110,575 results match your criteria injury decreased

Stroke-related alterations in inter-areal communication.

Neuroimage Clin 2021 Sep 11;32:102812. Epub 2021 Sep 11.

Institut de Neurosciences de la Timone UMR 7289, Aix Marseille Université, CNRS, Marseille 13005, France. Electronic address:

Beyond causing local ischemia and cell damage at the site of injury, stroke strongly affects long-range anatomical connections, perturbing the functional organization of brain networks. Several studies reported functional connectivity abnormalities parallelling both behavioral deficits and functional recovery across different cognitive domains. FC alterations suggest that long-range communication in the brain is altered after stroke. Read More

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September 2021

Early detection relationship of cerebral palsy markers using brain structure and general movements in infants born <32 weeks gestational age.

Early Hum Dev 2021 Aug 25;163:105452. Epub 2021 Aug 25.

Department of Rehabilitation, Children's Hospital, Fudan University, Shanghai 201102, China.

Aim: To detect early brain structural and clinical functional markers of brain injury and development based on a magnetic resonance imaging (MRI) scoring system and a general movement assessment (GMA) for preterm infants later diagnosed with cerebral palsy (CP).

Study Design: Retrospective cohort study. General movements (GMs) were scored according to a semiquantitative scoring system: the GMs optimality score (GMOS) at preterm and term ages and the Motor Optimality Score (MOS) at the corrected age of 3 months after birth. Read More

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Reevaluating clinical assessment outcomes after unrestricted return to play following sport-related concussion.

Brain Inj 2021 Sep 20:1-7. Epub 2021 Sep 20.

UVA Department of Kinesiology, The University of Virginia, Charlottesville, Virginia, USA.

Primary Objective: The objective of this study was to examine neurocognition, postural control, and symptomology at multiple timepoints following concussion. We hypothesized that collegiate athletes would perform similar to or better than their baseline in terms of each outcome at both timepoints.

Research Design: This was a retrospective study of 71 collegiate athletes (18. Read More

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September 2021

Pre-injury chronic alcohol abuse predicts intracranial hemorrhagic progression, unfavorable clinical outcome, and mortality in severe traumatic brain injury.

Brain Inj 2021 Sep 20:1-8. Epub 2021 Sep 20.

Department of Neuroscience, Section of Neurosurgery, Uppsala University, Uppsala, Sweden.

Objective: We aimed to determine the incidence of pre-injury alcohol abuse in TBI at our neurointensive care unit (NICU), the relation to intracranial hemorrhage evolution, and clinical outcome.

Methods: Patients with TBI treated at our NICU at Uppsala university hospital, Sweden, 2008-2018, were included. Clinical, radiological, and outcome variables were evaluated. Read More

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September 2021

Neural stem cell treatment for perinatal brain injury: A systematic review and meta-analysis of preclinical studies.

Stem Cells Transl Med 2021 Sep 20. Epub 2021 Sep 20.

The Ritchie Centre, Hudson Institute of Medical Research, Clayton, Victoria, Australia.

Perinatal brain injury can lead to significant neurological and cognitive deficits and currently no therapies can regenerate the damaged brain. Neural stem cells (NSCs) have the potential to engraft and regenerate damaged brain tissue. The aim of this systematic review was to evaluate the preclinical literature to determine whether NSC administration is more effective than controls in decreasing perinatal brain injury. Read More

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September 2021

Upregulation of miR‑335 exerts protective effects against sepsis‑induced myocardial injury.

Mol Med Rep 2021 Nov 20;24(5). Epub 2021 Sep 20.

Department of Clinic, Medicine School, Changsha Social Work College, Changsha, Hunan 410004, P.R. China.

Septicemia is associated with excessive inflammation, oxidative stress and apoptosis, causing myocardial injury that results in high mortality and disability rates worldwide. The abnormal expression of multiple microRNAs (miRNAs/miRs) is associated with more severe sepsis‑induced myocardial injury (SIMI) and miR‑335 has been shown to protect cardiomyocytes from oxidative stress. The present study aimed to investigate the role of miR‑335 in SIMI. Read More

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November 2021

Hypophosphatemia is an independent risk factor for AKI among hospitalized patients with COVID-19 infection.

Ren Fail 2021 Dec;43(1):1329-1337

Department of Nephrology, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai, China.

