11,631 results match your criteria initiated 2018


Cytomegalovirus prevention in thoracic organ transplantation: A single-center evaluation of letermovir prophylaxis.

J Heart Lung Transplant 2021 Dec 22. Epub 2021 Dec 22.

Division of Infectious Diseases, Duke University School of Medicine, Durham, North Carolina.

Background: Cytomegalovirus (CMV) infection is common following thoracic organ transplantation and causes substantial morbidity and mortality. Letermovir is a novel antiviral agent used off-label in this population for CMV prevention. Our goal was to understand patterns of letermovir use and effectiveness when applied for CMV prophylaxis after thoracic transplantation. Read More

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December 2021

Trends in treatment patterns and costs of care among patients with advanced stage cervical cancer.

Gynecol Oncol 2022 Jan 11. Epub 2022 Jan 11.

Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

Background: Current treatments for recurrent or metastatic cervical cancer (r/mCC) do not offer satisfactory clinical benefits, with most patients progressing beyond first-line (1L) treatment. With new treatments under investigation, understanding current treatment patterns, the impact of newly approved therapies, and total costs of care for r/mCC are important.

Methods: A retrospective analysis of a US commercial insurance claims database to identify adult patients with r/mCC between 2015 and Q1-2020; defining 1L treatment as the first administration of systemic treatment without concomitant chemoradiation or surgery. Read More

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January 2022

Cushing's syndrome due to ectopic adrenocorticotropin secretion by a parotid carcinoma.

Arch Endocrinol Metab 2022 Jan 13. Epub 2022 Jan 13.

Centro de Oncologia, Hospital Sírio-Libanês, São Paulo, SP, Brasil.

We report a rare case of Cushing's syndrome in a 37-year-old female who initially presented with localized acinic cell carcinoma of the parotid gland. In January 2014, she underwent a right parotidectomy with facial nerve preservation and adjuvant radiotherapy. In August 2018, she presented a histologically-proven local regional relapse. Read More

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January 2022

Shoe Allergens: A Retrospective Analysis of Cross-sectional Data From the North American Contact Dermatitis Group, 2005-2018.

Dermatitis 2022 Jan-Feb 01;33(1):62-69

Department of Dermatology, Keck School of Medicine, University of Southern California, Los Angeles.

Background: Shoe contact allergy can be difficult to diagnose and manage.

Objective: The aim of the study was to characterize demographics, clinical characteristics, patch test results, and occupational data for the North American Contact Dermatitis Group patients with shoe contact allergy.

Methods: This is a retrospective study of 33,661 patients, patch tested from 2005 to 2018, with a shoe source, foot as 1 of 3 sites of dermatitis, and final primary diagnosis of allergic contact dermatitis. Read More

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January 2022

Tofacitinib and risk of cardiovascular outcomes: results from the Safety of TofAcitinib in Routine care patients with Rheumatoid Arthritis (STAR-RA) study.

Ann Rheum Dis 2022 Jan 13. Epub 2022 Jan 13.

Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women's Hospital, Boston, Massachusetts, USA

Objectives: Recent results from 'ORAL Surveillance' trial have raised concerns regarding the cardiovascular safety of tofacitinib in patients with rheumatoid arthritis (RA). We further examined this safety concern in the real-world setting.

Methods: We created two cohorts of patients with RA initiating treatment with tofacitinib or tumour necrosis factor inhibitors (TNFI) using deidentified data from Optum Clinformatics (2012-2020), IBM MarketScan (2012-2018) and Medicare (parts A, B and D, 2012-2017) claims databases: (1) A 'real-world evidence (RWE) cohort' consisting of routine care patients and (2) A 'randomised controlled trial (RCT)-duplicate cohort' mimicking inclusion and exclusion criteria of the ORAL surveillance trial to calibrate results against the trial findings. Read More

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January 2022

Annual report of the Committee on Gynecologic Oncology, the Japan Society of Obstetrics and Gynecology: Annual Patient Report for 2018 and Annual Treatment Report for 2013.

