217,584 results match your criteria injury compared

Functional significance of 8-isoprostanes in sinonasal disease and asthma.

Respir Med 2021 Jun 9;185:106506. Epub 2021 Jun 9.

Larner College of Medicine, University of Vermont, Burlington, VT, USA. Electronic address:

Background: The purpose of this study was to investigate how 8-isoprostanes, used as a marker of airway oxidative stress, were related to sinus disease and asthma.

Methods: We analyzed samples and data from two separate studies, one investigating sinonasal disease in asthma, the other investigating the effect of BMI on airway disease. We measured airway (nasal lavage) 8-isoprostanes and investigated the relationship with measures of sinus and asthma symptoms, asthma control and lung function. Read More

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Effective connectivity between emotional and motor brain regions in people with psychogenic nonepileptic seizures (PNES).

Epilepsy Behav 2021 Jun 21;122:108085. Epub 2021 Jun 21.

Medical Physics and Biomedical Engineering Department, Tehran University of Medical Sciences (TUMS), Tehran, Iran; Physical Medicine and Rehabilitation Department, Northwestern University, United States. Electronic address:

Objective: To characterize the effective connectivity (EC) between the emotion and motor brain regions in patients with psychogenic nonepileptic seizures (PNES), based on resting-state spectral dynamic causal modeling (spDCM).

Methods: Twenty-three patients with PNES and twenty-five healthy control (HC) subjects underwent resting-state fMRI scanning. The coupling parameters indicating the causal interactions between eight brain regions associated with emotion, executive control, and motion were estimated for both groups, using resting-state fMRI spDCM. Read More

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Thalamic Deep Brain Stimulation for Post-Traumatic Neuropathic Limb Pain: Efficacy at Five Years' Follow-Up and Effective Volume of Activated Brain Tissue.

Neurochirurgie 2021 Jun 21. Epub 2021 Jun 21.

Faculdade de Medicina da Universidade do Porto, Portugal; Neurosciences Research Centre, Institute of Molecular and Clinical Neurosciences, St. George's, University of London, London, United Kingdom.

Chronic neuropathic pain affects 7%-10% of the population. Deep brain stimulation (DBS) has shown variable but promising results in its treatment. This study prospectively assessed the long-term effectiveness of DBS in a series of patients with chronic neuropathic pain, correlating clinical results with neuroimaging. Read More

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Association of Acute Kidney Injury Receiving Kidney Replacement Therapy With Prognosis of Critically Ill Patients With and Without Cancer: A Retrospective Study.

Crit Care Med 2021 Jun 24. Epub 2021 Jun 24.

Department of Medicine III, Division of Nephrology, Medical University of Vienna, Vienna, Austria. Division of General Anaesthesiology, Emergency and Intensive Care Medicine, Medical University of Graz, Graz, Austria. Department of Medicine I, Intensive Care Unit, Medical University of Vienna, Vienna, Austria. Austrian Center for Documentation and Quality Assurance in Intensive Care (ASDI), Vienna, Austria. Center for Medical Statistics, Informatics, and Intelligent Systems, Medical University of Vienna, Vienna, Austria.

Objectives: To assess outcomes of cancer patients receiving kidney replacement therapy due to acute kidney injury in ICUs and compare these with other patient groups receiving kidney replacement therapy in ICUs.

Design: Retrospective registry analysis.

Setting: Prospectively collected database of 296,424 ICU patients. Read More

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Pattern of Brain Injury in Patients With Thrombotic Thrombocytopenic Purpura in the Precaplacizumab Era.

Crit Care Med 2021 Jun 24. Epub 2021 Jun 24.

Service de Médecine Intensive-Réanimation, Hôpital Saint-Louis, APHP, Paris, France. Université de Paris, Paris, France. Service de réanimation médico-chirurgicale, Centre Hospitalier de Versailles - Site André Mignot, Le Chesnay, France. Service d'Hématologie Biologique, Hôpital Lariboisière, APHP, Paris, France. Department of Clinical Immunology, Hôpital Saint-Louis, APHP, Paris, France. Hématologie, Hôpital Saint-Antoine, AP-HP, Sorbonne University, Paris, France. Sorbonne Université, Paris, France.

Objectives: To describe short- and long-term neurologic prognosis of patients with thrombotic thrombocytopenic purpura and to identify clusters associated with evolution.

Design: Prospective French cohort.

Setting: ICU in a reference center. Read More

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Validity of Research Based on Public Data in Sports Medicine: A Quantitative Assessment of Anterior Cruciate Ligament Injuries in the National Football League.

