129,811 results match your criteria injury potential

Biological variation of cardiac myosin-binding protein C in healthy individuals.

Clin Chem Lab Med 2021 Jun 23. Epub 2021 Jun 23.

Department of Medical Biochemistry and Pharmacology, Haukeland University Hospital, Bergen, Norway.

Objectives: Cardiac myosin-binding protein C (cMyC) is a novel biomarker of myocardial injury, with a promising role in the triage and risk stratification of patients presenting with acute cardiac disease. In this study, we assess the weekly biological variation of cMyC, to examine its potential in monitoring chronic myocardial injury, and to suggest analytical quality specification for routine use of the test in clinical practice.

Methods: Thirty healthy volunteers were included. Read More

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The Role of Exosomes in the Treatment, Prevention, Diagnosis, and Pathogenesis of COVID-19.

Eur J Pediatr Surg 2021 Jun 23. Epub 2021 Jun 23.

Division of General and Thoracic Surgery, Hospital for Sick Children, Toronto, Ontario, Canada.

The novel coronavirus disease 2019 (COVID-19) pandemic, caused by the severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2), continues to be a major health concern. In search for novel treatment strategies against COVID-19, exosomes have attracted the attention of scientists and pharmaceutical companies worldwide. Exosomes are small extracellular vesicles, secreted by all types of cells, and considered as key mediators of intercellular communication and stem-cell paracrine signaling. Read More

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Metabolism as Disease Tolerance: Implications for Sepsis-Associated Acute Kidney Injury.

Sarah C Huen

Nephron 2021 Jun 23:1-4. Epub 2021 Jun 23.

Departments of Internal Medicine-Nephrology and Pharmacology, The University of Texas Southwestern Medical Center, Dallas, Texas, USA.

Sepsis is a significant cause for mortality among critically ill patients. Metabolic derangements that develop in sepsis are often considered to be pathologic, contributing to sepsis morbidity and mortality. However, alterations in metabolism during sepsis are multifaceted and are incompletely understood. Read More

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Oral Wound Healing Models and Emerging Regenerative Therapies.

Transl Res 2021 Jun 20. Epub 2021 Jun 20.

Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Emory University, Atlanta, GA, USA; Department of Otolaryngology, Emory University, Atlanta, GA, USA; Department of Pediatric Otolaryngology, Children's Healthcare of Atlanta, Atlanta, GA, USA. Electronic address:

Following injury, the oral mucosa undergoes complex sequences of biological healing processes to restore homeostasis. While general similarities exist, there are marked differences in the genomics and kinetics of wound healing between the oral cavity and cutaneous skin. The lack of successful therapy for oral mucosal wounds has influenced clinicians to explore alternative treatments and potential autotherapies to enhance intraoral healing. Read More

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Long-term survivors of murine sepsis are predisposed to enhanced LPS-induced lung injury and pro-inflammatory immune reprogramming.

Am J Physiol Lung Cell Mol Physiol 2021 06 23. Epub 2021 Jun 23.

Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, United States.

Millions of people who survive sepsis each year are rehospitalized and die due to late pulmonary complications. In order to prevent and treat these complications, biomarkers and molecular mediators must be identified. Persistent immune reprogramming in the form of immunoparalysis and impaired host defense is proposed to mediate late pulmonary complications after sepsis, particularly new pulmonary infections. Read More

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What Is the Failure Rate After Arthroscopic Repair of Bucket-Handle Meniscal Tears? A Systematic Review and Meta-analysis.

Am J Sports Med 2021 Jun 23:3635465211015425. Epub 2021 Jun 23.

Orthopaedic and Traumatologic Unit, Umberto I Hospital, Azienda Sanitaria Provinciale di Enna, Enna, Italy.

Background: Meniscal repair has become the treatment of choice for meniscal tears, especially in the subset of bucket-handle meniscal tears (BHMTs). However, a comprehensive estimate of the corresponding failure rate is not available, thus maintaining doubts about the healing potential of these tears. Furthermore, a wide range of factors to predict high failure rates have been reported but with conflicting evidence. Read More

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The cardioprotective effects of hydrogen sulfide by targeting endoplasmic reticulum stress and the Nrf2 signaling pathway: A review.