J Obstet Gynaecol Res 2022 Jan 13. Epub 2022 Jan 13.

Department of Gynecology and Obstetrics, Tohoku University Graduate School of Medicine, Sendai, Japan.

To provide information including the trend of gynecological malignancies in Japan, we hereby present the Annual Patient Report for 2018 and the Annual Treatment Report for 2013, on the outcomes of patients who started treatment in 2013. The Japan Society of Obstetrics and Gynecology maintains an annual tumor registry, where information on gynecological malignancies from various participating institutions is gathered. The data of patients whose treatment with gynecologic malignancies was initiated in 2018 were analyzed retrospectively. Read More

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January 2022

A minimal monitoring approach for the treatment of hepatitis C virus infection (ACTG A5360 [MINMON]): a phase 4, open-label, single-arm trial.

Lancet Gastroenterol Hepatol 2022 Jan 10. Epub 2022 Jan 10.

Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Background: Despite widespread availability of direct-acting antivirals including generic formulations, limited progress has been made in the global adoption of hepatitis C virus (HCV) treatment. Barriers to treatment scale-up include availability and access to diagnostic and monitoring tests, health-care infrastructure, and requirement for frequent visits during treatment.

Methods: ACTG A5360 was a phase 4, open-label, single-arm trial across 38 sites in Brazil, South Africa, Thailand, Uganda, and the USA. Read More

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January 2022

Cerebral sinovenous thrombosis in children: clinical presentation, locations, and acquired and inherited prothrombotic risk factors.

Turk J Pediatr 2021 ;63(6):1028-1037

Divisions of Pediatric Hematology and Oncology, Department of Pediatrics, Eskişehir Osmangazi University Faculty of Medicine, Eskişehir, Turkey.

Background: Cerebral sinovenous thrombosis (CSVT) in children is a rare and life-threatening cerebrovascular disease. Hence, we evaluated its clinical presentations, inherited and acquired prothrombotic risk factors along with the accompanying diseases, the thrombosis locations as well as the outcomes of anticoagulant therapy in children with CSVT.

Methods: The medical records of pediatric CSVT patients treated between January 2011 and September 2018 were analyzed retrospectively. Read More

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January 2021

Molecular and Antigenic Characterization of Avian H9N2 Viruses in Southern China.

Microbiol Spectr 2022 Jan 12:e0082221. Epub 2022 Jan 12.

Shanghai Veterinary Research Institutegrid.464410.3, Chinese Academy of Agriculture Sciences, Shanghai, China.

The H9N2 subtype avian influenza virus (AIV) has become endemic in poultry globally; however due to its low pathogenicity, it is not under primary surveillance and control in many countries. Recent reports of human infection caused by H9N2 AIV has increased public concern. This study investigated the genetic and antigenic characteristics of H9N2 AIV isolated from local markets in nine provinces in Southern China from 2013 to 2018. Read More

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January 2022

The Experience of Organizing Blood Donation Camp through Student Initiative.

J Pharm Bioallied Sci 2021 Nov 10;13(Suppl 2):S1488-S1495. Epub 2021 Nov 10.

Department of Physiology, Sri Guru Ram Das University of Health Sciences, Amritsar, Punjab, India.

Introduction: A blood donation camp was organized in the institute which was a student initiative and a street play on blood donation awareness was carried out at different parts of the institute. For this reason, the study aimed at assessing the knowledge, attitude, and practises among the voluntary donors was carried out to bring out further awareness programs.

Materials And Methods: The study is a Cross-sectional analysis to know about the knowledge, attitude, and practises among the donors as well as collect information regarding the rare blood groups. Read More

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November 2021

Emergency department interventions that could be conducted in subacute care settings for patients with nonemergent conditions transported by paramedics: a modified Delphi study.

CMAJ Open 2022 Jan-Mar;10(1):E1-E7. Epub 2022 Jan 11.

