1,470 results match your criteria ingredients formula


A quantitative detection of mung bean in chestnut paste using duplex digital PCR.

Curr Res Food Sci 2022 18;5:34-40. Epub 2021 Dec 18.

Guangzhou Customs Technology Center, No. 66 Huacheng Avenue, Tianhe District, Guangzhou, China.

Highly manufacturing process of chestnut paste leaves a considerable space for Economically Motivated Adulteration (EMA) with cheaper ingredients such as mung bean. In this paper a novel quantitative detection of mung bean in chestnut paste using duplex digital PCR was reported. Two sets of primers and probes were designed according to mung bean and chestnut specific genomic genes suitable for duplex droplet digital PCR (ddPCR) and duplex chip digital PCR (cdPCR) to set up a mass ratio quantitative detection method for mung bean, a common alternative plant-derived ingredient in chestnut paste products. Read More

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December 2021

Ginseng in vascular dysfunction: A review of therapeutic potentials and molecular mechanisms.

Phytother Res 2022 Jan 13. Epub 2022 Jan 13.

Jilin Ginseng Academy, Key Laboratory of Active Substances and Biological Mechanisms of Ginseng Efficacy, Ministry of Education, Jilin Provincial Key Laboratory of Bio-Macromolecules of Chinese Medicine, Changchun University of Chinese Medicine, Changchun, China.

Vascular dysfunction can lead to a variety of fatal diseases, including cardiovascular and cerebrovascular diseases, metabolic syndrome, and cancer. Although a large number of studies have reported the therapeutic effects of natural compounds on vascular-related diseases, ginseng is still the focus of research. Ginseng and its active substances have bioactive effects against different diseases with vascular dysfunction. Read More

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January 2022

The effect of casein glycomacropeptide versus free synthetic amino acids for early treatment of phenylketonuria in a mice model.

PLoS One 2022 11;17(1):e0261150. Epub 2022 Jan 11.

Department of Clinical Genetics, Kennedy Center, Copenhagen University Hospital, Rigshospitalet, Denmark.

Introduction: Management of phenylketonuria (PKU) is mainly achieved through dietary control with limited intake of phenylalanine (Phe) from food, supplemented with low protein (LP) food and a mixture of free synthetic (FS) amino acids (AA) (FSAA). Casein glycomacropeptide (CGMP) is a natural peptide released in whey during cheese making by the action of the enzyme chymosin. Because CGMP in its pure form does not contain Phe, it is nutritionally suitable as a supplement in the diet for PKU when enriched with specific AAs. Read More

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January 2022

A comprehensive strategy for quality evaluation of Wushe Zhiyang Pills by integrating UPLC-DAD fingerprint and multi-ingredients rapid quantitation with UPLC-MS/MS technology.

J Pharm Biomed Anal 2021 Dec 29;210:114556. Epub 2021 Dec 29.

State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, China. Electronic address:

Wushe Zhiyang Pills (WZP), a classical traditional Chinese medicine (TCM) formula, has been extensively used for the treatment of chronic urticaria and other relevant dermatologic diseases. In this study, a holistic method combining ultra-performance liquid chromatography coupled with diode array detector (UPLC-DAD) fingerprint and multi-components quantitative analysis was developed and validated for quality evaluation of WZP. As a result, a total of 34 characteristic peaks were screened to assess the chemical similarities of 16 batches of WZP samples. Read More

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December 2021

Phytochemical Analysis Using UPLC-MS/MS Combined with Network Pharmacology Methods to Explore the Biomarkers for the Quality Control of Lingguizhugan Decoction.

Evid Based Complement Alternat Med 2021 22;2021:7849032. Epub 2021 Dec 22.

College of Integrative Medicine, Hebei University of Chinese Medicine, Shijiazhuang 050091, China.

As a classic TCM prescription, LGZG has been widely used in clinical prevention and treatment of heart failure, nonalcoholic fatty liver, and hyperlipidemia. However, there are few studies on chemical components in recent years, and the basis of quality evaluation is not sufficient. This study was to find the active ingredients of the Lingguizhugan decoction using UPLC-MS/MS and network pharmacology. Read More

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December 2021

Kampo Formulae for the Treatment of Neuropathic Pain ∼ Especially the Mechanism of Action of ∼.

Front Mol Neurosci 2021 14;14:705023. Epub 2021 Dec 14.

Department of Physiology, School of Medicine, Showa University, Tokyo, Japan.