Biofactors 2021 Jun 23. Epub 2021 Jun 23.

Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.

Cardiac diseases are emerging due to lifestyle, urbanization, and the accelerated aging process. Oxidative stress has been associated with cardiac injury progression through interference with antioxidant strategies and endoplasmic reticulum (ER) function. Hydrogen sulfide (H S) is generated endogenously from l-cysteine in various tissues including heart tissue. Read More

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Quadriplegia, an Unusual Outcome After Anterior Cervical Discectomy and Fusion: A Case Report.

JBJS Case Connect 2021 06 23;11(2). Epub 2021 Jun 23.

Department of Intraoperative Neurophysiology, Mount Sinai West Hospital, New York, New York.

Case: A 68-year-old woman who underwent a C5 to C6 anterior cervical discectomy and fusion (ACDF) surgery presented with new-onset postoperative quadriplegia. During discectomy, intraoperative neurophysiological monitoring alerted of a spinal cord (SC) dysfunction. The surgery was halted, and measures to ensure adequate SC perfusion were initiated. Read More

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Interleukin-6 is an activator of pituitary stem cells upon local damage, a competence quenched in the aging gland.

Proc Natl Acad Sci U S A 2021 Jun;118(25)

Laboratory of Tissue Plasticity in Health and Disease, Cluster of Stem Cell and Developmental Biology, Department of Development and Regeneration, Leuven Stem Cell Institute, Katholieke Universiteit Leuven, 3000 Leuven, Belgium;

Stem cells in the adult pituitary are quiescent yet show acute activation upon tissue injury. The molecular mechanisms underlying this reaction are completely unknown. We applied single-cell transcriptomics to start unraveling the acute pituitary stem cell activation process as occurring upon targeted endocrine cell-ablation damage. Read More

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A Review on Chitosan in Drug Delivery for the Treatment of Neurological and Psychiatric Disorders.

Curr Pharm Biotechnol 2021 Jun 22. Epub 2021 Jun 22.

Department of Psychiatry, Arak University of Medical Sciences, Arak, Iran.

Neurological diseases are known as global health problems with a growing number of patients annually. Neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease as well as spinal cord injury, hypoxic ischemia injury, epilepsy, depression etc., are some examples of neurological diseases. Read More

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[Renal toxicity of antineoplasic agents].

Rev Prat 2021 Feb;71(2):193-197

"Service de néphrologie, dialyse et transplantation, hôpital Foch, Suresnes, France".

"Renal toxicity of antineoplasic agents Renal toxicity of antineoplasic agents is a common complication faced by oncologists and nephrologists whose incidence depends on therapeutic classes used and patient's comorbidities. Nephrotoxicity is variable, according to mecanisms, chronology and potential reversibility. Besides acute kidney injury and/or chronic kidney disease, clinical features include several urinary abnormalities (mainly proteinuria). Read More

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February 2021

Advances in the mechanism and treatment of mitochondrial quality control involved in myocardial infarction.

J Cell Mol Med 2021 Jun 23. Epub 2021 Jun 23.

Department of Cardiovascular Medicine, The Second Xiangya Hospital, Central South University, Changsha, China.

Mitochondria are important organelles in eukaryotic cells. Normal mitochondrial homeostasis is subject to a strict mitochondrial quality control system, including the strict regulation of mitochondrial production, fission/fusion and mitophagy. The strict and accurate modulation of the mitochondrial quality control system, comprising the mitochondrial fission/fusion, mitophagy and other processes, can ameliorate the myocardial injury of myocardial ischaemia and ischaemia-reperfusion after myocardial infarction, which plays an important role in myocardial protection after myocardial infarction. Read More

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Fluid Metabolic Pathways after Subarachnoid Hemorrhage.

J Neurochem 2021 Jun 23. Epub 2021 Jun 23.

Department of Neurosurgery and State Key Laboratory of Trauma, Burn and Combined Injury, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, 400038, China.