Am J Sports Med 2021 Jun 24:3635465211015435. Epub 2021 Jun 24.

Department of Orthopaedic Surgery, Washington University School of Medicine, Saint Louis, Missouri, USA.

Background: Numerous researchers have leveraged publicly available Internet sources to publish publicly obtained data (POD) studies concerning various orthopaedic injuries in National Football League (NFL) players.

Purpose: To provide a comprehensive systematic review of all POD studies regarding musculoskeletal injuries in NFL athletes and to use anterior cruciate ligament (ACL) injuries in NFL players to quantify the percentage of injuries identified by these studies.

Study Design: Systematic review; Level of evidence, 4. Read More

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Analysis of genes associated with proinflammatory and profibrotic pathways upregulated in ischemia-induced chronic kidney disease in cats.

Am J Vet Res 2021 Jul;82(7):589-597

Objective: To use RNA sequencing (RNAseq) to characterize renal transcriptional activities of genes associated with proinflammatory and profibrotic pathways in ischemia-induced chronic kidney disease (CKD) in cats.

Samples: Banked renal tissues from 6 cats with experimentally induced CKD (renal ischemia [RI] group) and 9 healthy cats (control group).

Procedures: Transcriptome analysis with RNAseq, followed by gene ontology and cluster analyses, were performed on banked tissue samples of the right kidneys (control kidneys) from cats in the control group and of both kidneys from cats in the RI group, in which unilateral (right) RI had been induced 6 months before the cats were euthanized and the ischemic kidneys (IKs) and contralateral nonischemic kidneys (CNIKs) were harvested. Read More

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Effect of strict intraoperative blood pressure management strategy on postoperative acute kidney injury in non-cardiac surgery: a meta-analysis of randomised controlled trials.

Int J Clin Pract 2021 Jun 24:e14570. Epub 2021 Jun 24.

Department of Anesthesiology, Huashan Hospital of Fudan University.

Background: Acute kidney injury (AKI) is one of the most serious perioperative complications. 20% to 40% of high-risk patients who undergo non-cardiac surgery have AKI and those with AKI are eight-times more likely to die within 30 days after surgery. It may be related to intraoperative hypotension, which is mainly caused by vasodilatory and cardiodepressant effects of anaesthesia, and/or hypovolemia. Read More

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Neurological Instability in Ischemic Stroke: Relation with Outcome, Latency Time, and Molecular Markers.

Transl Stroke Res 2021 Jun 24. Epub 2021 Jun 24.

Clinical Neurosciences Research Laboratory, Health Research Institute of Santiago de Compostela (IDIS), 15706, Santiago de Compostela, Spain.

The National Institutes of Health Stroke Scale (NIHSS) is commonly used to evaluate stroke neurological deficits and to predict the patient's outcome. Neurological instability (NI), defined as the variation of the NIHSS in the first 48 h, is a simple clinical metric that reflects dynamic changes in the area of the brain affected by the ischemia. We hypothesize that NI may represent areas of cerebral instability known as penumbra, which could expand or reduce brain injury and its associated neurological sequels. Read More

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Intravitreally Injected Methylene Blue Protects Retina against Acute Ocular Hypertension in Rats.

Curr Eye Res 2021 Jun 24. Epub 2021 Jun 24.

Institute of Advanced Materials for Nano-Bio Applications, School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, Zhejiang, China.

: To assess the neuroprotective effects of methylene blue (MB) in a rat model of acute ocular hypertension (AOH) and explore its possible mechanisms.: Our AOH rat model was obtained with anterior chamber perfusion for 60 min. After that, 100 μM MB was injected into the vitreous cavity immediately after injury. Read More

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Hindlimb Somatosensory Information Influences Trunk Sensory and Motor Cortices to Support Trunk Stabilization.

Cereb Cortex 2021 Jun 24. Epub 2021 Jun 24.

Department of Biomedical Engineering, Science, and Health Systems, Drexel University, Philadelphia, 19104 PA, USA.

Sensorimotor integration in the trunk system is poorly understood despite its importance for functional recovery after neurological injury. To address this, a series of mapping studies were performed in the rat. First, the receptive fields (RFs) of cells recorded from thoracic dorsal root ganglia were identified. Read More

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Physical activity, sports participation and exercise-related constraints in adult women with primary hypothyroidism treated with thyroid hormone replacement therapy.

J Sports Sci 2021 Jun 24:1-10. Epub 2021 Jun 24.

Department of Rehabilitation, Physical Therapy Science and Sport, University Medical Center Utrecht, Utrecht, The Netherlands.

