371,008 results match your criteria initial diagnosis

Circulating humanin is lower in coronary artery disease and is a prognostic biomarker for major cardiac events in humans.

Biochim Biophys Acta Gen Subj 2021 Sep 12:130010. Epub 2021 Sep 12.

The Cardiovascular Center, First Hospital of Jilin University, 71 Xinmin Road, Changchun, Jilin 130021, China. Electronic address:

Background: Humanin is an endogenous mitochondria-derived peptide that plays critical roles in oxidative stress, inflammation and CAD. In this study, we measured the levels of circulating humanin, markers of oxidative stress and inflammation in patients with unstable angina and MI and studied the relationship between these parameters and major adverse cardiac events (MACE).

Methods: A total of 327 subjects were recruited from the inpatient department at First Hospital of Jilin University and divided into 3 groups [control, angina and myocardial infarction (MI)] based on the clinical data and the results of the angiography. Read More

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September 2021

Vestibular mapping assessment in idiopathic sudden sensorineural hearing loss.

Ear Hear 2021 Sep 14. Epub 2021 Sep 14.

Department of Otolaryngology-Head and Neck Surgery, College of Medicine, Hanyang University, Seoul, Republic of Korea.

Objective: The aim of this study was to investigate patterns of semicircular canal (SCC) and otolith organ dysfunction by vestibular mapping, and to determine the clinical implications of treatment outcomes in idiopathic sudden sensorineural hearing loss (ISSNHL).

Methods: We retrospectively reviewed 135 consecutive patients diagnosed with ISSNHL from January 2016 to December 2020. Patients underwent video-head impulse tests (vHIT) for each SCC, cervical vestibular-evoked myogenic potential test for the saccules, ocular vestibular-evoked myogenic potential test for the utricles, and hearing tests. Read More

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September 2021

Initial visit symptoms in probable Behçet's syndrome is predictive of ISG criteria fulfillment in Behçet's syndrome: data from New York and Amsterdam cohorts.

Clin Exp Rheumatol 2021 Sep 13. Epub 2021 Sep 13.

New York University School of Medicine, New York, NY, USA.

Objectives: Behçet's syndrome (BS) is a systemic vasculitis with heterogeneous clinical presentation and a relapsing disease course. The International Study Group (ISG) criteria are most often used for classification. A significant proportion of patients is classified as probable BS because they do not fulfil the criteria at initial presentation. Read More

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September 2021

Prediction of Early Treatment Response in Multiple Myeloma Using MY-RADS Total Burden Score, ADC, and Fat Fraction From Whole-Body MRI: Impact of Anemia on Predictive Performance.

AJR Am J Roentgenol 2021 Sep 15. Epub 2021 Sep 15.

Department of lymphoma, Chinese Academy of Medical Sciences Institute of Hematology and Blood Diseases Hospital, Tianjin, Tianjin, CN 300020.

The recently released Myeloma Response Assessment and Diagnosis System (MY-RADS) for multiple myeloma (MM) evaluation by whole-body MRI (WB-MRI) describes the total burden score. However, assessment is confounded by red bone marrow hyperplasia in anemia. To assess utility of the MY-RADS total burden score, ADC, and fat fraction (FF) from WB-MRI in predicting early treatment response in patients with newly diagnosed MM and to compare these measures' utility between patients with and without anemia. Read More

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September 2021

Hereditary Hemochromatosis: Rapid Evidence Review.

Am Fam Physician 2021 Sep;104(3):263-270

University of North Carolina, Chapel Hill, NC, USA.

Hereditary hemochromatosis is an autosomal recessive disorder that disrupts iron homeostasis, resulting in systemic iron overload. It is the most common inherited disorder among people of northern European ancestry. Despite the high prevalence of the gene mutation, there is a low and variable clinical penetrance. Read More

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September 2021

Lessons learnt from MDM2 FISH analysis on 439 mature lipomatous lesions with emphasis on atypical lipomatous tumours / well-differentiated liposarcoma (ALT/WDLPS) lacking cytological atypia.

Histopathology 2021 Sep 14. Epub 2021 Sep 14.

Department of Anatomical Pathology, Sonic Healthcare - Douglass Hanly Moir Pathology, Macquarie Park, Australia.