Background: This study sought to investigate incidence and risk factors for acute kidney injury (AKI) in hospitalized COVID-19.

Methods: In this retrospective study, we enrolled 823 COVID-19 patients with at least two evaluations of renal function during hospitalization from four hospitals in Wuhan, China between February 2020 and April 2020. Clinical and laboratory parameters at the time of admission and follow-up data were recorded. Read More

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December 2021

Morphological and Molecular Evaluation of the Tissue Repair following Nasal Septum Biopsy in a Sheep Model.

Cartilage 2021 Sep 19:19476035211046040. Epub 2021 Sep 19.

Department of Biology, Faculty of Science, University of Zagreb, Zagreb, Croatia.

Objective: Nasal septal pathologies requiring surgical intervention are common in the population. Additionally, nasal chondrocytes are becoming an important cell source in cartilage tissue engineering strategies for the repair of articular cartilage lesions. These procedures damage the nasal septal cartilage whose healing potential is limited due to its avascular, aneural, and alymphatic nature. Read More

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September 2021

Autophagy gene ATG7 regulates albumin transcytosis in renal tubule epithelial cells.

Am J Physiol Renal Physiol 2021 Sep 20. Epub 2021 Sep 20.

Department of Medicine and Clinical Science, Graduate School of Medical Sciences, grid.177174.3Kyushu University, Fukuoka, Fukuoka, Japan.

Receptor-mediated albumin transport in proximal tubule epithelial cells (PTECs) is important to control proteinuria. Autophagy is an evolutionarily conserved degradation pathway and its role in intracellular trafficking through interaction with the endocytic pathway has recently been highlighted. Here, we determined whether autophagy regulates albumin transcytosis in PTECs and suppresses albumin-induced cytotoxicity using human proximal tubule (HK-2) cells. Read More

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September 2021

Effects of time on differential leucocyte counts and biochemical parameters of ovariohysterectomy, gastrotomy and intestinal resection and anastomosis in Nigerian indigenous dogs.

Vet Anim Sci 2021 Dec 30;14:100203. Epub 2021 Aug 30.

Department of Veterinary Surgery and Diagnostic Imaging, College of Veterinary Medicine, Federal University of Agriculture, Makurdi, Benue State, Nigeria.

Differential leucocytes counts and some biochemical parameters could be affected over time by surgical procedures leading to kidney failure. Hence this study evaluates the effects of ovariohysterectomy (OVH), gastrotomy (GAT) and intestinal resection and anastomosis (ITR) on differential leucocyte counts and some biochemical parameters in Nigerian dogs. Twelve dogs of both sexes weighing 10. Read More

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December 2021

Baicalin improves podocyte injury in rats with diabetic nephropathy by inhibiting PI3K/Akt/mTOR signaling pathway.

Open Med (Wars) 2021 2;16(1):1286-1298. Epub 2021 Sep 2.

Department of Neurology, Shenzhen Fuyong People's Hospital, Shenzhen, Guangdong 518103, China.

Objective: To investigate the effect of baicalin on diabetic nephropathy (DN) rats and podocytes and its mechanism.

Methods: The rat models with DN were established by high-fat and high-sugar diet and intraperitoneal injection of streptozotocin. The fasting blood glucose (FBG) and weight of rats in each group were measured at 0, 1, 2, 3, and 4 weeks. Read More

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September 2021

Perilipin 2 Impacts Acute Kidney Injury via Regulation of PPAR.

J Immunol Res 2021 9;2021:9972704. Epub 2021 Sep 9.

Department of Nephrology, Zhongshan Hospital, Fudan University, Shanghai, China.

Renal ischemia-reperfusion (I/R) can induce oxidative stress and injury via the generation of reactive oxygen species (ROS). Renal proximal tubular cells are susceptible to oxidative stress, and the dysregulation of renal proximal tubular cellular homeostasis can damage cells via apoptotic pathways. A recent study showed that the generation of ROS can increase perilipin 2 (Plin2) expression in HepG2 cells. Read More

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September 2021

Superimposition of metabolic syndrome magnifies post-stenotic kidney injury in dyslipidemic pigs.

Am J Transl Res 2021 15;13(8):8965-8976. Epub 2021 Aug 15.