Kampo medicine has been practiced as traditional medicine (TM) in Japan. Kampo medicine uses Kampo formulae that are composed of multiple crude drugs to make Kampo formulae. In Japan, Kampo formulae are commonly used instead of or combined with Western medicines. Read More

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December 2021

Qingluotongbi formula regulates the LXRα-ERS-SREBP-1c pathway in hepatocytes to alleviate the liver injury caused by Tripterygium wilfordii Hook. f.

J Ethnopharmacol 2021 Dec 27;287:114952. Epub 2021 Dec 27.

The First Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing, 210023, PR China. Electronic address:

Ethnopharmacological Relevance: Tripterygium wilfordii Hook. f. (TW) is widely used to treat autoimmune and inflammatory diseases; however, its development and application is limited by its significant association with liver injury. Read More

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December 2021

Effect of Processing of Whey Protein Ingredient on Maillard Reactions and Protein Structural Changes in Powdered Infant Formula.

J Agric Food Chem 2022 Jan 30;70(1):319-332. Epub 2021 Dec 30.

Department of Food Science, Faculty of Science, University of Copenhagen, Rolighedsvej 26, 1958 Frederiksberg C, Denmark.

The most widely used whey protein ingredient in an infant formula (IF) is the whey protein concentrate (WPC). The processing steps used in the manufacturing of both a powdered IF and a WPC introduce protein modifications that may decrease the nutritional quality. A gently processed whey protein ingredient (serum protein concentrate; SPC) was manufactured and used for the production of a powdered IF. Read More

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January 2022

To Predict Anti-Inflammatory and Immunomodulatory Targets of Guizhi Decoction in Treating Asthma Based on Network Pharmacology, Molecular Docking, and Experimental Validation.

Evid Based Complement Alternat Med 2021 20;2021:9033842. Epub 2021 Dec 20.

Shenzhen Research Institute, Beijing University of Chinese Medicine, Shenzhen 518118, China.

Asthma, characterized by the continuous inflammatory response caused by a variety of immune cells, is one of the most common chronic respiratory diseases worldwide. Relevant clinical trials proved that the traditional Chinese medicine formula Guizhi Decoction (GZD) had multitarget and multichannel functions, which might be an effective drug for asthma. However, the effective ingredients and mechanisms of GZD against asthma are still unclear. Read More

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December 2021

Transcriptional profiling and network pharmacology analysis identify the potential biomarkers from Chinese herbal formula Huosu Yangwei Formula treated gastric cancer in vivo.

Chin J Nat Med 2021 Dec;19(12):944-953

Department of Gastroenterology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China; Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China. Electronic address:

Huosu Yangwei (HSYW) Formula is a traditioanl Chinese herbal medicine that has been extensively used to treat chronic atrophic gastritis, precancerous lesions of gastric cancer and advanced gastric cancer. However, the effective compounds of HSYW and its related anti-tumor mechanisms are not completely understood. In the current study, 160 ingredients of HSYW were identified and 64 effective compounds were screened by the ADMET evaluation. Read More

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December 2021

Term Infant Formulas Influencing Gut Microbiota: An Overview.

Nutrients 2021 Nov 23;13(12). Epub 2021 Nov 23.

Department of Paediatric Gastroenterology, and Nutrition, Intestinal Failure Rehabilitation Centre, National Reference Centre for Rare Digestive Diseases, Necker-Enfants Malades Hospital, Paris Centre University and Paris-Descartes School of Medicine, 75000 Paris, France.

Intestinal colonization of the neonate is highly dependent on the term of pregnancy, the mode of delivery, the type of feeding [breast feeding or formula feeding]. Postnatal immune maturation is dependent on the intestinal microbiome implementation and composition and type of feeding is a key issue in the human gut development, the diversity of microbiome, and the intestinal function. It is well established that exclusive breastfeeding for 6 months or more has several benefits with respect to formula feeding. Read More

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November 2021

Photo-aging evaluation - In vitro biological endpoints combined with collagen density assessment with multi-photon microscopy.

J Dermatol Sci 2021 Dec 8. Epub 2021 Dec 8.

L'Oréal Research and Innovation, Shanghai, PR China. Electronic address:

Background: Ultraviolet exposure has profound effect on the dermal connective tissue of human skin.

Objective: We aimed to develop and validate an evaluation method/methodology using a full-thickness reconstructed skin model, to assess the anti-photoaging efficacy of cosmetic ingredients and sunscreen formulas by blending multi relevant biological endpoints including the newly developed dermal collagen quantification method with Multi-photon microscopy.

