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Patient satisfaction and savings, and clinical outcomes of televisits in female pelvic medicine and reconstructive surgery at an urban academic center.

Neurourol Urodyn 2021 Aug 3. Epub 2021 Aug 3.

Albert Einstein College of Medicine, Bronx, New York, USA.

Aim: To evaluate patient satisfaction and savings, and compare visit outcomes based on chief complaint (CC) of women presenting for a televisit to a female pelvic medicine and reconstructive surgery (FPMRS) clinic at an urban academic center.

Methods: A cross-sectional study of women completing a televisit with an FPMRS specialist at our institution from June 19, 2020 to July 17, 2020 was conducted. A telephone questionnaire was administered to patients to assess satisfaction and savings (travel costs/time avoided). Read More

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Longitudinal evaluation of diastema closure in patients submitted to labial frenectomy in different phases of the mixed dentition: A historical cohort.

J Indian Soc Pedod Prev Dent 2021 Apr-Jun;39(2):159-163

Professor, Universidade Católica Portuguesa, Center for Interdisciplinary Research in Health (CIIS), Faculty of Dental Medicine, Viseu, Portugal.

Background: There is a controversy in the literature concerning the indications for frenectomy to treat interincisal diastema. Aims and Objectives: The aim of this study was to evaluate the spontaneous closure of the interincisal diastema in patients submitted to upper labial frenectomy (ULF) during the mixed dentition.

Materials And Methods: Records from patients treated between 2009 and 2014 in the course of Pediatric Dentistry Surgery at Fundecto-USP were evaluated to select those that were submitted to ULF during the mixed dentition using the Chelotti technique. Read More

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Femoral hernia in children: How to avoid misdiagnosis?

Afr J Paediatr Surg 2021 Jul-Sep;18(3):164-167

Department of Pediatric Surgery, Medical School of Monastir, Fattouma Bourguiba Hospital, Monastir University, Research Laboratory LR12SP13, Tunisia.

Background: Femoral hernias are an uncommon groin pathology among pediatric patients. Therefore, they are frequently misdiagnosed. In the present study, we review our experience with this rare surgical entity during the past 25 years. Read More

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Parents' experiences of their child's assessment on an epilepsy surgery pathway: A qualitative study.

Seizure 2021 Jul 17;91:456-461. Epub 2021 Jul 17.

Institute of Population Health, Department of Public Health, Policy and Systems, University of Liverpool, Liverpool L69 3G, United Kingdom. Electronic address:

Purpose: Children's epilepsy surgery services (CESS) in the UK aim to improve outcomes for young children by increasing access to surgery. Consideration for surgery is complex and time consuming, yet there is lack of research exploring how this process might impact on families. This study aimed to explore parents' experiences of their child consideration for epilepsy surgery to inform future service development and delivery. Read More

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Kawasaki disease associated pulmonary involvement in infants.

Pediatr Pulmonol 2021 Aug 2. Epub 2021 Aug 2.

Department of Rheumatology and Immunology, Shenzhen Children's hospital, Shenzhen, China.

Objectives: Kawasaki disease (KD) is an acute, self-limited multisystemic vasculitis of unknown cause. Pulmonary involvement has been reported in case reports and limited small case series, which is not commonly recognized, especially in younger patients <1 year. Here, we describe clinical and radiological features of infants with KD-associated pulmonary involvement (KD-PI). Read More

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Towards real-time diagnosis for pediatric sepsis using graph neural network and ensemble methods.

Eur Rev Med Pharmacol Sci 2021 Jul;25(14):4693-4701

University of Chinese Academy of Sciences, Beijing, China.

Objective: The rapid onset of pediatric sepsis and the short optimal time for resuscitation pose a severe threat to children's health in the ICU. Timely diagnosis and intervention are essential to curing sepsis, but there is a lack of research on the prediction of sepsis at shorter time intervals. This study proposes a predictive model towards real-time diagnosis of sepsis to help reduce the time to first antibiotic treatment. Read More

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Episodic formation of refractory inclusions in the Solar System and their presolar heritage.

Earth Planet Sci Lett 2020 Apr 28;535:116088. Epub 2020 Jan 28.

Centre for Star and Planet Formation, Natural History Museum of Denmark, University of Copenhagen, Copenhagen DK-1350, Denmark.

