233,993 results match your criteria infusion

Quantification of vitamin D and 25-hydroxyvitamin D in food - The impact of eluent additives and labelled internal standards on matrix effects in LC-MS/MS analysis.

Food Chem 2021 Mar 13;357:129588. Epub 2021 Mar 13.

National Food Institute, Technical University of Denmark, Research Group for Bioactives - Analysis and Application, Kemitorvet, 2800 Kgs. Lyngby, Denmark. Electronic address:

Deuterated vitamin D standards are used commonly as internal standards in LC-MS/MS analysis of vitamin D and 25-hydroxyvitamin D in food. However, the use of various eluent additives, such as methylamine, formic acid and ammonium formate, also contributes to matrix effects and the performance of analysis by affecting accuracy and robustness. For the first time, continuous post-column infusion experiments of isotopically labelled vitamin D-[d] were performed to evaluate ion-suppression in a wide variety of food (salmon, cheese, pork fat, pork meat, and egg yolk). Read More

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Subvisible Particles in Solutions of Remicade in Intravenous Saline Activate Immune System Pathways in In Vitro Human Cell Systems.

J Pharm Sci 2021 Apr 14. Epub 2021 Apr 14.

Department of Pharmaceutical Sciences, University of Colorado, Anschutz Medical Campus, Aurora, Colorado, 80045. Electronic address:

Among patients that receive Remicade® therapy, more than 20% have adverse infusion related reactions and approximately 50% have immunogenic responses. Upon characterization of initial Remicade®-IV solution we observed a high concentration of subvisible particles that could inadvertently be delivered to patients. This solution was processed through the IV infusion system, mimicking the typical clinical administration setup - either with or without an in-line filter connected to the IV line. Read More

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Neuroprotective and antioxidative effects of pioglitazone in brain tissue adjacent to the ischemic core are mediated by PI3K/Akt and Nrf2/ARE pathways.

J Mol Med (Berl) 2021 Apr 16. Epub 2021 Apr 16.

Institute of Experimental and Clinical Pharmacology, Faculty of Medicine, University Hospital of Schleswig-Holstein, Campus Kiel, Arnold Heller Strasse 3, 24105, Kiel, Germany.

The present study elucidates the neuroprotective mechanisms of the PPARγ (peroxisome proliferator-activated receptor γ) agonist pioglitazone in survival of ischemic neurons following middle cerebral artery occlusion with reperfusion (MCAO). Intracerebroventricular infusion of pioglitazone over 5 days before and 24 or 48 h after MCAO alleviated neurological impairments, inhibited apoptosis 24 h, and activated the PI3K/Akt pathway along with increased phosphorylation of Akt (ser473) and GSK-3β (ser9) in the peri-infarct cortical areas 48 h after MCAO. In primary cortical neurons, pioglitazone suppressed the glutamate-induced release of lactate dehydrogenase by a PPARγ-dependent mechanism. Read More

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Application of quality control circle to improve conformity rate of time limits of infusion.

X Chen J Feng Y Jiang

Transfus Clin Biol 2021 Apr 1. Epub 2021 Apr 1.

Department of Laboratory Medicine, West China Second University Hospital, Sichuan University, China; Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, China.

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Effects of Pair Housing on Patency of Jugular Catheters in Rats (Rattus norvegicus).

J Am Assoc Lab Anim Sci 2021 Apr 16. Epub 2021 Apr 16.

Chronic vascular access devices are widely used in a variety of species for repeated blood sampling or substance administration. Jugular catheters are commonly used for studying addiction-related behaviors in rats. Rats with catheters have historically been individually housed for the duration of the study to prevent cage mates from damaging the catheter. Read More

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Effects of once-yearly zoledronic acid on bone density and incident vertebral fractures in nonmetastatic castration-sensitive prostate cancer patients with osteoporosis.

BMC Cancer 2021 Apr 17;21(1):422. Epub 2021 Apr 17.

Department of Palliative Medicine, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan.

Background: Androgen deprivation therapy (ADT) is the effective treating prostate cancer but is often accompanied by cancer treatment-induced bone loss (CTIBL), which impairs the patient's quality of life. In patients with nonmetastatic castration-sensitive prostate cancer (M0CSPC) who already have osteoporosis before starting ADT, appropriate bone-modifying agent intervention must be performed in parallel, as the patient has a high risk of future fracture. However, little is known about therapeutic interventions aimed at preventing the progression of CTIBL and new fractures. Read More

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Dual Regeneration of Muscle and Nerve by Intramuscular Infusion of Mitochondria in a Nerve Crush Injury Model.