Methods: The response of ex vivo human skin to UVA exposure was first characterized with multiphoton microscopy. Read More

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December 2021

[Review of chemical composition, pharmacological effects, and clinical application of Salviae Miltiorrhizae Radix et Rhizoma and prediction of its Q-markers].

Zhongguo Zhong Yao Za Zhi 2021 Nov;46(21):5496-5511

School of Pharmacy, Anhui University of Chinese Medicine Hefei 230012, China Synergetic Innovation Center of Anhui Authentic Chinese Medicine Quality Improvement Hefei 230012, China Anhui Provincial Key Laboratory of Chinese Medicinal Formula Hefei 230012, China.

Salviae Miltiorrhizae Radix et Rhizoma is a Chinese herbal medicine that promotes blood circulation to remove blood stasis, nourishes blood to tranquilize the mind, and cools blood to disperse carbuncles. Salviae Miltiorrhizae Radix et Rhizoma has microcirculation-improving, blood vessel-dilating, atherosclerosis-preventing, anti-inflammatory, anti-tumor, and blood pressure-and blood lipid-lowering activities. As research progresses, the chemical composition, pharmacological effect, and clinical application of Salviae Miltiorrhizae Radix et Rhizoma have attracted much attention. Read More

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November 2021

Confocal Raman Spectroscopic Imaging for Evaluation of Distribution of Nano-Formulated Hydrophobic Active Cosmetic Ingredients in Hydrophilic Films.

Molecules 2021 Dec 8;26(24). Epub 2021 Dec 8.

EA 6295 Nanomédicaments et Nanosondes, Faculté de Pharmacie, Université de Tours, 31 Avenue Monge, 37200 Tours, France.

Film-forming systems are highly relevant to the topical administration of active ingredients (AI) to the body. Enhanced contact with the skin can increase the efficacy of delivery and penetration during prolonged exposure. However, after the evaporation of volatile solvents to form a thin film, the distribution of the ingredient should remain homogenous in order to ensure the effectiveness of the formula. Read More

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December 2021

Scientifically Formulated Avocado Fruit Juice: Phytochemical Analysis, Assessment of Its Antioxidant Potential and Consumer Perception.

Molecules 2021 Dec 7;26(24). Epub 2021 Dec 7.

Department of Biology, College of Science and Humanities, Prince Sattam Bin Abdulaziz University, Alkharj 11942, Saudi Arabia.

The study's purpose was to find and create a nourishing fruit juice made from avocado to suit nutritional and health demands. In this regard, the avocado juice was formulated using a statistical technique, and its biochemical and phytochemical characteristics were evaluated. Statistically formulated fruit juice was evaluated for its sensory characteristics, proximate composition, nutrients and vitamins, total phenols and flavonoids, and for its antioxidant ability, in addition to a shelf-life test. Read More

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December 2021

Optimization of barley flour and inulin addition for pasta formulation using mixture design approach.

J Food Sci 2021 Dec 23. Epub 2021 Dec 23.

Field Crops Laboratory (LR16INRAT02), National Agricultural Research Institute of Tunisia (INRAT), University of Carthage, Ariana, Tunisia.

The aim of the present work was to optimize the formulation of a new functional pasta containing durum wheat semolina, whole barley flour, and inulin ingredients to enhance both the technological and textural properties of this product using the mixture design approach. Optimally formulated pasta with acceptable technological and textural properties as close as possible to those of control pasta was studied. The microstructure analysis of cooked and uncooked pasta was performed. Read More

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December 2021

Anticancer Action of Xiaoxianxiong Tang in Non-Small Cell Lung Cancer by Pharmacological Analysis and Experimental Validation.

Evid Based Complement Alternat Med 2021 13;2021:9930082. Epub 2021 Dec 13.

Department of Oncology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.

Xiaoxianxiong Tang (XXXT) is a well-known traditional Chinese medicine formula. Evidence is emerging supporting the benefits of XXXT in ameliorating therapy for non-small cell lung cancer (NSCLC). The purpose of this study aimed to explore the effects and mechanisms of XXXT through network pharmacological analysis and biological validation. Read More

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December 2021

Monitor gastrointestinal tolerance in children who have switched to an "enteral formula with food-derived ingredients": A national, multicenter retrospective chart review (RICIMIX study).

Nutr Clin Pract 2021 Dec 21. Epub 2021 Dec 21.

Medical Affairs, Nestlé Health Science, Gatwick, United Kingdom.