Refractory inclusions [Ca-Al-rich Inclusions (CAIs) and Amoeboid Olivine Aggregates (AOAs)] in primitive meteorites are the oldest Solar System solids. They formed in the hot inner protoplanetary disk and, as such, provide insights into the earliest disk dynamics and physicochemical processing of the dust and gas that accreted to form the Sun and its planetary system. Using the short-lived Al to Mg decay system, we show that bulk refractory inclusions in CV (Vigarano-type) and CR (Renazzo-type) carbonaceous chondrites captured at least two distinct Al-rich (Al/Al ratios of ~5 × 10) populations of refractory inclusions characterized by different initial Mg/Mg isotope compositions (μMg*). Read More

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SARS-CoV-2/DENV co-infection: a series of cases from the Federal District, Midwestern Brazil.

BMC Infect Dis 2021 Jul 31;21(1):727. Epub 2021 Jul 31.

Programa de Pós-Graduação em Ciências Médicas, Faculdade de Medicina, Universidade de Brasília - UnB, Brasília, Brazil.

Background: Since the novel coronavirus disease outbreak, over 179.7 million people have been infected by SARS-CoV-2 worldwide, including the population living in dengue-endemic regions, particularly Latin America and Southeast Asia, raising concern about the impact of possible co-infections.

Methods: Thirteen SARS-CoV-2/DENV co-infection cases reported in Midwestern Brazil between April and September of 2020 are described. Read More

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The status quo of early burn wound excision: Insights from the German burn registry.

Burns 2021 Jul 10. Epub 2021 Jul 10.

Department of Hand, Plastic and Reconstructive Surgery, Burn Center, BG Trauma Center Ludwigshafen, Plastic- and Hand Surgery, University of Heidelberg, Germany. Electronic address:

Background: There is a common, well-known and established recommendation to excise burn wounds within 24-72 h in order to mitigate the systemic inflammatory and immunomodulatory response, shorten length of hospitalization through early grafting and optimize patient survival. Despite this apparent consensus, surprisingly few systematic studies have evaluated the actual adherence to this practice and its implications on patient outcomes. In this registry study, we sought to objectify the current status of early burn wound excision, its influencing factors and impact on patient outcomes for all German burn centers. Read More

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Dietary supplements and herbal medicine for COVID-19: A systematic review of randomized control trials.

Clin Nutr ESPEN 2021 Aug 1;44:50-60. Epub 2021 Jun 1.

Medical College of Acu-Moxi and Rehabilitation, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China; Department of Rehabilitation, Shenzhen Hospital of Guangzhou University of Chinese Medicine (Futian), Shenzhen, Guangdong, China. Electronic address:

Background: The world is currently struggling with the Coronavirus disease 2019 (COVID-19) pandemic. Dietary supplements (DSs) and herbal medicine provide a potentially convenient and accessible method for its recovery, but direct evidence is limited.

Objective: This study aims to investigate the effectiveness of DSs and herbs in patients with COVID-19. Read More

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The chest radiographic scoring system in initial diagnosis of COVID-19: Is a radiologist needed?

Adv Clin Exp Med 2021 Jul 30. Epub 2021 Jul 30.

Department of General Radiology, Interventional Radiology and Neuroradiology, Wroclaw Medical University, Poland.

Background: Lung imaging, next to a polymerase chain reaction (PCR) test, is a key diagnostic tool in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. The degree of abnormalities correlates with clinical outcome. Imaging of the lungs using chest radiography (CXR) at the peak of a pandemic is considered a basic diagnostic tool at the triage stage. Read More

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Durable responses in patients with genitourinary cancers following immune checkpoint therapy rechallenge after moderate-to-severe immune-related adverse events.

J Immunother Cancer 2021 Jul;9(7)

Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA

Background: Immune checkpoint therapy (ICT) prolongs survival in subsets of patients with cancer but can also trigger immune-related adverse events (irAEs) requiring treatment discontinuation. Recent studies have investigated safety of ICT rechallenge after irAEs, and evidence suggests that rechallenge may be associated with improved antitumor responses. However, data are limited on response duration after ICT rechallenge, particularly after severe irAEs. Read More

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Duration and management of sepsis-associated hypotension at rapid response team call-outs to patients subsequently admitted to the intensive care unit: A case series.

Aust Crit Care 2021 Jul 26. Epub 2021 Jul 26.