Neurosurgery 2021 Apr 16. Epub 2021 Apr 16.

Institute of Biomedical Sciences, National Chung-Hsing University, Taichung, Taiwan.

Background: Peripheral nerve injuries result in muscle denervation and apoptosis of the involved muscle, which subsequently reduces mitochondrial content and causes muscle atrophy. The local injection of mitochondria has been suggested as a useful tool for restoring the function of injured nerves or the brain.

Objective: To determine outcomes following the administration of isolated mitochondria into denervated muscle after nerve injury that have not been investigated. Read More

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Factors behind why nursing students do not recognize patient needs occurring while confirming intravenous infusion even when they observe them: A comparative descriptive design study.

Nurse Educ Today 2021 Apr 8;101:104886. Epub 2021 Apr 8.

Aomori University of Health and Welfare Graduate School of Health Sciences, Japan. Electronic address:

Background: Novice nurses are often unable to watch their surroundings closely when concentrating on their work or recognize them even when observing them closely. However, factors behind this have not been previously explored.

Objectives: The purpose of this study was to clarify why nursing students did not recognize the patient's needs while checking an infusion. Read More

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An assessment of the potency related to Cannabis-based products in the South African market.

Forensic Sci Int 2021 Mar 17;322:110754. Epub 2021 Mar 17.

North West University, Potchefstroom Campus, 11 Hoffman Street, Potchefstroom, South Africa; South African Medical Research Council, Francie Van Zyl Rd, Parow, Cape Town.

It was the aim of this study to analyse a portion of the South African cannabis-based products market and provide a detailed overview of their THC and CBD profiles. To date, no data of this kind exists in South Africa. Samples were submitted to a contract laboratory. Read More

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Finding alternative sites for intraosseous infusions in newborns.

Resuscitation 2021 Apr 13. Epub 2021 Apr 13.

Department of Radiology, University of Cologne, Kerpener Str.62, 50937 Cologne, Germany.

Aim: Intraosseous (IO)-access plays an alternative route during resuscitation. Our study in preterm and term stillborns was performed to find alternative IO puncture sites beside the recommended proximal tibia.

Methods: The cadavers used were legal donations. Read More

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Neoadjuvant chemotherapy with FOLFIRINOX and preoperative chemoradiotherapy for patients with locally advanced rectal cancer (UNICANCER-PRODIGE 23): a multicentre, randomised, open-label, phase 3 trial.

Lancet Oncol 2021 Apr 13. Epub 2021 Apr 13.

Hôpital Nord Franche-Comté, Montbéliard, France; University Hospital of Besançon, Besançon, France.

Background: Treatment of locally advanced rectal cancer with chemoradiotherapy, surgery, and adjuvant chemotherapy controls local disease, but distant metastases remain common. We aimed to assess whether administering neoadjuvant chemotherapy before preoperative chemoradiotherapy could reduce the risk of distant recurrences.

Methods: We did a phase 3, open-label, multicentre, randomised trial at 35 hospitals in France. Read More

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Peripheral Administration of a Cell-Penetrating MOTS-c Analogue Enhances Memory and Attenuates Aβ- or LPS-Induced Memory Impairment through Inhibiting Neuroinflammation.

ACS Chem Neurosci 2021 Apr 16. Epub 2021 Apr 16.

Institute of Biochemistry and Molecular Biology, School of Life Sciences, Lanzhou University, 222 Tianshui South Road, Lanzhou, Gansu 730000, China.

MOTS-c is a 16-amino acid mitochondrial derivative peptide reported to be involved in regulating insulin and metabolic homeostasis via the AMP activated protein kinase (AMPK). AMPK agonist AICAR has been reported to improve cognition. Previous reports also pointed out that MOTS-c may be effective as a therapeutic option toward the prevention of the aging processes. Read More

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Casimersen: First Approval.

Matt Shirley

Drugs 2021 Apr 16. Epub 2021 Apr 16.

Springer Nature, Mairangi Bay, Private Bag 65901, Auckland, 0754, New Zealand.

