664 results match your criteria infrapatellar fat

Mass Spectrometry-based Biomarkers for Knee Osteoarthritis: A Systematic Review.

Expert Rev Proteomics 2021 Jul 6. Epub 2021 Jul 6.

Maastricht MultiModal Molecular Imaging Institute (M4i), Division of Imaging Mass Spectrometry, Maastricht University Universiteitssingel 50, 6229 ER Maastricht, The Netherlands.

: Knee osteoarthritis (OA) is a joint disease, affecting multiple tissues in the joint. Early detection and intervention may delay OA development and avoid total knee arthroplasty. Specific biomarker profiles for early detection and guiding clinical decision-making of OA have not yet been identified. Read More

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Shape-Defined microPlates for the Sustained Intra-articular Release of Dexamethasone in the Management of Overload-Induced Osteoarthritis.

ACS Appl Mater Interfaces 2021 Jul 1;13(27):31379-31392. Epub 2021 Jul 1.

Laboratory of Nanotechnology for Precision Medicine, Istituto Italiano di Tecnologia, Via Morego 30, Genoa 16163, Italy.

Osteoarthritis (OA) is treated with the intra-articular injection of steroids such as dexamethasone (DEX) to provide short-term pain management. However, DEX treatment suffers from rapid joint clearance. Here, 20 × 10 μm, shape-defined poly(d,l-lactide-co-glycolide)acid microPlates (μPLs) are created and intra-articularly deposited for the sustained release of DEX. Read More

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Disseminated Coccidioidomycosis of the Knee Joint Requiring Synovectomy and Arthrotomy.

J Orthop Case Rep 2021 Feb;11(2):76-80

Department of Orthopaedic, Joe R. and Teresa Lozano Long School of Medicine, University of Texas Health at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229.

Introduction: Coccidioidomycosis is a fungal infection endemic to the Southwestern United States, Mexico, and South America. While uncommon, inhalation of spores or direct cutaneous contact can lead to disseminated infection in the immunocompetent, with the involvement of the musculoskeletal and integumentary systems.

Case Report: A 49-year-old patient with a history of pulmonary coccidioidomycosis presented with the right knee pain and multiple symptomatic abscesses beneath the suprapatellar and infrapatellar fat pads. Read More

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February 2021

Sulfated carboxymethylcellulose conjugated electrospun fibers as a growth factor presenting system for tissue engineering.

Carbohydr Polym 2021 Sep 27;268:118256. Epub 2021 May 27.

Department of Biological Sciences and Bioengineering, Indian Institute of Technology Kanpur, Kanpur, Uttar Pradesh 208016, India; Mehta Family Centre for Engineering in Medicine, Indian Institute of Technology Kanpur, Kanpur, Uttar Pradesh 208016, India. Electronic address:

Inspired by the natural electrostatic interaction of cationic growth factors with anionic sulfated glycosaminoglycans in the extracellular matrix, we developed electrospun poly(hydroxybutyrate)/gelatin (PG) fibers conjugated with anionic sulfated carboxymethylcellulose (sCMC) to enable growth factor immobilization via electrostatic interaction for tissue engineering. The fibrous scaffold bound cationic molecules, was cytocompatible and exhibited a remarkable morphological and functional stability. Transforming growth factor-β1 immobilized on the sCMC conjugated fibers was retained for at least 4 weeks with negligible release (3%). Read More

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September 2021

Measuring and Modeling Oxygen Transport and Consumption in 3D Hydrogels Containing Chondrocytes and Stem Cells of Different Tissue Origins.

Front Bioeng Biotechnol 2021 25;9:591126. Epub 2021 May 25.

Trinity Centre for Biomedical Engineering, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.

