234,550 results match your criteria infusion rate

Assessment of the Cytoprotective Effects of High-Dose Valproic Acid Compared to a Clinically Used Lower Dose.

J Surg Res 2021 May 11;266:125-141. Epub 2021 May 11.

Department of Surgery, University of Michigan Health System, Ann Arbor, Michigan; Department of Surgery, Feinberg School of Medicine/Northwestern University, Chicago, Illinois. Electronic address:

Objective: Valproic acid (VPA) treatment improves survival in animal models of injuries on doses higher than those allowed by Food and Drug Administration (FDA). We investigated the proteomic alterations induced by a single high-dose (140mg/kg) of VPA (VPA140) compared to the FDA-approved dose of 30mg/kg (VPA30) in healthy humans. We also describe the proteomic and transcriptomic changes induced by VPA140 in an injured patient. Read More

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Trait dissociation as a predictor of induced dissociation by ketamine or esketamine in treatment-resistant depression: Secondary analysis from a randomized controlled trial.

J Psychiatr Res 2021 May 8;138:576-583. Epub 2021 May 8.

Laboratório de Neuropsicofarmacologia, Serviço de Psiquiatria do Hospital Universitário Professor Edgard Santos, Universidade Federal da Bahia, Salvador, Brazil; Programa de Pós-Graduação em Medicina e Saúde, Faculdade de Medicina da Bahia, Universidade Federal da Bahia, Salvador, Brazil; Departamento de Neurociências e Saúde Mental, Faculdade de Medicina da Bahia, Universidade Federal da Bahia, Salvador, Brazil. Electronic address:

Dissociative symptoms are common, possibly severe, side effects associated with the use of ketamine and esketamine in depression. We investigated the relationship between trait dissociation and dissociation induced by ketamine and esketamine used as augmentation therapy in treatment-resistant depression (TRD). Adults with TRD were randomly assigned to receive a single intravenous infusion, with a duration of 40 min, of either esketamine 0. Read More

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Patient expectations about a clinical diagnostic test may influence the clinician's test interpretation.

Musculoskelet Sci Pract 2021 May 6;54:102387. Epub 2021 May 6.

Menzies Health Institute Queensland, Griffith University, Brisbane & Gold Coast, Australia.

Background: With medical information widely available, patients often have preconceived ideas regarding diagnostic procedures and management strategies.

Objectives: To investigate whether expectations, such as beliefs about the source of symptoms and knowledge about diagnostic tests, influence pain perception during a clinical diagnostic test.

Design: Cross-sectional study. Read More

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Universal Engraftment after Allogeneic Hematopoietic Cell Transplantation Using Cryopreserved CD34 Selected Grafts.

Transplant Cell Ther 2021 May 12. Epub 2021 May 12.

Department of Medicine, Adult Bone Marrow Transplant Service, Memorial Sloan Kettering Cancer Center, New York, NY; Department of Medicine, Weill Cornell Medical College, New York, NY.

Background: As a result of the COVID-19 pandemic, most centers performing allogeneic hematopoietic cell transplant (allo-HCT) have switched to the use of cryopreserved grafts. Previous investigators have suggested that cryopreserved allografts may heighten risk of nonengraftment. To date, no study has investigated the effect of cryopreservation of CD34-selected hematopoietic progenitor cells (CD34+HPC) used as the sole graft source. Read More

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Disparities in Utilization and Outcomes with Continuous Subcutaneous Insulin Infusion in Young Adults with T1D.

Endocr Pract 2021 May 12. Epub 2021 May 12.

Department of Health & Clinical Outcomes Research, Saint Louis University School of Medicine, St. Louis, Missouri, USA; Advanced HEAlth Data (AHEAD) Institute, Saint Louis University, St. Louis, Missouri, USA.

Objective: To evaluate what factors determine utilization patterns and outcomes of continuous subcutaneous insulin infusion (CSII) in young adults with type 1 diabetes (T1D).

