439,458 results match your criteria injury patients

The 2018 Adult Heart Allocation Policy Change Benefits Low-Volume Transplant Centers.

Clin Transplant 2021 Jun 21. Epub 2021 Jun 21.

Cardiovascular Outcomes Research Laboratories (CORELAB), Division of Cardiac Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.

The effect of the 2018 adult heart allocation policy change at an institution-level remains unclear. The present study assessed the impact of the policy change by transplant center volume. The United Network for Organ Sharing database was queried for all adults undergoing isolated heart transplantation from November 2016 to September 2020. Read More

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C-C motive chemokine ligand 2 and thromboinflammation in COVID-19-associated pneumonia: A retrospective study.

Thromb Res 2021 Jun 8;204:88-94. Epub 2021 Jun 8.

Centro Dipartimentale di Biologia Cellulare Cardiorespiratoria, Dipartimento di Patologia Chirurgica, Medica, Molecolare e dell'Area Critica, University of Pisa, Pisa, Italy; UO Pneumologia, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy. Electronic address:

Purpose: A derangement of the coagulation process and thromboinflammatory events has emerged as pathologic characteristics of severe COVID-19, characterized by severe respiratory failure. CC motive chemokine ligand 2 (CCL2), a chemokine originally described as a chemotactic agent for monocytes, is involved in inflammation, coagulation activation and neoangiogenesis. We investigated the association of CCL2 levels with coagulation derangement and respiratory impairment in patients with COVID-19. Read More

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Evaluation of Injury Recidivism Using the Electronic Medical Record.

J Surg Res 2021 Jun 18;267:217-223. Epub 2021 Jun 18.

Department of Surgery, University of Alabama at Birmingham, Birmingham, AL. Electronic address:

Background: Traumatic injuries remain one of the leading causes of death in the United States. Patients who survive traumatic injuries but return to the emergency department with repeat injuries are said to suffer from injury recidivism. Numerous studies have described trends in injury recidivism using trauma registry and survey data. Read More

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Management and Outcomes after Upper Versus Lower Extremity Vascular Trauma.

Ann Vasc Surg 2021 Jun 18. Epub 2021 Jun 18.

Department of Surgery, Division of Vascular Surgery, Emory University, Atlanta, GA. Electronic address:

Objectives: While significant literature exists regarding peripheral vascular injury management, the vast majority focuses on lower extremity arterial injury. As a result, clinical management of arterial injury in the upper extremities is often guided by literature specific to lower extremity vessel injury. The purpose of this study is to use the largest series of patients reported in the literature to compare management and outcomes of upper and lower extremity traumatic vascular injuries. Read More

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High Mortality and Venous Thromboembolism Risk Following Major Penetrating Abdominal Venous Injuries.

Ann Vasc Surg 2021 Jun 18. Epub 2021 Jun 18.

Division of Vascular Surgery, University of Massachusetts Medical Center, Worcester, MA. Electronic address:

Introduction: Penetrating injuries to the inferior vena cava (IVC) and/or iliac veins are a source of hemorrhage but may also predispose patients to venous thromboembolism (VTE). We sought to determine the relationship between iliocaval injury, VTE and mortality.

Methods: The National Trauma Data Bank was queried for penetrating abdominal trauma from 2015-2017. Read More

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Pulmonary Thrombosis and Thromboembolism in COVID-19.

Hooman D Poor

Chest 2021 Jun 18. Epub 2021 Jun 18.

Division of Pulmonary, Critical Care, and Sleep Medicine, Icahn School of Medicine at Mount Sinai, NY, NY. Electronic address:

Coronavirus disease 2019 (COVID-19), the disease responsible for the devastating pandemic that began at the end of 2019, has been associated with a significantly increased risk of pulmonary thrombosis, even in patients receiving prophylactic anticoagulation. The predilection for thrombosis in COVID-19 may be driven by at least two distinct, but interrelated, processes: a hypercoagulable state responsible for large vessel thrombosis and thromboembolism, and direct vascular and endothelial injury responsible for in situ microvascular thrombosis. The presence of pulmonary thrombosis may explain why hypoxemia is out of proportion to impairment in lung compliance in some patients with COVID-19 pneumonia. Read More

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Drug-induced liver injury associated with severe cutaneous adverse drug reactions: A nationwide study in Taiwan.

