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Propionibacterium freudenreichii thrives in microaerobic conditions by complete oxidation of lactate to CO.

Environ Microbiol 2021 May 6. Epub 2021 May 6.

Laboratory of Food Microbiology, Wageningen University & Research, P.O. Box 17, Wageningen, 6700AA, The Netherlands.

In this study we show increased biomass formation for four species of food-grade propionic acid bacteria (Acidipropionibacterium acidipropionici, Acidipropionibacterium jensenii, Acidipropionibacterium thoenii and Propionibacterium freudenreichii) when exposed to oxygen, implicating functional respiratory systems. Using an optimal microaerobic condition, P. freudenreichii DSM 20271 consumed lactate to produce propionate and acetate initially. Read More

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Polio Outbreak Investigation and Response in The Horn of Africa: 2013-2016.

J Immunol Sci 2021 Apr;Spec Issue(2):1104

WHO Regional Office for Africa (WHO AFRO).

Background: There has been civil strife, spanning more than two decades in some countries and recurrent natural disasters in the Horn of Africa (HoA). This has consistently maintained these countries in chronic humanitarian conditions. More important however is the fact that these crises have also denied populations of these countries access to access to lifesaving health services. Read More

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Sedentary behaviour levels in adults with an intellectual disability: a systematic review protocol.

HRB Open Res 2020 26;3:57. Epub 2020 Aug 26.

School of Nursing and Midwifery, Trinity College, Dublin, Ireland.

Sedentary behaviour contributes to non-communicable diseases, which account for almost 71% of world deaths. Of these, cardiovascular disease is one of the largest causes of preventable death. It is not yet fully understood what level of sedentary behaviour is safe. Read More

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Picosecond Charge Localization Dynamics in CHNHPbI Perovskite Probed by Infrared-Activated Vibrations.

J Phys Chem Lett 2021 May 5:4428-4433. Epub 2021 May 5.

Physik-Department, Lehrstuhl für Laser- und Röntgenphysik, Technische Universität München, James-Franck-Str. 1, 85748 Garching, Germany.

Hybrid metal halide perovskites exhibit well-defined semiconducting properties and efficient optoelectronic performance considering their soft crystal structure and low-energy lattice motions. The response of such a crystal lattice to light-induced charges is a fundamental question, for which experimental insight into ultrafast time scales is still sought. Here, we use infrared-activated vibrations (IRAV) of the organic components within the hybrid perovskite lattice as a sensitive probe for local structural reorganizations after photoexcitation, with femtosecond resolution. Read More

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Influence of malocclusion on oral health-related quality of life in children: a seven-year cohort study.

Dental Press J Orthod 2021 30;26(2):e2119244. Epub 2021 Apr 30.

Universidade Federal de Santa Maria, Departamento de Estomatologia, Faculdade de Odontologia (Santa Maria/RS, Brazil).

Objective: To assess the influence of early childhood malocclusion on oral health-related quality of life (OHRQoL).

Methods: 7-year cohort study involving 639 preschoolers (1 to 5 years) who had been evaluated initially with a survey conduced in 2010. Children completed the Brazilian version of the Child Perception Questionnaire (CPQ8-10) to assess OHRQoL during the follow-up period. Read More

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Infantile Rhabdomyosarcomas With VGLL2 Rearrangement Are Not Always an Indolent Disease: A Study of 4 Aggressive Cases With Clinical, Pathologic, Molecular, and Radiologic Findings.

Am J Surg Pathol 2021 Jun;45(6):854-867

Genetics Unit, Department of Tumor Biology.

VGLL2-rearranged rhabdomyosarcomas (RMS) are rare low-grade tumors with only favorable outcomes reported to date. We describe 4 patients with VGLL2-rearranged RMS confirmed by molecular studies, who experienced local progression and distant metastases, including 2 with fatal outcomes. Tumors were diagnosed at birth (n=3) or at 12 months of age (n=1), and were all localized at initial diagnosis, but unresectable and therefore managed with chemotherapy and surveillance. Read More

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Maternal Mental Health Symptoms and Clusters Predict Toddler Sleep in Low-Income Homes.

J Genet Psychol 2021 May 5:1-17. Epub 2021 May 5.

Crane Center for Early Childhood Research and Policy, The Ohio State University, Columbus, Ohio, USA.