Aims: MDM2 gene amplification, usually detected by fluorescence in situ hybridization (FISH), is the key driving event in atypical lipomatous tumours/well-differentiated liposarcomas (ALT/WDL). We sought to determine the concordance between the histopathological findings and MDM2 FISH in the diagnosis of ALT/WDL and to identify the histological features of MDM2 amplified tumours lacking classic atypia.

Methods And Results: We performed a retrospective analysis of all mature lipomatous lesions subjected to MDM2 FISH analysis at our institution. Read More

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September 2021

Time course of symptoms in posttraumatic stress disorder with delayed expression: a systematic review.

Acta Psychiatr Scand 2021 Sep 15. Epub 2021 Sep 15.

Centre for Neuropsychiatric Depression Research, Mental Health Centre Glostrup and Clinical Institute, University of Copenhagen, Copenhagen, Denmark.

Objective: to examine the hypothesis that PTSD with delayed expression in some cases occur without subthreshold PTSD symptoms above background levels bridging the gap between the traumatic exposure(s) and the clinical diagnosis.

Methods: We performed systematic searches of peer-reviewed papers in English referenced in Pubmed, Embase or PsycINFO and ascertained 34 prospective studies of PTSD symptom trajectories identified by latent class growth statistical modeling. Studies with delayed and low-stable trajectories provided appropriate data for this study. Read More

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September 2021

Myeloperoxidase immunohistochemical staining can identify glomerular endothelial cell injury in dense deposit disease.

Pediatr Nephrol 2021 Sep 14. Epub 2021 Sep 14.

Department of Pathology, Beaumont Laboratories, Beaumont Health, Royal Oak, MI, USA.

Background: Previous studies have demonstrated residual complement-mediated deposits in repeat kidney biopsies of C3 glomerulopathies (C3G) (dense deposit disease (DDD) and C3 glomerulonephritis) following eculizumab treatment, despite some clinical improvement. With residual complement deposition, it is difficult to determine whether there is a reduced complement-mediated endothelial cell injury. We validated that myeloperoxidase (MPO) immunohistochemical staining identified glomerular endothelial cell injury in crescentic glomerulonephritis and C3G. Read More

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September 2021

Rapid Destruction of the Hip Joint After Acetabular Fracture in an Elderly Patient.

Arthroplast Today 2021 Oct 4;11:122-126. Epub 2021 Sep 4.

Department of Orthopaedic Surgery, Teikyo University School of Medicine, Tokyo, Japan.

Cases of rapidly progressive destruction of the hip joint after acetabular fractures are rarely reported. A 78-year-old woman fell from a chair. There was no fracture diagnosis; however, retrospective evaluation of the plain radiograph showed a slightly displaced fracture of the acetabulum. Read More

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October 2021

A Rare Case of Primary Pleural Neurofibroma.

Cureus 2021 Aug 10;13(8):e17062. Epub 2021 Aug 10.

Department of Surgical Oncology, All India Institute of Medical Sciences, Rishikesh, Rishikesh, IND.

Metastatic deposits are the most common cause of pleural masses, solitary or multiple. Primary pleural neoplasms are rare entities that are occasionally encountered. Of these, the tumors of neurogenic origin are exceedingly rare with only a few cases reported in the literature. Read More

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Clinical Detection of Primary Pulmonary Angiosarcoma.

Cureus 2021 Aug 10;13(8):e17059. Epub 2021 Aug 10.

Department of Medical Education, Lake Erie College of Osteopathic Medicine, Erie, USA.

Pulmonary angiosarcomas (PAS) are rare malignant vascular tumors that due to their aggressive and metastatic nature, are often diagnosed at a late stage, resulting in a poorer prognosis. Here we present a 53-year-old male who was initially found to have recurring episodes of dyspnea and syncope, with initial workup showing bilateral saddle pulmonary embolisms on computerized tomography, presumed secondary to newly discovered atrial fibrillation with sinus node dysfunction. Further investigation over subsequent months and subsequent biopsy of a potential lung mass ultimately revealed pulmonary angiosarcoma of the spindle cell line. Read More

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The Correlation Between Parkinson's Disease and Rapid Eye Movement Sleep Behavior Disorder: A Systematic Review.

Cureus 2021 Aug 9;13(8):e17026. Epub 2021 Aug 9.

Internal Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA.

