596 results match your criteria ingredient combinations

Fixed-Combination Halobetasol Propionate and Tazarotene in the Treatment of Psoriasis: Narrative Review of Mechanisms of Action and Therapeutic Benefits.

Dermatol Ther (Heidelb) 2021 Jun 9. Epub 2021 Jun 9.

Ortho Dermatologics, Bausch Health US, LLC (an Affiliate of Bausch Health Companies Inc.), Bridgewater, NJ, USA.

Psoriasis is a lifelong disease associated with cycles of remission and relapse. Topical treatments are the front line of psoriasis therapy for most patients and have antiproliferative, anti-inflammatory, and immunosuppressive mechanisms of action. Novel fixed-dose combinations of topical therapeutic agents are becoming increasingly available, leveraging multiple mechanisms of action to improve safety and efficacy with formulations that are easier to use and may allow for the use of lower doses of active ingredients. Read More

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Use of Nutraceutical Ingredient Combinations in the Management of Tension-Type Headaches with or without Sleep Disorders.

Nutrients 2021 May 13;13(5). Epub 2021 May 13.

Child Neurology and Psychiatry Medicine, Systems Medicine Department, Tor Vergata University of Rome, Via Montpellier 1, 00133 Rome, Italy.

Headache is the most common pain complaint in the pediatric population, with tension type headache (TTH) having a prevalence of 10-15% in children. Up to 70% of pediatric patients with chronic headache also experience sleep disruption, with a likely bidirectional relationship between headache and poor sleep. Treatment options include specific pharmacological approaches as well as non-pharmacological alternatives; nutraceuticals have the advantage of a relative lack of side effects. Read More

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Exploring the Role of Anti-solvent Effects during Washing on Active Pharmaceutical Ingredient Purity.

Org Process Res Dev 2021 Apr 12;25(4):969-981. Epub 2021 Mar 12.

EPSRC Continuous Manufacturing & Advanced Crystallisation (CMAC) Future Manufacturing Research Hub, University of Strathclyde, Glasgow G1 1RD, U.K.

Washing is a key step in pharmaceutical isolation to remove the unwanted crystallization solvent (mother liquor) from the active pharmaceutical ingredient (API) filter cake. This study looks at strategies for optimal wash solvent selection, which minimizes the dissolution of API product crystals while preventing the precipitation of product or impurities. Selection of wash solvents to avoid both these phenomena can be challenging but is essential to maintain the yield, purity, and particle characteristics throughout the isolation process. Read More

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Efficacy of Herbal Medicines Intervention for Colorectal Cancer Patients With Chemotherapy-Induced Gastrointestinal Toxicity - a Systematic Review and Meta-Analysis.

Front Oncol 2021 25;11:629132. Epub 2021 Mar 25.

Li Ka Shing Faculty of Medicine, School of Chinese Medicine, The University of Hong Kong, Hong Kong, China.

Chemotherapy-induced gastrointestinal (CIGI) toxicity affects the quality of life of patients with colorectal cancer (CRC) and the clinical application of treatment drugs. This review aims to evaluate the efficacy of traditional herbal medicines (HMs) in alleviating symptoms of CIGI toxicity (including nausea and vomiting, anorexia, diarrhea, constipation, oral mucositis, abdominal pain, and abdominal distension), and to explore further individual herb or herbal combinations in alleviating the CIGI toxicity. Nine electronic databases were screened from 2010 to 2020. Read More

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Deciphering the synergistic network regulation of active components from SiNiSan against irritable bowel syndrome via a comprehensive strategy: Combined effects of synephrine, paeoniflorin and naringin.

Phytomedicine 2021 Jun 24;86:153527. Epub 2021 Feb 24.