Awareness of physical activity (PA) constraints in patients with primary hypothyroidism on thyroid hormone replacement therapy (THR) is important. Hence, this cross-sectional matched case-control study aimed to determine PA and sports participation (SP) in patients with hypothyroidism on THR in comparison to control subjects. Accordingly, survey questions were selected from the National Survey on Injuries and Physical Activity in the Netherlands (IPAN), supplemented with questions related to self-reported clinical characteristics and exercise-related constraints (ERC) of patients. Read More

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A prognostic study on the effect of post-traumatic stress disorder on cerebral ischaemia reperfusion-induced stroke.

World J Biol Psychiatry 2021 Jun 24:1-15. Epub 2021 Jun 24.

Department of Pharmacology, University College of Pharmaceutical Sciences, Acharya Nagarjuna University, Nagarjuna Nagar, India.

Objectives: Previous studies have been established that persons who experienced a stroke are soon likely to develop several anxiety disorders. In which one of the major anxiety disorders is Post-traumatic Stress Disorder (PTSD). Yet, the likelihood of PTSD in conjunction with cerebral stroke has not been well described. Read More

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Vitamin D Status and Clinical Outcomes in Acute Respiratory Distress Syndrome: A Secondary Analysis From the Assessment of Low Tidal Volume and Elevated End-Expiratory Volume to Obviate Lung Injury (ALVEOLI) Trial.

J Intensive Care Med 2021 Jun 24:8850666211028139. Epub 2021 Jun 24.

Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.

Background: Acute respiratory distress syndrome (ARDS) is a highly morbid condition that has limited therapeutic options. Optimal vitamin D status has been linked to immunological effects that may benefit critically ill patients. Therefore, we investigated whether admission 25-hydroxyvitamin D levels (25OHD) are associated with clinical outcomes in ARDS patients. Read More

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Cross-cultural and psychometric property assessment of the Moorong Self-Efficacy Scale in Chinese patients with spinal cord injury.

Disabil Rehabil 2021 Jun 24:1-7. Epub 2021 Jun 24.

School of Nursing, Sun Yat-sen University, Guangzhou, China.

Purpose: To translate the Moorong Self-Efficacy Scale (MSES) into Chinese and to examine its reliability and validity in patients with spinal cord injury (SCI).

Methods: A cross-sectional study design was employed. The MSES was translated into Chinese by forward- and back-translation and its psychometric properties were examined among 176 patients with SCI recruited from four rehabilitation centers in China using convenience sampling. Read More

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Mast Cells Regulate Ductular Reaction and Intestinal Inflammation in Cholestasis via Farnesoid X Receptor Signaling.

Hepatology 2021 Jun 23. Epub 2021 Jun 23.

Richard L. Roudebush VA Medical Center, Indiana University School of Medicine, Indianapolis, IN, USA.

Background & Aim: Cholestasis is characterized by increased total bile acid (TBA) levels, which are regulated by farnesoid X receptor (FXR)/fibroblast growth factor 15 (FGF15). Primary sclerosing cholangitis (PSC) patients typically present with inflammatory bowel disease (IBD). Mast cells (MCs) (i) express FXR and (ii) infiltrate the liver during cholestasis promoting liver fibrosis. Read More

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Changes in Training, Lifestyle, Psychological and Demographic Factors, and Associations With Running-Related Injuries During COVID-19.

Front Sports Act Living 2021 7;3:637516. Epub 2021 Jun 7.

School of Kinesiology, Auburn University, Auburn, AL, United States.

The primary purpose of this study was to examine how the type and magnitude of changes in running behavior, as a consequence of COVID-19 pandemic restrictions, influence running-related injuries. Secondarily, we aimed to examine how lifestyle and psychosocial well-being measures may influence running behavior change. An online survey was advertised to individuals over the age of 18 that currently run or have previously participated in running for exercise. Read More

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A novel, minimally invasive technique to establish the animal model of spinal cord injury.

Ann Transl Med 2021 May;9(10):881

Department of Orthopedics, Tianjin Medical University General Hospital, Tianjin, China.

Background: Spinal cord injury (SCI) is a traumatic disease that is associated with high morbidity, disability, and mortality worldwide. The animal spinal cord contusion model is similar to clinical SCI; therefore, this model is often used to study the pathophysiological changes and treatment strategies for humans after SCI. The present study aimed to introduce a novel, minimally invasive technique to establish an SCI model, and to evaluate its advantages compared with conventional methods. Read More

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Lidocaine-eluting endotracheal tube effectively attenuates intubation related airway response.