Department of Health Research Methods, Evidence, and Impact (Strum, Worster, Griffith, Costa), McMaster Institute for Research and Aging (Griffith), Emergency Medicine Division (Worster), Department of Medicine, and Department of Medicine (Costa), McMaster University, Hamilton, Ont.; The Wilson Centre (Tavares), University of Toronto, Toronto, Ont.; York Region Paramedic and Senior Services (Tavares), Regional Municipality of York, Newmarket, Ont.

Background: As the number of patients with nonemergent conditions who are transported by paramedics continues to increase in Ontario, redirecting specific patients to subacute settings may be more beneficial and suitable for both patients and emergency departments. We aimed to evaluate whether emergency department interventions conducted on patients with nonemergent conditions who are transported by paramedics could be conducted in subacute health centres.

Methods: We conducted a RAND/UCLA modified Delphi study in Ontario between Oct. Read More

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January 2022

One-year Outcome after Percutaneous Coronary Intervention in Nonagenarians: Insights from the J-PCI OUTCOME Registry.

Am Heart J 2022 Jan 8. Epub 2022 Jan 8.

Department of Cardiovascular Medicine, Tokai University, Isehara, Japan.

Background: Nonagenarian patients who undergo percutaneous coronary intervention (PCI) are increasing, and a few previous studies have reported their long-term outcomes. However, differences in their long-term outcomes between generations remain unclear. This study aimed to investigate one-year all-cause and cardiovascular (CV) mortality, and major adverse cardiovascular events (MACE; cardiovascular death, myocardial infarction, and stroke) of nonagenarian patients who underwent PCI compared with the other elder patients, using a nationwide registration system. Read More

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January 2022

First Maintenance Therapy for Chronic Obstructive Pulmonary Disease: Retrospective Analyses of US and UK Healthcare Databases.

Pulm Ther 2022 Jan 10. Epub 2022 Jan 10.

Division of Pulmonary, Allergy and Critical Care Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.

Introduction: Inhaled corticosteroids (ICS) are often prescribed inappropriately alongside long-acting bronchodilators for chronic obstructive pulmonary disease (COPD). We aimed to investigate if prescribing habits in the US and UK differ from recommendations for initiation of COPD maintenance therapy.

Methods: We used healthcare data from the US IBM MarketScan and UK Clinical Practice Research Datalink databases to assess exacerbations and comorbidities in patients with COPD initiating first maintenance therapy (1MT) between 2015 and 2018. Read More

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January 2022

Treatment Transitions in Chronic Obstructive Pulmonary Disease: Retrospective Analyses of US and UK Healthcare Databases.

Pulm Ther 2022 Jan 10. Epub 2022 Jan 10.

Division of Pulmonary, Allergy and Critical Care Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.

Introduction: Previous studies have reported that more patients receive inhaled corticosteroid (ICS)-containing therapies than would be expected based on exacerbation history, suggesting overprescribing. We aimed to describe patterns of treatment switching from first (1MT) to second maintenance therapy (2MT) among COPD patients in the US and UK.

Methods: We used healthcare data from the US IBM MarketScan and UK Clinical Practice Research Datalink databases (2015 - 2018) to assess transitions between 1MT and 2MT among COPD patients. Read More

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January 2022

Integrating Quality of Life in the Care Pathway of Cancer Patients Undergoing Immunotherapy Treatment: Descriptive, Cross-sectional Survey of an Online Patient Community's Experiences and Expectations.

J Med Internet Res 2022 Jan 11;24(1):e25792. Epub 2022 Jan 11.

Bristol-Myers Squibb France, Rueil-Malmaison, France.

Background: New cancer treatments, such as immune checkpoint inhibitors (ICIs), can improve survival and health-related quality of life (HRQoL) in patients with cancer. Although long-term monitoring of HRQoL has been shown to improve survival, integration of HRQoL into everyday practice remains poorly documented.