College of Life Sciences, Nanjing Normal University, Nanjing 210023, China. Electronic address:

Background: SiNiSan (SNS) is an ancient Chinese herbal prescription, and the current clinical treatment of irritable bowel syndrome (IBS) is effective. In the previous study of the research team, the multi-functional co-synergism of SNS against IBS was presented. Some potential drug targets and candidate ligands were predicted. Read More

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Network-based modeling of herb combinations in traditional Chinese medicine.

Brief Bioinform 2021 Apr 8. Epub 2021 Apr 8.

Faculty of Medicine of the University of Helsinki and Group Leader of Network Pharmacology for Precision Medicine group, Finland.

Traditional Chinese medicine (TCM) has been practiced for thousands of years for treating human diseases. In comparison to modern medicine, one of the advantages of TCM is the principle of herb compatibility, known as TCM formulae. A TCM formula usually consists of multiple herbs to achieve the maximum treatment effects, where their interactions are believed to elicit the therapeutic effects. Read More

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Effect of pH and heat treatment conditions on physicochemical and acid gelation properties of liquid milk protein concentrate.

J Dairy Sci 2021 Jun 25;104(6):6609-6619. Epub 2021 Mar 25.

Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON, Canada N1G 2W1.

Milk protein concentrates (MPC) are typically dried high-protein powders with functional and nutritional properties that can be tailored through modification of processing conditions, including temperature, pH, filtration, and drying. However, the effects of processing conditions on the structure-function properties of liquid MPC (fluid ultrafiltered milk), specifically, are understudied. In this report, the pH of liquid MPC [13% protein (70% protein DM basis), pH 6. Read More

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Targeted mass spectrometry quantification of total soy protein residues from commercially processed ingredients for food allergen management.

J Proteomics 2021 05 20;239:104194. Epub 2021 Mar 20.

Food Allergy Research and Resource Program, Department of Food Science and Technology, University of Nebraska-Lincoln, Lincoln, NE 68588, United States. Electronic address:

Soybean is one of the most commonly allergenic foods in the U.S. However, the variety of commercial soy ingredients used in the food industry makes soybean a challenging allergen to detect and quantify. Read More

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Is Universal Health Coverage Affordable? Estimated Costs and Fiscal Space Analysis for the Ethiopian Essential Health Services Package.

Health Syst Reform 2021 Jan;7(1):e1870061

Bergen Centre for Ethics and Priority Setting, Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway.

Estimating the required resources for implementing an essential health services package (EHSP) is vital to examine its feasibility and affordability. This study aimed to estimate the financial resources required to implement the Ethiopian EHSP from 2020 to 2030. Furthermore, we explored potential alternatives to increase the fiscal space for health in Ethiopia. Read More

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January 2021

Development of a HPLC-DAD stability-indicating method and compatibility study of azathioprine and folic acid as a prerequisite for a monolayer fixed-dose combination.

Anal Methods 2021 03 9;13(11):1422-1431. Epub 2021 Mar 9.

University of Zagreb Faculty of Pharmacy of Biochemistry, A. Kovačića 1, 10000 Zagreb, Croatia.

Adherence in chronic diseases is a major problem which can be combated by prescribing fixed-dose combinations in the therapy of the disease. Thus, a combination of azathioprine and folic acid in the treatment of inflammatory bowel disease is highly required, but prior to formulation development, chemical compatibility of the two drugs needs to be investigated. In this work, differential scanning calorimetry, isothermal stress testing, in vitro dissolution and forced degradation studies were utilized to investigate compatibility. Read More

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Quantifying pesticide emission fractions for tropical conditions.

Chemosphere 2021 Jul 22;275:130014. Epub 2021 Feb 22.

Quantitative Sustainability Assessment, Department of Technology, Management and Economics, Technical University of Denmark, Produktionstorvet 424, 2800, Kgs. Lyngby, Denmark. Electronic address:

The inventory model 'PestLCI Consensus', originally developed for temperate conditions, estimates initial pesticide emission fractions to air, to off-field surfaces by drift deposition, and to field crop and field soil surfaces according to crop foliar interception characteristics. Since crop characteristics and application techniques differ in tropical conditions, these aspects need to be included in the model in support of evaluating pesticide emissions under tropical conditions. Based on published literature, a consistent set of crop foliar interception fractions was developed as function of crop characteristics and spraying techniques for tropical crops. Read More

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Carotenoids from persimmon juice processing.