Research Design & Methods: Utilizing the Optum® de-identified Electronic Health Record (EHR) dataset between 2008 to 2018 to perform a retrospective, cohort study, we identified 2104 subjects with T1D aged 18-30 years. We evaluated the effect of race on determining CSII utilization, HbA1c (%) and hospital admission for diabetic ketoacidosis (DKA). Read More

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Elezanumab, a human anti-RGMa monoclonal antibody, promotes neuroprotection, neuroplasticity, and neurorecovery following a thoracic hemi-compression spinal cord injury in non-human primates.

Neurobiol Dis 2021 May 12:105385. Epub 2021 May 12.

Department of Neurosurgery and The Miami Project to Cure Paralysis, The Miller School of Medicine, University of Miami, Miami, FL, United States.

Spinal cord injury (SCI) is a devastating condition characterized by loss of function, secondary to damaged spinal neurons, disrupted axonal connections, and myelin loss. Spontaneous recovery is limited, and there are no approved pharmaceutical treatments to reduce ongoing damage or promote repair. Repulsive guidance molecule A (RGMa) is upregulated following injury to the central nervous system (CNS), where it is believed to induce neuronal apoptosis and inhibit axonal growth and remyelination. Read More

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Activation state of the supramammillary nucleus regulates body composition and peripheral fuel metabolism.

Neuroscience 2021 May 12. Epub 2021 May 12.

VeroScience LLC, Tiverton, RI 02878, United States. Electronic address:

Whole body fuel metabolism and energy balance are controlled by an interactive brain neuronal circuitry involving multiple brain centers regulating cognition, circadian rhythms, reward, feeding and peripheral biochemical metabolism. The hypothalamic supramammillary nucleus (SuMN) comprises an integral node having connections with these metabolically relevant centers, and thus could be a key central coordination center for regulating peripheral energy balance. This study investigated the effect of chronically diminishing or increasing SuMN neuronal activity on body composition and peripheral fuel metabolism. Read More

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Atrial natriuretic peptide does not degrade the endothelial glycocalyx: a secondary analysis of a randomized porcine model.

Acta Anaesthesiol Scand 2021 May 15. Epub 2021 May 15.

Department of Anaesthesiology and Intensive Care Medicine, Institute of Clinical Sciences at the Sahlgrenska Academy, University of Gothenburg, Sahlgrenska University Hospital, Section of Cardiothoracic Anaesthesia and Intensive Care, Gothenburg, Sweden.

Background: The atrial natriuretic peptide released from the heart regulates intravascular volume and is suspected to increase capillary permeability. Contradictory results regarding ANP and glycocalyx degradation have been reported. The aim of this study was to investigate if an infusion of ANP causes degradation of the endothelial glycocalyx. Read More

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Real life Study on the Pharmacokinetic of Remdesivir in ICU patients admitted for Severe COVID-19 Pneumonia.

Br J Clin Pharmacol 2021 May 14. Epub 2021 May 14.

Laboratory of Clinical Pharmacology and Pharmacogenetics, Amedeo di Savoia Hospital, Department of Medical Sciences, University of Turin, Italy.

Remdesivir is one of the most encouraging treatments against SARS-CoV-2 infection. After intravenous infusion, RDV is rapidly metabolized (T 1h) within the cells to its active adenosine triphosphate analogue form (GS-443902) and, then, it can be found in plasma in its nucleoside analogue form (GS-441524). In this real life study we describe the Remdesivir and GS-441524 concentrations at 3 time points in nine ICU patients, through a validated UHPLC-MS/MS method. Read More

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Feasibility, efficacy, and safety of ethanol infusion into the vein of Marshall for atrial fibrillation: a meta-analysis.

Pacing Clin Electrophysiol 2021 May 14. Epub 2021 May 14.

Heart Center, the First Hospital of Lanzhou University, Lanzhou, China.