Understanding how the local cellular environment influences cell metabolism, phenotype and matrix synthesis is crucial to engineering functional tissue grafts of a clinically relevant scale. The objective of this study was to investigate how the local oxygen environment within engineered cartilaginous tissues is influenced by factors such as cell source, environmental oxygen tension and the cell seeding density. Furthermore, the subsequent impact of such factors on both the cellular oxygen consumption rate and cartilage matrix synthesis were also examined. Read More

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Infrapatellar Coronal Plane Plica in a 60-Year-Old: A Case Report.

JBJS Case Connect 2021 06 8;11(2). Epub 2021 Jun 8.

Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, India.

Case: We report a rare case of coronal plane infrapatellar plica, also called "Bib-like plica," in a 60-year-old patient. The start-up pain she experienced before arthroscopic excision completely resolved after the procedure. As far as we know, this is the first case of this plica in the literature in a 60-year-old patient who had associated articular cartilage loss over the medial femoral condyle adjacent to the plica, with positive magnetic resonance imaging findings outlining the structure, possibly impinging the infrapatellar fat pad. Read More

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Bone marrow derived mast cells injected into the osteoarthritic knee joints of mice induced by sodium monoiodoacetate enhanced spontaneous pain through activation of PAR2 and action of extracellular ATP.

PLoS One 2021 4;16(6):e0252590. Epub 2021 Jun 4.

Multidisciplinary Pain Center, Aichi Medical University, Nagakute, Aichi, Japan.

Conditions that resemble osteoarthritis (OA) were produced by injection of sodium monoiodoacetate (MIA) into the knee joints of mice. Bone marrow derived mast cells (BMMCs) injected into the OA knee joints enhanced spontaneous pain. Since no spontaneous pain was observed when BMMCs were injected into the knee joints of control mice that had not been treated with MIA, BMMCs should be activated within the OA knee joints and release some pain-inducible factors. Read More

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Treadmill running induces remodeling of the infrapatellar fat pad in an intensity-dependent manner.

J Orthop Surg Res 2021 Jun 1;16(1):354. Epub 2021 Jun 1.

Department of Rehabilitation Medicine, The First Affiliated Hospital of Fujian Medical University, Fuzhou, People's Republic of China.

Objective: To investigate the response of the infrapatellar fat pad (IFP) to running at different intensities and further explore the underlying mechanisms of these responses under different running-induced loadings.

Methods: Animals were randomly assigned into the sedentary (SED), low-intensity running (LIR), medium-intensity running (MIR), and high-intensity running (HIR) groups. The rats in the LIR, MIR, and HIR groups were subjected to an 8-week treadmill running protocol. Read More

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Age-Dependent Remodeling in Infrapatellar Fat Pad Adipocytes and Extracellular Matrix: A Comparative Study.

Front Med (Lausanne) 2021 10;8:661403. Epub 2021 May 10.

Department of Neuroscience, Institute of Human Anatomy, University of Padova, Padova, Italy.

The infrapatellar fat pad (IFP) is actively involved in knee osteoarthritis (OA). However, a proper description of which developmental modifications occur in the IFP along with age and in absence of joint pathological conditions, is required to adequately describe its actual contribution in OA pathophysiology. Here, two IFP sources were compared: (a) IFP from healthy young patients undergoing anterior-cruciate ligament (ACL) reconstruction for ACL rupture ( = 24); (b) IFP from elderly cadaver donors ( = 23). Read More

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The infrapatellar fat pad produces interleukin-6-secreting T cells in response to a proteoglycan aggrecan peptide and provides dominant soluble mediators different from that present in synovial fluid.

Int J Rheum Dis 2021 Jun 18;24(6):834-846. Epub 2021 May 18.

Immunology Division, Department of Microbiology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.

Objective: The purpose of this study was to investigate the effects of osteoarthritis (OA) peripheral blood mononuclear cell (PBMC) -stimulating proteoglycan aggrecan peptides on T cells present in infrapatellar fat pads (IPFPs) and synovial tissues, and to correlate these findings with mediators present in synovial fluid of OA patients.

