29,439 results match your criteria initially identified


There is no gene for CVID - novel monogenetic causes for primary antibody deficiency.

Curr Opin Immunol 2021 Jun 18;72:176-185. Epub 2021 Jun 18.

Institute for Immunodeficiency, Center for Chronic Immunodeficiency, Medical Center, Faculty of Medicine, Albert-Ludwigs-University of Freiburg, Freiburg, Germany; DZIF - German Center for Infection Research, Satellite Center Freiburg, Freiburg, Germany; CIBSS - Centre for Integrative Biological Signalling Studies, Albert-Ludwigs University, Freiburg, Germany; RESIST - Cluster of Excellence 2155 to Hanover Medical School, Satellite Center Freiburg, Freiburg, Germany. Electronic address:

'There is no gene for fate' (citation from the movie 'GATTACA') - and there is no gene for CVID. Common Variable ImmunoDeficiency (CVID) is the most prevalent primary immunodeficiency in humans. CVID is characterized by an increased susceptibility to infections, hypogammaglobulinemia, reduced switched memory B cell numbers in peripheral blood and a defective response to vaccination, often complicated by autoimmune and autoinflammatory conditions. Read More

View Article and Full-Text PDF

Temporal subsidence patterns of cemented polished taper-slip stems: a systematic review.

EFORT Open Rev 2021 May 4;6(5):331-342. Epub 2021 May 4.

The Academic Surgical Unit, South West London Elective Orthopaedic Centre, UK.

The literature was reviewed to establish the levels of stem subsidence for both double and triple-tapered implants in order to determine whether there were any differences in subsidence levels with regard to the methods of measurement, the magnitude and rate of subsidence and clinical outcomes.All studies reporting subsidence of polished taper-slip stems were identified. Patient demographics, implant design, radiological findings, details of surgical technique, methods of measurement and levels of subsidence were collected to investigate which factors were related to increased subsidence. Read More

View Article and Full-Text PDF

Massive Pneumomediastinum and Subcutaneous Emphysema Secondary to Foreign Body Aspiration.

J Emerg Med 2021 Jun 17. Epub 2021 Jun 17.

Department of Pediatrics, Soroka University Medical Center, Beer Sheva, Israel; Pediatric Pulmonary Unit, Soroka University Medical Center, Beer Sheva, Israel; Faculty of Health Sciences, Ben-Gurion, University of the Negev, Beer Sheva, Israel.

Background: Spontaneous pneumomediastinum (SPM) occurs in cases of mediastinal leaks that are not caused by trauma, mechanical ventilation, or other surgical procedures. In most cases, in the pediatric population a trigger can be identified, most commonly asthma. SPM caused by foreign body aspiration is not a common entity. Read More

View Article and Full-Text PDF

Early head CT in post-cardiac arrest patients: a helpful tool or contributor to self-fulfilling prophecy?

Resuscitation 2021 Jun 17. Epub 2021 Jun 17.

Department of Neurology, Yale School of Medicine, New Haven, CT, 06510, United States.

Objective: Neuroprognostication guidelines suggest that early head computed tomography (HCT) might be useful in the evaluation of cardiac arrest (CA) patients following return of spontaneous circulation. We aimed to determine the impact of early HCT, performed within the first 6 hours following CA, on decision-making following resuscitation.

Methods: We identified a cohort of initially unconscious post-CA patients at a tertiary care academic medical center from 2012 to 2017. Read More

View Article and Full-Text PDF

Concomitant intraductal carcinoma of the prostate and response to hormonal therapy in metastatic prostate carcinoma.

Actas Urol Esp (Engl Ed) 2021 Jun 16. Epub 2021 Jun 16.

Servicio Urología, Hospital del Mar, Barcelona, Spain.

Introduction And Objective: Most prostate cancers are classified as acinar adenocarcinoma. Intraductal carcinoma of the prostate (IDC-P) is a distinct histologic entity that is believed to represent retrograde spread of invasive acinar adenocarcinoma into prostatic ducts and acini. We have analyzed the impact of IDC-P in hormonal naïve and castration resistant metastatic prostate cancer patients. Read More

View Article and Full-Text PDF

Hydroxyurea-induced genital ulcers and erosions: Two case reports.