Food Res Int 2021 03 10;141:109882. Epub 2020 Nov 10.

Instituto de Investigación, Desarrollo e Innovación en Biotecnología Sanitaria de Elche (IDiBE), Edificio Torregaitán, Universidad Miguel Hernández de Elche (UMH), Avenida de la Universidad s/n, 03202 Elche, Alicante, Spain. Electronic address:

The aim of this study was the use and revalorization of two persimmon by-products A and B generated in the juice production process. The by-product B resulting from a pectinase enzymatic treatment of peels and pulp to optimize juice extraction was especially suitable for recovery of valuable bioactive carotenoids. The extraction solvents and solvent combinations used were: ethanol, acetone, ethanol/acetone (50:50 v/v) and ethanol/acetone/hexane (25:25:50 v/v/v). Read More

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Thymoquinone: A Tie-Breaker in SARS-CoV2-Infected Cancer Patients?

Cells 2021 02 2;10(2). Epub 2021 Feb 2.

Molecular Pharmacology Research Group, Department of Pharmacology and Toxicology, Faculty of Pharmacy and Biotechnology, German University in Cairo, 11835 Cairo, Egypt.

Since the beginning of the SARS-CoV-2(severe acute respiratory syndrome-coronavirus-2) pandemic, arace to develop a vaccine has been initiated, considering the massive and rather significant economic and healthcare hits that this virus has caused. The pathophysiology occurring following COVID-19(coronavirus disease-2019) infection has givenhints regarding the supportive and symptomatic treatments to establish for patients, as no specific anti-SARS-CoV-2 is available yet. Patient symptoms vary greatly and range from mild symptoms to severe fatal complications. Read More

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February 2021

Bradyrhizobium arachidis mediated enhancement of (oxy)matrine content in the medicinal legume Sophora flavescens.

Lett Appl Microbiol 2021 May 2;72(5):570-577. Epub 2021 Feb 2.

Department of Research and Development, Biotechnology, Uttaranchal University, Dehradun, Uttarakhand, India.

Effect of rhizobial inoculation and nitrate application on the content of bioactive compounds in legume plants is an interesting aspect for interactions among microbes, plants and chemical fertilizers, as well as for cultivated practice of legumes. In this study, nitrate (0, 5 and 20 mmol l ) and Bradyrhizobium arachidis strain CCBAU 051107 were applied, individually or in combination, to the root rhizosphere of the medicinal legume Sophora flavescens Aiton (SFA). Then the plant growth, nodulation and active ingredients including (oxy)matrine of SFA were determined and compared. Read More

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Ingredient-Dependent Extent of Lipid Oxidation in Margarine.

Antioxidants (Basel) 2021 Jan 13;10(1). Epub 2021 Jan 13.

Department of Physiological Chemistry, Faculty of Chemistry, University of Vienna, 1090 Vienna, Austria.

This study reports the impact of margarine-representative ingredients on its oxidative stability and green tea extract as a promising antioxidant in margarine. Oil-in-water emulsions received much attention regarding factors that influence their oxidative stability, however, water-in-oil emulsions have only been scarcely investigated. Margarine, a widely consumed water-in-oil emulsion, consists of 80-90% fat and is thermally treated when used for baking. Read More

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January 2021

Preparation and Characterization of Planar-Type ZnO Powder with High Aspect Ratio for Application in Ultraviolet- and Heat-Shield Cosmetics.

J Nanosci Nanotechnol 2021 03;21(3):1897-1903

Department of Advanced Materials Engineering, Korea Polytechnic University, Siheung 15073, Korea.

