417,763 results match your criteria injectable


Georgian Med News 2021 Mar(312):7-14

Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University (Sechenov University) of the Ministry of Health of the Russian Federation.

The aim of the study was to study the effectiveness of complex treatment of decompensated chronic venous insufficiency (CVI) using innovative techniques and proteolysis inhibitors with a wide spectrum of activity in patients with SARS-CoV-2 (COVID-19) in COVID hospital. This study was performed in the surgical department of COVID hospital on the basis of the Clinical Hospital No. 4 of the First Moscow State Medical University named I. Read More

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Methods and techniques for in vitro subcellular localization of radiopharmaceuticals and radionuclides.

Nucl Med Biol 2021 Apr 22;98-99:18-29. Epub 2021 Apr 22.

Department of Imaging Chemistry and Biology, School of Biomedical Engineering and Imaging Sciences, King's College London, London SE1 7EH, United Kingdom. Electronic address:

In oncology, the holy grail of radiotherapy is specific radiation dose deposition in tumours with minimal healthy tissue toxicity. If used appropriately, injectable, systemic radionuclide therapies could meet these criteria, even for treatment of micrometastases and single circulating tumour cells. The clinical use of α and β particle-emitting molecular radionuclide therapies is rising, however clinical translation of Auger electron-emitting radionuclides is hampered by uncertainty around their exact subcellular localisation, which in turn affects the accuracy of dosimetry. Read More

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The Efficacy of Platelet-Rich Plasma on Improving Pain and Function for Lateral Epicondylitis: A Systematic Review and Meta-analysis with Risk-of-Bias Assessment.

Arthroscopy 2021 May 5. Epub 2021 May 5.

Department of Orthopaedic Surgery, Keck School of Medicine of USC, Los Angeles, California. Electronic address:

Purpose: To assess the efficacy of PRP for lateral epicondylitis and evaluate its impact on pain and functional outcomes.

Methods: This study followed Preferred Reporting Items and Systematic Reviews and Meta-Analyses guidelines. A comprehensive literature search was conducted in September 2019 and repeated in April 2020 using electronic databases PubMed, MEDLINE, and the Cochrane Library. Read More

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Injectable Hydrogel for Co-Delivery of 5-Azacytidine in Zein Protein Nanoparticles with Stem Cells for Cardiac Function Restoration.

Int J Pharm 2021 May 5:120673. Epub 2021 May 5.

Stem cell and Molecular Biology Laboratory, Bhupat and Jyoti Mehta School of Biosciences, Department of Biotechnology, Indian Institute of Technology Madras, Chennai-600036, TN, India. Electronic address:

Heart failure is major cause of mortality associated with mostly Myocardial infarction (MI). Transplanting mesenchymal stem cells (MSC) have exhibited potential role in myocardial regeneration. Secretion of immune-modulatory cytokines and various growth factors after transplantation plays significant role in remodelling process of MI region. Read More

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The Lure of the Lüer Connector Non-Lüer Connectors in Regional Anaesthesia.

Acta Anaesthesiol Scand 2021 May 8. Epub 2021 May 8.

Department of Anaesthesia and Perioperative Medicine, Royal Brisbane and Women's Hospital & The University of Queensland, Brisbane, QLD, Australia.

Health service professionals do not have perfect vigilance. There will always be the possibility that a serious untoward incident can occur due to crossover injections of medication being administered via the wrong route. The universality of the Lüer connector made it very easy to connect several medical devices for different therapeutic uses. Read More

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Immune Checkpoint-Bioengineered Beta Cell Vaccine Reverses Early-Onset Type 1 Diabetes.

Adv Mater 2021 May 8:e2101253. Epub 2021 May 8.

Laboratory of Nano- and Translational Medicine, Carolina Center for Cancer Nanotechnology Excellence, Carolina Institute of Nanomedicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.

Type 1 diabetes mellitus (T1DM) is a chronic autoimmune disease that results from autoreactive T cells destroying insulin-producing pancreatic beta (β) cells. The development of T1DM is associated with the deficiency of co-inhibitory immune checkpoint ligands (e.g. Read More

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Cardiac metabolic imaging using hyperpolarized [1- C]lactate as a substrate.

NMR Biomed 2021 May 8:e4532. Epub 2021 May 8.

Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.