J Tissue Viability 2021 Jun 6. Epub 2021 Jun 6.

Harvard Medical School, Boston, MA, USA; Department of Dermatology, Brigham and Women's Hospital, Boston, MA, USA. Electronic address:

Hydroxyurea is a chemotherapeutic agent used for myeloproliferative disorders and sickle cell anemia that is well known to cause painful mucocutaneous ulcers, typically involving the legs or mouth. However, genital ulcerations due to hydroxyurea therapy are a rare, and likely underrecognized, adverse effect with only a few cases reported in the literature to date. Ulcers of the lower legs caused by hydroxyurea are associated with a diagnostic delay, and this is likely exacerbated in cases of genital ulceration due to a lack of awareness. Read More

View Article and Full-Text PDF

Cerebrospinal fluid from COVID-19 patients with olfactory/gustatory dysfunction: A review.

Clin Neurol Neurosurg 2021 Jun 12;207:106760. Epub 2021 Jun 12.

Department of Neurology, NYU Langone Medical Center, New York, NY 10016, USA; Department of Neurosurgery, NYU Langone Medical Center, New York, NY 10016, USA.

Objective: We reviewed the literature on cerebrospinal fluid (CSF) testing in patients with altered olfactory/gustatory function due to COVID-19 for evidence of viral neuroinvasion.

Methods: We performed a systematic review of Medline and Embase to identify publications that described at least one patient with COVID-19 who had altered olfactory/gustatory function and had CSF testing performed. The search ranged from December 1, 2019 to November 18, 2020. Read More

View Article and Full-Text PDF

[Asynchronous Tele-Expertise (ASTE) in obstetrical ultrasound: is it equivalent to face-to-face consultation?]

Gynecol Obstet Fertil Senol 2021 Jun 16. Epub 2021 Jun 16.

Centre Image2, 6 rue Rocca, Marseille, France; Service de Gynécologie-Obstétrique, Hôpital Saint Joseph, 26 Bd de Louvain, Marseille, France. Electronic address:

Introduction: The demand for remote advice has expanded since the advent of information and communication technology. This study aims to evaluate the use of asynchronous tele-expertise (ASTE) in providing a quality expert opinion in the field of obstetric ultrasound.

Materials And Methods: Requests for expert opinions on pregnant patients were considered retrospectively over a 24-month period (01/09/2018 to 01/21/2020). Read More

View Article and Full-Text PDF

Haemophilia Carriers Experience Study (CARES): A mixed method exploration into the experience of women who are carriers of Haemophilia.

Haemophilia 2021 Jun 19. Epub 2021 Jun 19.

Haemophilia Department, Southern Haemophilia Network, Uplands House, Basingstoke and North Hampshire Hospital, Basingstoke, Hampshire, UK.

Introduction: Haemophilia research has traditionally focused on patients diagnosed with haemophilia and although research priorities are rapidly changing, there is still a lot more we need to understand about the experiences and psychosocial issues facing women who are diagnosed as carriers of haemophilia (Haemophilia, https://doi.org/10.1111/hae. Read More

View Article and Full-Text PDF

Multilevel Airway Stenosis Being Bypassed by a Customized Tracheostomy Tube in an Infant with Myhre Syndrome.

Pediatr Allergy Immunol Pulmonol 2021 Jun;34(2):83-87

Department of Pediatrics, Seoul National University Children's Hospital, Seoul National University College of Medicine, Seoul, Korea.

Myhre syndrome is a rare connective tissue disorder caused by heterozygous pathogenic variants in the gene. Although recognizing Myhre syndrome in early childhood is challenging, it is important to manage airway stenosis in patients with Myhre syndrome. We report the case of a 2-month-old boy who initially presented with severe multilevel airway stenosis, dysmorphic face, and multiple abnormalities. Read More

View Article and Full-Text PDF

Initiation of Otx2 expression in the developing mouse retina requires a unique enhancer and either Ascl1 or Neurog2 activity.

Development 2021 Jun 18;148(12). Epub 2021 Jun 18.

Department of Ophthalmology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.