Sir Charles Gairdner Hospital, Perth, Australia; University of Western, Australia. Electronic address:

Background: Sepsis-related hypotension in hospital patients is a common reason for rapid response team (RRT) attendance and transfer to intensive care, but little is known about the duration and management of hypotension during these RRT call-outs.

Objectives: We aimed to describe the duration and management of hypotension during RRT call-outs to patients with sepsis-related hypotension who required transfer to intensive care.

Methods: RRT call-outs during 2018 for hypotension with transfer to intensive care were identified from a prospectively maintained database of RRT call-outs at a single tertiary hospital. Read More

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Sri Lanka's early success in the containment of COVID-19 through its rapid response: Clinical & epidemiological evidence from the initial case series.

PLoS One 2021 29;16(7):e0255394. Epub 2021 Jul 29.

Department of Community Medicine, Faculty of Medical Sciences, University of Sri Jayewardenepura, Nugegoda, Sri Lanka.

Background: Despite the rising global burden, Sri Lanka reported a relatively low caseload and mortality (13 deaths as of 20 October 2020) for COVID-19. This warrants exploration of the clinical and epidemiological characteristics of the case series during the initial passive case detection phase in Sri Lanka, in order to understand the success in containment of the disease for more than nine months in the country through its initial early and rapid pandemic response.

Methods: A retrospective study was conducted using secondary data (hospital records and investigation reports) extracted from all laboratory-confirmed patients admitted to the three main state-sector hospitals in Sri Lanka from 11 March to 7 April 2020. Read More

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Civilian Penetrating Neck Trauma at a Level I Trauma Centre: A Five-Year Retrospective Case Note Review.

Clin Otolaryngol 2021 Jul 29. Epub 2021 Jul 29.

College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.

Objectives: To report the experience of civilian penetrating neck trauma (PNT) at a UK level I trauma centre, propose an initial management algorithm and assess the degree of correlation between clinical signs of injury, operative findings, and radiological reports.

Design: Retrospective case note review SETTING: UK level I trauma centre April 2012-November 2017 PARTICIPANTS: 310 cases of PNT were drawn from electronic patient records. Data was extracted on hard and soft signs of vascular or aerodigestive tract injury, clinical management, radiological imaging and patient outcomes. Read More

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Greenspace Inversely Associated with the Risk of Alzheimer's Disease in the Mid-Atlantic United States.

Earth (Basel) 2021 Feb;2(1):140-150

US EPA, Office of Research and Development, Center for Public Health and Environmental Assessment, Research Triangle Park, Durham, NC 27711, USA.

Alzheimer's disease (AD) is a chronic neurodegenerative disease and the most common form of dementia in older adults. Treatment of AD symptoms is very challenging and expensive. Appropriate diet as well as mental and physical activity may delay or reduce the occurrence of AD. Read More

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February 2021

Impact of admission hours on each stage of care and total reperfusion delays in patients with ST elevation myocardial infarction.

Am J Cardiovasc Dis 2021 15;11(3):382-390. Epub 2021 Jun 15.

Postgraduate Program in Cardiology, School of Medicine, Universidade Federal do Rio Grande do Sul Rua Ramiro Barcelos, 2400, 2º. Andar, Santa Cecilia, Porto Alegre 90035-003, RS, Brazil.

Background: ST segment elevation myocardial infarction (STEMI) is preferably treated by prompt primary percutaneous coronary intervention (pPCI). Delays in initial stages of care of STEMI patients admitted off versus routine hours are controversial. The aim of this study was to evaluate time periods in each stage of care of STEMI patients submitted to pPCI in a private tertiary hospital during on- off-hours, and the adherence to current guidelines recommended times. Read More

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Prediction of treatment outcome in burning mouth syndrome patients using machine learning based on clinical data.

Sci Rep 2021 Jul 28;11(1):15396. Epub 2021 Jul 28.

Department of Oral Medicine and Oral Diagnosis, School of Dentistry and Dental Research Institute, Seoul National University, 101, Daehak-ro, Jongno-gu, Seoul, 03080, South Korea.

The purpose of this study is to apply a machine learning approach to predict whether patients with burning mouth syndrome (BMS) respond to the initial approach and clonazepam therapy based on clinical data. Among the patients with the primary type of BMS who visited the clinic from 2006 to 2015, those treated with the initial approach of detailed explanation regarding home care instruction and use of oral topical lubricants, or who were prescribed clonazepam for a minimum of 1 month were included in this study. The clinical data and treatment outcomes were collected from medical records. Read More

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Global epidemiology of hip fractures: a study protocol using a common analytical platform among multiple countries.