Parkinson's disease (PD) is a neurodegenerative disease caused due to the destruction of dopaminergic neurons and the deposition of α-synuclein proteins, known as Lewy bodies. Generally, the diagnosis of PD is centered around motor symptoms. However, the early recognition of non-motor symptoms such as autonomic dysfunction, sleep disturbances, and cognitive and psychiatric disturbances are gaining increased attention for the early diagnosis of PD. Read More

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Angiosarcoma of the pulmonary artery mimicking pulmonary thromboembolism.

SA J Radiol 2021 10;25(1):2150. Epub 2021 Aug 10.

Department of Radiology, Faculty of Medicine, Prince of Songkla University, Hatyai, Thailand.

Primary pulmonary angiosarcomas (PPAs) are rare, and often, their diagnosis is delayed because of insidious clinical symptoms and imaging findings mimicking pulmonary thromboembolism (PE). A 33-year-old female patient presented with chest pain and progressive dyspnoea. Her initial diagnosis, based on clinical symptoms and CT pulmonary angiography (PA) findings, was PE. Read More

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Synthol systemic complications: Hypercalcemia and pulmonary granulomatosis. A case report.

Ann Med Surg (Lond) 2021 Sep 3;69:102771. Epub 2021 Sep 3.

Mount Lebanon Hospital, Department of Urology, Lebanon.

Introduction: Synthol injection for body contouring has been used by bodybuilders for some time. We report two extremely rare systemic complications; pulmonary granulomatosis and hypercalcemia, in a woman who has received Synthol injections for buttocks augmentation.

Presentation Of Case: The case discussed in this report is of a 36-year-old lady who presented for severe hypercalcemia and nephrocalcinosis. Read More

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September 2021

Xanthogranulomatous Pyelonephritis: A Narrative Review with Current Perspectives on Diagnostic Imaging and Management, Including Interventional Radiology Techniques.

Int J Nephrol Renovasc Dis 2021 7;14:359-369. Epub 2021 Sep 7.

Division of Interventional Radiology, Department of Radiology, University Hospital Waterford, Waterford City, X91 DWX0, Ireland.

Xanthogranulomatous Pyelonephritis (XGP) is a rare, chronic granulomatous inflammatory condition thought to arise secondary to a combination of obstruction, recurrent bacterial infection and an incomplete immune response resulting in focal or diffuse renal destruction. This destruction may be profound with the potential to infiltrate surrounding tissues and viscera. The imaging features of XGP can be ambiguous, mimicking malignancy, tuberculosis (TB) and malakoplakia earning the title of "the great imitator". Read More

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September 2021

Multiplex Real-Time Polymerase Chain Reaction on Sputum for the Diagnosis of Pneumonia in Children: A Retrospective Study.

Infect Drug Resist 2021 7;14:3627-3635. Epub 2021 Sep 7.

Department of Pediatrics, Xiangya Hospital, Central South University, Changsha, People's Republic of China.

Background: pneumonia (PCP) is a serious opportunistic infection in immunocompromised children. Real-time polymerase chain reaction (PCR) is widely used for the diagnosis of PCP due to its good accuracy. However, the diagnostic performance of multiplex real-time PCR on sputum in children with PCP has never been explored. Read More

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September 2021

Wall eyed bilateral internuclear ophthalmoplegia (WEBINO) syndrome as a false localising sign in intracranial haemorrhage due to snake bite.

BMJ Case Rep 2021 Sep 14;14(9). Epub 2021 Sep 14.

Internal Medicine, Mahatma Gandhi Mission's Medical College Kamothe, Navi Mumbai, Maharashtra, India.

A 48-year-old woman presented with sudden-onset altered sensorium 2 days after a snake bite (unidentified species) and was found to have a large right frontal intracerebral haemorrhage (ICH) with transtentorial herniation (TTH) causing brain stem compression. A day later, neurological examination revealed internuclear ophthalmoplegia (INO) fitting the clinical description of wall eyed bilateral INO syndrome. INO is a rare ocular motor sign, the most common causes being brain stem infarction, haemorrhage or demyelinating disease. Read More

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September 2021

High diagnostic yield of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) in the diagnosis of adolescent pulmonary tuberculosis.

BMC Infect Dis 2021 Sep 14;21(1):946. Epub 2021 Sep 14.

Department of Pediatrics and Adolescent Medicine, University Medical Center, Medical Faculty, University of Freiburg, Freiburg, Germany.