During retinal development, a large subset of progenitors upregulates the transcription factor Otx2, which is required for photoreceptor and bipolar cell formation. How these retinal progenitor cells initially activate Otx2 expression is unclear. To address this, we investigated the cis-regulatory network that controls Otx2 expression in mice. Read More

View Article and Full-Text PDF

First Report of Tomato Powdery Mildew Caused by in Taiwan.

Plant Dis 2021 Jun 18. Epub 2021 Jun 18.

Taiwan Agricultural Research Institute, 56091, Plant Pathology, Taichung, Taiwan;

Tomato ( L.) is one of the common and important economic crops in Taiwan. In July 2018, tomato leaves with unusual yellowing and lesions were observed in Taichung, Changhua, Nantou, and Yunlin counties in Taiwan. Read More

View Article and Full-Text PDF

The Value of Songs for Teaching and Learning Cardiopulmonary Resuscitation (CPR) Competencies: A Systematic Review.

Cureus 2021 May 16;13(5):e15053. Epub 2021 May 16.

Emergency Medicine, Brown University, Providence, USA.

We sought to summarize, in a systematic review, the effectiveness of songs to support learning, performance, and recall of quality characteristics of cardiopulmonary resuscitation (CPR) compression rate, and depth. We systematically reviewed the literature from eight academic indexes from the fields of medicine, nursing, allied health, and education, from 2014 to 2020 to identify studies that evaluated an intervention of song use during CPR training against control and reported outcomes of compression rate and depth. There were 185 studies initially identified for review, eight met criteria for inclusion and analysis. Read More

View Article and Full-Text PDF

Plug-related canaliculitis: a rare or underdiagnosed disease?

Clin Exp Optom 2021 Jun 17:1-7. Epub 2021 Jun 17.

Department of Ophthalmology, Taipei Veterans General Hospital, Taipei, Taiwan.

Clinical Relevance: Conjunctivitis, chalazion and blepharitis are routinely managed by optometrists. However, it is especially important to consider the diagnosis of canaliculitis in patients with chronic or recurrent conditions.

Background: This study aimed to report the clinical features, radiological findings and treatment outcomes in patients with plug-related canaliculitis. Read More

View Article and Full-Text PDF

Disseminated nocardiosis involving the central nervous system in the context of newly diagnosed HIV infection: A case report.

Int J STD AIDS 2021 Jun 17:9564624211000970. Epub 2021 Jun 17.

Department of Infectious Disease, Nanjing Second Hospital, Nanjing University of Chinese Medicine, Nanjing, China.

Background: A newly diagnosed HIV patient with tuberculosis-like symptoms was confirmed with disseminated nocardiosis involving the central nervous system (CNS). This case report provides novel insights into the diagnosis and treatment of nocardiosis.

Case Presentation: A 44-year-old male newly diagnosed HIV patient presented on March 20, 2017, with the major symptoms of fever and headache. Read More

View Article and Full-Text PDF

Exploring factors associated with acquisition and chronicity of infection in bronchiectasis: A population-based study.

Respir Med 2021 Jun 8;185:106487. Epub 2021 Jun 8.

Pulmonology Institute Carmel Medical Center, Haifa, Israel; CF Center, Carmel Medical Center, Haifa, Israel; Ruth and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel. Electronic address:

Introduction: Chronic infection is associated with adverse outcomes among people with bronchiectasis. However, it is not known which factors are associated with a bacterial infection, and with persistence of an infection after the first episode. We aimed to determine factors associated with a new infection and with chronicity of Pseudomonas aeruginosa (PA) and H. Read More

View Article and Full-Text PDF

[Effectiveness of treadmill training on the motor development of children with cerebral palsy and Down syndrome].

Medicina (B Aires) 2021 ;81(3):367-374

Departamento de Enfermería, Fisioterapia y Terapia Ocupacional, Facultad de Fisioterapia y Enfermería, Universidad de Castilla-La Mancha, España.

Cerebral palsy and Down syndrome are two conditions that present with a deficit in motor development. Treadmill interventions were found to improve this delay in development. This work aimed to describe and analyze the methodological quality of studies that applied treadmill interventions alone or combined with other therapies to promote gait and balance in children under 12 years of age with cerebral palsy and Down syndrome. Read More

View Article and Full-Text PDF

Opioid use following a total shoulder arthroplasty: who requires refills and for how long?