BMJ Open 2021 07 28;11(7):e047258. Epub 2021 Jul 28.

School of Pharmacy, Sungkyunkwan University, Suwon, South Korea.

Introduction: Hip fractures are associated with a high burden of morbidity and mortality. Globally, there is wide variation in the incidence of hip fracture in people aged 50 years and older. Longitudinal and cross-geographical comparisons of health data can provide insights on aetiology, risk factors, and healthcare practices. Read More

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Features and Outcomes of Children with Ulcerative Colitis who Undergo a Diagnostic Change: A Single-Center Experience.

Pediatr Gastroenterol Hepatol Nutr 2021 Jul 5;24(4):357-365. Epub 2021 Jul 5.

Center for Pediatric Inflammatory Bowel Disease, Division of Gastroenterology, National Center for Child Health and Development, Tokyo, Japan.

Purpose: A change in diagnosis from ulcerative colitis (UC) to Crohn's disease (CD) has been reported in pediatric inflammatory bowel disease; however, only a few clinical characteristics and predictors of this diagnostic change have been reported. We aimed to describe the clinical characteristics of patients with UC who underwent a change in diagnosis to CD and identify variables associated with the change.

Methods: The medical records of pediatric patients with UC who were followed up at the National Center for Child Health and Development between 2006 and 2019 were retrospectively reviewed. Read More

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Prognostic Value of Standard Coronary Computed Tomography Angiography Reporting System (CAD-RADS).

Authors:
Sedat Altay

Indian J Radiol Imaging 2021 Jan 31;31(1):37-42. Epub 2021 May 31.

Department of Radiology, Izmir Katip Celebi University Ataturk Research and Training Hospital, İzmir, Turkey.

 This study evaluated the clinical prospects of Coronary Artery Disease-Reporting and Data System (CAD-RADS) scoring in coronary computed tomography angiography (CTA). The aim of the study was to determine the guidance value of CAD-RADS scoring in patient follow-up after CTA.  Reports of cases reported between 2010 and 2013 were reevaluated with CAD-RADS scoring. Read More

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January 2021

Analysis of UK eye casualty presentations.

Clin Exp Optom 2021 Jul 27:1-7. Epub 2021 Jul 27.

College of Health and Life Sciences, Aston University, Birmingham, UK.

Clinical Relevance: Optometrists upskilling and participating in enhanced optometric schemes has the potential to improve service accessibility and alleviate pressure on hospital eye services.

Background: There is a growing demand for eye care in the UK with rising hospital attendances thought to be due in part to an ageing population and a shift in behaviour to favour emergency secondary care.

Methods: Records of first-time presentations to the eye casualty department at the County Hospital (Wye Valley NHS Trust), Hereford, UK, over a month were analysed retrospectively and sequentially. Read More

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Oxygenation, Life, and the Planetary System during Earth's Middle History: An Overview.

Astrobiology 2021 Jul 27. Epub 2021 Jul 27.

State Key Laboratory of Biogeology and Environmental Geology, China University of Geosciences, Wuhan, China.

The long history of life on Earth has unfolded as a cause-and-effect relationship with the evolving amount of oxygen (O) in the oceans and atmosphere. Oxygen deficiency characterized our planet's first 2 billion years, yet evidence for biological O production and local enrichments in the surface ocean appear long before the first accumulations of O in the atmosphere roughly 2.4 to 2. Read More

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Augmented Medial Rectus Recession with Non-Absorbable Suture Loops is Effective in the Treatment of Convergence Excess Esotropia.

Semin Ophthalmol 2021 Jul 27:1-5. Epub 2021 Jul 27.

Haydarpasa Numune Research and Training Hospital, Caaddebostan, İstanbul- Turkey.

Aim: To evaluate the surgical outcomes of augmented medial rectus recession with non-absorbable 5.0 white braided polyester suture (Alcon Laboratories, Forth Worth, Texas, USA) loops in patients diagnosed with convergence excess esotropia. Methods: Clinical records of 21 patients with convergence excess esotropia who have been operated with symmetric medial rectus recessions augmented with non-absorbable suture loops were reviewed. Read More

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Resveratrol and Markers of Polycystic Ovary Syndrome: a Systematic Review of Animal and Clinical Studies.