In this study, a [0001]-plane planar-type ZnO ceramic powder material with a high aspect ratio ranging from 20:1-50:1 is synthesized using the electrolyte collected from zinc air battery power generation. This high aspect ratio may be due to the Zn(OH)₄ anion dissolved in the electrolyte. The obtained planar-type ZnO exhibits excellent formulation stability and applicability, even when formulated as a cosmetic with a single inorganic ingredient. Read More

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Combining crystalline and polymeric excipients in API solid dispersions - Opportunity or risk?

Eur J Pharm Biopharm 2021 Jan 6;158:323-335. Epub 2020 Dec 6.

TU Dortmund University, Department of Chemical and Biochemical Engineering, Laboratory of Thermodynamics, Emil-Figge-Str. 70, D-44227 Dortmund, Germany. Electronic address:

Amorphous solid dispersions (ASDs) are often metastable against crystallization of the active pharmaceutical ingredient (API) and thus might undergo unwanted changes during storage. The crystallization tendency of ASDs is influenced by the API crystallization driving force (CDF) and the mobility of the molecules in the ASD. Low molecular weight-excipients are known to stabilize amorphous APIs in so-called co-amorphous formulations. Read More

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January 2021

FTIR combined with chemometric tools (fingerprinting spectroscopy) in comparison to HPLC: which strategy offers more opportunities as a green analytical chemistry technique for pharmaceutical analysis.

Anal Methods 2020 12;12(48):5893-5907

Analytical Chemistry Department, Faculty of Pharmacy, Cairo University, El-Kasr El-Aini Street, ET-11562 Cairo, Egypt.

Fourier transform infrared spectroscopy (FTIR) is a widespread technique that can provide a chemical signature (fingerprints) of solid, liquid, or gas samples with a wide range of analytical applications. High-performance liquid chromatography (HPLC) is a leading analytical strategy for pharmaceutical analysis. Here we present a side-by-side comparison of the potential of these techniques for quantitative analysis of pharmaceutical active ingredient combinations in light of green analytical chemistry (GAC) principles. Read More

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December 2020

Comparative Study of the Structural Properties, Color, Bioactive Compounds Content and Antioxidant Capacity of Aerated Gelatin Gels Enriched with Cryoconcentrated Blueberry Juice during Storage.

Polymers (Basel) 2020 Nov 24;12(12). Epub 2020 Nov 24.

Laboratory of Cryoconcentration, Department of Food Engineering, Universidad del Bío-Bío, Av. Andrés Bello 720, Casilla 447, Chillán 3780000, Chile.

Cryoconcentrated blueberry juice (CBJ) was incorporated into aerated gelatin gel and the effects on the mechanical properties, phenolic compounds and antioxidant activity (AA) were evaluated at day 1 and day 28 under refrigerated storage. At day 1, 8 g of gelatin gel and 40 g of CBJ (called M5) exhibited a soft texture and heterogeneous and non-spherical small bubbles, with values close to 10.5, 8. Read More

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November 2020

Self-Selection of Agricultural By-Products and Food Ingredients by (Coleoptera: Tenebrionidae) and Impact on Food Utilization and Nutrient Intake.

Insects 2020 Nov 24;11(12). Epub 2020 Nov 24.

Beta Hatch Inc., 200 Titchenal Road, Cashmere, WA 98815, USA.

Nutrient self-selection was used to determine optimal intake ratios of macro-nutrients by L. larvae. Self-selection experiments consisted of 9 combinations (treatments) of 8 ingredients, from a total of 20 choices, radially distributed in a multiple-choice arena presented to groups of 100 larvae (12th-13th instar). Read More

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November 2020

Price of a hepatitis C cure: Cost of production and current prices for direct-acting antivirals in 50 countries.

J Virus Erad 2020 Sep 18;6(3):100001. Epub 2020 Jun 18.