Background: Contemporary radiofrequency catheter ablation (RFCA) approaches for atrial fibrillation (AF) have reached an efficacy "ceiling". Ethanol infusion into the vein of Marshall (EI-VOM) has shown potential in preliminary studies. Data on EI-VOM are largely limited to small single-center reports, and clinical benefits and risks have not been systematically examined. Read More

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Plasma volume and atrial natriuretic peptide during induction of anaesthesia.

Acta Anaesthesiol Scand 2021 May 15. Epub 2021 May 15.

Department of Anaesthesiology and Intensive Care Medicine, Institute of Clinical Sciences at the Sahlgrenska Academy, University of Gothenburg, Sahlgrenska University Hospital, Section of Cardiothoracic Anaesthesia and Intensive Care, Gothenburg, Sweden.

We thank Dr Saito for the interest in our paper "Effects of different mean arterial pressure targets on plasma volume, ANP and glycocalyx-A randomized trial" where cardiac surgery patients were randomised to a mean arterial pressure (MAP) of 60 or 90 mm Hg using norepinephrine (NE) infusion. The plasma volume (PV) and the Mid Regional-pro Atrial Natriuretic Peptide (MR-proANP) increased in the group randomised to lower MAP. All patients had a normal left ventricular ejection fraction of 45% or more. Read More

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Prehospital shock index and systolic blood pressure are highly specific for pediatric massive transfusion.

J Trauma Acute Care Surg 2021 May 10. Epub 2021 May 10.

University of Texas Health Science Center, Department of Trauma and Emergency Surgery, San Antonio, TX 78229-3900 Trauma Surgery, Naval Medical Center Camp Lejeune, Camp Lejeune, NC 28547 University Hospital in San Antonio, Trauma Services, San Antonio, TX 78229-3900 University of Texas Health Science Center, Department of Pathology, San Antonio, TX 78229-3900 Southwest Texas Regional Advisory Council, San Antonio, TX, 78227 University of Texas Health Science Center, Department of Emergency Health Sciences, San Antonio, TX 78229-3900.

Background: While massive transfusion protocols (MTP) are associated with decreased mortality in adult trauma patients, there is limited research on the impact of MTP on pediatric trauma patients. The purpose of this study was to compare pediatric trauma patients requiring massive transfusion to all other pediatric trauma patients to identify triggers for MTP activation in injured children.

Methods: Using our level I trauma center's registry, we retrospectively identified all pediatric trauma patients from January 2015 to January 2018. Read More

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Comparison of non-myeloablative lymphodepleting preconditioning regimens in patients undergoing adoptive T cell therapy.

J Immunother Cancer 2021 May;9(5)

Ella Lemelbaum Institute for Immuno-Oncology, Sheba Medical Center at Tel Hashomer, Tel Hashomer, Israel

Background: Adoptive cell therapy with T cells genetically engineered to express a chimeric antigen receptor (CAR-T) or tumor-infiltrating T lymphocytes (TIL) demonstrates impressive clinical results in patients with cancer. Lymphodepleting preconditioning prior to cell infusion is an integral part of all adoptive T cell therapies. However, to date, there is no standardization and no data comparing different non-myeloablative (NMA) regimens. Read More

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Systematic review of the stability of antimicrobial agents in elastomeric devices for outpatient parenteral antimicrobial therapy services based on NHS Yellow Cover Document standards.

Eur J Hosp Pharm 2021 May 14. Epub 2021 May 14.

Quality Assurance, Torbay and South Devon NHS Foundation Trust, Torquay, Torbay, UK.

Background: In order to use aseptically prepared elastomeric infusers, outpatient parenteral antimicrobial therapy (OPAT) services require extended stability data for antimicrobial agents to assign a product shelf-life. In the UK, the relevant standards for stability testing and shelf-life assignment are published in 'A Standard Protocol for Deriving and Assessment of Stability-Part 1 (Aseptic Preparations-Small Molecules), commonly called the Yellow Covered Document (YCD). A previous systematic review published in 2017 failed to identify data on the stability of antimicrobials in elastomeric devices for OPAT services that met YCD requirements in force at the time. Read More

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Effect of focused cardiopulmonary ultrasonography on clinical outcome of septic shock: a randomized study.