Casimersen (Amondys 45™) is an antisense oligonucleotide of the phosphorodiamidate morpholino oligomer subclass developed by Sarepta Therapeutics for the treatment of Duchenne muscular dystrophy (DMD) in patients who have a mutation in the DMD gene that is amenable to exon 45 skipping. Administered by intravenous infusion, casimersen is designed to bind to exon 45 of the DMD gene pre-mRNA, resulting in skipping of this exon during mRNA processing, intended to allow for production of an internally truncated but functional dystrophin protein in patients with DMD. Casimersen received its first approval on 25 February 2021, in the USA, for the treatment of DMD in patients who have a confirmed mutation of the DMD gene that is amenable to exon 45 skipping. Read More

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Serum microRNA-30d is a sensitive biomarker for angiotensin II-induced cardiovascular complications in rats.

Heart Vessels 2021 Apr 16. Epub 2021 Apr 16.

Department of Pathophysiology, Oita University School of Medicine, Yufu, Oita, 879-5593, Japan.

We tested the hypothesis that angiotensin II (Ang II)-induced cardiovascular complications are distinguished from what catecholamine-induced by their serum circulating biomarkers in rats. Infusion of Ang II (1.68 mg/kg/day) significantly increased systolic and diastolic blood pressure assessed at week one or later, accompanied by an increase of heart/body weight ratio. Read More

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Benefits of immunoglobulin substitution in primary and secondary immunodeficiencies: Interim analysis of a prospective, long-term non-interventional study.

Int J Clin Pharmacol Ther 2021 Apr 16. Epub 2021 Apr 16.

Objective: To assess the safety, tolerability, and effectiveness of the intravenous immunoglobulin (IVIG) Intratect 100 g/L in a prospective, large-scale non-interventional study (NIS) of patients with a wide range of antibody deficiencies as well as other indications for IVIG, risk factors, and frequency of pre-treatments.

Materials And Methods: Patients were enrolled at 53 practices and clinics in Germany. After recording of baseline information, each patient was treated according to need, as judged by the physician and guided by the SmPC. Read More

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Isotope tracing reveals glycolysis and oxidative metabolism in childhood tumors of multiple histologies.

Med (N Y) 2021 Apr 23;2(4):395-410. Epub 2021 Feb 23.

Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.

Background: Survival among children with high-risk solid tumors remains poor. Reprogrammed metabolism promotes tumor growth and may contain therapeutic liabilities. Tumor metabolism has been assessed in adults using intra-operative C-glucose infusions. Read More

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Septic Shock Due to Capnocytophaga canimorsus Infection in a Splenectomized Patient.

Cureus 2021 Mar 10;13(3):e13815. Epub 2021 Mar 10.

Internal Medicine Department, Centro Hospitalar de Vila Nova de Gaia/Espinho, Vila Nova de Gaia, PRT.

is a gram-negative rod that is part of the commensal flora of dogs' mouths. Among splenectomized patients who maintain close contact with dogs, the bacteria can lead to infection and fulminant sepsis even without evidence of a skin breach. In this report, we describe the case of a 71-year-old woman who had undergone splenectomy 35 years ago. Read More

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A novel small-molecule PROTAC selectively promotes tau clearance to improve cognitive functions in Alzheimer-like models.

Theranostics 2021 11;11(11):5279-5295. Epub 2021 Mar 11.

Department of Pathophysiology, School of Basic Medicine, Key Laboratory of Education Ministry of China/Hubei Province for Neurological Disorders, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.

Intracellular accumulation of tau is a hallmark pathology in Alzheimer disease (AD) and the related tauopathies, thus targeting tau could be promising for drug development. Proteolysis Targeting Chimera (PROTAC) is a novel drug discovery strategy for selective protein degradation from within cells. A novel small-molecule PROTAC, named as C004019 with a molecular mass of 1,035. Read More

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A Phase II Trial of Melphalan Based Reduced-Intensity Conditioning for Transplantation of T-Replete HLA-Haploidentical Peripheral Blood Stem Cells with Posttransplant Cyclophosphamide in Patients with Hematologic Malignancies.

Adv Hematol 2021 23;2021:8868142. Epub 2021 Mar 23.

Blood and Marrow Transplant Program at Northside Hospital, Atlanta, GA, USA.