Methods: We tested for interleukin-6 (IL-6) -producing T cells in IPFPs of patients with knee OA using ELISPOT. Cytokine and cytotoxic mediator production from OA PBMCs, IPFPs, synovial tissues, and synovial fluids in response to proteoglycan aggrecan peptides were quantified by cytometric bead array. Read More

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Hypoperfusion of the infrapatellar fat pad and its relationship to MRI T2* relaxation time changes in a 5/6 nephrectomy model.

Sci Rep 2021 May 11;11(1):9924. Epub 2021 May 11.

Department and Graduate Institute of Biology and Anatomy, National Defense Medical Center, No.161, Sec. 6, Minquan E. Rd., Neihu Dist., Taipei, 11490, Taiwan.

The purpose of present study was to longitudinally investigate the alterations in infrapatellar fat pad (IPFP) vascularity in 5/6 nephrectomized rats by using dynamic contrast enhanced (DCE) MRI and IPFP degeneration by using MRI T2* relaxation time. Twelve male Sprague-Dawley rats were assigned to a control group and a 5/6 nephrectomy CKD group. The right knees of all rats were longitudinally scanned by 4. Read More

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Correction to: Infrapatellar fat pad-derived mesenchymal stem cell-based spheroids enhance their therapeutic efficacy to reverse synovitis and fat pad fibrosis.

Stem Cell Res Ther 2021 May 11;12(1):282. Epub 2021 May 11.

Department of Orthopedics, UHealth Sports Medicine Institute, Miller School of Medicine, University of Miami, 1450 NW 10th Ave (3014), Miami, FL, 33136, USA.

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Comment on "Recent Advance in Source, Property, Differentiation, and Applications of Infrapatellar Fat Pad Adipose-Derived Stem Cells".

Stem Cells Int 2021 13;2021:9824616. Epub 2021 Apr 13.

Department of Neurosciences, Institute of Human Anatomy, University of Padova, Padova, Italy.

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Macroporous scaffold surface modified with biological macromolecules and piroxicam-loaded gelatin nanofibers toward meniscus cartilage repair.

Int J Biol Macromol 2021 Jul 29;183:1327-1345. Epub 2021 Apr 29.

Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies, Shahrekord University of Medical Sciences, Shahrekord, Iran; Cellular and Molecular Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran. Electronic address:

Meniscus cartilage has poor self-healing capacity in the inner zone and its damage leads to articular cartilage degeneration. Here we have developed hybrid constructs using polycaprolactone (PCL) and polyurethane (PU) surface modified by gelatin (G), chitosan (C), and hyaluronic acid (H) biomacromolecules and piroxicam-loaded gelatin nanofibers (PCL/PU/GCH/P). The surface of constructs was crosslinked using EDC and NHS. Read More

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Biofunctionalized Structure and Ingredient Mimicking Scaffolds Achieving Recruitment and Chondrogenesis for Staged Cartilage Regeneration.

Front Cell Dev Biol 2021 25;9:655440. Epub 2021 Mar 25.

Institute of Orthopedics, The First Medical Center, Chinese PLA General Hospital, Beijing Key Lab of Regenerative Medicine in Orthopedics, Key Laboratory of Musculoskeletal Trauma & War Injuries PLA, Beijing, China.

It remains scientifically challenging to regenerate injured cartilage in orthopedics. Recently, an endogenous cell recruitment strategy based on a combination of acellular scaffolds and chemoattractants to specifically and effectively recruit host cells and promote chondrogenic differentiation has brought new hope for articular cartilage regeneration. In this study, a transforming growth factor-β3 (TGF-β3)-loaded biomimetic natural scaffold based on demineralized cancellous bone (DCB) and acellular cartilage extracellular matrix (ECM) was developed and found to improve chondral repair by enhancing cell migration and chondrogenesis. Read More

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Effects of Diet Induced Weight Reduction on Cartilage Pathology and Inflammatory Mediators in the Joint Tissues.