Objective: This study describes experiences and expectations of patients treated with ICIs regarding a discussion of HRQoL with health care professionals (HCPs) in cancer management. Read More

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January 2022

Analysis of Medical Management in Geriatric Patients in the Hospital Emergency Department by Example of Selected Cities with County Status in Poland: A Retrospective Cohort Study.

Int J Environ Res Public Health 2021 Dec 21;19(1). Epub 2021 Dec 21.

Department of Emergency Medicine, Faculty of Health Sciences, Pope John Paul II State School of Higher Education in Biała Podlaska, 21-500 Biała Podlaska, Poland.

The aim of this study was to analyse medical management in geriatric patients in the Hospital Emergency Departments in the Biała Podlaska County and Chełm County (Poland) between 2016 and 2018 in a group of patients ≥65 years of age. We analysed medical records of 829 patients transported to Hospital Emergency Departments by Medical Emergency Teams. The research was conducted in the period from June 2019 to March 2020. Read More

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December 2021

Safer in care: A pandemic-tested model of integrated HIV/OUD care.

Drug Alcohol Depend 2021 Dec 24;231:109241. Epub 2021 Dec 24.

University of Alabama at Birmingham, Division of Psychiatry and Behavioral Neurobiology, SC 560, 1720 2nd Ave S, Birmingham, AL 35294-0017, USA.

Background: Rural, poor, persons with HIV (PWH) and substance use are among the most vulnerable to SARS-CoV-2 and related health service disruptions. The objective of the study was to evaluate the health outcomes and utilization of PWH at an Outpatient-based Opioid Treatment (OBOT) Clinic.

Methods: We evaluated a clinic-based cohort at the University of Alabama at Birmingham HIV clinic from November 2018 to May 2021. Read More

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December 2021

Early vs late initiation of sodium glycerophosphate: Impact on hypophosphatemia in preterm infants <32 weeks.

Clin Nutr 2021 Dec 10;41(2):415-423. Epub 2021 Dec 10.

Ankara City Hospital, Ankara, Turkey.

Background & Aims: Early electrolyte and mineral imbalances have emerged as a conspicuous problem in very preterm babies since the revision of nutrition guidelines and the eventual implementation of early aggressive parenteral nutrition (PN). We opted to carry out a study with the introduction of phosphorus as sodium glycerophosphate in PN from the first day onward to reveal the impact on serum phosphorus and calcium levels following the surge in the incidence of hypercalcemia and hypophosphatemia.

Methods: In this single-center, prospective, observational cohort study, inborn babies <32 gestational weeks and <1500 g between August 2017 and July 2018 were enrolled consecutively. Read More

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December 2021

Maximizing Regulatory Review Efficiency: The Evolution of the FDA OCE RTOR Pilot.

Ther Innov Regul Sci 2022 Jan 10. Epub 2022 Jan 10.

Product Development Regulatory, Hoffmann-La Roche Ltd, Mississauga, ON, Canada.

To promote the efficient review of oncology drug applications, the US Food and Drug Administration (FDA) Oncology Center of Excellence (OCE) launched the Real-Time Oncology Review (RTOR) pilot program in 2018. RTOR allows FDA to review individual sections of eCTD modules of a drug application for oncology drugs in contrast to requiring the applicant to submit complete modules or the complete application before review is initiated. Initially, the program accepted only supplemental applications with simple study designs and easily interpretable endpoints, but the scope has since been expanded to include applications for New Molecular Entities (NME), and other applications with more complex features. Read More

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January 2022

Direct and Indirect Costs of Asthma Burden in Abu Dhabi: A Retrospective Analysis of Insurance Claims Data from 2015 to 2018.

Clinicoecon Outcomes Res 2021 29;13:969-980. Epub 2021 Dec 29.

Respiratory Medicine Division, Zayed Military Hospital, Abu Dhabi, United Arab Emirates.