T-replete haploidentical donor transplants using posttransplant cyclophosphamide (haplo) have greatly expanded donor availability and are increasingly utilized. Haplo were originally performed using truly nonmyeloablative conditioning and a bone marrow graft. We have also developed myeloablative conditioning and peripheral blood stem cell (PBSC) grafts for use with haplo. Read More

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Acute Effects of Ketamine Infusion on Postoperative Mood Scores in Patients Undergoing Dilation and Curettage: A Randomized Double-Blind Controlled Study.

Anesthesiol Res Pract 2021 23;2021:6674658. Epub 2021 Mar 23.

Department of Anesthesia, Intensive Care and Pain Management, Ain Shams University, Cairo, Egypt.

Background: Emotional and psychological effects following abortion are more common than physical side effects and can range from mild regret to more serious complications such as depression. In the last decade, it has been suggested that low dose of ketamine is a fast-acting antidepressant.

Purpose: The aim of this study was to investigate the impact of intraoperative ketamine infusion on postoperative mood score in patients undergoing Dilation and Curettage (D&C) under spinal anesthesia. Read More

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Clinical Outcome and Cost-Effectiveness Analysis of CSII Versus MDI in Children and Adolescent With Type 1 Diabetes Mellitus in a Public Health Care System of China.

Front Endocrinol (Lausanne) 2021 30;12:604028. Epub 2021 Mar 30.

Paediatric Endocrinology and Metabolism Department, Qingdao Women and Children's Hospital, Qingdao, China.

Objectives: To evaluate the clinical and economic consequences of continuous subcutaneous insulin infusion (CSII) vs. multiple daily injections (MDI) in children and adolescents with type 1 diabetes mellitus (T1DM) from a public health care system in developed areas of developing country, considering changes in glycemic Control, daily insulin requirements, lipid profile, body mass index (BMI), frequency of severe hypoglycemia and Diabetic Ketoacidosis (DKA) and diabetic complications.

Methods: This was a retrospective cohort study of children and adolescents with T1DM. Read More

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Pinocembrin attenuates hemorrhagic transformation after delayed t-PA treatment in thromboembolic stroke rats by regulating endogenous metabolites.

Acta Pharmacol Sin 2021 Apr 15. Epub 2021 Apr 15.

Beijing Key Laboratory of Drug Targets Identification and Drug Screening, Centre for Pharmaceutical Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China.

Hemorrhagic transformation (HT) is a common serious complication of stroke after thrombolysis treatment, which limits the clinical use of tissue plasminogen activator (t-PA). Since early diagnosis and treatment for HT is important to improve the prognosis of stroke patients, it is urgent to discover the potential biomarkers and therapeutic drugs. Recent evidence shows that pinocembrin, a natural flavonoid compound, exerts anti-cerebral ischemia effect and expands the time window of t-PA. Read More

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The impact of immune checkpoint therapy on the latent reservoir in HIV infected individuals with cancer on antiretroviral therapy.

AIDS 2021 Apr 15. Epub 2021 Apr 15.

Department of Infectious Diseases, Alfred Hospital and Monash University, Melbourne, Australia The Peter Doherty Institute for Infection and Immunity, The University of Melbourne and Royal Melbourne Hospital, Melbourne, Australia The Westmead Institute for Medical Research, University of Sydney, Westmead, Australia Victorian Infectious Diseases Service, Royal Melbourne Hospital at the Peter Doherty Institute for Infection and Immunity.

Objective: To quantify HIV specific immunological and virological changes in people living with HIV (PLWH) on antiretroviral therapy (ART) with malignancy who received immune checkpoint blockade (ICB).

Design: Observational cohort study.

Methods: Blood samples were collected before and after four cycles of ICB in HIV positive adults on ART. Read More

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Successful multidisciplinary treatment of Doege-Potter syndrome: hypoglycaemia caused by paraneoplastic IGF-2 production by a metastatic haemangiopericytoma.

BMJ Case Rep 2021 Apr 15;14(4). Epub 2021 Apr 15.

Department of Medicine, The University of British Columbia Faculty of Medicine, New Westminster, British Columbia, Canada.

Hypoglycaemia due to insulin-like growth factor (IGF)-2 secretion is a paraneoplastic complication of malignancy with significant morbidity that can often go unrecognised due to its uncommon presentation. We report on a case of a 51-year-old man with metastatic haemangiopericytoma presenting with refractory hypoglycaemia, requiring continuous dextrose 10% infusion while in hospital. IGF-2 levels were significantly elevated, in keeping with a rare entity associated with solitary fibrous tumours, known as Doege-Potter syndrome. Read More

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Incompatibility of remimazolam besylate with Ringer's acetate infusion resulting in total occlusion of an intravenous catheter.