The authors examined the association of maternal mental health symptoms and symptom clusters with the sleeping behaviors of toddlers living in low-income homes. The sample is comprised of 174 racially diverse mother and toddler (15-19 months old) dyads who were participating in a longitudinal birth cohort study. Dyads were initially recruited from Women, Infant, and Children clinics in a Midwestern county of the United States. Read More

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Changes in Thyroid Stimulating Hormone Receptor Antibody Levels Following Total Thyroidectomy or Radioiodine Therapy in Patients with Refractory Graves' Disease.

Thyroid 2021 May 5. Epub 2021 May 5.

Samsung Medical Center, 36626, Division of Endocrinology and Metabolism, Department of Medicine, Gangnam-gu, Seoul, Korea (the Republic of).

Background: The actions of thyrotropin-binding inhibitory immunoglobulins (TBIIs) against thyrotropin receptors in thyroid follicular cells have been studied as important etiological factors in Graves' disease (GD). The purpose of this study was to investigate changes in the TBII levels of patients undergoing total thyroidectomy (TTx) or radioactive iodine (RAI) therapy for GD refractory to antithyroid drugs (ATD).

Methods: We enrolled patients who underwent TTx or RAI for GD with previous ATD use between January 2011 and December 2017 at the Samsung Seoul Hospital in Seoul, Korea. Read More

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Highly Conductive Al/Al Interfaces in Ultrafine Grained Al Compact Prepared by Low Oxygen Powder Metallurgy Technique.

Nanomaterials (Basel) 2021 Apr 30;11(5). Epub 2021 Apr 30.

Magnetic Powder Metallurgy Research Center, National Institute of Advanced Industrial Science and Technology, 2266-98 Anagahora, Shimoshidami, Moriyama, Nagoya 463-8560, Japan.

The low oxygen powder metallurgy technique makes it possible to prepare full-dense ultrafine-grained (UFG) Al compacts with an average grain size of 160 nm by local surface bonding at a substantially lower temperature of 423 K from an Al nanopowder prepared by a low oxygen induction thermal plasma process. By atomic level analysis using transmission electron microscopy, it was found that there was almost no oxide layer at the Al/Al interfaces (grain boundaries) in UFG Al compact. The electrical conductivity of the UFG Al compact reached 3. Read More

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Use of intravenous cangrelor and stenting in acute ischemic stroke interventions: a new single center analysis and pooled-analysis of current studies.

Interv Neuroradiol 2021 May 4:15910199211014417. Epub 2021 May 4.

Department of Neurosurgery, Albany Medical Center, Albany, NY, USA.

Introduction: Emergent stenting of both extra- and intracranial occlusions during acute ischemic stroke procedures is complicated by the need for immediate platelet inhibition to prevent thromboembolic complications. IV cangrelor is a relatively new antiplatelet that was initially approved for coronary interventions. Five prior case series have been published evaluating the results of IV cangrelor in neurointerventional procedures. Read More

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Transitional states of sarcopenia: the trajectory of fat accumulation and glucose fluctuation on risk of metabolic syndrome.

Ann N Y Acad Sci 2021 May 4. Epub 2021 May 4.

Division of Family Medicine, Department of Family and Community Medicine, Tri-Service General Hospital, and School of Medicine, National Defense Medical Center, Taipei, Taiwan, Republic of China.

The association between sarcopenia and metabolic syndrome (MetS) has been well established. Nevertheless, the transition process between normal and low muscle mass (LMM) states and the effect of this transition on MetS has been less explored. Our study here examined whether the direction toward or away from LMM alters the risks of MetS. Read More

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Proof-of-concept for clinical effects of oral rilzabrutinib, the first Bruton tyrosine kinase inhibitor for pemphigus vulgaris: the phase 2 BELIEVE study.

Br J Dermatol 2021 May 3. Epub 2021 May 3.

Department of Dermatology, Rouen University Hospital, Centre de Référence des Maladies Bulleuses Autoimmunes, and INSERM U1234, Normandie University, Rouen, France.

Background: Bruton tyrosine kinase (BTK) inhibition targets B-cell and other non-T-cell immune cells implicated in pemphigus pathophysiology, an autoimmune disease driven by anti-desmoglein autoantibodies. Rilzabrutinib is a new reversible, covalent BTK inhibitor demonstrating preclinical efficacy as monotherapy in canine pemphigus foliaceus.

Objectives: Evaluate efficacy and safety of oral rilzabrutinib in pemphigus vulgaris patients in a multicenter, proof-of-concept, phase 2 trial. Read More

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The effect of solvation on electron capture revealed using anion two-dimensional photoelectron spectroscopy.

