35,994 results match your criteria influenza vaccine

The influenza vaccine for nursing and care professionals at emergency services in Flanders.

Hum Vaccin Immunother 2021 Apr 12:1-4. Epub 2021 Apr 12.

University of Antwerp, Faculty of Medicine and Health Sciences, Master of Nursing and Midwifery, Campus Drie Eiken, Wilrijk, Belgium.

: The Belgian Superior Health Council recommends seasonal influenza vaccination for people working in the health care sector in order to reduce the risk of the influenza virus being transmitted to people at risk. The aim of this study is to provide more insight into the current vaccination rate in nurses and health care professionals in emergency services in Flanders. In addition, the influence of influenza vaccination on absenteeism will be investigated, as well as the motivation to get vaccinated or not. Read More

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Human CD8 T stem cell memory subsets phenotypic and functional characterisation are defined by expression of CD122 or CXCR3.

Eur J Immunol 2021 Apr 12. Epub 2021 Apr 12.

Viral Immunology Systems Program (VISP), The Kirby Institute, University of New South Wales, Sydney, 2052, Australia.

Long-lived T memory stem cells (T ) are key to both naturally-occurring, and vaccine-conferred protection against infection. These cells are characterised by the CD45RA CCR7 CD95 phenotype. Significant heterogeneity within the T population is recognised, but distinguishing surface markers and functional characterisation of potential subsets are lacking. Read More

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Characterization of HIV-1 virus-like particles and determination of Gag stoichiometry for different production platforms.

Biotechnol Bioeng 2021 Apr 12. Epub 2021 Apr 12.

Grup d'Enginyeria Cel·lular i Bioprocessos, Escola d'Enginyeria, Universitat Autònoma de Barcelona, Campus de Bellaterra, Cerdanyola del Vallès, 08193, Barcelona, Spain.

The importance of developing new vaccine technologies towards versatile platforms that can cope with global virus outbreaks has been evidenced with the most recent SARS-CoV-2 pandemic. Virus-like particles (VLPs) are a highly immunogenic, safe and robust approach that can be used to base several vaccine candidates on. Particularly, HIV-1 Gag VLPs are a flexible system comprising a Gag core surrounded by a lipid bilayer that can be modified to present diverse types of membrane proteins or antigens against several diseases, like Influenza, dengue, west Nile virus or HPV, where it has been proven successful. Read More

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Differences in Administration of Influenza Vaccine to Elderly Adults by Physician Sex, 2006-2016.

Dan P Ly

JAMA Intern Med 2021 Apr 12. Epub 2021 Apr 12.

Division of General Internal Medicine and Health Services Research, David Geffen School of Medicine at University of California Los Angeles.

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Analysis of Epidemiological and Clinical Characteristics of COVID-19 in Northwest Mexico and the Relationship Between the Influenza Vaccine and the Survival of Infected Patients.

Front Public Health 2021 25;9:570098. Epub 2021 Mar 25.

Centro de Investigación Aplicada a la Salud Pública (CIASaP), School of Medicine, Autonomous University of Sinaloa, Culiacan, Mexico.

The first cases of unexplained pneumonia were reported in Wuhan, China, in December of 2019. Later, a novel coronavirus (SARS-CoV-2) was identified as the causal agent of pneumonia. This virus has since spread to more than 180 countries and has been declared a pandemic by the World Health Organization. Read More

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Preclinical development of a molecular clamp-stabilised subunit vaccine for severe acute respiratory syndrome coronavirus 2.

Clin Transl Immunology 2021 5;10(4):e1269. Epub 2021 Apr 5.

School of Chemistry and Molecular Biosciences The University of Queensland St Lucia QLD Australia.

Objectives: Efforts to develop and deploy effective vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continue at pace. Here, we describe rational antigen design through to manufacturability and vaccine efficacy of a prefusion-stabilised spike (S) protein, Sclamp, in combination with the licensed adjuvant MF59 'MF59C.1' (Seqirus, Parkville, Australia). Read More

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A molecular survey of canine respiratory viruses in New Zealand.

N Z Vet J 2021 Apr 12:1-29. Epub 2021 Apr 12.