J Int Med Res 2021 May;49(5):3000605211013176

Department of Critical Care Medicine, Xiangya Hospital, Central South University, Changsha, China.

Objective: To investigate the effect of focused ultrasonography on clinical outcomes of septic shock.

Methods: Patients with septic shock were randomized into an integrated cardiopulmonary ultrasonography (ICUS) group and conventional (CON) group. Within 1 hour of admission, the ICUS group underwent ICUS examination for hemodynamic decision-making, while the CON group received standard treatment. Read More

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Massive Transfusion Protocols in Obstetric Hemorrhage: Theory versus Reality.

Am J Perinatol 2021 May 14. Epub 2021 May 14.

Depatment of Obstetrics and Gynecology, Baylor College of Medicine, Houston, Texas.

Objective:  Massive transfusion protocols are widely implemented in obstetrical practice in case of severe hemorrhage; however, different recommendations exist regarding the appropriate ratios of blood product components to be transfused. We report our extensive experience with massive component transfusion in a referral center in which the standard massive transfusion protocol is modified by ongoing clinical and laboratory evaluation.

Study Design:  A retrospective chart review of all patients who had massive transfusion protocol activation in a level 4 referral center for obstetrical practice was performed from January 2014 to January 2020. Read More

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Evaluation of a patient-specific algorithm for predicting distribution for convection-enhanced drug delivery into the brainstem of patients with diffuse intrinsic pontine glioma.

J Neurosurg Pediatr 2021 May 14:1-9. Epub 2021 May 14.

2Department of Neurological Surgery, Weill Medical College of Cornell University, New York, New York.

Objective: With increasing use of convection-enhanced delivery (CED) of drugs, the need for software that can predict infusion distribution has grown. In the context of a phase I clinical trial for pediatric diffuse intrinsic pontine glioma (DIPG), CED was used to administer an anti-B7H3 radiolabeled monoclonal antibody, iodine-124-labeled omburtamab. In this study, the authors retrospectively evaluated a software algorithm (iPlan Flow) for the estimation of infusate distribution based on the planned catheter trajectory, infusion parameters, and patient-specific MRI. Read More

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Continuous Infusion, Therapeutic Drug Monitoring and Outpatient Parenteral Antimicrobial Therapy with Ceftazidime-Avibactam: a Retrospective Cohort Study.

J Glob Antimicrob Resist 2021 May 11. Epub 2021 May 11.

Department of Infectious Diseases and General Internal Medicine, University Hospital of Liège, Liège, Belgium. Electronic address:

Background: Based on recent PK/PD evidence, continuous infusion (CI) of β-lactam administration is increasingly recommended for serious infections. Since 2016, the combination of ceftazidime and avibactam (CAZ/AVI) is administered per manufacturer prescription as an intermittent infusion of 2.5g q8h. Read More

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Venous Anatomy of the Left Ventricular Summit: Therapeutic Implications for Ethanol Infusion.

Heart Rhythm 2021 May 11. Epub 2021 May 11.

Division of cardiac electrophysiology, Department of Cardiology, Houston Methodist DeBakey Heart and Vascular Center, Houston Methodist Hospital, Houston, Texas. Electronic address:

Background: Venous ethanol ablation (VEA) is effective for left ventricular summit (LVS) arrhythmias. The LVS venous anatomy is poorly understood and has inconsistent nomenclature.

Objective: Delineate the LVS venous anatomy by selective venography and 3D mapping during VEA and by venous-phase coronary computed tomographic angiography (vCTA). Read More

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Comparative study of neuron-specific promoters in mouse brain transduced by intravenously administered AAV-PHP.eB.