Liver Int 2021 Jun 21. Epub 2021 Jun 21.

Division of Gastroenterology and Hepatology, Department of Medicine, Taipei Veterans General Hospital, & National Yang-Ming Chiao Tung University School of Medicine, Taipei, Taiwan.

Background & Aims: Severe cutaneous adverse drug reactions (SCAR) including Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), drug reaction with eosinophilia and systemic symptoms (DRESS) and acute generalized exanthematous pustulosis (AGEP) are high-mortality adverse drug reactions. The risk factors and prognosis of drug-induced liver injury (DILI) concomitant with SCAR warrant clarification. We aimed to evaluate the characteristics and outcomes of DILI with SCAR. Read More

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Associations Between Preoperative Biomarkers and Cardiac Surgery-Associated Acute Kidney Injury in Elderly Patients: A Cohort Study.

Anesth Analg 2021 Jun 21. Epub 2021 Jun 21.

From the Department of Anesthesiology, Intensive Care, and Pain Medicine.

Background: Acute kidney injury (AKI) is associated with mortality after cardiac surgery. Novel risk factors may improve identification of patients at risk for renal injury. The authors evaluated the association between preoperative biomarkers that reflect cardiac, inflammatory, renal, and metabolic disorders and cardiac surgery-associated AKI (CSA-AKI) in elderly patients. Read More

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Evaluation of pelvic circular compression devices in severely injured trauma patients with pelvic fractures.

Prehosp Emerg Care 2021 Jun 21:1-12. Epub 2021 Jun 21.

Department of Trauma and Orthopedic Surgery, University Medical Center, Hamburg-Eppendorf, Martinistrasse 52, 20246, Hamburg, Germany.

The role of pelvic circumferential compression devices (PCCD) is to temporarily stabilize the pelvic ring, reduce its volume and to tamponade bleeding. The purpose of this study was to evaluate the effect of PCCDs on mortality and bleeding in severely injured trauma patients, using a large registry database. We performed a retrospective analysis of all patients registered in the Trauma Register DGU® between 2015 and 2016. Read More

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Analysis of Later Stage Morbidity and Mortality after Pancreatic Surgery Because of Abdominal Trauma.

Surg Infect (Larchmt) 2021 Jun 21. Epub 2021 Jun 21.

Department of General Surgery, Jinling Hospital, Jiangsu Nanjing, China.

Pancreatic trauma surgery is a complicated surgical procedure for severe pancreatic injuries, accompanied by a high incidence of complications and mortality. This study was designed to explore the long-term prognosis of pancreatic surgery because of abdominal trauma. The clinical data of 103 patients who were admitted to Jinling Hospital between August 2012 and August 2019 who had pancreatic trauma surgery were analyzed retrospectively. Read More

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Reno-protective effects of melatonin against vancomycin-related acute kidney injury in hospitalized patients: a retrospective cohort study.

Antimicrob Agents Chemother 2021 Jun 21:AAC0046221. Epub 2021 Jun 21.

Department of Pharmacy Practice and Administration; Ernest Mario School of Pharmacy; Rutgers, The State University of New Jersey; Piscataway, NJ, US.

Vancomycin is associated with nephrotoxicity and the mechanism may in part be related to oxidative stress. and preclinical studies suggest melatonin supplementation decreases oxidative stress. The objective of this study was to evaluate concomitant use of melatonin and vancomycin and the incidence of acute kidney injury (AKI). Read More

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Drug-induced liver injury at a tertiary care centre in Germany: Model for End-stage Liver Disease is the best predictor of outcome.

Liver Int 2021 Jun 21. Epub 2021 Jun 21.

Department of Medicine, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.

Background & Aims: Agents most frequently inducing idiosyncratic drug-induced liver injury (DILI) differ between countries worldwide. Besides, there is no consistent data on the best model predicting mortality or the need for liver transplantation in DILI. We here analysed the DILI cohort of our centre with regard to causative drugs and clinical outcome. Read More

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Increased procedural safety of cryoballoon pulmonary vein isolation with a double 120 seconds freeze protocol.

Pacing Clin Electrophysiol 2021 Jun 21. Epub 2021 Jun 21.