School of Veterinary Science, Massey University, Palmerston North New Zealand.

Aims: The aim of this study was to identify viruses associated with canine infectious respiratory disease syndrome (CIRDS) among a population of New Zealand dogs.

Methods: : Convenience samples of oropharyngeal swabs were collected from 116 dogs, including 56 CIRDS-affected and 60 healthy dogs from various locations in New Zealand between March 2014 and February 2016. Pooled samples from CIRDS-affected (n=50) and from healthy (n=50) dogs were tested for the presence of canine respiratory viruses using next generation sequencing (NGS). Read More

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Decomposing Racial and Ethnic Disparities in Nursing Home Influenza Vaccination.

J Am Med Dir Assoc 2021 Apr 7. Epub 2021 Apr 7.

Department of Health Services, Policy, and Practice, Brown University School of Public Health, Providence, RI, USA; Center for Gerontology and Healthcare Research, Brown University School of Public Health, Providence, RI, USA; Department of Epidemiology, Brown University School of Public Health, Providence, RI, USA; Center of Innovation in Long-Term Services and Supports, Providence Veterans Affairs Medical Center, Providence, RI, USA.

Objectives: Quantify how observable characteristics contribute to influenza vaccination disparities among White, Black, and Hispanic nursing home (NH) residents.

Design: Retrospective cohort.

Setting And Participants: Short- and long-stay U. Read More

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Value of influenza vaccines in cancer patients during the coronavirus (COVID-19) pandemic: a cross-sectional study.

Support Care Cancer 2021 Apr 10. Epub 2021 Apr 10.

Department of Biostatics and Epidemiology, Shahid Sadoughi University of Medical Science, Yazd, Iran.

Background: According to the recommendation of the Centers for Disease Control and Prevention (CDC), getting influenza vaccines during the coronavirus (COVID-19) pandemics is especially important for people with certain underlying medical conditions, like cancer. Due to the similarities between the symptoms of influenza and COVID-19, receiving the flu vaccine in suspicious cases can be helpful because it will make it easier to request a medical test and diagnosis. In this study, the value of influenza vaccination in the cancer population was investigated. Read More

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One "misunderstood" health issue: demonstrating and communicating the safety of influenza a vaccination in pregnancy: a systematic review and meta-analysis.

BMC Public Health 2021 Apr 9;21(1):703. Epub 2021 Apr 9.

Department of Broadcasting and Television, School of Journalism and Information Communication, Huazhong University of Science and Technology, Wuhan, 430000, People's Republic of China.

Background: The American College of Obstetricians and Gynecologists (ACOG) makes certain recommendations including the annual influenza vaccination of pregnant and pre-pregnant women during influenza (flu) season with an inactivated influenza vaccine as soon as it becomes available. The Centers for Disease Control and Prevention's (CDC) Advisory Committee on Immunization Practices in association with ACOG state that the vaccine is safe to be given any trimester during pregnancy. However, due to a lack of communication, the public is unaware of the effects of influenza A vaccination in pregnancy. Read More

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Effects of weather-related social distancing on city-scale transmission of respiratory viruses: a retrospective cohort study.

BMC Infect Dis 2021 Apr 9;21(1):335. Epub 2021 Apr 9.

Institute for Disease Modeling, Bellevue, WA, USA.

Background: Unusually high snowfall in western Washington State in February 2019 led to widespread school and workplace closures. We assessed the impact of social distancing caused by this extreme weather event on the transmission of respiratory viruses.

Methods: Residual specimens from patients evaluated for acute respiratory illness at hospitals in the Seattle metropolitan area were screened for a panel of respiratory viruses. Read More

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Highly Pathogenic Avian Influenza A(H5N8) Virus in Swans, China, 2020.

Emerg Infect Dis 2021 Apr 9;27(6). Epub 2021 Apr 9.

In October 2020, highly pathogenic avian influenza A(H5N8) viruses were detected in 2 dead swans in Inner Mongolia, China. Genetic analysis showed that the H5N8 isolates belong to clade 2.3. Read More

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Performance of International AIDS Vaccine Initiative African clinical research laboratories in standardised ELISpot and peripheral blood mononuclear cell processing in support of HIV vaccine clinical trials.