Neurosci Lett 2021 May 11:135956. Epub 2021 May 11.

Department of Neurophysiology and Neural Repair, Gunma University Graduate School of Medicine, 3-39-22, Gunma, 371-8511, Japan; Viral Vector Core, Gunma University Initiative for Advanced Research (GIAR), Gunma, 371-8511, Japan. Electronic address:

Adeno-associated virus (AAV)- PHP.B and AAV-PHP.eB (PHP. Read More

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Exploring Strategies toward Synthetic Precision Control within Core-Shell Nanowires.

Acc Chem Res 2021 May 14. Epub 2021 May 14.

Department of Chemistry, State University of New York at Stony Brook, Stony Brook, New York 11794-3400, United States.

ConspectusAchieving precision and reproducibility in terms of physical structure and chemical composition within arbitrary nanoscale systems remains a "holy grail" challenge for nanochemistry. Because nanomaterials possess fundamentally distinctive size-dependent electronic, optical, and magnetic properties with wide-ranging applicability, the ability to produce homogeneous and monodisperse nanostructures with precise size and shape control, while maintaining a high degree of sample quality, purity, and crystallinity, remains a key synthetic objective. Moreover, it is anticipated that the methodologies developed to address this challenge ought to be reasonably simple, scalable, mild, nontoxic, high-yield, and cost-effective, while minimizing reagent use, reaction steps, byproduct generation, and energy consumption. Read More

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Herbal Extracts as Potential Antioxidant, Anti-Aging, Anti-Inflammatory, and Whitening Cosmeceutical Ingredients.

Chem Biodivers 2021 May 14. Epub 2021 May 14.

Huachiew Chalermprakiet University, Pharmaceutical Science, Samutprakarn, 10250, Mueang, THAILAND.

The aim of this research was to investigate and compare the antioxidant, anti-tyrosinase, anti-aging, and anti-inflammatory activities of 16 herbal extracts for topical application in cosmetic/cosmeceutical products. Herbal plant materials were extracted by infusion in boiled water for 15 min. The total phenolic content and total flavonoid content of each extract were investigated by the Folin-Ciocalteu and aluminum chloride methods, respectively. Read More

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Neuregulin-1 Compensates for Endothelial Nitric Oxide Synthase Deficiency.

Am J Physiol Heart Circ Physiol 2021 May 14. Epub 2021 May 14.

Laboratory of Physiopharmacology, University of Antwerp, Universiteitsplein 1, 2610 Antwerp, Belgium; Department of Cardiology, University Hospital Antwerp, Belgium.

Endothelial cells (ECs) secrete different paracrine signals that modulate the function of adjacent cells; two examples of these paracrine signals are nitric oxide (NO) and neuregulin-1 (NRG1), a cardioprotective growth factor. Currently, it is undetermined whether one paracrine factor can compensate for the loss of another. Herein, we hypothesized that NRG1 can compensate for endothelial NO synthase (eNOS) deficiency. Read More

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Severe Hyponatremia and Seizure From Peripheral Infusion of Norepinephrine Diluted in Dextrose 5% in Water: A Case Report.

A A Pract 2021 May 14;15(5):e01479. Epub 2021 May 14.

Department of Anesthesiology and Pain Medicine, University of Toronto, Toronto, Ontario, Canada.

Recent studies have demonstrated that vasopressors can be delivered safely through peripheral intravenous lines. While norepinephrine is usually delivered at a concentration of 16 to 32 μg/mL, out of concern for extravasation and interstitial necrosis, some patients receive more dilute norepinephrine solutions through peripheral intravenous catheters. We describe a case of severe hyponatremia and seizure resulting from administration of norepinephrine concentrated at 4 μg/mL in dextrose 5% in water. Read More

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Portal Vein Thrombosis may Be More Strongly Associated With Islet Infusion Than Extreme Thrombocytosis After Total Pancreatectomy With Islet Autotransplantation.

Transplantation 2021 Jan 19. Epub 2021 Jan 19.