Department of Translational Medicine, University of Liverpool, UK.

Objectives: Seven years after the introduction of direct-acting antivirals (DAAs) for the treatment of hepatitis C, high prices remain a barrier for treatment programs worldwide. This study seeks to describe current prices for originator DAAs in 50 countries and evaluate the relationship between prices and GDP per capita.

Methods: Data on prices of sofosbuvir, daclatasvir, sofosbuvir/ledipasvir, sofosbuvir/velpatasvir, and glecaprevir/pibrentasvir were collected from national databases for 50 countries. Read More

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September 2020

Multi-residue Analysis of Pesticides in Turmeric (Powder and Rhizome) Using Gas Chromatography Tandem Mass Spectrometry.

J AOAC Int 2020 Nov;103(6):1498-1511

National Referral Laboratory, ICAR-National Research Centre for Grapes, P.O. Manjri Farm, Pune 412307, India.

Background And Objectives: Turmeric is widely used as an ingredient of food and medicinal products. There exists no validated method for multi-residue analysis of pesticides in turmeric.

Objective: This study was undertaken to develop a simple and robust method for the quantitative determination of multi-class pesticides in turmeric powder and rhizome by GC-MS/MS. Read More

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November 2020

Short Persistence and Vector Susceptibility to Ficam 80WP (bendiocarb active ingredient) During Pilot Application of Indoor Residual Spraying in Burkina Faso, West Africa.

J Med Entomol 2021 03;58(2):781-786

Biomedical and Public Health Department, Institut de Recherche en Sciences de la Santé, Direction Regionale, Avenue de la liberté, 01 BP 545, Bobo-Dioulasso 01, Burkina Faso.

Indoor residual spraying (IRS) was applied in addition to the use of long-lasting insecticidal nets in the South West in Burkina Faso, where Anopheles gambiae s.l. the major malaria vector was resistant to pyrethroids. Read More

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Evolution of the adaptogenic concept from traditional use to medical systems: Pharmacology of stress- and aging-related diseases.

Med Res Rev 2021 01 25;41(1):630-703. Epub 2020 Oct 25.

Department of Pharmacy, Center for Pharma Research, Ludwig-Maximilians-Universität München, Munich, Germany.

Adaptogens comprise a category of herbal medicinal and nutritional products promoting adaptability, resilience, and survival of living organisms in stress. The aim of this review was to summarize the growing knowledge about common adaptogenic plants used in various traditional medical systems (TMS) and conventional medicine and to provide a modern rationale for their use in the treatment of stress-induced and aging-related disorders. Adaptogens have pharmacologically pleiotropic effects on the neuroendocrine-immune system, which explain their traditional use for the treatment of a wide range of conditions. Read More

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January 2021

3D printing of extended-release tablets of theophylline using hydroxypropyl methylcellulose (HPMC) hydrogels.

Int J Pharm 2020 Dec 13;591:119983. Epub 2020 Oct 13.

Food Science and Human Nutrition Department, Iowa State University, Ames, IA 50011, USA. Electronic address:

An extrusion based 3D printer was used to prepare the semi-solid tablets with different drug loading dosages (75, 100, 125 mg) under ambient temperature. The active pharmaceutical ingredient, theophylline, was uploaded within the hydrogels prepared of hydroxypropyl methylcellulose (HPMC) K4M or E4M. The HPMC concentrations were adjusted to different levels (10 and 12% w/w) to fulfill the requirements for 3D printing. Read More

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December 2020

Mechanisms dissection of the combination GRS derived from ShengMai preparations for the treatment of myocardial ischemia/reperfusion injury.

J Ethnopharmacol 2021 Jan 15;264:113381. Epub 2020 Sep 15.