Afr J Lab Med 2021 17;10(1):1056. Epub 2021 Feb 17.

International AIDS Vaccine Initiative (IAVI), Human Immunology Laboratory, Imperial College, London, United Kingdom.

Background: Standardisation of procedures for performing cellular functional assays across laboratories participating in multicentre clinical trials is key for generating comparable and reliable data.

Objective: This article describes the performance of accredited laboratories in Africa and Europe on testing done in support of clinical trials.

Methods: For enzyme-linked immunospot assay (ELISpot) proficiency, characterised peripheral blood mononuclear cells (PBMCs) obtained from 48 HIV-negative blood donors in Johannesburg, South Africa, were sent to participating laboratories between February 2010 and February 2014. Read More

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February 2021

Are patients with rheumatic diseases on immunosuppressive therapies protected against preventable infections? A cross-sectional cohort study.

RMD Open 2021 Apr;7(1)

Rheumatology, Rheumazentrum Ruhrgebiet, Herne, Germany.

Objective: To evaluate the prevalence of infections, prevalence of hospitalisation due to infections, the vaccination status and perceived screening of infections prior to the start of biologic disease modifying antirheumatic drugs (bDMARDs) of a patient cohort with chronic inflammatory rheumatic diseases (CIRD).

Methods: Consecutive CIRD patients reporting to our specialised centre were prospectively included (n=975) in this cross-sectional study. Data on comorbidities including infections, treatment, vaccination status, screening for latent tuberculosis infection (LTBI) and hepatitis B (HepB) were collected. Read More

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The impact of influenza vaccination on cardiovascular disease.

Med Clin (Barc) 2021 Apr 5. Epub 2021 Apr 5.

Servicio de Microbiología, Hospital Universitario Río Hortega, Valladolid, España.

Influenza infection has been identified as a triggering or exacerbating factor for cardiovascular events. To analyse the effect of influenza vaccination on cardiovascular disease, a systematic search of studies published between 2009-2019 was conducted. All the studies that evaluated the effect of vaccination against influenza on cardiovascular events and their outcome were considered. Read More

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Efficacy and safety of influenza vaccination during pregnancy: realizing the potential of maternal influenza immunization.

Expert Rev Vaccines 2021 Apr 8. Epub 2021 Apr 8.

Department of Pediatrics, Section of Infectious Diseases, Baylor College of Medicine, Houston TX.

Introduction: Pregnant women are at higher risk of severe complications following influenza infection compared to the general population. Influenza vaccination during pregnancy can offer direct protection to pregnant women and passive immunity to infants up to six months of age via maternal antibodies. Pregnant women are a high priority group for influenza immunization. Read More

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Annual influenza vaccination effect on the susceptibility to COVID-19 infection.

Cent Eur J Public Health 2021 Mar;29(1):14-17

Infectious Diseases Department, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey.

Objectives: We aimed to study the effect of seasonal influenza (flu) vaccination on the susceptibility to coronavirus disease 2019 (COVID-19).

Methods: A total of 203 healthcare workers of a pandemic centre of Istanbul, Turkey, were included in this retrospective study. According to the presence or absence of flu vaccination, participants were divided into group 1 and group 2. Read More

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The Causal Interpretation of "Overall Vaccine Effectiveness" in Test-Negative Studies.

Am J Epidemiol 2021 Apr 8. Epub 2021 Apr 8.

Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China.

Test-negative studies are commonly used to estimate influenza vaccine effectiveness (VE). In a typical study, an "overall VE" estimate may be reported based on data from the entire sample. However, there may be heterogeneity in VE, particularly by age. Read More

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Investigating the procurement system for understanding seasonal influenza vaccine brand availability in Europe.

PLoS One 2021 8;16(4):e0248943. Epub 2021 Apr 8.

Seqirus, Amsterdam, The Netherlands.