Background: Enteral tube feeding intolerances, such as diarrhea, are commonly reported in children. In the pediatric population, interest is growing in the use of blended diets for the management of enteral feeding intolerances. Fiber within a blended diet stimulates the growth of beneficial gut bacteria, which in turn produce short-chain fatty acids, which are utilized as energy substrates for enterocytes. Read More

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December 2021

Developing a Reference Database for Typical Body and Organ Growth of the Artificially Reared Pig as a Biomedical Research Model.

Front Pediatr 2021 1;9:746471. Epub 2021 Dec 1.

Traverse Science, Champaign, IL, United States.

The pig is a common model utilized to support substantiation of novel bioactive components in infant formula. However, reference ranges for outcomes to determine safety are unclear. Our objective was to use historical data to objectively define typical body and organ growth metrics of the domesticated pig in research. Read More

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December 2021

Quantum simulation of lattice gauge theories in more than one space dimension-requirements, challenges and methods.

Authors:
Erez Zohar

Philos Trans A Math Phys Eng Sci 2022 Feb 20;380(2216):20210069. Epub 2021 Dec 20.

Racah Institute of Physics, The Hebrew University of Jerusalem, Givat Ram, Jerusalem 91904, Israel.

Over recent years, the relatively young field of quantum simulation of lattice gauge theories, aiming at implementing simulators of gauge theories with quantum platforms, has gone through a rapid development process. Nowadays, it is not only of interest to the quantum information and technology communities. It is also seen as a valid tool for tackling hard, non-perturbative gauge theory problems by particle and nuclear physicists. Read More

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February 2022

Cell membrane-coated biomimetic magnetic nanoparticles for the bio-specific extraction of components from Gualou Guizhi decoction exhibiting activities against oxygen-glucose deprivation/reperfusion injury.

J Pharm Biomed Anal 2022 Feb 9;209:114528. Epub 2021 Dec 9.

The Fifth Affiliated Hospital, Southern Medical University, 566 Congcheng Avenue, Conghua District, Guangzhou 510900, Guangdong, China.

Gua-Lou-Gui-Zhi decoction (GLGZD) is a classical multiherb traditional Chinese medicine formula that has ameliorative effects on oxygen-glucose deprivation/reperfusion (OGD/R) injury and has been applied for the treatment of stroke in clinical practice; however, its active ingredients remain unknown. The aim of this study was to develop an effective method for screening for components of GLGZD with potential therapeutic activity against OGD/R injury. Brain microvascular endothelial cell membrane-coated magnetic beads ([email protected]) were incubated with the GLGZD extract; the bound material was eluted and the constituents were identified using solid phase extraction and ultra-performance liquid chromatography-Orbitrap Fusion Tribrid mass spectrometry (UPLC-Orbitrap Fusion Tribrid MS). Read More

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February 2022

Metabolism of Du Zhong Formula in rats using UPLC-Q-TOF/MS.

J Mass Spectrom 2022 Jan;57(1):e4795

State Key Laboratory of Component-Based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China.

Du Zhong Formula (DZF), a traditional Chinese medicine formula derived from BeiJiQianJinYaoFang, is used to treat kidney deficiency and lumbago. In this study, ultra-high-performance liquid chromatography quadrupole time-of-flight mass spectrometer (UPLC-Q-TOF/MS) technique combined with pattern recognition analysis was applied for analysis of metabolic profiles of the bioactive components of the DZF in rat biological samples. In this experiment, a total of 73 compounds, including 53 prototype components and 20 metabolites, were identified tentatively in vivo compared with blank urine, plasma, feces, and cerebrospinal fluid (CSF). Read More

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January 2022

Quantification of Lactose in Free-Lactose and Low-Lactose Milk and Milk Products by BIOMILK 300 Lac Biosensor: First Action 2020.09.

J AOAC Int 2021 Dec 14. Epub 2021 Dec 14.

BIOLAN Microbiosensores S.L., Parque Tecnológico de Bizkaia, Laida Bidea 409, 48170 Zamudio, Bizkaia, Spain.

Background: In 2018, the AOAC Stakeholder Panel on Strategic Food Analytical Methods approved SMPR 2018.009, for Lactose in Low-Lactose or Lactose-Free Milk, Milk Products, and Products Containing Dairy Ingredients, establishing the minimum recommended performance characteristics to be addressed during the evaluation of methods. Subsequently, AOAC INTERNATIONAL opened a call for methods under the Official Method of Analysis SM Program with the aim of finding a candidate method for confirming compliance with regulatory standards and dispute resolution. Read More

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December 2021

UHT treatment and storage of liquid infant formula affects protein digestion and release of bioactive peptides.

Food Funct 2022 Jan 4;13(1):344-355. Epub 2022 Jan 4.