Front Med (Lausanne) 2021 22;8:628843. Epub 2021 Mar 22.

School of Mechanical, Medical, and Process Engineering, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, QLD, Australia.

Obesogenic diets contribute to the pathology of osteoarthritis (OA) by altering systemic and local metabolic inflammation. Yet, it remains unclear how quickly and reproducibly the body responds to weight loss strategies and improve OA. In this study we tested whether switching obese diet to a normal chow diet can mitigate the detrimental effects of inflammatory pathways that contribute to OA pathology. Read More

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Total Infrapatellar Fat Pad Excision Leads to Worse Isokinetic Performance in Total Knee Arthroplasty: A Randomized Controlled Trial.

J Knee Surg 2021 Mar 31. Epub 2021 Mar 31.

Department of Orthopaedic and Traumatology, Aksaray University Education and Research Hospital, Aksaray, Turkey.

There are concerns that total infrapatellar fat pad (IPFP) excision in total knee arthroplasty (TKA) results in patellar tendon shortening due to ischemic contracture, but individual preference of the surgeon is still the main determinant between total or partial excision. The aim of this randomized controlled study was to compare isokinetic performance and clinical outcome of TKAs with total and partial excision of the IPFP. Seventy-two patients scheduled to undergo TKA for primary knee osteoarthritis by a single surgeon were randomly assigned to either total or partial excision group. Read More

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Changes in Infrapatellar Fat Pad Volume From 6 to 12 months Following Anterior Cruciate Ligament Reconstruction and Associations with Patient-Reported Knee Function.

J Athl Train 2021 Mar 31. Epub 2021 Mar 31.

b MOTION Science Institute, Department of Exercise and Sport Science, 209 Fetzer Hall, University of North Carolina at Chapel Hill, Chapel Hill 27599, NC, United States.

Context: Hypertrophy of the Infrapatellar Fat Pad (IFP) in idiopathic knee osteoarthritis has been linked to deleterious synovial changes and joint pain related to mechanical tissue impingement; yet, little is known regarding the IFP's volumetric changes following anterior cruciate ligament reconstruction (ACLR).

Objective: To examine changes in IFP volume between 6 and 12 months following ACLR and determine associations between patient-reported outcomes and IFP volume at each time point, as well as volume change over time. In a subset of individuals, we examined inter-limb IFP volume differences 12 months post-ACLR. Read More

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Hoffa's fat pad thickness: a measurement method with sagittal MRI sequences.

Radiol Med 2021 Jun 27;126(6):886-893. Epub 2021 Mar 27.

Department of Clinical and Experimental Medicine, School of Medicine, Foggia University, Viale L. Pinto, 1, 71121, Foggia, Italy.

Background: Hoffa's fat pad is a structure located within the fibrous joint capsule of the knee joint, but outside the synovial cavity. It plays an important biomechanical and metabolic role in knee joint, reducing the impact of forces generated by loading and producing cytokines. Changes in its size can induce modifications in the knee homeostasis. Read More

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Exosomes from Kartogenin-Pretreated Infrapatellar Fat Pad Mesenchymal Stem Cells Enhance Chondrocyte Anabolism and Articular Cartilage Regeneration.

Stem Cells Int 2021 9;2021:6624874. Epub 2021 Mar 9.

Department of Orthopedics, Shanghai Changzheng Hospital, Naval Medical University, Shanghai 200003, China.

Objective: To evaluate the effect of Kartogenin-pretreated exosomes derived from infrapatellar fat pad mesenchymal stem cells on chondrocyte in vitro and articular cartilage regeneration in vivo.