Background: The microbiological diagnosis of pulmonary tuberculosis (Tb) in a pediatric population is hampered by both low pathogen burden and noncompliance with sputum sampling. Although endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) has been found useful for the evaluation of mediastinal pathologies in adults, for children, sparse data are available. Here, we have evaluated EBUS-TBNA as a diagnostic procedure in children and adolescents with suspected pulmonary Tb. Read More

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September 2021

Posterior Fossa Teratomas in Adults : A Systematic Review.

J Korean Neurosurg Soc 2021 Sep 15. Epub 2021 Sep 15.

Department of Pathology, Asan Medical Center, College of Medicine, University of Ulsan, Seoul, Korea.

Objective: The occurrence of posterior fossa teratomas in adulthood is extremely rare. In this study, we aimed to report our experience with two cases of posterior fossa mature teratoma in adults who underwent surgical resection. We also performed a systematic review of published papers available to date. Read More

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September 2021

[Clinical manifestation and treatment of temporal bone tympanic plate fracture].

W N Chen Q Lin

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2021 Aug;56(8):801-805

Department of Otolaryngology Head and Neck Surgery, the First Affiliated Hospital, Medical College, Xiamen University, Teaching Hospital of Fujian Medical University, Xiamen Key Laboratory of Otolaryngology Head and Neck Surgery, Xiamen 361003, China.

To elucidate the clinical manifestations of temporal bone tympanic plate fracture and the correlation between treatment time after injury and its prognosis, and to discuss the importance of early treatment of tympanic fracture. Retrospective analysis was carried out on the clinical data of 15 patients(17 ears)with temporal bone tympanic plate fracture from March 2006 to July 2019. The course of disease was less than 1 month (initial stage) in 7 cases (7 ears), 1 month to 6 months (middle stage) in 2 cases (3 ears), and 6 months or more (late stage) in 6 cases (7 ears). Read More

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Misdiagnosis and delay of diagnosis in hemorrhagic meningioma: a case series and review of the literature.

World Neurosurg 2021 Sep 11. Epub 2021 Sep 11.

Department of Radiology, First Affiliated Hospital, Shantou University Medical, College, Shantou, Guangdong, 515041, P. R. China.

Objective: To evaluate the clinico-radiological characteristics of hemorrhagic meningiomas (HMs) that are missed or misdiagnosed on radiological imaging studies.

Methods: Clinical and radiological data from six patients with HM who were initially misdiagnosed were collected and recorded respectively. In addition, we performed a literature review for misdiagnosed HM and summarized the results. Read More

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September 2021

The effect of systemic antidepressant treatments in early stage on neurocognitive function of euthymic bipolar patients initiated with a depressive onset: An observational, cross-sectional, single-blind study protocol.

Brain Behav 2021 Sep 14:e32360. Epub 2021 Sep 14.

School of Nursing, Sun Yat-sen University, Guangzhou, China.

Objectives: Patients with bipolar disorder (BD) have a wide range of neurocognitive dysfunction even in euthymic state, leading to impaired psychosocial function and reduced quality of life. However, the understanding on risk factors related to neurocognitive impairment in such group of people is limited. In view of significantly delayed diagnosis of BD and common use of antidepressants prior to the BD diagnosis, the study aims to clarify whether systemic antidepressant use in early stage, defined as from the initial depressive episode to the diagnosis of BD, could impact neurocognitive function of euthymic bipolar patients. Read More

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September 2021

Improvement in constipation and diarrhea is associated with improved abdominal pain in patients with functional bowel disorders.

Neurogastroenterol Motil 2021 Sep 14:e14253. Epub 2021 Sep 14.

Division of Gastroenterology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.

Background: Abdominal pain is a bothersome and lifestyle limiting symptom in patients with functional bowel disorders. It is associated with decreased quality of life in affected individuals, as well as significant annual healthcare expenditure. Knowledge of specific factors that predict improvement in abdominal pain in those with functional bowel disorders is thus far limited. Read More

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September 2021

Moraxella Keratitis: A Case Series.

Eye Contact Lens 2021 Sep 10. Epub 2021 Sep 10.

Department of Ophthalmology, University of Texas Health San Antonio, San Antonio, TX.

Objective: To report the ocular and systemic risk factors, clinical manifestations, and management outcomes of Moraxella keratitis.