Department of Food Science, University of Copenhagen, 1958 Frederiksberg C, Denmark.

Ready-to-feed liquid infant formulas (IF) were subjected to direct (D) or indirect (ID) ultra-high-temperature (UHT) treatment and then stored at 40 °C under aseptic conditions for 60-120 days simulating global transportation which accelerates the Maillard reaction. Low pasteurized and unstored IF (LP) was included as a control for the UHT treatments. Simulated infant digestion was conducted. Read More

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January 2022

Antidepressant Mechanism of Traditional Chinese Medicine Formula Xiaoyaosan in CUMS-Induced Depressed Mouse Model via RIPK1-RIPK3-MLKL Mediated Necroptosis Based on Network Pharmacology Analysis.

Front Pharmacol 2021 19;12:773562. Epub 2021 Nov 19.

School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China.

Depression is a stress-related disorder that seriously threatens people's physical and mental health. Xiaoyaosan is a classical traditional Chinese medicine formula, which has been used to treat mental depression since ancient times. More and more notice has been given to the relationship between the occurrence of necroptosis and the pathogenesis of mental disorders. Read More

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November 2021

The Identification of the Biomarkers of Sheng-Ji Hua-Yu Formula Treated Diabetic Wound Healing Using Modular Pharmacology.

Front Pharmacol 2021 16;12:726158. Epub 2021 Nov 16.

Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.

Sheng-Ji Hua-Yu (SJHY) formula has been proved to reduce the severity of diabetic wound healing without significant adverse events in our previous clinical trials. However, based on multi-target characteristics, the regulatory network among herbs, ingredients, and hub genes remains to be elucidated. The current study aims to identify the biomarkers of the SJHY formula for the treatment of diabetic wound healing. Read More

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November 2021

Derivation of the no expected sensitization induction level for dermal quantitative risk assessment of fragrance ingredients using a weight of evidence approach.

Food Chem Toxicol 2022 Jan 25;159:112705. Epub 2021 Nov 25.

Research Institute for Fragrance Materials, Inc. (RIFM), 50 Tice Boulevard, Woodcliff Lake, NJ, 07677, USA.

Some fragrance ingredients may have the potential to induce skin sensitization in humans but can still be safely formulated into consumer products. Quantitative Risk Assessment (QRA) for dermal sensitization is required to determine safe levels at which potential skin sensitizers can be incorporated into consumer products. The no expected sensitization induction level or NESIL is the point of departure for the dermal QRA. Read More

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January 2022

High-Protein Bar as a Meal Replacement in Elite Sports Nutrition: A Pilot Study.

Foods 2021 Oct 29;10(11). Epub 2021 Oct 29.

Institute of Food Technology in Novi Sad, University of Novi Sad, Bulevar cara Lazara 1, 21000 Novi Sad, Serbia.

This study was focused on the creation of high-protein bars formulated using whey protein isolate (24%) and soy protein isolate (6%) as the sources of proteins; oat flakes and inulin, both abundant in dietary fibres, and creatine monohydrate and other minor ingredients (vitamin and mineral mixture, potassium sorbate) to achieve the requirements for a meal replacement formula for physically active people. The nutritional profile of the high-protein bar was examined (energy 1215 kJ/288 kcal; protein 34.1 ± 0. Read More

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October 2021

Development of High-Protein Vegetable Creams by Using Single-Cell Ingredients from Some Microalgae Species.

Foods 2021 Oct 22;10(11). Epub 2021 Oct 22.

Food Safety and Functionality Programme, Institute of Agriculture and Food Research and Technology (IRTA), 17121 Monells, Spain.

The aim of this paper was to develop high-protein vegetable creams through the incorporation of microalgae. Single-cell ingredients from (spirulina), , , and were incorporated at two levels of addition (1.5% and 3. Read More

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October 2021

Metabolomics combined with network pharmacology to study the mechanism of Shentong Zhuyu decoction in the treatment of rheumatoid arthritis.

J Ethnopharmacol 2022 Mar 24;285:114846. Epub 2021 Nov 24.

Sichuan Industrial Institute of Antibiotics, School of Pharmacy, Chengdu University, Chengdu, 610106, China. Electronic address:

Ethnopharmacological Relevance: Shentong Zhuyu decoction (STZYD) was first recorded in the classic of "Yilin Gaicuo" written by Wang Qingren, and recognized by the Chinese National Administration of Traditional Chinese Medicine as one of the 100 classic formulas. The formula has been widely used in the treatment of rheumatoid arthritis (RA) with significant clinical effects. However, its mechanism of action is not completely clear. Read More

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