Hyperpolarized (HP) [1- C]lactate is an attractive alternative to [1- C]pyruvate as a substrate to investigate cardiac metabolism in vivo: it can be administered safely at a higher dose and can be polarized to a degree similar to pyruvate via dynamic nuclear polarization. While C cardiac experiments using HP lactate have been performed in small animal models, they have not been demonstrated in large animal models or humans. Utilizing the same hardware and data acquisition methods as the first human HP C cardiac study, C metabolic images were acquired following injections of HP [1- C]lactate in porcine hearts. Read More

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[Calpain activation promotes dialysis-associated peritoneal fibrosis in rats].

F Li X Hong J Jiang

Nan Fang Yi Ke Da Xue Xue Bao 2021 Apr;41(4):593-599

Department of Nephrology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.

Objective: To explore the role of calpain activation in the progression of peritoneal fibrosis.

Objective: Twenty-four male Sprague-Dawley rats were randomized equally into control group, MDL28170 (a calpain inhibitor)+normal saline group, peritoneal dialysis (PD) model group and PD + MDL28170 group. In the latter two groups, the rats received daily intraperitoneal injections of 100 mL/kg of 4. Read More

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Intraovarian injection of platelet-rich plasma in assisted reproduction: too much too soon?

Hum Reprod 2021 May 8. Epub 2021 May 8.

Centre for Atherothrombosis and Metabolic Disease, Hull York Medical School, University of Hull, Hull, UK.

The prospect of ovarian rejuvenation offers the tantalising prospect of treating age-related declines in fertility or in pathological conditions such as premature ovarian failure. The concept of ovarian rejuvenation was invigorated by the indication of the existence of oogonial stem cells (OSCs), which have been shown experimentally to have the ability to differentiate into functional follicles and generate oocytes; however, their clinical potential remains unknown.  Furthermore, there is now growing interest in performing ovarian rejuvenation in situ. Read More

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Epidural abscess after lumbar medial branch blocks in a patient on disease-modifying anti-rheumatic drug and corticosteroid.

Reg Anesth Pain Med 2021 May 6. Epub 2021 May 6.

Anesthesiology and Critical Care Medicine, George Washington University School of Medicine and Health Sciences, Washington, DC, USA

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Review of Current Evidence for Minimally Invasive Posterior Sacroiliac Joint Fusion.

Int J Spine Surg 2021 May 7. Epub 2021 May 7.

Department of Anesthesiology, University of Kansas Medical Center, Kansas City, Kansas.

The sacroiliac joint (SIJ) is a large, irregularly shaped, serpentine joint structure bordered anteriorly and posteriorly by the sacroiliac ligaments. With increased recognition of the SIJ as a pain source, treatments have been historically nonsurgical in nature. Common treatments include bracing, medications, activity modification, manual therapy, chiropractic manipulation, physical therapy, and intra-articular SIJ injections. Read More

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Mechanisms of sterile inflammation after intravitreal injection of antiangiogenic drugs: a narrative review.

Int J Retina Vitreous 2021 May 7;7(1):37. Epub 2021 May 7.

Department of Ophthalmology, Federal University of São Paulo, São Paulo, Brazil.

Background: Intraocular inflammation is an uncommon but potentially vision-threatening adverse event related to anti-VEGF therapy. This is of increasing importance given both the volume of injections performed, as well as the increased prevalence of inflammation seen with newer anti-VEGF agents. Brolucizumab, the newest anti-VEGF agent, has been associated with an inflammatory retinal vasculitis and the underlying mechanism is unclear. Read More

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Pre-clinical evaluation of immunoPET imaging using agonist CD40 monoclonal antibody in pancreatic tumor-bearing mice.

Nucl Med Biol 2021 Apr 21;98-99:8-17. Epub 2021 Apr 21.

Department of Radiology, Molecular Imaging Program at Stanford (MIPS), Stanford University, Stanford, CA, USA. Electronic address:

Background: A novel [Cu]Cu-NOTA-aCD40 immunoPET tracer was developed to image a CD40 pancreatic tumor model in C57BL/6 mice and to study the biodistribution profile of the agonist CD40 (aCD40) monoclonal antibody (mAb) alone or combined with other mAbs.