Methods: Infrapatellar fat pad mesenchymal stem cells (IPFP-MSCs) were isolated from rabbits to harvest exosomes. After identification of mesenchymal stem cells and exosomes, rabbit chondrocytes were divided into three groups for further treatment: the EXO group (chondrocytes treated with exosomes isolated from infrapatellar fat pad mesenchymal stem cells), KGN-EXO group (chondrocytes treated with exosomes isolated from infrapatellar fat pad mesenchymal stem cells pretreated with KGN), and control group. Read More

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Pore geometry influences growth and cell adhesion of infrapatellar mesenchymal stem cells in biofabricated 3D thermoplastic scaffolds useful for cartilage tissue engineering.

Mater Sci Eng C Mater Biol Appl 2021 Mar 3;122:111933. Epub 2021 Feb 3.

Instituto de Investigación Biosanitaria de Granada (ibs.GRANADA), University Hospitals of Granada-University of Granada, Granada, Spain; Biopathology and Regenerative Medicine Institute (IBIMER), Centre for Biomedical Research (CIBM), University of Granada, Granada, Spain; Department of Human Anatomy and Embryology, Faculty of Medicine, University of Granada, Granada, Spain; Excellence Research Unit "Modeling Nature" (MNat), University of Granada, Granada, Spain. Electronic address:

The most pressing need in cartilage tissue engineering (CTE) is the creation of a biomaterial capable to tailor the complex extracellular matrix of the tissue. Despite the standardized used of polycaprolactone (PCL) for osteochondral scaffolds, the pronounced stiffness mismatch between PCL scaffold and the tissue it replaces remarks the biomechanical incompatibility as main limitation. To overcome it, the present work was focused in the design and analysis of several geometries and pore sizes and how they affect cell adhesion and proliferation of infrapatellar fat pad-derived mesenchymal stem cells (IPFP-MSCs) loaded in biofabricated 3D thermoplastic scaffolds. Read More

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A task-relevant experimental pain model to target motor adaptation.

J Physiol 2021 05 25;599(9):2401-2417. Epub 2021 Mar 25.

School of Kinesiology, University of British Columbia, Vancouver, Canada.

Key Points: Motor adaptation is thought to be a strategy to avoid pain. Current experimental pain models do not allow for consistent modulation of pain perception depending on movement. We showed that low-frequency sinusoidal stimuli delivered at painful intensity result in minimal habituation of pain perception (over 60 s) and minimal stimulation artefacts on electromyographic signals. Read More

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Experimental Hand and Knee Pain Cause Differential Effects on Corticomotor Excitability.

J Pain 2021 Jul 3;22(7):789-796. Epub 2021 Feb 3.

Health and Rehabilitation Research Institute, Auckland University of Technology, Auckland, New Zealand.

Acute pain elicits a well-known inhibitory effect on upper limb corticomotor excitability, whereas the temporal effects of lower-limb experimental pain and pain in a remote limb are less clear. The aim of this study was to compare the temporal corticomotor excitability changes in the upper and lower limbs in response to acute upper and lower limb pain. In a cross-over design, 13 participants (age 29 ± 9 years; 12 male) attended 2 sessions where experimental pain was induced by injecting hypertonic saline into either the first dorsal interosseous (FDI) muscle or infrapatellar fat pad at the knee, inducing a short-lasting pain experience scored on a numerical rating scale (NRS). Read More

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Validation of the 1,4-butanediol thermoplastic polyurethane as a novel material for 3D bioprinting applications.

Bioeng Transl Med 2021 Jan 14;6(1):e10192. Epub 2020 Nov 14.

Biosanitary Research Institute of Granada (ibs.GRANADA) University Hospitals of Granada-University of Granada Granada Spain.

Tissue engineering (TE) seeks to fabricate implants that mimic the mechanical strength, structure, and composition of native tissues. Cartilage TE requires the development of functional personalized implants with cartilage-like mechanical properties capable of sustaining high load-bearing environments to integrate into the surrounding tissue of the cartilage defect. In this study, we evaluated the novel 1,4-butanediol thermoplastic polyurethane elastomer (b-TPUe) derivative filament as a 3D bioprinting material with application in cartilage TE. Read More

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January 2021

A New Procedure for Ultrasound-Guided Hydrorelease for the Scarring After Arthroscopic Knee Surgery.