Background: Timely knowledge of which influenza vaccine brands are procured and where is of interest to inform site-selection for brand-specific influenza vaccine effectiveness (VE) studies. Vaccine procurement is a key determinant of brand availability. We therefore sought to understand how the procurement for seasonal influenza vaccine in Europe is organized, how this drives brand availability and how procurement data could enable to determine brand availability pre-season. Read More

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Better, Faster, Stronger: mRNA Vaccines Show Promise for Influenza Vaccination in Older Adults.

Immunol Invest 2021 Apr 8:1-11. Epub 2021 Apr 8.

Center on Aging and Department of Immunology, University of Connecticut School of Medicine, Farmington, Connecticut, USA.

Older adults have diminished immune responses that lead to increased susceptibility and severity of infectious diseases. Influenza is a leading killer of older adults despite the availability of seasonal influenza vaccination. Influenza vaccines are strain specific, and their efficacy varies greatly year to year based on how well the vaccine virus matches the circulating strains. Read More

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Influenza A virus infection-induced macroautophagy facilitates MHC class II-restricted endogenous presentation of an immunodominant viral epitope.

FEBS J 2020 Dec 5. Epub 2020 Dec 5.

Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Bundoora, Vic., Australia.

CD4 T cells recognize peptides presented by major histocompatibility complex class II molecules (MHC-II). These peptides are generally derived from exogenous antigens. Macroautophagy has been reported to promote endogenous antigen presentation in viral infections. Read More

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December 2020

SARS-CoV-2 show no infectivity at later stages in a prolonged COVID-19 patient despite positivity in RNA testing.

J Med Virol 2021 Apr 8. Epub 2021 Apr 8.

Department of Pathology, University of Missouri, Columbia, Missouri, USA.

Inpatient COVID-19 cases present enormous costs to patients and health systems in the United States. Many hospitalized patients may continue testing COVID-19 positive even after resolution of symptoms. Thus, a pressing concern for clinicians is the safety of discharging these asymptomatic patients if they have any remaining infectivity. Read More

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Relationship Between Influenza, Temperature, and Type 1 Myocardial Infarction: An Ecological Time-Series Study.

J Am Heart Assoc 2021 Apr 8:e019608. Epub 2021 Apr 8.

Clinical Pharmacology Unit Hospital Universitario Príncipe de Asturias Alcalá de Henares Madrid Spain.

Background Previous studies investigating the relationship of influenza with acute myocardial infarction (AMI) have not distinguished between AMI types 1 and 2. Influenza and cold temperature can explain the increased incidence of AMI during winter but, because they are closely related in temperate regions, their relative contribution is unknown. Methods and Results The temporal relationship between incidence rates of AMI with demonstrated culprit plaque (type 1 AMI) from the regional primary angioplasty network and influenza, adjusted for ambient temperature, was studied in Madrid region (Spain) during 5 influenza seasons (from June 2013 to June 2018). Read More

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The moderating effect of autonomy on promotional health messages encouraging healthcare professionals' to get the influenza vaccine.

J Exp Psychol Appl 2021 Apr 8. Epub 2021 Apr 8.

Department of Management.

Rates of flu vaccination among healthcare professionals often remain lower than recommended guidelines. We tested whether autonomy-supportive communication styles could improve the effectiveness of statements seeking to promote professionals' flu vaccination uptake. A pilot study established that statements presented in an autonomy-supportive communication style (i. Read More

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SARS-CoV-2 infection and H1N1 vaccination: does a relationship between the two factors really exist? A retrospective analysis of a territorial cohort in Ferrara, Italy.

Eur Rev Med Pharmacol Sci 2021 Mar;25(6):2795-2801

Department of Translational Medicine, University of Ferrara, Ferrara, Italy.

Objective: SARS-CoV-2 has been compared with other strains of coronaviruses, SARS-CoV and MERS-CoV, and with the flu viruses: all of them manifest themselves with respiratory symptoms and, although their genetic patterns are similar, the spread of SARS-CoV-2 infection has quickly reached global dimensions, demonstrating that SARS-CoV-2 is a virus with greater spreading capacity, albeit less lethal. Compared with influenza viruses, coronaviruses have a longer incubation period and the patients with coronaviruses' syndromes develop more severe diseases requiring frequent hospitalizations and intensive care admissions. The aim was to explore the relationships between seasonal influenza vaccination and coronavirus infection and to understand whether this hypothetic role by the flu vaccines modifies SARS-CoV-2 infection's outcomes. Read More

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Attitudes towards COVID-19 vaccination, vaccine hesitancy and intention to take the vaccine.