Procedures: Copper-64 ([Cu]Cu) labeled NOTA-aCD40 and NOTA-IgG (10 μg; 7 MBq) were injected intravenously into C57BL/6 mice with subcutaneous mT4 tumors to assess specificity 48 h post injection (p.i. Read More

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Update on corticosteroid, hyaluronic acid and platelet-rich plasma injections in the management of osteoarthritis.

Joint Bone Spine 2021 May 4:105204. Epub 2021 May 4.

Service de Rhumatologie, AP-HP, Hôpital Lariboisière, F-75010 Paris, France.

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Time-dependent changes in striatal monoamine levels and gene expression following single and repeated amphetamine administration in rats.

Eur J Pharmacol 2021 May 4:174148. Epub 2021 May 4.

Instituto de Investigaciones Psicológicas; Centro de Investigación en Neurociencias, Universidad de Costa Rica. Electronic address:

As drug addiction may result from pathological usurpations of learning and memory's neural mechanisms, we focused on the amphetamine-induced time-dependent neurochemical changes associated with neural plasticity. We used juvenile rats as the risk for drug abuse is higher during adolescence. Experiment 1 served to define the appropriate amphetamine dose and the neurochemical effects of a single administration. Read More

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Antinociceptive synergism upon the joint use of methadone and Phα1β in a model of cancer-related pain in C57BL/6J mice.

Life Sci 2021 May 4:119582. Epub 2021 May 4.

Programa de pós graduação em ciências da saúde, Santa Casa de Belo Horizonte Ensino e Pesquisa, Belo Horizonte, Minas Gerais, Brazil. Electronic address:

Opioids are the first-line treatment for cancer pain. Incomplete pain relief and the high rate of adverse effects of these compounds bring a need to combine them with other drugs acting on different targets.

Aims: We here evaluate the antinociceptive interaction and adverse events of methadone combined with recombinant Phα1β, an analgesic toxin from Phoneutria nigriventer. Read More

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Imaging features of gluteal in vitro fertilization injection granulomas, with delayed clinical presentation simulating soft tissue sarcoma.

Skeletal Radiol 2021 May 7. Epub 2021 May 7.

Department of Surgery, University of Toronto Musculoskeletal Oncology Unit, Mount Sinai Hospital, and Division of Orthopedic Surgery, University of Toronto, Toronto, Ontario, Canada.

Objectives: To review the clinical and imaging findings of patients with remote history of intramuscular (IM) in vitro fertilization (IVF) gluteal injections, presenting with signs and symptoms of a possible gluteal soft tissue sarcoma.

Methods And Methods: Retrospective review of consecutive patients with a history of prior IVF therapy referred for MRI evaluation of a gluteal soft tissue mass was performed. Six patients were reviewed, with 5 patients meeting study inclusion criteria. Read More

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Role of magnetic resonance neurography in intercostal neuralgia; diagnostic utility and efficacy.

Br J Radiol 2021 May 7:20200603. Epub 2021 May 7.

Department of Radiology, Musculoskeletal Radiology, University of Texas Southwestern Medical Center, Dallas, TX, USA.

Objective: To evaluate the utility and efficacy of MR neurography (MRN) in the diagnostic work-up for intercostal neuralgia and to assess the treatment course and outcomes in MRN-imaged clinically suspected intercostal neuropathy cases of chronic chest and abdominal wall pain syndromes.

Methods: Following a retrospective cross-sectional study, a consecutive series of patients who underwent MRN of torso for suspected intercostal neuralgia were included. Patient demographics, pain location/level/duration, previous work-up for the same indication, MRN imaging results, and MRN cost per patient were recorded. Read More

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Optimization, and and evaluation of etomidate intravenous lipid emulsion.

Drug Deliv 2021 Dec;28(1):873-883

School of Pharmacy, North China University of Science and Technology, Tangshan, China.

The aim of this investigation was to develop an etomidate intravenous lipid emulsion (ETM-ILE) and evaluate its properties and . Etomidate (ETM) is a hydrophobic drug, and organic solvents must be added to an etomidate injectable solution (ETM-SOL) to aid dissolution, that causes various adverse reactions on injection. Lipid emulsions are a novel drug formulation that can improve drug loading and reduce adverse reactions. Read More

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December 2021

Should we use a patient's port as the preferred intravenous route rather than inserting an additional venous access?

J Vasc Access 2021 May 7:11297298211015058. Epub 2021 May 7.