BMJ Case Rep 2021 Apr 15;14(4). Epub 2021 Apr 15.

Anesthesiology, University of Toyama Faculty of Medicine Graduate School of Medicine and Pharmaceutical Science for Education, Toyama, Japan.

Remimazolam besylate is an ultra-short-acting benzodiazepine derivative recently approved in Japan for general anaesthesia. However, less attention has been paid to the compatibility of remimazolam with infusion solutions, and the mechanism underlying the incompatibility remains unknown. The patient was a 65-year-old man who underwent a high tibial osteotomy. Read More

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Mortality benefit of crystalloids administered in 1-6 hours in septic adults in the ED systematic review with narrative synthesis.

Emerg Med J 2021 Apr 15. Epub 2021 Apr 15.

Department of Emergency Medicine, University of Pecs, Pécs, Baranya, Hungary.

Background: Based on the 2018 update of the Surviving Sepsis Campaign, the Committee for Quality Improvement of the NHSs of England recommended the instigation of the elements of the 'Sepsis-6 bundle' within 1 hour to adult patients screened positive for sepsis. This bundle includes a bolus infusion of 30 mL/kg crystalloids in the ED. Besides the UK, both in the USA and Australia, compliance with similar 1-hour targets became an important quality indicator. Read More

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Randomized Trial of Interleukin-6 Receptor Inhibition in Patients With Acute ST-Segment Elevation Myocardial Infarction.

J Am Coll Cardiol 2021 Apr;77(15):1845-1855

Department of Cardiology, Oslo University Hospital Rikshospitalet, Oslo, Norway; K. G. Jebsen Cardiac Research Centre and Centre for Heart Failure Research, University of Oslo, Oslo, Norway; Faculty of Medicine, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.

Background: Prompt myocardial revascularization with percutaneous coronary intervention (PCI) reduces infarct size and improves outcomes in patients with ST-segment elevation myocardial infarction (STEMI). However, as much as 50% of the loss of viable myocardium may be attributed to the reperfusion injury and the associated inflammatory response.

Objectives: This study sought to evaluate the effect of the interleukin-6 receptor inhibitor tocilizumab on myocardial salvage in acute STEMI. Read More

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Cold agglutinin-induced hemolytic anemia during room temperature fluid resuscitation: a case report.

J Med Case Rep 2021 Apr 16;15(1):169. Epub 2021 Apr 16.

Niigata City General Hospital Emergency & Critical Care Medicine, 463-7 Shumoku, Chuo-ku, Niigata, 950-1197, Japan.

Background: Cold agglutinin disease can cause the agglutination of red blood cells and hemolytic anemia due to cold temperature. Herein, we report a case of progressive hemolytic anemia due to cold agglutinin disease during fluid resuscitation and in the absence of exposure to cold.

Case Presentation: A 71-year-old Japanese man was admitted to the emergency department with signs of hypotension and disturbed consciousness. Read More

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Pressurized submucosal water infusion as a novel endoscopic principle to optimize defect margin assessment after cold snare mucosectomy.

V Zimmer

Clin Res Hepatol Gastroenterol 2021 Apr 12;45(4):101642. Epub 2021 Apr 12.

Department of Medicine, Marienhausklinik St. Josef Kohlhof, Neunkirchen, Germany; Department of Medicine II, Saarland University Medical Center, Saarland University Homburg, Germany. Electronic address:

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Propofol for Induction and Maintenance of Anesthesia in Patients With Brugada Syndrome: A Single-Center, 25-Year, Retrospective Cohort Analysis.

Anesth Analg 2021 Apr 15. Epub 2021 Apr 15.

From the Department of Anesthesiology and Perioperative Medicine.

Background: Propofol administration in patients with Brugada syndrome (BrS) is still a matter of debate. Despite lacking evidence for its feared arrhythmogenicity, up to date, expert cardiologists recommend avoiding propofol. The main aim of this study is to assess the occurrence of malignant arrhythmias or defibrillations in patients with BrS, during and 30 days after propofol administration. Read More

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