Cardioangiologisches Centrum Bethanien (CCB) / Kardiologie, Medizinische Klinik III, Agaplesion Markus Krankenhaus, Akademisches Lehrkrankenhaus der Goethe-Universität Frankfurt am Main, Frankfurt am Main, Germany.

Background: recently a double 120 seconds freeze cryoballoon (CB) pulmonary vein isolation (PVI) protocol proved to be non inferior to a double 240 seconds freeze protocol in terms of atrial fibrillation recurrences. We hypothesized that this approach could also result in an increased procedure safety.

Methods: 80 consecutive patients treated with a double 120 seconds freeze protocol (Group CB120) were compared with 80 previous consecutive patients treated with a single 240 seconds freeze protocol (Group CB240). Read More

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Salvage neck dissection for isolated neck recurrences in head and neck tumors: Intra and postoperative complications.

J Surg Oncol 2021 Jun 21. Epub 2021 Jun 21.

Head and Neck Oncology and Robotic Surgery, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy.

Background And Objectives: The current evidence regarding complications after salvage neck dissection (ND) for isolated regional recurrences (IRRs) in head and neck cancers is poor. The aim of this study is to evaluate the incidence and differences in complication rates of salvage ND after primary surgery, radiotherapy, chemoradiotherapy, or combined treatments.

Methods: This was a multicentric retrospective study on 64 patients who underwent salvage ND for IRR in three Italian institutes between 2008 and May 2020. Read More

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A 10-year study of penetrating head and neck injury by assault in the North East of England.

Oral Maxillofac Surg 2021 Jun 21. Epub 2021 Jun 21.

Department of Oral and Maxillofacial Surgery, Royal Victoria Infirmary, Queen Victoria Road, Newcastle upon Tyne, NE1 4LP, UK.

Introduction: Assaults inflicting penetrating head and neck trauma have potential for serious morbidity or mortality. This paper studies in-depth all cases treated at a level one trauma centre in the North East of England over 10 years.

Methods: All patients assaulted with sharp implements to the head and neck treated from 2010 to 2019 were identified using clinical codes. Read More

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Efficacy of Smartphone Active and Passive Virtual Reality Distraction vs Standard Care on Burn Pain Among Pediatric Patients: A Randomized Clinical Trial.

JAMA Netw Open 2021 Jun 1;4(6):e2112082. Epub 2021 Jun 1.

Center for Pediatric Trauma Research, Nationwide Children's Hospital, Columbus, Ohio.

Importance: It is unknown whether smartphone-based virtual reality (VR) games are effective in reducing pain among pediatric patients in real-world burn clinics.

Objective: To evaluate the efficacy of a smartphone VR game on dressing pain among pediatric patients with burns.

Design, Setting, And Participants: This randomized clinical trial included children aged 6 to 17 years who seen in the outpatient clinic of a large American Burn Association-verified pediatric burn center and level I pediatric trauma center between December 30, 2016, and January 23, 2019. Read More

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Atypical resting state functional connectivity in mild traumatic brain injury.

Brain Behav 2021 Jun 21. Epub 2021 Jun 21.

Department of Radiology, McGill University Health Centre, Montreal, Quebec, Canada.

Objectives: This study aimed to investigate changes in three intrinsic functional connectivity networks (IFCNs; default mode network [DMN], salience network [SN], and task-positive network [TPN]) in individuals who had sustained a mild traumatic brain injury (mTBI).

Methods: Resting-state functional magnetic resonance imaging (rs-fMRI) data were acquired from 27 mTBI patients with persistent postconcussive symptoms, along with 26 age- and sex-matched controls. These individuals were recruited from a Level-1 trauma center, at least 3 months after a traumatic episode. Read More

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The Intraseptal Course of the Superficial Peroneal Nerve: An Anatomic Study[Formula: see text].

Foot Ankle Int 2021 Jun 19:10711007211002508. Epub 2021 Jun 19.

Service de Chirurgie Orthopédique et Traumatologie de l'appareil locomoteur Hôpitaux Universitaires de Genève, Geneva, Switzerland.