Nat Chem 2021 May 3. Epub 2021 May 3.

Department of Chemistry, Durham University, Durham, UK.

The reaction of low-energy electrons with neutral molecules to form anions plays an important role in chemistry, being involved in, for example, various biological and astrochemical processes. However, key aspects of electron-molecule interactions, such as the effect of incremental solvation on the initially excited electronic resonances, remain poorly understood. Here two-dimensional photoelectron spectroscopy of anionic anthracene and nitrogen-substituted derivatives-solvated by up to five water molecules-reveals that for an incoming electron, resonances red-shift with increasing hydration; but for the anion, the excitation energies of the resonances remain essentially the same. Read More

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Evidence of integrated health service delivery during COVID-19 in low and lower-middle-income countries: protocol for a scoping review.

BMJ Open 2021 05 3;11(5):e042872. Epub 2021 May 3.

International Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA.

Introduction: The importance of integrated, people-centred health systems has been recognised as a central component of Universal Health Coverage. Integration has also been highlighted as a critical element for building resilient health systems that can withstand the shock of health emergencies. However, there is a dearth of research and systematic synthesis of evidence on the synergistic relationship between integrated health services and pandemic preparedness, response, and recovery in low-income and lower-middle-income countries (LMICs). Read More

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Staff perceptions of military chemical-biological-radiological-nuclear (CBRN) air-purifying masks during a simulated clinical task in the context of SARS-CoV-2.

Anaesth Intensive Care 2021 May 3:310057X20984787. Epub 2021 May 3.

Department of Intensive Care Medicine, Royal Brisbane and Women's Hospital, Herston, Australia.

Air-purifying full-face masks, such as military chemical-biological-radiological-nuclear masks, might offer superior protection against severe acute respiratory syndrome coronavirus 2 compared to disposable polypropylene P2 or N95 masks. In addition, disposable masks are in short supply, while military chemical-biological-radiological-nuclear masks can be disinfected then reused. It is unknown whether such masks might be appropriate for civilians with minimal training in their use. Read More

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Spontaneous pulmonary artery thrombus in a neonate.

Egypt Heart J 2021 May 3;73(1):43. Epub 2021 May 3.

Department of Cardiology, Advanced Cardiac Centre, Post Graduate Institute for Medical Education and Research (PGIMER) Chandigarh, Sector 12, Chandigarh, 160 012, India.

Background: Pulmonary artery thrombosis is rare in neonates and mimics as persistent pulmonary hypertension or congenital heart disease. Risk factors include septicemia, dehydration, polycythemia, maternal diabetes, asphyxia, and inherited thrombophilias. They present with cyanosis and respiratory distress. Read More

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Intravascular fasciitis of the hip joint in a postpartum female: misdiagnosed as low grade fibromyxoid sarcoma.

Int J Clin Exp Pathol 2021 15;14(4):519-525. Epub 2021 Apr 15.

Department of Pathology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine Shanghai 200025, P. R. China.

Intravascular fasciitis is a special type of nodular fasciitis. It is an uncommon lesion. We report here the first case of intravascular fasciitis involving the deep muscle of the hip joint. Read More

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A Prospective Randomized Controlled Trial Using Propofol or Dexmedetomidine for Conscious Sedation in Pediatric Patients Undergoing Sclerotherapy.

J Pediatr Neurosci 2020 Oct-Dec;15(4):379-385. Epub 2021 Jan 19.

Department of Anaesthesia, Postgraduate Institute of Medical Education & Research (PGIMER), Chandigarh, India.

Aim: Sodium tetradecyl sulfate (STS) sclerotherapy in pediatric patients is usually undertaken under sedation inside digital subtraction angiography (DSA) suite. These patients are day-care patients and need adequate sedation for small duration. We performed this study to compare propofol and dexmedetomidine as sedative agents in these patients. Read More

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January 2021

Personalized prophylactic anticoagulation in hospitalized patients with Covid-19 - The role of anti-Xa monitoring.

Clin Microbiol Infect 2021 Apr 29. Epub 2021 Apr 29.

Department of Internal Medicine & Infectious Diseases, University Hospital of Heraklion, Heraklion, Crete, Greece.

Due to the strong association between severe COVID-19 and a prothrombotic state, most experts suggest an intensified anticoagulation regimen, mostly including an intermediate dose of low-molecular heparin, even though there is no clear clinical evidence supporting the efficacy of this strategy. In our hospital, among 16 patients admitted due to COVID-19, initially treated with enoxaparin 40mg/daily, 81.3% needed dose adjustment due to lower than 0. Read More

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Broad respiratory testing to identify SARS-CoV-2 viral co-circulation and inform diagnostic stewardship in the COVID-19 pandemic.