Purpose: Asthma causes a high economic burden on the health-care system. Previous research on the cost of asthma in Abu Dhabi was in 2011 and revealed high medical costs. This work aimed to estimate both direct and indirect costs of asthma with trend analysis over a period of four years. Read More

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December 2021

Quality Initiative to Reduce Extrauterine Growth Restriction in Very Low Birth Weight Infants.

Hosp Pediatr 2022 Jan 10. Epub 2022 Jan 10.

Tennessee Initiative for Perinatal Quality Care Nashville Tennessee.

Background: We report a statewide quality improvement initiative aimed to decrease the incidence of extrauterine growth restriction among very low birth weight infants cared for in Tennessee NICUs.

Methods: The cohort consisted of infants born appropriate for gestational age between May 2016 and December 2018 from 9 NICUs across Tennessee. The infants were 23 to 32 weeks gestation and 500 to 1499 g birth weight. Read More

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January 2022

Low HCV-viremia prevalence yet continued barriers to direct-acting antiviral treatment in people living with HIV in the Netherlands.

AIDS 2022 Jan 6. Epub 2022 Jan 6.

Department of Internal Medicine and Infectious Diseases, UMC Utrecht, Utrecht, the Netherlands Department of Internal Medicine, Division of Infectious Diseases, Amsterdam Institute for Infection and Immunity, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, the Netherlands Stichting HIV Monitoring, Amsterdam, the Netherlands Department of Infectious Diseases, Research and Prevention, Public Health Service of Amsterdam, Amsterdam, the Netherlands Department of Internal Medicine and Infectious Diseases, Onze Lieve Vrouwe Gasthuis, Amsterdam, the Netherlands Department of Internal Medicine, Section Infectious Diseases, Erasmus MC, University Medical Center, Rotterdam, Netherlands Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, the Netherlands Department of Internal Medicine, Division of Infectious Diseases, Maastricht University Medical Center, Maastricht, The Netherlands.

Objective: To describe hepatitis C virus (HCV)-viremia prevalence and barriers to direct-acting antiviral (DAA) treatment during unrestricted access to DAA in a nationwide cohort of people living with HIV (PLWH).

Design: Retrospective analysis of prospectively-collected data.

Methods: We calculated yearly HCV-viremia prevalence as proportion of HCV RNA-positive individuals ever HCV-tested. Read More

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January 2022

[End-of-life care in a rural small-town region in Lower Saxony: a retrospective cross-sectional analysis based on routinely collected general practice data].

Z Evid Fortbild Qual Gesundhwes 2022 Jan 6. Epub 2022 Jan 6.

Institut für Allgemeinmedizin und Palliativmedizin, Medizinische Hochschule Hannover.

Introduction: Up to 90% of people at the end of life are in need of palliative care. The majority can be cared for within general outpatient palliative care (AAPV) by general practitioners. Previous studies have described outpatient palliative care to fall short behind the estimated needs and to be initiated rather late in the health care process. Read More

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January 2022

Proton pump inhibitor treatment initiated prior to endoscopic diagnosis in upper gastrointestinal bleeding.

Cochrane Database Syst Rev 2022 Jan 7;1:CD005415. Epub 2022 Jan 7.

Department of Medicine, Division of Gastroenterology, McMaster University, Hamilton, Canada.

Background: Upper gastrointestinal (GI) bleeding is a common reason for emergency hospital admission. Proton pump inhibitors (PPIs) reduce gastric acid production and are used to manage upper GI bleeding. However, there is conflicting evidence regarding the clinical efficacy of proton pump inhibitors initiated before endoscopy in people with upper gastrointestinal bleeding. Read More

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January 2022

Initiation of hemodialysis at one month following fistulogram in patients with advanced kidney disease.

Vascular 2022 Jan 7:17085381211068231. Epub 2022 Jan 7.

Department of Surgery, Community Medical Center, 4598RWJ/Barnabas Health, Tom's River, NJ, USA.

Objective: Previous studies have demonstrated that low contrast volume used in access-related interventions had limited effects on the progression of chronic kidney disease (CKD) after fistulography, but studies are limited and heterogeneous. We sought to evaluate the rate of and factors associated with progression to dialysis (HD) within 1 month after fistulography for patients with advanced CKD.