Background: Anatomic and clinical studies show many variants of the superficial peroneal nerve (SPN) course and branching within the compartments and at the suprafascial layer. The anatomy of the transition zone from the compartment to the subcutaneous layer has been occasionally described in the literature, mainly in studies reporting the intraseptal SPN variant in 6.6% to 13. Read More

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Postoperative Myocardial Injury in Patients Classified as Low Risk Preoperatively Is Associated With a Particularly Increased Risk of Long-Term Mortality After Noncardiac Surgery.

J Am Heart Assoc 2021 Jun 19:e019379. Epub 2021 Jun 19.

Department of Medicine Heart and Vascular Center MetroHealth Medical Center Case Western Reserve University School of Medicine Cleveland OH.

Background Prior studies have shown an association between myocardial injury after noncardiac surgery (MINS) and all-cause mortality in patients following noncardiac surgery. However, the association between preoperative risk assessments, Revised Cardiac Risk Index and American College of Surgeons National Surgical Quality Improvement Program, and postoperative troponin elevations and long-term mortality is unknown. Methods and Results A retrospective chart review identified 548 patients who had a troponin I level drawn within 14 days of noncardiac surgery that required an overnight hospital stay. Read More

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Exertional rhabdomyolysis in newly enrolled cadets of a military academy.

Muscle Nerve 2021 Jun 20. Epub 2021 Jun 20.

Medical School of Chinese PLA, Beijing, China.

Introduction/aims: Exertional rhabdomyolysis (ER) often occurs during prolonged intense exercise in hot environments, posing a threat to the health of military personnel. This study aimed to investigate possible risk factors for ER and provide further empirical data for prevention and clinical treatment strategies.

Methods: A retrospective investigation of 116 concurrent ER cases was conducted. Read More

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Association Between Perineal Burns Injury and In-hospital Mortality: A Retrospective Observational Study from the Nation-Wide Burn Registry in Japan.

J Burn Care Res 2021 Jun 3. Epub 2021 Jun 3.

Department of Emergency and Critical Care Medicine, University of Tsukuba Hospital, Ibaraki, Japan.

Although perineal burn injury is included in the burn center referral criteria for Advanced Burn Life Support, clinical evidence that perineal burn injury increases mortality risk is limited, especially from Asian countries. The objective of this study was to investigate whether perineal burns affect in-hospital mortality. Using data from the nation-wide burn registry collected from April 1, 2011 to March 31, 2019, we retrospectively identified 10,179 hospitalized burn patients over 16 years of age. Read More

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Impact of pre-existing heart failure on 60-day outcomes in patients hospitalized with COVID-19.

Am Heart J Plus 2021 Jun 15:100022. Epub 2021 Jun 15.

Division of Cardiology, Rush University Medical Center, Chicago, IL, United States of America.

Background: In the coronavirus disease 2019 (COVID-19) global pandemic, patients with cardiovascular disease represent a vulnerable population with higher risk for contracting COVID-19 and worse prognosis with higher case fatality rates. However, the relationship between COVID-19 and heart failure (HF) is unclear, specifically whether HF is an independent risk factor for severe infection or if other accompanying comorbidities are responsible for the increased risk.

Methods: This is a retrospective analysis of 1331 adult patients diagnosed with COVID-19 infection between March and June 2020 admitted at Rush University System for Health (RUSH) in metropolitan Chicago, Illinois, USA. Read More

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Hepatocyte proteomes reveal the role of protein disulfide isomerase 4 in alpha 1-antitrypsin deficiency.

JHEP Rep 2021 Aug 24;3(4):100297. Epub 2021 Apr 24.

University of Bordeaux, CNRS, INSERM, BaRITOn, U1053, Bordeaux, France.

Background & Aims: A single point mutation in the Z-variant of alpha 1-antitrypsin (Z-AAT) alone can lead to both a protein folding and trafficking defect, preventing its exit from the endoplasmic reticulum (ER), and the formation of aggregates that are retained as inclusions within the ER of hepatocytes. These defects result in a systemic AAT deficiency (AATD) that causes lung disease, whereas the ER-retained aggregates can induce severe liver injury in patients with ZZ-AATD. Unfortunately, therapeutic approaches are still limited and represents the option To overcome this limitation, a better understanding of the molecular basis of ER aggregate formation could provide new strategies for therapeutic intervention. Read More

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Aramchol downregulates stearoyl CoA-desaturase 1 in hepatic stellate cells to attenuate cellular fibrogenesis.

