J Trauma Acute Care Surg 2021 Sep 16. Epub 2021 Sep 16.
Department of Surgery, School of Medicine University of Colorado Denver, Aurora Department of Surgery, Denver Health Medical Center, Denver Department of Biochemistry and Molecular Genetics Department of Pediatrics, School of Medicine University of Colorado Denver, Aurora Vitalant Research Institute, Vitalant Mountain Division, Denver, CO.
Background: Severe injury predisposes patients to trauma-induced coagulopathy (TIC), which may be subdivided by the state of fibrinolysis. Systemic hyperfibrinolysis (HF) occurs in ~25% of these patients with mortality as high as 70%. Severe injury also causes the release of numerous intracellular proteins which may affect coagulation, one of which is hemoglobin, and hemoglobin substitutes induce HF in vitro. Read More