Methods: This retrospective study included patients with culture-proven Moraxella keratitis in South Texas between 2012 and 2018. Clinical data including demographics, ocular and systemic risk factors, clinical presentation, speciation, and treatment course were collected. Read More

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September 2021

Educational strategy based on the NutrIMSS program in patients with prediabetes.

Rev Med Inst Mex Seguro Soc 2020 09 1;58(5):566-573. Epub 2020 Sep 1.

Instituto Mexicano del Seguro Social, Unidad de Medicina Familiar No. 80, Coordinación de Educación e Investigación en Salud.

Background: Prediabetes is an altered metabolic state of glucose; it does not present symptoms, it is considered an intermediate stage in the progression to diabetes; it is possible to detect it early to avoid or delay the disease. NutrIMSS strategy was implemented so that these patients achieve a healthy lifestyle.

Objective: To evaluate the impact of an educational intervention based on the NutrIMSS strategy on somatometric and biochemical parameters in patients with prediabetes. Read More

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September 2020

Neonatal hydrocephalus: an atypical presentation of malignant infantile osteopetrosis.

Childs Nerv Syst 2021 Sep 14. Epub 2021 Sep 14.

Department of Neurological Surgery and Pediatrics, St. Louis Children's Hospital, Washington University in St. Louis, Saint Louis, MO, USA.

Purpose: Autosomal recessive osteopetrosis has a variable presentation, most commonly including failure to thrive, hypocalcemia, seizures, hepatosplenomegaly, hydrocephalus, vision or hearing loss, and cytopenias. Multiple symptoms are usually seen at presentation. The variability of presentation often delays diagnosis and subsequent treatment. Read More

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September 2021

An mHealth-Based Intervention for Adolescents With Type 1 Diabetes and Their Parents: Pilot Feasibility and Efficacy Single-Arm Study.

JMIR Mhealth Uhealth 2021 Sep 14;9(9):e23916. Epub 2021 Sep 14.

Pediatric Endocrinology, University of Michigan Medical School, Ann Arbor, MI, United States.

Background: Type 1 diabetes (T1D) affects more than 165,000 individuals younger than 20 years in the United States of America. The transition from parent management to parent-child team management, with the child taking on increased levels of self-care, can be stressful and is associated with a deterioration in self-management behaviors. Therefore, a mobile app intervention, MyT1DHero, was designed to facilitate diabetes-specific positive parent-adolescent communication and improve diabetes-related outcomes. Read More

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September 2021

Ocular dermoids in 13 cats: a multicentre retrospective study.

J Feline Med Surg 2021 Sep 14:1098612X211043819. Epub 2021 Sep 14.

Centre Hospitalier Vétérinaire Saint Martin, Saint Martin Bellevue, France.

Objectives: The aim of this multicentre retrospective study was to review the clinical data, outcomes and histopathological features of cats that had been treated for ocular surface dermoids.

Methods: Thirteen cats from various private practices in France with a clinical diagnosis of ocular surface dermoid were included in the study.

Results: The mean age of the study population at the time of diagnosis was 5 months. Read More

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September 2021

Retinal arteriolar macroaneurysms with supravalvular pulmonic stenosis in the United Arab Emirates.

Ophthalmic Genet 2021 Sep 14:1-6. Epub 2021 Sep 14.

Eye Institute, Cleveland Clinic Abu Dhabi, Abu Dhabi, UAE.

Purpose: Retinal arteriolar macroaneurysms with supravalvular pulmonic stenosis (RAMSVPS) is a rare syndrome that to date has only been reported in Saudi Arabian families. All tested patients have been homozygous for a single splice variant (NM_001553.2:c. Read More

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September 2021

Haemophagocytic lymphohistiocytosis in an adult with postacute COVID-19 syndrome.

BMJ Case Rep 2021 Sep 13;14(9). Epub 2021 Sep 13.

Division of Critical Care Medicine, McGill University Health Centre, Montreal, Québec, Canada

Haemophagocytic lymphohistiocytosis (HLH) causing multiorgan failure has been reported as an acute clinical presentation of COVID-19. However, the literature surrounding HLH in the context of a postacute COVID-19 syndrome is limited. This report presents a case of a life-threatening HLH occurring 6 weeks after a pauci-symptomatic COVID-19 infection in a previously healthy adult. Read More

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September 2021