Virol J 2021 05 1;18(1):93. Epub 2021 May 1.

Division of Diagnostic and Applied Microbiology, Department of Laboratory Medicine and Pathology, Faculty of Medicine and Dentistry, University of Alberta, 2B4.01, Walter C. Mackenzie Centre, Provincial Laboratory of Public Health, 8440 - 112 Street, Edmonton, AB, T6G 2J2, Canada.

Background: SARS-CoV-2 infection can present with a broad clinical differential that includes many other respiratory viruses; therefore, accurate tests are crucial to distinguish true COVID-19 cases from pathogens that do not require urgent public health interventions. Co-circulation of other respiratory viruses is largely unknown during the COVID-19 pandemic but would inform strategies to rapidly and accurately test patients with respiratory symptoms.

Methods: This study retrospectively examined 298,415 respiratory specimens collected from symptomatic patients for SARS-CoV-2 testing in the three months since COVID-19 was initially documented in the province of Alberta, Canada (March-May, 2020). Read More

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A study of Kollicoat® MAE100P film's Structure and Properties.

Int J Pharm 2021 Apr 28:120622. Epub 2021 Apr 28.

College of Pharmacy, University of Iowa, Iowa City, Iowa, USA.

Generally, an organic-solvent-based film is denser and tougher than a corresponding aqueous-dispersion-based film. However, Kollicoat® MAE100P films prepared from aqueous dispersions had greater tensile strengths compared to the films cast from organic solutions. It was proposed that MAE100P polymer particles in aqueous media had a core-shell structure with a hydrophilic shell and a hydrophobic core. Read More

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TLR4 expression and functionality are downregulated in glioblastoma cells and in tumor-associated macrophages: a new mechanism of immune evasion?

Biochim Biophys Acta Mol Basis Dis 2021 Apr 28:166155. Epub 2021 Apr 28.

Programa de Pós-Graduação em Ciências da Saúde, Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA), Porto Alegre, RS, Brazil; Programa de Pós-Graduação em Biociências, UFCSPA, Porto Alegre, RS, Brazil; Instituto de Cardiologia do Rio Grande do Sul/Fundação Universitária do Instituto de Cardiologia (IC-FUC), Porto Alegre, RS, Brazil. Electronic address:

Glioblastoma (GB) is the most common and aggressive form of primary brain tumor, in which the presence of an inflammatory environment, composed mainly by tumor-associated macrophages (TAMs), is related to its progression and development of chemoresistance. Toll-Like Receptors (TLRs) are key components of the innate immune system and their expression in both tumor and immune-associated cells may impact the cell communication in the tumor microenvironment (TME), further modeling cancer growth and response to therapy. Here, we investigated the participation of TLR4-mediated signaling as a mechanism of induced-immune escape in GB. Read More

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[Gigantic prepatellar "tumor" in rheumatoid arthritis-a case report].

Z Rheumatol 2021 Apr 30. Epub 2021 Apr 30.

Klinik für Orthopädie und Unfallchirurgie, AGAPLESION MARKUS KRANKENHAUS, Wilhelm-Epstein-Str. 4, 60431, Frankfurt am Main, Deutschland.

In soft tissue tumors of the extremities it is of utmost importance to differentiate between benign and malignant entities. The majority of the swellings vary from benign tissue changes through soft tissue sarcomas up to pseudotumors. Because of the low incidence of malignancy and the predominantly benign alterations together with a high heterogeneity, there is a need for a reproducible diagnostic and therapeutic concept for the treatment of all tumors of the extremities. Read More

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DNMT3A-mediated silence in ADAMTS9 expression is restored by RNF180 to inhibit viability and motility in gastric cancer cells.

Cell Death Dis 2021 Apr 30;12(5):428. Epub 2021 Apr 30.

Department of Gastroenterology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer; Key Laboratory of Cancer Prevention and Therapy, Tianjin; Tianjin's Clinical Research Center for Cancer, Tianjin, 300060, China.

ADAMTS9 belongs to the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family, and its expression is frequently silenced due to promoter hypermethylation in various human cancers. However, the underlying mechanisms remain largely unknown. In this study, we investigated the inhibitory effects of ADAMTS9 on gastric cancer (GC) cells. Read More

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Essential role of papillae flexibility in nectar capture by bees.