Pharm Pract (Granada) 2021 Jan-Mar;19(1):2317. Epub 2021 Mar 22.

BSc.,MSc, PhD. Professor. Department of Mathematics, Faculty of Science, University of Malta. Msida (Malta).

Background: The pandemic is at a paradoxical stage, with vaccine roll out initiated but a significantly elevated level of infection and death. Hope for recovery lies in high equitable vaccine uptake.

Objective: The study aimed to: i) explore attitudes and factors influencing attitudes, towards the COVID-19 vaccine amongst people living in Malta, ii) identify the reasons as to why individuals are unsure or unwilling to take the vaccine. Read More

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Transmission and protection against re-infection in the ferret model with the SARS-CoV-2 USA-WA1/2020 reference isolate.

J Virol 2021 Apr 7. Epub 2021 Apr 7.

Department of Veterinary and Biomedical Science, The Pennsylvania State University, University Park, Pennsylvania, USA.

SARS-CoV-2 has initiated a global pandemic and several vaccines have now received emergency use authorization. Using the reference strain SARS-CoV-2 USA-WA1/2020, we evaluated modes of transmission and the ability of prior infection or vaccine-induced immunity to protect against infection in ferrets. Ferrets were semi-permissive to infection with the USA-WA1/2020 isolate. Read More

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Development of a Genetically Stable Live Attenuated Influenza Vaccine Strain using an Engineered High-Fidelity Viral Polymerase.

J Virol 2021 Apr 7. Epub 2021 Apr 7.

Department of Microbiology, Kawasaki Medical School, Okayama, Japan

RNA viruses demonstrate a vast range of variants, called quasispecies, due to error-prone replication by viral RNA-dependent RNA polymerase. Although live attenuated vaccines are effective in preventing RNA virus infection, there is a risk of reversal to virulence post their administration. To test the hypothesis that high-fidelity viral polymerase reduces the diversity of influenza virus quasispecies, resulting in inhibition of reversal of the attenuated phenotype, we first screened for a high-fidelity viral polymerase using serial virus passages under selection with a guanosine analog ribavirin. Read More

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Broadly protective CD8 T cell immunity to highly conserved epitopes elicited by heat shock protein gp96-adjuvanted influenza monovalent split vaccine.

J Virol 2021 Apr 7. Epub 2021 Apr 7.

Key Laboratory of Pathogenic Microbiology and Immunology, Center for Biosafety Mega-Science, Chinese Institute of Microbiology, Chinese Academy of Sciences (CAS), Beijing, China

Currently, immunization with inactivated influenza virus vaccines is the most prevalent method to prevent infections. However, licensed influenza vaccines provide only strain-specific protection and need to be updated and administered yearly; thus, new vaccines that provide broad protection against multiple influenza subtypes are required. In this study, we demonstrated that intradermal immunization with gp96-adjuvanted seasonal influenza monovalent H1N1 split vaccine could induce cross-protection against both group 1 and group 2 influenza A viruses in BALB/c mice models. Read More

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Hospitalist perspectives on barriers to recommend and potential benefit of the COVID-19 vaccine.

Hosp Pract (1995) 2021 Apr 7. Epub 2021 Apr 7.

Division of Hospital Internal Medicine, Mayo Clinic, Rochester, MN.

Background: Hospitalists, comprised of nurse practitioners and physician assistants (collectively, advanced practice providers [APPs]) and physicians, have opportunities to counsel patients and reduce SARS-CoV-2 related coronavirus disease 2019 (COVID-19) vaccine hesitancy. However, hospitalist perspectives on the COVID-19 vaccine and potential differences between APPs and physicians are unknown. Understanding hospitalist perspectives could help to address vaccine hesitancy among patients. Read More

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