Catholic University Hospital, Rome, Italy.

Early in 2021, the Infusion Nursing Society has released the latest version of the Infusion Therapy Standards of Practice. In the last two decades, these Standards have been representing one of the most important evidence-based documents available in the world of venous access. Nevertheless, we were quite concerned reading a recommendation included in chapter 26 (Vascular Access Device Planning: practice recommendation I, C): "Use a patient's port, unless contraindicated (e. Read More

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Vascular endothelial growth factor inhibitors for predominantly Caucasian myopic choroidal neovascularization: 2-year treatment outcomes in clinical practice: data from the Fight Retinal Blindness! Registry.

Acta Ophthalmol 2021 May 6. Epub 2021 May 6.

Discipline of Ophthalmology, Save Sight Institute, Sydney Medical School, The University of Sydney, Sydney, NSW, Australia.

Purpose: To report the 24-month outcomes of vascular endothelial growth factor (VEGF) inhibitors for myopic choroidal neovascularization (mCNV) in predominantly Caucasian eyes in routine clinical practice.

Methods: Retrospective analysis of treatment-naïve eyes starting intravitreal injection of VEGF inhibitors of either bevacizumab (1.25 mg) or ranibizumab (0. Read More

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A phase I open label dose-escalation study to evaluate the tolerability, safety and immunological efficacy of sub-urothelial durvalumab injection in adults with muscle-invasive or high-risk non-muscle-invasive bladder cancer (SUBDUE-1, SUB-urothelial DUrvalumab injection-1 study): clinical trial protocol.

BJU Int 2021 May 6. Epub 2021 May 6.

University of Western Australia (UWA) Medical School, University of Western Australia, Perth, WA, Australia.

Objectives: This article presents the clinical trial protocol for a phase I open label dose-escalation study to evaluate the tolerability, safety and immunological efficacy of sub-urothelial durvalumab injection in adults with muscle-invasive or high-risk non-muscle-invasive bladder cancer (NMIBC), the SUB-urothelial DUrvalumab injection-1 study (SUBDUE-1). The primary objectives of this study are to assess the safety of sub-urothelial injection of durvalumab using patient reported outcome measures and observed local or systemic adverse events. The secondary objectives are to examine the local immunological efficacy of sub-urothelial administration of durvalumab. Read More

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Efficacy and safety of subcutaneous prophylaxis with dalcinonacog alfa in adults with haemophilia B.

Haemophilia 2021 May 6. Epub 2021 May 6.

Catalyst Biosciences, San Francisco, CA, USA.

Aim: Phase 2b study to assess efficacy, safety, thrombogenicity, immunogenicity and tolerability with 28 days of daily dosing of subcutaneous (SQ) dalcinonacog alfa as prophylaxis for haemophilia B (HB).

Methods: Adult males with a confirmed diagnosis of congenital HB (factor IX [FIX] activity <2%) received daily dalcinonacog alfa 100 IU/kg SQ until day 28. The primary efficacy endpoint was the number of participants who achieved a steady-state FIX activity level ≥12%. Read More

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mRNA technology as one of the promising platforms for the SARS-CoV-2 vaccine development.

Vavilovskii Zhurnal Genet Selektsii 2020 Nov;24(7):802-807

State Research Center of Virology and Biotechnology "Vector", Koltsovo, Novosibirsk region, Russia.

After the genome sequence of SARS-CoV-2 (Severe acute respiratory syndrome-related coronavirus 2) was published and the number of infected people began to increase rapidly, many global companies began to develop a vaccine. Almost all known approaches to vaccine design were applied for this purpose, including inactivated viruses, mRNA and DNA-vaccines, vaccines based on various viral vectors, synthetically generated peptides and recombinant proteins produced in cells of insects and mammals. This review considers one of the promising vaccine platforms based on messenger RNA. Read More

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November 2020

Injection-Based Management of Osteoarthritis of the Knee: A Systematic Review of Guidelines.

Front Pharmacol 2021 20;12:661805. Epub 2021 Apr 20.

Section of Orthopaedics, Department of General Surgery and Medical Surgical Specialties, A.O.U. Policlinico Rodolico - San Marco, University of Catania, Catania, Italy.