Division of Nephrology and Hypertension, Mayo Clinic Rochester, MN 55905, The United States.

Background: Dyslipidemia aggravates kidney injury distal to atherosclerotic renal artery stenosis (ARAS). Besides dyslipidemia, metabolic syndrome (MetS) also involves development of obesity and insulin-resistance (IR). We hypothesized that concurrent obesity and IR magnify swine stenotic-kidney damage beyond dyslipidemia. Read More

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lncRNA PART1 mitigates MPP-induced neuronal injury in SH-SY5Y cells via micRNA-106b-5p/MCL1 axis.

Am J Transl Res 2021 15;13(8):8897-8908. Epub 2021 Aug 15.

Department of Orthopedics, The First Affiliated Hospital, Harbin Medical University Harbin, Heilongjiang Province, China.

Objective: Parkinson's disease (PD) is a neurodegenerative disease caused by the loss of dopaminergic neurons. Here, we aimed to explore the function of LncRNA PART1 in PD and its underlying mechanisms.

Methods: An MPTP-induced mouse model of PD was generated and the SH-SY5Y cells were treated with MPP to induce neuronal damage . Read More

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High uric acid promotes mitophagy through the ROS/CaMKIIδ/Parkin pathway in cardiomyocytes and .

Am J Transl Res 2021 15;13(8):8754-8765. Epub 2021 Aug 15.

Department of Cardiology, The Second Affiliated Hospital of Shantou University Medical College Shantou, Guangdong Province, China.

Background: Increasing evidence has suggested that high uric acid (HUA) is closely related to cardiovascular disease (CVD). Mitophagy abnormalities have been reported to participate in multiple pathogenic processes of CVD. However, the potential molecular mechanisms remain unclear. Read More

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Neuroprotective role of epigallocatechin-3-gallate in acute glaucoma via the nuclear factor-κB signalling pathway.

Exp Ther Med 2021 Nov 31;22(5):1235. Epub 2021 Aug 31.

Department of Ophthalmology, The Third Xiangya Hospital of Central South University, Changsha, Hunan 410013, P.R. China.

Glaucoma is a disease involving impaired visual function accompanied by degeneration and necrosis of the optic nerve. Epigallocatechin-3-gallate (EGCG) exerts a neuroprotective effect against the degeneration of retinal ganglion cells. However, whether EGCG can relieve glaucoma and the possible mechanisms remain unclear. Read More

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November 2021

Strategies to Improve the Quality and Freshness of Human Bone Marrow-Derived Mesenchymal Stem Cells for Neurological Diseases.

Stem Cells Int 2021 8;2021:8444599. Epub 2021 Sep 8.

Department of Physiology, Ajou University School of Medicine, Suwon, Republic of Korea.

Human bone marrow-derived mesenchymal stem cells (hBM-MSCs) have been studied for their application to manage various neurological diseases, owing to their anti-inflammatory, immunomodulatory, paracrine, and antiapoptotic ability, as well as their homing capacity to specific regions of brain injury. Among mesenchymal stem cells, such as BM-MSCs, adipose-derived MSCs, and umbilical cord MSCs, BM-MSCs have many merits as cell therapeutic agents based on their widespread availability and relatively easy attainability and in vitro handling. For stem cell-based therapy with BM-MSCs, it is essential to perform ex vivo expansion as low numbers of MSCs are obtained in bone marrow aspirates. Read More

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September 2021

High-Fat Diet Increased Oxidative Stress and Mitochondrial Dysfunction Induced by Renal Ischemia-Reperfusion Injury in Rat.

Front Physiol 2021 3;12:715693. Epub 2021 Sep 3.

School of Chemical and Biotechnology, SASTRA Deemed University, Thanjavur, India.

Renal ischemia-reperfusion (IR) injury is one of the major causes of acute kidney injury influenced by the ischemic duration and the presence of comorbidities. Studies have reported that high-fat diet consumption can induce renal lipotoxicity and metabolic dyshomeostasis that can compromise the vital functions of kidney. This study aimed to evaluate the impact of a high-fat diet in the recovery of renal tissue from IR and explored the cellular pathology. Read More

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September 2021

Esculetin Alleviates Acute Liver Failure following Lipopolysaccharide/D-Galactosamine in Male C57BL/6 Mice.