JSES Int 2021 May 3;5(3):346-352. Epub 2021 Apr 3.

Emory University School of Medicine, Department of Orthopaedics, Atlanta, GA, USA.

Introduction: Pain control following a total shoulder arthroplasty (TSA) is multifactorial. The current standard of care includes the utilization of a multimodal analgesic approach including breakthrough prescription opioid medication in an effort to provide postoperative analgesia. While this original opioid prescription is sufficient for the majority of patients, some go on to require prolonged opioid use. Read More

View Article and Full-Text PDF

Survival Outcomes and Treatment Decision by Human Papillomavirus Status Among Patients With Stage IVC Head and Neck Squamous Cell Carcinoma.

Front Oncol 2021 31;11:668066. Epub 2021 May 31.

Department of Radiation Oncology, The First Affiliated Hospital of Xiamen University, Xiamen, China.

Purpose: To investigate the influence of human papillomavirus (HPV) status on survival outcomes and treatment decisions for patients with stage IV head and neck squamous cell cancers (HNSCC).

Methods: Patients initially diagnosed with stage IVC HNSCC between 2010 and 2015 were identified from the Surveillance, Epidemiology, and End Results database. Cox multivariable analyses were performed to determine prognostic factors associated with head and neck cancers specific survival (HNCSS) and overall survival (OS). Read More

View Article and Full-Text PDF

Invasive Klebsiella pneumoniae Syndrome in Qatar: A Case Report.

Cureus 2021 May 13;13(5):e15015. Epub 2021 May 13.

Internal Medicine, Hamad Medical Corporation, Doha, QAT.

is a Gram-negative bacteria that can infect most of the body's organs, from the lungs to the central nervous system. It is notorious for causing pneumonia in alcoholic, diabetic, and hospitalized patients. It is now emerging as a cause of abscesses involving multiple organs. Read More

View Article and Full-Text PDF

Phylogenetic and Structural Analysis of NIN-Like Proteins With a Type I/II PB1 Domain That Regulates Oligomerization for Nitrate Response.

Front Plant Sci 2021 31;12:672035. Epub 2021 May 31.

Department of Life Science, College of Life Science, National Taiwan University, Taipei, Taiwan.

Absorption of macronutrients such as nitrogen is a critical process for land plants. There is little information available on the correlation between the root evolution of land plants and the protein regulation of nitrogen absorption and responses. -like protein () transcription factors contain a Phox and Bem1 (PB1) domain, which may regulate nitrate-response genes and seem to be involved in the adaptation to growing on land in terms of plant root development. Read More

View Article and Full-Text PDF

Effects of Training Programs on Decision-Making in Youth Team Sports Players: A Systematic Review and Meta-Analysis.

Front Psychol 2021 31;12:663867. Epub 2021 May 31.

Escola Superior Desporto e Lazer, Instituto Politécnico de Viana do Castelo, Rua Escola Industrial e Comercial de Nun'Álvares, Viana do Castelo, Portugal.

Background: The use of dedicated training programs for improving decision-making (DM) in team sports players has grown in the last several years. Approaches such as imagery training, video-based training, or game-based drills are some of the interventions used in youth players in order to improve DM. However, no systematic reviews or meta-analyses have been conducted to summarize the main evidence regarding the effects of these programs on the players and identify the magnitude of the effects compared to control groups. Read More

View Article and Full-Text PDF

The Prevalence of Generalized Anxiety Disorder Among Health Care Workers During the COVID-19 Pandemic: A Systematic Review and Meta-Analysis.

Front Psychiatry 2021 31;12:658846. Epub 2021 May 31.

Department of Health in Disasters and Emergencies, School of Public Health and Safety, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Health care workers, due to be involved in caring for COVID-19 patients may experience various psychological problems including anxiety disorders. This study aimed to investigate the prevalence of Generalized Anxiety Disorder (GAD) among health care workers during the COVID-19 pandemic by systematic review and meta-analysis. The PRISMA guideline was used for conducting this study. Read More

View Article and Full-Text PDF

Characterization and management of NMIBC recurrences after TMT: a matched cohort analysis.

Urol Oncol 2021 Jun 13. Epub 2021 Jun 13.