Ann Transl Med 2021 May;9(10):871

Department of Anesthesiology, Laboratory of Anesthesia & Critical Care Medicine, Translational Neuroscience Center, West China Hospital of Sichuan University, Chengdu, China.

Background: Lidocaine (LDC) is a local anesthetic widely used to relieve intubation-related airway responses. However, low drug concentration and short effective duration of LDC is inadequate to provide a satisfactory anesthetic effect on the surface of the airway. The present study sought to develop a LDC-delivery endotracheal tube (ETT) to achieve high local drug concentration and sustained drug release with the aim of attenuating an intubation-related airway response. Read More

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Evaluation of postoperative outcomes in patients following multi-level surgical reconstructions with the use Avive soft tissue membrane on nerve after traumatic injury of the upper extremity and lower extremity.

SAGE Open Med 2021 6;9:20503121211023356. Epub 2021 Jun 6.

Department of Orthopaedic Surgery, Texas Tech University Health Sciences Center, Lubbock, TX, USA.

Background: Treatment of patients with traumatic axonotmesis presents challenges. Processed human umbilical cord membrane has been recently developed with improved handling and resorption time compared to other amniotic membrane wraps, and may be beneficial in nerve reconstruction. This study evaluates postoperative outcomes after traumatic peripheral nerve injury after placement of commercially available processed human umbilical cord membrane. Read More

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Combined T2 Mapping and Diffusion Tensor Imaging: A Sensitive Tool to Assess Myofascial Trigger Points in a Rat Model.

J Pain Res 2021 14;14:1721-1731. Epub 2021 Jun 14.

Department of Medical Ultrasound, Minzu Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, 530001, People's Republic of China.

Background: Myofascial trigger points (MTrPs) are defined as very small and hypersensitive points in skeletal muscle that are palpable, and produce localized pain on compression. The aim of this study was to explore the feasibility of combining T2 mapping with diffusion tensor imaging (DTI) for assessing MTrPs in a rat model and to investigate properties of the pathophysiological mechanisms.

Methods: Twenty-four Sprague-Dawley rats (model group, n = 14; control group, n = 10) underwent a magnetic resonance imaging (MRI) examination on a 3 T-MRI-scanner with a protocol consisting of T2 mapping and DTI. Read More

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Effect of National Early Warning Scoring System Implementation on Cardiopulmonary Arrest, Unplanned ICU Admission, Emergency Surgery, and Acute Kidney Injury in an Emergency Hospital, Egypt.

J Multidiscip Healthc 2021 15;14:1431-1442. Epub 2021 Jun 15.

Anesthesia and Critical Care, Faculty of Medicine, Cairo University, Cairo, Egypt.

Purpose: To evaluate the effect of national early warning scoring system (NEWS) implementation in identifying patients at risk of clinical deterioration at an emergency hospital.

Background: Early warning score has been developed to facilitate early detection of deterioration by categorizing a patients' severity of illness and prompting nursing staff to request a medical review at specific trigger points.

Patients And Methods: A prospective, control/intervention groups', quasi-experimental design was utilized. Read More

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Pharmacologic targeting of Cdc42 GTPase by a small molecule Cdc42 activity-specific inhibitor prevents platelet activation and thrombosis.

Sci Rep 2021 Jun 23;11(1):13170. Epub 2021 Jun 23.

Department of Biomedical Sciences, Heritage College of Osteopathic Medicine, Ohio University, Athens, OH, 45701, USA.

Gene targeting of Cdc42 GTPase has been shown to inhibit platelet activation. In this study, we investigated a hypothesis that inhibition of Cdc42 activity by CASIN, a small molecule Cdc42 Activity-Specific INhibitor, may down regulate platelet activation and thrombus formation. We investigated the effects of CASIN on platelet activation in vitro and thrombosis in vivo. Read More

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Ischemic heart injury leads to HIF1-dependent differential splicing of CaMK2γ.

Sci Rep 2021 Jun 23;11(1):13116. Epub 2021 Jun 23.

Center for Cardiovascular Research, John A. Burns School of Medicine, University of Hawaii, 651 Ilalo St. BSB 311, Honolulu, HI, 96813, USA.

Ischemic heart disease is a leading cause of heart failure and hypoxia inducible factor 1 (HIF1) is a key transcription factor in the response to hypoxic injury. Our lab has developed a mouse model in which a mutated, oxygen-stable form of HIF1α (HIF-PPN) can be inducibly expressed in cardiomyocytes. We observed rapid cardiac dilation and loss of contractility in these mice due to lower expression of excitation-contraction coupling genes and reduced calcium flux. Read More

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Blunt adrenal gland injury: The impact of extra-abdominal injury.