Iran J Med Sci 2021 Sep;46(5):373-382

Neurophysiology Research Center, Shahed University, Tehran, Iran.

Background: Acute liver failure (ALF) is a fatal clinical situation that rapidly leads to the loss of normal liver function. Esculetin is a natural herbal compound used for the management of various diseases such as cardiovascular and renal disorders. In this study, we evaluated the protective effects of esculetin in a mouse model of ALF. Read More

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September 2021

Racial Disparities in Triage of Adolescent Patients After Bullet Injury.

J Trauma Acute Care Surg 2021 Sep 14. Epub 2021 Sep 14.

Department of Surgery, Washington University in St. Louis School of Medicine, St. Louis, MO President of Power4STL.

Introduction: While pediatric trauma centers (PTCs) and adult trauma centers (ATCs) exhibit equivalent trauma mortality, the optimal care environment for traumatically injured adolescents remains controversial. Race has been shown to effect triage within emergency departments (EDs) with people of color receiving lower acuity triage scores. We hypothesized that African-American adolescents were more likely triaged to an ATC than a PTC compared to their Caucasian peers. Read More

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September 2021

The α-globin Chain of Hemoglobin Potentiates Tissue Plasminogen Activator Induced Hyperfibrinolysis in vitro.

J Trauma Acute Care Surg 2021 Sep 16. Epub 2021 Sep 16.

Department of Surgery, School of Medicine University of Colorado Denver, Aurora Department of Surgery, Denver Health Medical Center, Denver Department of Biochemistry and Molecular Genetics Department of Pediatrics, School of Medicine University of Colorado Denver, Aurora Vitalant Research Institute, Vitalant Mountain Division, Denver, CO.

Background: Severe injury predisposes patients to trauma-induced coagulopathy (TIC), which may be subdivided by the state of fibrinolysis. Systemic hyperfibrinolysis (HF) occurs in ~25% of these patients with mortality as high as 70%. Severe injury also causes the release of numerous intracellular proteins which may affect coagulation, one of which is hemoglobin, and hemoglobin substitutes induce HF in vitro. Read More

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September 2021

Effect of the "Time to Surgery" on Civil Cranial Gunshot Injuries: Syria War.

J Craniofac Surg 2021 Sep 17. Epub 2021 Sep 17.

Department of Neurosurgery, Faculty of Medicine, Usak University, Usak Kutahya Health Sciences University, Training and Research Center, Kutahya Department of Neurosurgery, Private OFM Antalya Hospital, Antalya, Turkey.

Abstract: Studies on cranial gunshot injuries in the Syrian war are present in the literature. However, the effect of surgical timing on the clinical outcomes of patients undergoing surgical treatment has not been discussed extensively. In this study, the time from injury to surgery is called "time to surgery. Read More

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September 2021

Amniotic fluid-derived extracellular vesicles: characterization and therapeutic efficacy in an experimental model of bronchopulmonary dysplasia.

Cytotherapy 2021 Sep 17. Epub 2021 Sep 17.

Organicell Regenerative Medicine, Inc, Miami, Florida, USA.

Background Aims: Extracellular vesicles (EVs) are being tested for their use as novel therapeutics. However, the optimal source of EVs is currently under investigation. Amniotic fluid (AF) is a natural source of EVs that can be easily obtained for use in regenerative medicine, yet AF-EV characterization has not been fully explored. Read More

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September 2021

A new Mfn-2 related synthetic peptide promotes vascular smooth muscle cell apoptosis via regulating the mitochondrial apoptotic pathway by inhibiting Akt signaling.

J Transl Med 2021 Sep 19;19(1):395. Epub 2021 Sep 19.

Department of Cardiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.

Background: Restenosis after angioplasty is a major challenge for the treatment of coronary artery diseases. Facilitation of vascular smooth muscle cell (VSMC) apoptosis may be an attractive approach to decrease the incidence of restenosis. We synthesized a 16-amino acid mitofusin-2 (Mfn-2) gene related peptide (MRSP) based on the sequence of the p21 signature motif, the smallest functional sequence of the Mfn-2 gene with proapoptotic properties in VSMC. Read More

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September 2021

Heterogeneous distribution of mature olfactory sensory neurons in human olfactory epithelium.