Aneurysmal subarachnoid hemorrhage (aSAH) is a devastating cerebrovascular disease with high mortality and morbidity. In recent years, a large number of studies have focused on the mechanism of early brain injury (EBI) and delayed cerebral ischemia (DCI), including vasospasm, neurotoxicity of hematoma and neuroinflammatory storm, after aSAH. Despite considerable efforts, no novel drugs have significantly improved the prognosis of patients in phase III clinical trials, indicating the need to further re-examine the multifactorial pathophysiological process that occurs after aSAH. Read More

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Glutamine Supplementation Attenuates the Inflammation Caused by LPS-Induced Acute Lung Injury in Mice by Regulating the TLR4/MAPK Signaling Pathway.

Inflammation 2021 Jun 23. Epub 2021 Jun 23.

College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, 210095, Jiangsu Province, China.

Bacterial infection is one of the main causes of bovine respiratory disease (BRD), which can cause tremendous losses for the herd farming industry worldwide. L-Glutamine (GLN), a neutral amino acid, has been reported to have anti-inflammatory properties. This study aims to explore the potential protective effects and mechanisms of GLN on acute lung injury (ALI) induced by lipopolysaccharide (LPS) in mice. Read More

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Glutathione conjugation and protein modification resulting from metabolic activation of venlafaxine and .

Xenobiotica 2021 Jun 23:1-39. Epub 2021 Jun 23.

Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, Liaoning 110016, P. R. China.

Venlafaxine (VLF), an antidepressant agent, is widely used to combat major depressive disorders, particularly for the treatment of selective serotonin reuptake inhibitor-resistant depression. VLF has been shown to cause liver injury. The present study aimed to investigate the metabolic activation of VLF and explore the mechanisms of hepatotoxicity induced by VLF. Read More

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Design and Usability Evaluations of a 3D-Printed Implantable Drug Delivery Device for Acute Liver Failure in Preclinical Settings.

Adv Healthc Mater 2021 Jun 23:e2100497. Epub 2021 Jun 23.

Department of Biotechnology, The Catholic University of Korea, 43 Jibong-ro, Bucheon-Si, Gyeonggi-do, 14662, Republic of Korea.

Acute liver failure (ALF) requiring liver transplantation is a disease that occurs due to rapid hepatocellular dysfunction. As liver transplantation has various limitations, including donor scarcity, high cost, and immuno-incompatibility, continuous local delivery of biopharmaceuticals to the liver tissue can be a promising ALF treatment option. Here, the in vivo safety and usability of a 3D-printed implantable drug delivery device for effective ALF treatment is evaluated. Read More

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3',4'-Dihydroxyflavonol (DiOHF) prevents DNA damage, lipid peroxidation and inflammation in ovarian ischaemia-reperfusion injury of rats.

J Obstet Gynaecol 2021 Jun 23:1-8. Epub 2021 Jun 23.

Department of Pathology, Meram Medical School, Necmettin Erbakan University, Konya, Turkey.

This study aimed to determine the effect of 3',4'-Dihydroxyflavonol (DiOHF) on lipid peroxidation, DNA damage and inflammation in ovarian ischaemia (I)-reperfusion (R) injury. This study was performed on 44 Wistar-albino female rats. Groups were designed as Control; Sham; I/R (the left ovary was ligated for 2 h and then reperfused for 2 h); I/R + DiOHF (after 2 h ischaemia and 2 h reperfusion, 30 mg/kg of DiOHF was given intraperitoneally and reperfusion was allowed for 2 h more); I + DiOHF + R (after 2 h I, 30 mg/kg of DiOHF was given at the beginning of 2 h reperfusion); DiOHF + I/R (2 h after DiOHF administration, the left ovary was ligated for 2 h and then reperfused for 2 h). Read More

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Head injury care in a low- and middle-income country tertiary trauma center: epidemiology, systemic lacunae, and possible leads.

Acta Neurochir (Wien) 2021 Jun 22. Epub 2021 Jun 22.

Department of Anesthesia, Postgraduate Institute of Medical Education & Research (PGIMER), Sector 12, Chandigarh, 160012, India.

Background: Although head injury (HI) from low- and middle-income countries (LMIC) heavily contributes to the global disease burden, studies are disproportionately less from this part of the world. Knowing the different epidemiological characteristics from high-income nations can target appropriate prevention strategies. This study aims to provide a comprehensive overview of the clinico-epidemiological data of HI patients, focusing on the existing challenges with possible solutions from a developing nation's perspective. Read More

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Metabolic depletion of synaptosomal enzymes linked with neurotoxicity and ovarian dysfunction by phenolic antioxidants of leaves in rats exposed to chronic mixture of anthropogenic toxicant.