Reprod Sci 2021 Jul 26. Epub 2021 Jul 26.

Nutrition Research Center, Department of Community Nutrition, Faculty of Nutrition and Food Science, Tabriz University of Medical Sciences, Tabriz, Iran.

Polycystic ovary syndrome (PCOS) is a common disorder affecting childbearing-age women, and is associated with reproductive and metabolic disturbances. The present study aimed to systematically review current animal studies and randomized placebo-controlled clinical trials (RCT) regarding the effects of resveratrol, a natural polyphenolic compound, on PCOS features. PubMed, Scopus, Web of Knowledge, and Google Scholar were comprehensively searched until December 2020. Read More

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IDEO energy-storing orthosis: Effects on lower extremity function and preservation.

Injury 2021 Jul 18. Epub 2021 Jul 18.

USU-WRNMMC Department of Surgery, Bethesda, MD, United States.

Introduction: The Intrepid Dynamic Exoskeletal Orthosis (IDEO) brace is a custom energy-storing orthosis design meant to improve gait, stability, and function after lower extremity injury or limb salvage. Early studies demonstrated the potential for the IDEO to improve functional performance, in conjunction with its paired return to run (RTR) rehabilitation program, compared to other brace types, and an impressively decreased rate of late amputation. The current study aimed to investigate these functional and revision outcomes from our institution to determine which patients may benefit most from IDEO bracing and what factors of the IDEO design and rehabilitation program are most important for improved outcomes after lower extremity trauma and/or loss of function. Read More

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Predicting clinically significant response to primary care treatment for depression from electronic health records of veterans.

J Affect Disord 2021 Jul 16;294:337-345. Epub 2021 Jul 16.

VA Center for Clinical Management Research, VA Ann Arbor Healthcare System, Ann Arbor, MI, USA; Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA.

Objective: To reduce delays in referral to specialty mental health care, we evaluated clinical prediction models estimating the likelihood of response to primary care treatment of depression in the VA healthcare system.

Methods: We included patients with a primary care depression diagnosis between October 1, 2015 and December 31, 2017, an initial PHQ-9 score ≥ 10 within 30 days, a follow-up PHQ-9 score within 2-8 months, and no specialty mental health care within three months prior to depression diagnosis. We evaluated eight ordinary least squares regression models, each with a different procedure for selecting predictors of percentage change in PHQ-9 score from baseline to follow-up. Read More

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Effectiveness of a Care Transitions Intervention for Older Adults Discharged Home from the Emergency Department: A Randomized Controlled Trial.

Acad Emerg Med 2021 Jul 26. Epub 2021 Jul 26.

BerbeeWalsh Department of Emergency Medicine, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin, USA.

Background: Improving care transitions following emergency department (ED) visits may reduce post-ED adverse events among older adults (e.g., ED revisits, decreased function). Read More

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A Retrospective Study of Touchless Spray for Pediatric Perineal Burns Treatment.

J Burn Care Res 2021 Jul 26. Epub 2021 Jul 26.

Department of Surgery, Division of Pediatric Surgery, Children's Hospital of Michigan/Wayne State University, Detroit, MI, USA.

Background: Silver-based topical treatments have seen widespread use for the management of burns due to silver's antimicrobial activity. Recent studies suggest silver nanoparticles could negatively impact healing time due to their toxic effect on keratinocytes and fibroblasts at higher concentrations [1, 2]. Zinc oxide antimicrobial activity has been demonstrated in vitro [3, 4] and results from animal studies are promising for burn management [5]. Read More

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The significance of imaging examinations during follow-up for malignant melanoma.

Eur J Dermatol 2021 Jun;31(3):357-363

Department of Dermatology, Venerology and Oncodermatology, Medical School, Clinical Center - University of Pécs, 1. Akac Street, P.O.B.: H-7632 Pécs, Hungary.

Currently, there is a general lack of consensus regarding optimal strategy and imaging during follow-up for patients suffering from melanoma. Our aim was to analyse the utility of various imaging procedures, in particular CT scans, during the follow-up of patients with different stages of melanoma. A retrospective analysis of the medical records of patients suffering from melanoma diagnosed between 2001 and 2011 was carried out at the Department of Dermatology, University of Pécs. Read More

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