Osteoarthritis (OA) is a leading cause of disability among older adults. Numerous pharmaceutical and nonpharmaceutical interventions have been described. Intra-articular injections are commonly the first line treatment. Read More

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The Efficacy of Intraoperative Fluorescent Imaging Using Indocyanine Green for Cholangiography During Cholecystectomy and Hepatectomy.

Clin Exp Gastroenterol 2021 30;14:145-154. Epub 2021 Apr 30.

Division of Gastroenterological and General Surgery, Department of Surgery, School of Medicine, Showa University, Tokyo, Japan.

Purpose: Bile duct injury is one of the most serious complications of laparoscopic cholecystectomy. Intraoperative indocyanine green (ICG) cholangiography is a safe and useful navigation modality for confirming the biliary anatomy. ICG cholangiography is expected to be a routine method for helping avoid bile duct injuries. Read More

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Melatonin delays ovarian aging in mice by slowing down the exhaustion of ovarian reserve.

Commun Biol 2021 May 6;4(1):534. Epub 2021 May 6.

Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education, Huazhong Agricultural University, Wuhan, 430070, China.

Studies have shown that melatonin (MLT) can delay ovarian aging, but the mechanism has not been fully elucidated. Here we show that granulosa cells isolated from mice follicles can synthesize MLT; the addition of MLT in ovary culture system inhibited follicle activation and growth; In vivo experiments indicated that injections of MLT to mice during the follicle activation phase can reduce the number of activated follicles by inhibiting the PI3K-AKT-FOXO3 pathway; during the early follicle growth phase, MLT administration suppressed follicle growth and atresia, and multiple pathways involved in folliculogenesis, including PI3K-AKT, were suppressed; MLT deficiency in mice increased follicle activation and atresia, and eventually accelerated age-related fertility decline; finally, we demonstrated that prolonged high-dose MLT intake had no obvious adverse effect. This study presents more insight into the roles of MLT in reproductive regulation that endogenous MLT delays ovarian aging by inhibiting follicle activation, growth and atresia. Read More

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Thawed cryopreserved synovial mesenchymal stem cells show comparable effects to cultured cells in the inhibition of osteoarthritis progression in rats.

Sci Rep 2021 May 6;11(1):9683. Epub 2021 May 6.

Center for Stem Cell and Regenerative Medicine, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan.

Intra-articular injections of mesenchymal stem cells (MSCs) can inhibit the progression of osteoarthritis (OA). Previous reports have used cultured MSCs, but the ability to use thawed cryopreserved MSC stocks would be highly advantageous. Our purpose was to elucidate whether thawed cryopreserved MSCs show comparable inhibitory effects on OA progression in rats to those obtained with cultured MSCs. Read More

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Endophthalmitis after intravitreal injections during the COVID-19 pandemic with implementation of universal masking.

Retina 2021 Apr 23. Epub 2021 Apr 23.

Department of Ophthalmology, Baylor College of Medicine, Houston, TX USA Retina Consultants of Houston, Houston, TX USA Blanton Eye Institute, Houston Methodist Hospital, Houston, TX USA.

Purpose: To evaluate the rates of post-intravitreal injection related endophthalmitis during the COVID-19 pandemic with institution of both physician and patient face masking.

Methods: All eyes receiving intravitreal injections of any kind from a single large tertiary retina practice in Houston, TX, USA before (August 2017-March 22, 2020) and after (March 23, 2020-Sept 2020) COVID-19 pandemic universal masking protocols. The total number of injections and cases of acute injection-related endophthalmitis were determined from billing records and subsequent retrospective chart review. Read More

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A meta-analysis and meta-regression on the prevalence of lipohypertrophy in diabetic patients on insulin therapy.

Therapie 2021 Apr 20. Epub 2021 Apr 20.

Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, 210028 Nanjing, Jiangsu, P.R. China; Jiangsu Province Academy of Traditional Chinese Medicine, 210029 Nanjing, Jiangsu, P.R. China.

Aims Of The Study: This study aimed to assess the prevalence of lipohypertrophy (LH) in diabetes mellitus (DM) patients on insulin therapy and identify factors influencing the prevalence rates through a meta-analysis and meta-regression.

Methods: Databases of PubMed, Embase, Scopus, and Google Scholar were screened from inception to 20th Aug 2020. Data on prevalence was transformed using the logit transformation for pooling the proportions using the DerSimonian-Laird meta-analysis model. Read More

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