Proc Natl Acad Sci U S A 2021 May;118(19)

Nonlinear Physical Chemistry Unit, Université libre de Bruxelles, 1050 Bruxelles, Belgium;

Many bees possess a tongue resembling a brush composed of a central rod (glossa) covered by elongated papillae, which is dipped periodically into nectar to collect this primary source of energy. In vivo measurements show that the amount of nectar collected per lap remains essentially constant for sugar concentrations lower than 50% but drops significantly for a concentration around 70%. To understand this variation of the ingestion rate with the sugar content of nectar, we investigate the dynamics of fluid capture by as a model system. Read More

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The optimization of torque ripple reduction by using DTC-multilevel inverter.

ISA Trans 2021 Apr 16. Epub 2021 Apr 16.

Faculty of Electrical Engineering, Universiti Teknikal Malaysia Melaka (UTeM), Malaysia; Electrical Machine Design, Power Electronics and Drives Research Group, CeRIA, UTeM, Malaysia.

Direct Torque Control (DTC) scheme introduces a robust and simple control of electrical drive. However, its shortcomings such as broad torque ripple and variable switching frequency have offered several improvements like Space Vector Modulation (SVM) strategy, multilevel inverter (MLI) topology, etc. The conventional DTC which is fed by the two-level inverter has limited voltage vector, results in some difficulties to optimize the operation, especially at low operating speed. Read More

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Discordance between immunochemistry of mismatch repair proteins and molecular testing of microsatellite instability in colorectal cancer.

ESMO Open 2021 Apr 27;6(3):100120. Epub 2021 Apr 27.

Gastroenterology Department, Poitiers University Hospital, Poitiers, France; Faculty of Medicine, University of Poitiers, Poitiers, France; Medical Oncology Department, Poitiers University Hospital, Poitiers, France. Electronic address:

Background: DNA mismatch repair system deficiency (dMMR) is found in 15% of colorectal cancers (CRCs). Two methods are used to determine dMMR, immunohistochemistry (IHC) of MMR proteins and molecular testing of microsatellite instability (MSI). Only studies with a low number of patients have reported rates of discordance between these two methods, ranging from 1% to 10%. Read More

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Low serum albumin and the risk of hospitalization in COVID-19 infection: A retrospective case-control study.

PLoS One 2021 30;16(4):e0250906. Epub 2021 Apr 30.

Department of Critical Care Medicine, Cape Fear Valley Medical Center, Fayetteville, NC, United States of America.

Background: The data on the COVID-19 patients who were discharged to self-quarantine is lacking.

Aim: The aim of the study was to investigate the percentage of COVID-19 positive patients that were hospitalized within a three-week period after discharge from ED to self-quarantine.

Methods: The patients who had confirmed SARS-CoV-2 on RT-PCR of the nasopharyngeal swab and were discharged from ED of a tertiary care hospital in the USA to self-quarantine from March 01- July 31, 2020, were included. Read More

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Repositioning and Characterization of 1-(Pyridin-4-yl)pyrrolidin-2-one Derivatives as Cytoplasmic Prolyl-tRNA Synthetase Inhibitors.

ACS Infect Dis 2021 Apr 30. Epub 2021 Apr 30.

Medicines for Malaria Venture, ICC, Route de Pré-Bois 20, 1215 Geneva, Switzerland.

Prolyl-tRNA synthetase (PRS) is a clinically validated antimalarial target. Screening of a set of PRS ATP-site binders, initially designed for human indications, led to identification of 1-(pyridin-4-yl)pyrrolidin-2-one derivatives representing a novel antimalarial scaffold. Evidence designates cytoplasmic PRS as the drug target. Read More

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Natural Course of Residual Hearing with Reference to GJB2 and SLC26A4 Genotypes: Clinical Implications for Hearing Rehabilitation.

Ear Hear 2021 Jan 6;42(3):644-653. Epub 2021 Jan 6.

Department of Otorhinolaryngology-Head and Neck Surgery, Seoul National University Bundang Hospital, Seongnam, South Korea.

Background: Understanding the characteristics of residual hearing at low frequencies and its natural course in relation to molecular genetic etiology may be important in developing rehabilitation strategies. Thus, we aimed to explore the characteristics and natural course of residual hearing at low frequencies associated with the two most frequent deafness genes: GJB2 and SLC26A4.

Methods: Initially, 53 GJB2 and 65 SLC26A4 subjects were enrolled, respectively. Read More

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January 2021