Cureus 2020 Dec 31;12(12):e12405. Epub 2020 Dec 31.

Intelligent Orthopaedic System Development, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science, Okayama, JPN.

Postoperative scarring is one of the complications after arthroscopic knee surgery, which is usually treated with manual therapy or arthroscopic debridement. The incidence of symptomatic scarring requiring surgery within six months postoperatively has been reported to be approximately 0.06-6. Read More

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December 2020

Structural Consequences of a Partial Anterior Cruciate Ligament Injury on Remaining Joint Integrity: Evidence for Ligament and Bone Changes Over Time in an Ovine Model.

Am J Sports Med 2021 03 1;49(3):637-648. Epub 2021 Feb 1.

McCaig Institute for Bone and Joint Health, Cumming School of Medicine, University of Calgary, Calgary, Canada.

Background: Severe injury to the knee joint often results in accelerated posttraumatic osteoarthritis (PTOA). In an ovine knee injury model, altered kinematics and degradation of the cartilage have been observed at 20 and 40 weeks after partial anterior cruciate ligament (ACL) transection (p-ACL Tx) surgery. However, changes to the integrity of the remaining intact intra-articular ligaments (posterolateral [PL] band and posterior cruciate ligament [PCL]) as well as the subchondral bone after anteromedial (AM) band Tx remain to be characterized. Read More

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Paratenon of the cruciate ligaments of the knee: a macroscopic and histological study of human fetuses.

Folia Morphol (Warsz) 2021 Jan 29. Epub 2021 Jan 29.

Department of Anatomy, Tokyo Dental College, Tokyo, Japan.

Background: The paratenon is a sheath-like connective tissue that allows the tendon to move with minimal friction. The careful removal of the paratenon along the cruciate ligaments is a critical step of knee surgery. Thus, orthopedic surgeons and interventional radiologists consider the paratenon as a basic anatomical tissue along a ligament, not along a tendon. Read More

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January 2021

The clinical efficacy of arthroscopic therapy with knee infrapatellar fat pad cell concentrates in treating knee cartilage lesion: a prospective, randomized, and controlled study.

J Orthop Surg Res 2021 Jan 28;16(1):87. Epub 2021 Jan 28.

Department of Joint Surgery and Sports Medicine, Shanghai Changzheng Hospital, Naval Medical University, No.415 Fengyang Road, Shanghai, 200003, China.

Introduction: To evaluate the clinical efficacy of arthroscopic therapy with infrapatellar fat pad cell concentrates in treating knee cartilage lesions, we conducted a prospective randomized single-blind clinical study of controlled method.

Methods: Sixty cases from Shanghai Changzheng Hospital from April 2018 to December 2019 were chosen and randomly divided into 2 groups equally. Patients in the experiment group were treated through knee arthroscopy with knee infrapatellar fat pad cell concentrates containing mesenchymal stromal cells, while patients in the control group were treated through regular knee arthroscopic therapy. Read More

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January 2021

Hypoxic Preconditioning Induces Neuronal Differentiation of Infrapatellar Fat Pad Stem Cells through Epigenetic Alteration.

ACS Chem Neurosci 2021 02 29;12(4):704-718. Epub 2021 Jan 29.

Department of Biomedical Science, Bharathidasan University, Tiruchirappalli 620024, India.

Hypoxia is considered a key factor in cellular differentiation and proliferation, particularly during embryonic development; the process of early neurogenesis also occurs under hypoxic conditions. Apart from these developmental processes, hypoxia preconditioning or mild hypoxic sensitization develops resistance against ischemic stroke in deteriorating tissues. We therefore hypothesized that neurons resulting from hypoxia-regulated neuronal differentiation could be the best choice for treating brain ischemia, which contributes to neurodegeneration. Read More

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February 2021