Int Forum Allergy Rhinol 2021 Sep 19. Epub 2021 Sep 19.

Department of Otorhinolaryngology and Head and Neck Surgery, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo, Japan.

Background: The olfactory cleft (OC) comprising the olfactory epithelium (OE) is the most important anatomical location for olfactory function. Endoscopic sinus surgery (ESS) is used to treat diseases related to the OC and improve olfactory dysfunction. However, iatrogenic OE injury occasionally occurs. Read More

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September 2021

The role of bone morphogenetic protein 4 in corneal injury repair.

Exp Eye Res 2021 Sep 16:108769. Epub 2021 Sep 16.

Eye Center, The Second Hospital of Jilin University, Changchun, 130041, China. Electronic address:

Purpose: Corneal injury may cause neovascularization and lymphangiogenesis in cornea which have a detrimental effect to vision and even lead to blindness. Bone morphogenetic protein 4 (BMP4) regulates a variety of biological processes, which is closely relevant to the regulation of corneal epithelium and angiogenesis. Herein, we aimed to evaluate the effect of BMP4 on corneal neovascularization (CNV), corneal lymphangiogenesis (CL), corneal epithelial repair, and the role of BMP4/Smad pathway in these processes. Read More

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September 2021

Lacticaseibacillus rhamnosus TR08 alleviated intestinal injury and modulated microbiota dysbiosis in septic mice.

BMC Microbiol 2021 Sep 18;21(1):249. Epub 2021 Sep 18.

Department of Critical Care Medicine, Jinling Hospital of Nanjing Medical University, 305 East Zhongshan Road, Nanjing, 225001, China.

Background: Probiotics are widely used in intestinal microbiota imbalance caused by sepsis, however, the protective mechanism is still unclear. This study aimed to explore protective effect of Lacticaseibacillus rhamnosus TR08 on intestinal injury in septic mice.

Results: The levels of serum inflammatory factors were reduced significantly in septic mice treated with L. Read More

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September 2021

[Metabolic disorders of chronically critically ill patients caused by consequences of traumatic brain injury].

Vopr Pitan 2021 22;90(4):103-111. Epub 2021 Jul 22.

Federal Research and Clinical Center for Resuscitation and Rehabilitation, 107031, Moscow, Russian Federation.

The problem of chronic critical illness therapy is relevant all over the world. Revealing the metabolic function in patients in chronic critical condition is an important link in the development of adequate treatment and rehabilitation tactics. - identification of metabolic features in chronic critical patients after brain injury in the first 3 days from the moment of admission to the rehabilitation center. Read More

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Acute kidney injury and in-hospital mortality in patients with ST-elevation myocardial infarction of different age groups.

Int J Cardiol 2021 Sep 16. Epub 2021 Sep 16.

Centro Cardiologico Monzino IRCCS, Milan, Italy. Electronic address:

Background: Acute kidney injury (AKI) is a well-known complication of ST-elevation acute myocardial infarction (STEMI) with an adverse impact on prognosis. Since AKI develops more frequently in elderly patients, we hypothesized that its higher incidence in older STEMI patients might explain their increased in-hospital mortality. We assessed the relationship between AKI and in-hospital mortality in patients with STEMI of different age groups. Read More

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September 2021

Luteolin attenuates lipopolysaccharide-induced acute lung injury/acute respiratory distress syndrome by activating alveolar epithelial sodium channels via cGMP/PI3K pathway.

J Ethnopharmacol 2021 Sep 16:114654. Epub 2021 Sep 16.

Department of Stem Cells and Regenerative Medicine, College of Basic Medical Science, China Medical University, Shenyang, China. Electronic address:

Ethnopharmacological Relevance: Luteolin (Lut) was recently identified as the major active ingredient of Mosla scabra, which was a typical representative traditional Chinese medicine and had been used to treat pulmonary diseases for thousands of years.

Aim Of The Study: This study was to explore the effects and relative mechanisms of Lut in LPS-induced acute lung injury/acute respiratory distress syndrome (ALI/ARDS). The main characteristic of ALI/ARDS is pulmonary edema, and epithelial sodium channel (ENaC) is a key factor in effective removal of excessive alveolar edematous fluid, which is essential for repairing gas exchange and minimizing damage to the peripheral tissues. Read More

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September 2021