Metabol Open 2021 Jun 2;10:100097. Epub 2021 Jun 2.

Phytochemical Research Laboratory, Department of Industrial Pharmacy, Federal University of Santa Maria, Building 26, Room 1115, Santa Maria, CEP97105-900, Brazil.

A complex mixture of organic contaminants and metals is associated with neuron-fertility disorders and studies have demonstrated that phenolic antioxidants from herbal origin, possesses a strong protective potential. This study aimed to investigate the protection of phenolic croton zambesicus (C-ZAMB) leaves against neuro-ovarian damage in rats exposed to chronic mixture of anthropogenic toxicants (EOMABRSL). The animals were divided into five groups (n = 10): Group I was given 0. Read More

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Gastroprotective Effect of Ethanol Extracts from Bark of Magnolia officinalis on Ethanol-Induced Gastric Mucosal Damage in Rats.

Biomed Res Int 2021 31;2021:6688414. Epub 2021 May 31.

Pharmacy College, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.

Rehd. and Wils. is widely used in Asian countries because of its multiple pharmacological effects. Read More

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Curcumin plays a protective role against septic acute kidney injury by regulating the TLR9 signaling pathway.

Transl Androl Urol 2021 May;10(5):2103-2112

Department of Nephrology, General Hospital of the General Administration of Agriculture and Reclamation of Heilongjiang, Harbin, China.

Background: This study aims to evaluate the inhibitory effect of curcumin (Cur) on the progression of septic acute kidney injury (SAKI), in order to improve the survival rate in this patient population.

Methods: Acute kidney injury (AKI) was induced by cecal ligation perforation (CLP) in Sprague-Dawley (SD) rats. Using this AKI animal model, the survival rate of the rats was evaluated at different time points after Cur treatment to explore whether Cur can improve survival in an animal model of AKI. Read More

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Assessment of Kidney Function After Transcatheter Aortic Valve Replacement.

Can J Kidney Health Dis 2021 4;8:20543581211018029. Epub 2021 Jun 4.

Department of Cardiology, Tel Aviv Medical Center, Sackler School of Medicine, Tel Aviv University, Israel.

Background: Transcatheter aortic valve replacement (TAVR), although associated with an increased risk for acute kidney injury (AKI), may also result in improvement in renal function.

Objective: The aim of this study is to evaluate the magnitude of kidney function improvement (KFI) after TAVR and to assess its significance on long-term mortality.

Design: This is a prospective single center study. Read More

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Microbial and genetic-based framework identifies drug targets in inflammatory bowel disease.

Theranostics 2021 1;11(15):7491-7506. Epub 2021 Jun 1.

Department of Biomedical Sciences, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, ND 58202, USA.

With increasing incidence and prevalence of inflammatory bowel disease (IBD), it has become one of the major public health threats, and there is an urgent need to develop new therapeutic agents. Although the pathogenesis of IBD is still unclear, previous research has provided evidence for complex interplays between genetic, immune, microbial, and environmental factors. Here, we constructed a gene-microbiota interaction-based framework to discover IBD biomarkers and therapeutics. Read More

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Quantitative Profiling of Oxylipin Reveals the Mechanism of Pien-Tze-Huang on Alcoholic Liver Disease.

Evid Based Complement Alternat Med 2021 1;2021:9931542. Epub 2021 Jun 1.

Institute of Digestive Diseases, Longhua Hospital, China-Canada Center of Research for Digestive Diseases (ccCRDD), Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China.

Alcoholic liver disease (ALD) is a liver disease caused by long-term alcohol consumption. ROS-mediated oxidative stress is the leading cause of ALD. Pien-Tze-Huang (PZH), a traditional formula, is famous in China. Read More

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Silicon Application Modulates Growth, Physio-Chemicals, and Antioxidants in Wheat ( L.) Exposed to Different Cadmium Regimes.

Dose Response 2021 Apr-Jun;19(2):15593258211014646. Epub 2021 May 31.

Department of Botany, Government College University, Faisalabad, Pakistan.

