PLoS One 2013 8;8(11):e80606. Epub 2013 Nov 8.
Department of Neuroscience, University of Florida, Gainesville, Florida, United States of America ; Wilder Center of Excellence for Epilepsy Research, University of Florida, Gainesville, Florida, United States of America ; Department of Pediatrics, Division of Pediatric Neurology, University of Florida, Gainesville, Florida, United States of America.
Local drug delivery techniques, such as convention-enhanced delivery (CED), are promising novel strategies for delivering therapeutic agents otherwise limited by systemic toxicity and blood-brain-barrier restrictions. CED uses positive pressure to deliver infusate homogeneously into interstitial space, but its distribution is dependent upon appropriate tissue targeting and underlying neuroarchitecture. To investigate effects of local tissue pathology and associated edema on infusate distribution, CED was applied to the hippocampi of rats that underwent electrically-induced, self-sustaining status epilepticus (SE), a prolonged seizure. Read More