Jiangsu Key Laboratory of TCM Evaluation and Translational Research, Research Center for Traceability and Standardization of TCMs, School of Traditional Chinese Pharmacy, China Pharmaceutical University, 639 Longmian Road, Nanjing, 211198, PR China. Electronic address:

Ethnopharmacological Relevance: Recently, a new drug combination GRS comprising ginsenoside Rb1 (G-Rb1), ruscogenin (R-Rus) and schisandrin (S-SA) was screened based on ShengMai preparations, which exhibited a prominent cardioprotective effects against myocardial ischemia/reperfusion (MI/R) injury.

Aim Of The Study: To investigate their systemic and individual mechanism of each compound in combination GRS.

Materials And Methods: The mice model of MI/R and hypoxia/reoxygenation (H/R)-induced cardiomyocytes injury were performed to explore the respective characteristics of each compound in GRS against myocardial injury. Read More

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January 2021

Recent Advances in Treatment of Lung Cancer: Nanoparticle-based Drug and siRNA Delivery Systems.

Curr Drug Deliv 2021 ;18(2):103-120

Department of Pharmaceutical Technology, Faculty of Pharmacy, Hacettepe University, Ankara, Turkey.

Lung cancer is the second most diagnosed cancer in both men and women worldwide. Considering the high mortality rate of lung cancer and inadequacy of conventional treatment methods such as surgical resection, chemotherapy and radiotherapy; new treatment strategies are an emerging area of interest. Nanoparticle-based drug and small interfering RNA delivery systems such as lipid, polymeric, inorganic, micellar and dendrimer nanoparticles are designed to enhance the bioavailability, stability and retention of anti-cancer drugs in the targeted regions of the lung. Read More

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January 2021

Assessment of Pharmacologic Ingredients in Common Over-the-Counter Sinonasal Medications.

Edward D McCoul

JAMA Otolaryngol Head Neck Surg 2020 09;146(9):810-815

Department of Otorhinolaryngology, Ochsner Clinic Foundation, New Orleans, Louisiana.

Importance: Sinonasal remedies are the most frequently purchased category of over-the-counter (OTC) drugs in the United States. A variety of options for relief are available under proprietary names, although the actual number of available options may not be readily appreciated by the consumer or the clinician.

Objective: To determine the prevalence of specific ingredients in OTC sinonasal products. Read More

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September 2020

Nutritional Content and Ingredients of Commercial Infant and Toddler Food Pouches Compared With Other Packages Available in the United States.

Nutr Today 2019 Nov-Dec;54(6):305-312. Epub 2019 Dec 2.

is an assistant professor in the Department of Human Development & Family Studies at Purdue University in West Lafayette, Indiana.

The ingredients and nutrients of infant and toddler foods (ITFs) sold in pouches were compared with products available in other packages, such as jars/packs and other containers. Company websites (n = 21) and in-store shelf inventory (n = 3) were used to create a database of commercial ITFs containing vegetables (n = 548) sold in the United States. Results indicated that ITFs containing vegetables were most commonly packaged in pouches (50%), followed by "other" packages (25%) and jars/packs (25%). Read More

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December 2019

In vitroα-glucosidase inhibition by honeybush (Cyclopia genistoides) food ingredient extract-potential for dose reduction of acarbose through synergism.

Food Funct 2020 Jul 6;11(7):6476-6486. Epub 2020 Jul 6.

Plant Bioactives Group, Post-Harvest and Agro-processing Technologies, Agricultural Research Council (ARC) Infruitec-Nietvoorbij, Private Bag X5026, Stellenbosch 7599, South Africa.

Extracts of Cyclopia species are used as food ingredients. In vitroα-glucosidase (AG) inhibition by ultrafiltered C. genistoides extract, fractions enriched in xanthones (XEF) and benzophenones (BEF), as well as mangiferin, isomangiferin, 3-β-d-glucopyranosyliriflophenone (I3G) and 3-β-d-glucopyranosyl-4-O-β-d-glucopyranosyliriflophenone (IDG) was determined with acarbose as positive control. Read More

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