Methods: A single-institution retrospective cohort analysis of patients with CKD stage IV and V, not yet on HD, undergoing fistulography from 1 January 2014 to 31 December 2018 was performed. Read More

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January 2022

Treatment outcomes of HIV patients with hepatitis B and C virus co-infections in Southwest China: an observational cohort study.

Infect Dis Poverty 2022 Jan 6;11(1). Epub 2022 Jan 6.

SJTU-Yale Joint Center for Biostatistics and Data Science, Shanghai Jiao Tong University, Shanghai, China.

Background: Antiretroviral therapy (ART) has reduced mortality among people living with HIV (PLWH) in China, but co-infections of hepatitis B virus (HBV) and hepatitis C virus (HCV) may individually or jointly reduce the effect of ART. This study aimed to evaluate the impacts of HBV/HCV coinfections on treatment drop-out and mortality among PLWH on ART.

Methods: A retrospective cohort study analysis of 58 239 people living with HIV (PLWH) who initiated antiretroviral therapy (ART) during 2010-2018 was conducted in Guangxi Province, China. Read More

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January 2022

Developing a Parental Leave Policy in Undergraduate Medical Education: A Successful Student-Administration Collaboration.

Acad Med 2022 Jan 4. Epub 2022 Jan 4.

L. Gaghan is a medical student, University of North Carolina School of Medicine, Chapel Hill, North Carolina; ORCID: https://orcid.org/0000-0003-2412-9290. B. Parker is a medical student, University of North Carolina School of Medicine, Chapel Hill, North Carolina; ORCID: https://orcid.org/0000-0002-9430-1765.

Problem: Most medical schools lack parental leave policies, leaving medical students vulnerable to discrimination, diminished educational opportunities, delays in graduation or matching, and breaches of privacy. This report outlines the steps taken by student-leaders to advocate for such a policy and the lessons learned along the way.

Approach: In September 2018, leaders of the Family Support Initiative, a medical student interest group at the University of North Carolina School of Medicine, initiated the process of advocating for a clear, official parental leave policy. Read More

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January 2022

Exploring hepatitis C virus testing and treatment engagement over time in Melbourne, Australia: a study protocol for a longitudinal cohort study (EC-Experience Cohort study).

BMJ Open 2022 Jan 4;12(1):e057618. Epub 2022 Jan 4.

Disease Elimination Program, Burnet Institute, Melbourne, Victoria, Australia.

Introduction: The advent of direct acting antiviral therapy for hepatitis C virus (HCV) means the elimination of HCV is possible but requires sustained effort to achieve. Between 2016 and 2019, 44% of those living with HCV were treated in Australia. However, treatment uptake has declined significantly. Read More

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January 2022

Patients with severe gout treated in mixed settings.

Dan Med J 2021 Oct 18;68(11). Epub 2021 Oct 18.

INTRODUCTION We aimed to investigate whether patients with a definite gout diagnosis who were treated in mixed real-life settings (various hospital departments or general practice) followed treatment recommendations. METHODS We included all patients in the hospital's uptake area in 2015-2017 who had been diagnosed with gout after microscopy findings of urate crystals. Data regarding comorbidities and indications for urate-lowering therapy (ULT) were collected. Read More

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October 2021

Reducing Benzodiazepine Exposure by Instituting a Guideline for Dexmedetomidine Usage in the NICU.

Pediatrics 2021 Nov;148(5)

Division of Newborn Medicine, Department of Pediatrics, Boston Children's Hospital, Boston, Massachusetts.

Background: Midazolam is a benzodiazepine sedative used in NICUs. Because benzodiazepine's effects include respiratory depression and potential detrimental developmental effects, minimizing exposure could benefit neonates. Dexmedetomidine is routinely used for sedation in older pediatric populations. Read More

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November 2021