JHEP Rep 2021 Jun 28;3(3):100237. Epub 2021 Jan 28.

Division of Liver Diseases, Liver Cancer Program, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Background & Aims: Aramchol is a fatty acid-bile acid conjugate that reduces liver fat content and is being evaluated in a phase III clinical trial for non-alcoholic steatohepatitis (NASH). Aramchol attenuates NASH in mouse models and decreases steatosis by downregulating the fatty acid synthetic enzyme stearoyl CoA desaturase 1 (SCD1) in hepatocytes. Although hepatic stellate cells (HSCs) also store lipids as retinyl esters, the impact of Aramchol in this cell type is unknown. Read More

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Pattern of trauma admission and outcome among patients presented to Jimma University Specialized Hospital, south-western Ethiopia.

Trauma Surg Acute Care Open 2021 3;6(1):e000609. Epub 2021 Jun 3.

Surgery, Jimma University, College of Public Health and Medical Sciences, Jimma, Ethiopia.

Background: Trauma is an ever evolving world problem that needs close attention and devising means to prevent and treat. The aim of the study is to identify the main reason for trauma admissions and assess the patient outcome after intervention. Therefore, knowing its actual nature might aid in postulating possible intervention as well as prevention measures. Read More

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The Incidence of Common Complications, Including Ectropion and Entropion, in Transconjunctival and Subciliary Approaches for Treatment of ZMC Fractures.

J Dent (Shiraz) 2021 Jun;22(2):76-81

Resident Dept. of Oral and Maxillofacial Surgery, Sina hospital, Craniomaxillofacial Research Center, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Statement Of The Problem: Treating zygomaticomaxillary complex fractures (ZMC Fx) can result in postoperative complications that should be minimized by choosing the best surgical approach.

Purpose: This study compared incidence rates of some common postoperative complications with emphasis on ectropion (an outward curling of the lower eyelid) and entropion (an inward curling of the lower eyelid) occurring with transconjunctival or subciliary approaches for the treatment of ZMC fractures.

Materials And Method: This prospective study enrolled 80 patients with ZMC Fx who had been surgically treated. Read More

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Scrub Sponge as A Wound Debridement Device.

Mehdi Ayaz

Bull Emerg Trauma 2021 Apr;9(2):96-100

Amiralmomenin Hospital, Shiraz Burn Research Center, Department of Surgery, Shiraz University of Medical Science, Shiraz, Iran.

Introduction: Wound debridement is necessary before skin grafting or wound closure. Inappropriate wound bed preparation will led to graft rejection and sometimes catastrophic results, especially in large wounds,. Usage of popular debridement and excision devices such as dermatomes has some difficulties and disadvantages. Read More

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Ketamine Sub-Dissociative Dose Vs. Morphine Sulfate for Acute Pain Control in Patients with Isolated Limb Injuries in the Emergency Department: A Randomized, Double-blind, Clinical Trial.

Bull Emerg Trauma 2021 Apr;9(2):73-79

Prehospital and Hospital Emergency Research Center, Department of Emergency Medicine, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran.

Objective: To compare the ketamine efficacy at a sub-dissociative morphine dose to reduce pain in isolated limb traumatic injuries.

Methods: A double-blind randomized clinical trial study was carried out on patients referred to emergency departments (EDs) due to isolated limb traumatic injuries. Eligible patients were divided into two groups which one group received 0. Read More

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Impact and Modifications of In-Hospital Trauma Care Workflow Due to COVID 19 Pandemic: Lessons Learnt for the Future.

Bull Emerg Trauma 2021 Apr;9(2):60-66

Division of Trauma Surgery and Critical Care, Jai Prakash Narayan Apex Trauma Centre, AIIMS, New Delhi, India.

Objective: To describe the restructuring in-hospital systems of care at a Level -1 trauma center in India and to analyze an injury volume and patterns for future preparedness as well as to establish a specific injuries preventive measures during health emergencies like COVID-19.

Methods: Data was extracted from a prospectively managed trauma registry at level-1 trauma center in India. We have compared the data in lockdown period with the same day's number from the pre-lockdown period. Read More

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