechanical stability than other posterior cervical fixation methods. However, this technique is limited in clinical practice due to the complex anatomical structure and the adjacent relationship of the cervical pedicle, and the high risk of neurovascular injury. The purpose of this study was to describe a novel subaxial CPS insertion technique assisted by a special angular scale using lateral mass as a reference marker and to evaluate the accuracy of CPS placement and the distribution characteristics of CPS misplacement. Read More

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November 2020

Protosappanin A Maintains Neuronal Mitochondrial Homeostasis through Promoting Autophagic Degradation of Bax.

ACS Chem Neurosci 2020 12 23;11(24):4223-4230. Epub 2020 Nov 23.

State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China.

Cerebral ischemia is accompanied by mitochondrial integrity destruction. Thus, reversion of mitochondrial damage holds great potential for cerebral ischemia therapy. As a crucial Bcl-2 family member, pro-apoptotic Bax protein is a main effector of mitochondrial permeabilization and plays an important role in mitochondrial homeostasis. Read More

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December 2020

Optimizing and simplifying post-traumatic amnesia testing after moderate-severe traumatic brain injury despite common confounders in routine practice.

J Clin Neurosci 2020 Nov 25;81:37-42. Epub 2020 Sep 25.

Dept Psychology, James Cook University, Townsville 4810, Australia.

The duration of post-traumatic amnesia (PTA) following traumatic brain injury (TBI) is a key diagnostic and outcome indicator. However, concerningly, different PTA paradigms record different PTA durations: some over-estimate, others under-estimate, PTA. Thus, a compromise is implied. Read More

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November 2020

Initial displacement of the intra-articular surface after articular fracture correlates with PTA in C57BL/6 mice but not "superhealer" MRL/MpJ mice.

J Orthop Res 2020 Nov 12. Epub 2020 Nov 12.

Department of Orthopaedic Surgery, Duke University Medical Center, Durham, North Carolina, USA.

Posttraumatic arthritis (PTA) occurs commonly after articular fracture and may arise, in part, from joint surface incongruity after injury. MRL/MpJ (MRL) "super-healer" mice are protected from PTA compared to C57BL/6 (B6) mice following articular fracture. However, the relationship between the initial displacement of the articular surface, biologic response, and susceptibility to PTA after fracture remains unclear. Read More

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November 2020

Assessment and Management of Patients in the Acute Stages of Recovery after Traumatic Brain Injury in Adults: A Worldwide Survey.

J Neurotrauma 2021 Apr 14;38(8):1060-1067. Epub 2020 Dec 14.

Turner Institute for Brain and Mental Health, School of Psychological Sciences, Monash University, Clayton, Victoria, Australia.

Most individuals with traumatic brain injury (TBI) experience a period of confusion after emergence from coma, termed post-traumatic amnesia, post-traumatic confusional state, or delirium. Recent guidelines suggest the importance of assessment and consistent management during this phase, but current practice worldwide remains unknown. This survey aimed to elucidate current international practice in assessment and treatment of patients in the acute stages of recovery after TBI. Read More

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Traumatic axonal injury on clinical MRI: association with the Glasgow Coma Scale score at scene of injury or at admission and prolonged posttraumatic amnesia.

J Neurosurg 2020 Oct 23:1-12. Epub 2020 Oct 23.

Departments of1Neuromedicine and Movement Science and.

Objective: The aim in this study was to investigate if MRI findings of traumatic axonal injury (TAI) after traumatic brain injury (TBI) are related to the admission Glasgow Coma Scale (GCS) score and prolonged duration of posttraumatic amnesia (PTA).

Methods: A total of 490 patients with mild to severe TBI underwent brain MRI within 6 weeks of injury (mild TBI: median 2 days; moderate to severe TBI: median 8 days). The location of TAI lesions and measures of total TAI lesion burden (number and volume of lesions on FLAIR and diffusion-weighted imaging and number of lesions on T2*-weighted gradient echo or susceptibility-weighted imaging) were quantified in a blinded manner for clinical information. Read More

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October 2020

The Effect of Cerebrolysin on the Predictive Value of Baseline Prognostic Risk Score in Moderate and Severe Traumatic Brain Injury.