Division of Urology, Department of Surgery and Surgical Oncology, Princess Margaret Cancer Center, University Health Network, University of Toronto, Toronto, Canada.

Introduction And Objective: Bladder preservation with trimodal therapy (TMT) has emerged as a feasible alternative strategy to treat localized muscle invasive bladder cancer (MIBC). There is lack of consensus regarding the treatment of local recurrence following TMT. The aim of this paper is to determine whether traditional NMIBC therapies can be applied to the management of NMIBC recurrences following TMT. Read More

View Article and Full-Text PDF

Rapid identification of mutations caused by fast neutron bombardment in Medicago truncatula.

Plant Methods 2021 Jun 16;17(1):62. Epub 2021 Jun 16.

Guangdong Key Laboratory for Innovative Development and Utilization of Forest Plant Germplasm, College of Forestry and Landscape Architecture, South China Agricultural University, Guangzhou, 510642, Guangdong, China.

Background: Fast neutron bombardment (FNB) is a very effective approach for mutagenesis and has been widely used in generating mutant libraries in many plant species. The main type of mutations of FNB mutants are deletions of DNA fragments ranging from few base pairs to several hundred kilobases, thus usually leading to the null mutation of genes. Despite its efficiency in mutagenesis, identification of the mutation sites is still challenging in many species. Read More

View Article and Full-Text PDF

Combination of toothbrushing and chlorhexidine compared with exclusive use of chlorhexidine to reduce the risk of ventilator-associated pneumonia: A systematic review with meta-analysis.

Clinics (Sao Paulo) 2021;76:e2659. Epub 2021 Jun 11.

Area de Patologia, Faculdade de Odontologia, Universidade Federal de Uberlandia, Uberlandia, MG, BR.

This study aimed to compare the effectiveness of 0.12% chlorhexidine alone and 0.12% chlorhexidine in combination with toothbrushing to prevent ventilator-associated pneumonia (VAP) in mechanically ventilated patients. Read More

View Article and Full-Text PDF

Role of Intravenous Acyclovir in Treatment of Herpes Simplex Virus Stromal Keratitis with Ulceration: A Review of 2 Cases.

Am J Case Rep 2021 Jun 16;22:e930467. Epub 2021 Jun 16.

Department of Ophthalmology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

BACKGROUND Herpes simplex virus (HSV) stromal keratitis with ulceration is one of the most serious forms of herpes corneal infection and is one of the most difficult conditions in terms of clinical management. We assessed the efficacy of intravenous acyclovir in the treatment of this condition. CASE REPORT Two cases of HSV stromal keratitis with ulceration were reported in terms of clinical presentation, investigation, treatment, and outcome. Read More

View Article and Full-Text PDF

Reducing unscheduled hospital care for adults with diabetes following a hypoglycaemic event: which community-based interventions are most effective? A systematic review.

J Diabetes Metab Disord 2021 Jun 10:1-18. Epub 2021 Jun 10.

Faculty of Life and Health Sciences, School of Nursing, Ulster University, Magee, Northland Road, Derry, BT48 7JL UK.

Aim: To determine which community-based interventions are most effective at reducing unscheduled hospital care for hypoglycaemic events in adults with diabetes.

Methods: Medline Ovid, CINAHL Plus and ProQuest Health and Medical Collection were searched using both key search terms and medical subject heading terms (MeSH) to identify potentially relevant studies. Eligible studies were those that involved a community-based intervention to reduce unscheduled admissions in adults with diabetes. Read More

View Article and Full-Text PDF

Hypoxic TAM-derived exosomal miR-155-5p promotes RCC progression through HuR-dependent IGF1R/AKT/PI3K pathway.

Cell Death Discov 2021 Jun 15;7(1):147. Epub 2021 Jun 15.

Department of Urology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.

Hypoxic tumor-associated macrophages (TAMs) are related to poor prognosis of patients with clear cell renal cell carcinoma (ccRCC). Exosomes are small lipid-bilayer vesicles that implicated in tumor progression and metastasis. However, whether hypoxic TAM-derived exosomes affect RCC progression within the hypoxic tumor microenvironment has not been elucidated. Read More

View Article and Full-Text PDF