1 Department of Pediatrics, University of Minnesota Medical School, Minneapolis, MN. 2 Department of Medicine, University of Minnesota Medical School, Minneapolis, MN. 3 Division of Biostatistics, University of Minnesota School of Public Health, Minneapolis, MN. 4 Department of Surgery, University of Minnesota Medical School, Minneapolis, MN.

Background: Total pancreatectomy with islet autotransplantation (TPIAT) involves pancreatectomy, splenectomy, and reinjection of the patient's pancreatic islets into the portal vein. This process triggers a local inflammatory reaction and increase in portal pressure, threatening islet survival and potentially causing portal vein thrombosis. Recent research has highlighted a high frequency of extreme thrombocytosis (platelets ≥1000 x10/L) after TPIAT, but its etiology and association with thrombotic risk remain unclear. Read More

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January 2021

Does splenectomy significantly improve the prognosis of hepatocellular carcinoma patients with hypersplenism? A systematic review and meta-analysis.

Ann Transl Med 2021 Apr;9(8):641

Department of Biliary Tract Surgery I, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, China.

Background: Whether hepatocellular carcinoma (HCC) patients with hypersplenism can benefit from splenectomy is unclear. This study aimed at exploring the efficacy and safety of concurrent splenectomy for HCC patients with hypersplenism.

Methods: PubMed, EMBASE and Web of Science databases were systematically searched to compare data on the combination of hepatectomy or transhepatic arterial infusion (TAI) with splenectomy (the splenectomy group) with data on hepatectomy or TAI alone (the non-splenectomy group) for the treatment of HCC with hypersplenism. Read More

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SW178 sp. nov., an intestinal bacterium of feral chicken.

PeerJ 2021 27;9:e11050. Epub 2021 Apr 27.

Department of Veterinary and Biomedical Sciences, South Dakota State University, Brookings, South Dakota, United States.

A Gram-positive, coccobacillus, white raised and circular with an entire edge colony, and obligately anaerobic bacterium, strain SW178 was isolated from the cecum content of feral chickens in Brookings, South Dakota, USA. The most closely related strain based on 16S rRNA gene sequence analysis of strain SW178 was ATCC 27756 ( ATCC 27756) with 96.94% similarity. Read More

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Mas Receptor Blockade Promotes Renal Vascular Response to Ang II after Partial Kidney Ischemia/Reperfusion in a Two-Kidney-One-Clip Hypertensive Rats Model.

Int J Nephrol 2021 20;2021:6618061. Epub 2021 Apr 20.

Water and Electrolytes Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.

Background: Partial kidney ischemia-reperfusion (IR) injury is the principal cause of acute kidney injury. The renin-angiotensin system (RAS) and hypertension also may be influenced by renal IR injury. In two models of partial renal IR with and without ischemia preconditioning (IPC) and using Mas receptor (MasR) blockade, A779 or its vehicle, the renal vascular responses to angiotensin II (Ang II) administration in two-kidney-one-clip (2K1C) hypertensive rats were determined. Read More

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The Use of Low-Dose Intermittent Levosimendan Infusion Therapy as Bridge-to-Left Ventricular Assist Device in Advanced Chronic Heart Failure Secondary to Isolated Cardiac Sarcoidosis.

Heart Views 2020 Oct-Dec;21(4):291-295. Epub 2021 Jan 14.

Mayo Clinic, Rochester, MN, USA.

Heart failure (HF) is a progressive condition that usually involves a debilitating late course with poor health-related quality of life and increasing mortality rate. In this report, we demonstrate the efficacy and safety of intermittent levosimendan infusion as a bridging therapy to left ventricular assist device use in a patient suffering from cardiac sarcoidosis who failed to respond to optimized medical therapy. Levosimendan was administered in an outpatient infusion-therapy facility every 2 weeks as a single intravenous infusion over 6 h at dose and rate of 0. Read More

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January 2021