J Med Life 2020 Jul-Sep;13(3):283-288

Department of Neurosciences, "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania.

Cognitive dysfunction is a significant complaint among patients after moderate to severe traumatic brain injury (TBI), with devastating consequences on functional recovery and quality of life. Prognostic models allow a better assessment and management of neurotrauma patients. The aim of the study was to demonstrate the predictive value of the Baseline Prognostic Risk Score (BPRS) in moderate to severe TBI, in a sample of patients treated with neurotrophic factors. Read More

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November 2020

Gunshot Wounds to the Hip: Doomed to Failure?

J Surg Orthop Adv 2020 ;29(3):135-140

Hughston Clinic & Novant Health, Jacksonville, Florida.

The purpose is to evaluate hip fractures due to gunshot wounds (GSW) to the hip, which are treated surgically, and the complications. Patients who sustained a low velocity GSW with fracture to the femoral head/neck and intertrochanteric/peritrochantric region at three Level 1 Trauma Centers were eligible. There were 69 patients (63 males-91%), with an average age of 29 (18-60). Read More

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November 2020

Cleaning Up the MESS: Can Machine Learning Be Used to Predict Lower Extremity Amputation after Trauma-Associated Arterial Injury?

J Am Coll Surg 2021 Jan 3;232(1):102-113.e4. Epub 2020 Oct 3.

Department of Surgery, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Manhasset, NY; Divisions of Vascular and Endovascular Surgery, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Manhasset, NY. Electronic address:

Background: Thirty years after the Mangled Extremity Severity Score was developed, advances in vascular, trauma, and orthopaedic surgery have rendered the sensitivity of this score obsolete. A significant number of patients receive amputation during subsequent admissions, which are often missed in the analysis of amputation at the index admission. We aimed to identify risk factors for and predict amputation on initial admission or within 30 days of discharge (peritraumatic amputation [PTA]). Read More

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January 2021

Two Coarse Spatial Patterns of Altered Brain Microstructure Predict Post-traumatic Amnesia in the Subacute Stage of Severe Traumatic Brain Injury.

Front Neurol 2020 4;11:800. Epub 2020 Sep 4.

Danish Research Centre for Magnetic Resonance (DRCMR), Centre for Functional and Diagnostic Imaging Research, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark.

Diffuse traumatic axonal injury (TAI) is one of the key mechanisms leading to impaired consciousness after severe traumatic brain injury (TBI). In addition, preferential regional expression of TAI in the brain may also influence clinical outcome. We addressed the question whether the regional expression of microstructural changes as revealed by whole-brain diffusion tensor imaging (DTI) in the subacute stage after severe TBI may predict the duration of post-traumatic amnesia (PTA). Read More

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September 2020

Optimal levofloxacin dosing regimens in critically ill patients with acute kidney injury receiving continuous renal replacement therapy.

J Crit Care 2021 Jun 24;63:154-160. Epub 2020 Sep 24.

Department of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Songkhla, Thailand. Electronic address:

Purposes: To determine appropriate dosing of levofloxacin in critically ill patients receiving continuous renal replacement therapy (CRRT).

Methods: All necessary pharmacokinetic and pharmacodynamic parameters from critically ill patients were obtained to develop mathematical models with first order elimination. Levofloxacin concentration-time profiles were calculated to determine the efficacy based on the probability of target attainment (PTA) of AUC/MIC ≥50 for Gram-positive and AUC/MIC ≥125 for Gram-negative infections. Read More

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HS attenuates oxidative stress via Nrf2/NF-κB signaling to regulate restenosis after percutaneous transluminal angioplasty.

Exp Biol Med (Maywood) 2021 01 30;246(2):226-239. Epub 2020 Sep 30.

Department of Vascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.

Restenosis after angioplasty of peripheral arteries is a clinical problem involving oxidative stress. Hydrogen sulfide (HS) participates in oxidative stress regulation and activates nuclear factor erythroid 2-related factor 2 (Nrf2). This study investigated the effect of HS and Nrf2 on restenosis-induced arterial injury. Read More

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January 2021