J Trauma Acute Care Surg 2021 Jun 22. Epub 2021 Jun 22.

Department of Emergency Medicine, Fukui Prefectural Hospital, Fukui, Japan.

Background: Blunt adrenal gland injuries are considered uncommon. Moreover, the factors associated with the mechanisms of the injury following blunt trauma are unclear. In this study, we determined the factors associated with blunt adrenal gland injury. Read More

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A Randomized Controlled Trial for Parents of Hospitalized Children: Keeping Kids Safe From Guns.

Hosp Pediatr 2021 Jun 23. Epub 2021 Jun 23.

Departments of Pediatrics and.

Objectives: To assess an educational intervention (BeSMART) for parents of hospitalized children on behaviors, beliefs, and knowledge about firearm safety.

Methods: A randomized controlled, 3-arm preintervention and postintervention study compared BeSMART video and handout interventions (with and without physician review) to tobacco smoke videos and handouts (control) on parental behaviors, beliefs, and knowledge. Eligibility criteria included parents and/or guardians residing with hospitalized children aged <20 years. Read More

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Functional results of total-knee arthroplasty versus medial unicompartmental arthroplasty: two-year results of a randomised, assessor-blinded multicentre trial.

BMJ Open 2021 Jun 23;11(6):e046731. Epub 2021 Jun 23.

Department of Orthopedics and Traumatology, Turku University Hospital, Turku, Finland.

Objective: The primary objective of the trial was to assess the clinical effectiveness of medial unicompartmental knee arthroplasty versus total knee arthroplasty in patients with isolated medial osteoarthritis of the knee.

Design: Prospective, randomised, 2 years, assessor-blind, multicentre, superiority trial.

Setting: The patients were enrolled between December 2015 and May 2018 from the outpatient clinics of three public high-volume arthroplasty hospitals (Finland). Read More

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Inhibition of microRNA-130b Alleviated Podocyte Injury Induced by Puromycin Aminonucleoside .

Ann Clin Lab Sci 2021 May;51(3):393-399

Department of Nephrology, Lianshui People's Hospital, Kangda College of Nanjing Medical University, Huai'an city, Jiangsu, China

Objective: To investigate the effect of microRNA-130b (miR-130b) on podocyte injury induced by puromycin aminonucleoside (PAN) and its possible mechanisms.

Methods: The immortalized podocytes (HPC) were treated by 25, 50, or 100 μg/mL PAN, then real-time polymerase chain reaction (PCR) was used to detect the expression of miR-130b. The HPC were transfected with miR-130b inhibitor or normal control (NC) inhibitor, and then the cells were stimulated with 100 μg/mL PAN for 24h. Read More

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Dexmedetomidine Attenuates Myocardial Injury Induced by Renal Ischemia/Reperfusion by Inhibiting the HMGB1-TLR4-MyD88-NF-κB Signaling Pathway.

Ann Clin Lab Sci 2021 May;51(3):376-384

Department of Anesthesiology, The Affiliated Cancer Hospital of Xinjiang Medical University, Urumqi, China.

Objective: To investigate the effect of dexmedetomidine (DEX) on myocardial injury induced by renal ischemia/reperfusion (I/R) and to explore the role of the HMGB1-TLR4-MyD88-NF-κB signaling pathway.

Methods: Adult male Wistar rats were randomly allocated into the control group, renal I/R group, renal I/R group pretreated with a low dose of DEX (L-Dex+I/R), renal I/R group pretreated with a medium dose of DEX (M-Dex+I/R), and renal I/R group pretreated with a high dose of DEX (H-Dex+I/R). Outcome measures included the plasma concentrations of HMGB1, IL-6, IL-10, IL-17, and TnI, the expression levels of HMGB1, TLR4, MyD88, NF-κBp65, and P-NF-κBp65, the pathological change, and the cell apoptosis. Read More

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Surfing the clinical trials of mesenchymal stem cell therapy in ischemic cardiomyopathy.

Stem Cell Res Ther 2021 Jun 23;12(1):361. Epub 2021 Jun 23.

Department of Cardiology, Institute CARDIOMET, University Hospital of Toulouse, Toulouse, France.

While existing remedies failed to fully address the consequences of heart failure, stem cell therapy has been introduced as a promising approach. The present review is a comprehensive appraisal of the impacts of using mesenchymal stem cells (MSCs) in clinical trials mainly conducted on ischemic cardiomyopathy. The benefits of MSC therapy for dysfunctional myocardium are likely attributed to numerous secreted paracrine factors and immunomodulatory effects. Read More

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