Silicon (Si) application enhanced the tolerance of plants against different environmental stresses. Therefore, objective of the study revealed that foliar applied Si alleviates the adverse effect of Cd by enhancing the growth, metabolite accumulation, strengthening the antioxidant defense system, reducing oxidative injury, improving plant nutrient status, and decreasing the Cd uptake in wheat. The surface sterilized seeds of Sahar-2006 (tolerant) and Inqalab-91 (sensitive) having the differential metal tolerance capacity were sown in plastic pots containing normal and Cd spiked sandy loamy soil. Read More

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CBP22, a Novel Bacteriocin Isolated from ZJU-F1, Protects against LPS-Induced Intestinal Injury through Maintaining the Tight Junction Complex.

Mediators Inflamm 2021 1;2021:8032125. Epub 2021 Jun 1.

Key Laboratory of Molecular Animal Nutrition, Ministry of Education, College of Animal Sciences, Zhejiang University, Hangzhou, China.

A novel bacteriocin secreted by ZJU-F1 was isolated using ammonium sulfate fractionation, cation exchange chromatography, affinity chromatography, and reverse-phase high-performance liquid chromatography (RP-HPLC). The bacteriocin, named CBP22, contained 22 amino acids with the sequence PSAWQITKCAGSIAWALGSGIF. Analysis of its structure and physicochemical properties indicated that CBP22 had a molecular weight of 2264. Read More

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The Atr-Chek1 pathway inhibits axon regeneration in response to Piezo-dependent mechanosensation.

Nat Commun 2021 Jun 22;12(1):3845. Epub 2021 Jun 22.

Raymond G. Perelman Center for Cellular and Molecular Therapeutics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.

Atr is a serine/threonine kinase, known to sense single-stranded DNA breaks and activate the DNA damage checkpoint by phosphorylating Chek1, which inhibits Cdc25, causing cell cycle arrest. This pathway has not been implicated in neuroregeneration. We show that in Drosophila sensory neurons removing Atr or Chek1, or overexpressing Cdc25 promotes regeneration, whereas Atr or Chek1 overexpression, or Cdc25 knockdown impedes regeneration. Read More

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Ultrasound-guided platelet-rich plasma injections for post-traumatic greater occipital neuralgia: study protocol for a pilot randomized controlled trial.

Pilot Feasibility Stud 2021 Jun 22;7(1):130. Epub 2021 Jun 22.

Department of Clinical Neurosciences, Division of Physical Medicine and Rehabilitation, University of Calgary, 1403 29 Street NW, Calgary, Alberta, T2N 2T9, Canada.

Background: Post-traumatic headaches (PTH) are a common sequelae of traumatic brain injury (TBI) and greatly impact patient function and quality of life. Post-traumatic greater occipital neuralgia (GON) is a type of post-traumatic headache. Conventional treatment includes steroid/anesthetic injections which typically alleviate pain but have a short duration of effect. Read More

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Contralateral orbicularis oculi muscle transposition in facial paralysis: functional, aesthetic and electromyographic outcomes. A case report and literature update.

Orbit 2021 Jun 22:1-6. Epub 2021 Jun 22.

Ophthalmology, Príncipe de Asturias University Hospital, Alcalá de Henares, Spain.

: Many surgical approaches have been described for achieving satisfactory functionality in patients with facial paralysis, to ensure the protection of the cornea and the highest degree of physiological blinking. Out of all those available, dynamic techniques are indicated when motion recovery and synchrony are the goals pursued. transposition (OOT) allows a genuine restoration of blinking by means of contralateral reinnervation, with minimal insult for the donor site. Read More

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MicroRNA-30d-5p ameliorates lipopolysaccharide-induced acute lung injury via activating AMPKα.

Immunopharmacol Immunotoxicol 2021 Jun 23:1-12. Epub 2021 Jun 23.

Department of Pulmonary and Critical Care Medicine, Renmin Hospital of Wuhan University, Wuhan, China.

Objectives: Acute lung injury (ALI) is a devastating lung disease characterized by uncontrolled pulmonary inflammation and oxidative stress. Currently, no effective therapeutic strategies are available for ALI and its prognosis remains poor. The present study aims to investigate the role and potential mechanism of microRNA-30d-5p (miR-30d-5p) in the progression of ALI. Read More

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