114,298 results match your criteria influenza


Influenza vaccination uptake and factors influencing vaccination decision among patients with chronic kidney or liver disease.

PLoS One 2021 13;16(4):e0249785. Epub 2021 Apr 13.

Division of Gastroenterology and Hepatology, Department of Medicine III, Medical University of Vienna, Vienna, Austria.

Introduction: Seasonal influenza is a major global health problem causing substantial morbidity and health care costs. Yet, in many countries, the rates of influenza vaccination remain low. Chronic kidney or liver diseases (CKLD) predispose patients to severe influenza infections, but data on vaccination acceptance and status is limited in this risk population. Read More

View Article and Full-Text PDF

Influenza Antiviral Subversion: Now the Host is in on the Act.

Am J Respir Cell Mol Biol 2021 Apr 13. Epub 2021 Apr 13.

University of Alabama at Birmingham, 9968, Birmingham, Alabama, United States;

View Article and Full-Text PDF

Is Viral Coinfection A Risk Factor For Severe Lower Respiratory Tract Infection? A Retrospective Observational Study.

Pediatr Pulmonol 2021 Apr 13. Epub 2021 Apr 13.

Department of Pediatric Pulmonology, Ege University Medical Faculty, Ege University Children Hospital, Izmir, Turkey.

Objective: To determine whether viral coinfection is a risk for severe lower respiratory tract infection (LRTI).

Working Hypothesis: Children with viral coinfection had a higher risk for admission to the intensive care unit (ICU) than those with a single virus infection.

Study Design: Retrospective, observational study for ten years. Read More

View Article and Full-Text PDF

Metabolic and functional impairment of CD8 T cells from the lungs of influenza-infected obese mice.

J Leukoc Biol 2021 Apr 13. Epub 2021 Apr 13.

Department of Nutrition, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina, USA.

Obesity is an independent risk factor for morbidity and mortality in response to influenza infection. However, the underlying mechanisms by which obesity impairs immunity are unclear. Herein, we investigated the effects of diet-induced obesity on pulmonary CD8 T cell metabolism, cytokine production, and transcriptome as a potential mechanism of impairment during influenza virus infection in mice. Read More

View Article and Full-Text PDF

The role of host cell Rab GTPases in influenza A virus infections.

Future Microbiol 2021 Apr 13. Epub 2021 Apr 13.

Department of Laboratory Medicine, The Affiliated People's Hospital, Jiangsu University, Zhenjiang, China.

Influenza A virus (IAV) is a crucial cause of respiratory infections in humans worldwide. Therefore, studies should clarify adaptation mechanisms of IAV and critical factors of the viral pathogenesis in human hosts. GTPases of the Rab family are the largest branch of the Ras-like small GTPase superfamily, and they regulate almost every step during vesicle-mediated trafficking. Read More

View Article and Full-Text PDF

Reciprocal regulation of RIG-I and XRCC4 connects DNA repair with RIG-I immune signaling.

Nat Commun 2021 04 12;12(1):2187. Epub 2021 Apr 12.

Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, USA.

The RNA-sensing pathway contributes to type I interferon (IFN) production induced by DNA damaging agents. However, the potential involvement of RNA sensors in DNA repair is unknown. Here, we found that retinoic acid-inducible gene I (RIG-I), a key cytosolic RNA sensor that recognizes RNA virus and initiates the MAVS-IRF3-type I IFN signaling cascade, is recruited to double-stranded breaks (DSBs) and suppresses non-homologous end joining (NHEJ). Read More

View Article and Full-Text PDF

Attitudes towards influenza and uptake of the flu vaccine: A survey of pharmacy staff working in English hospitals.

Vaccine 2021 Apr 9. Epub 2021 Apr 9.

Pharmacy Department, University Hospitals of Leicester NHS Trust, Leicester LE1 5WW, United Kingdom.

Objectives: Pharmacy staff working in hospitals are at risk of contracting and disseminating influenza. Previous research focuses on community pharmacists' attitudes towards influenza and vaccination. This survey investigates the beliefs and attitudes of pharmacists and other pharmacy staff working in English Hospitals regarding influenza and the vaccine and how this relates to vaccine uptake. Read More

View Article and Full-Text PDF

Clinical characteristics and outcome of influenza virus infection among adults hospitalized with severe COVID-19: a retrospective cohort study from Wuhan, China.

BMC Infect Dis 2021 Apr 12;21(1):341. Epub 2021 Apr 12.

Department of Pulmonary and Critical Care Medicine, Beijing Hospital, National Center of Gerontology, the Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, People's Republic of China.

Background: Coronavirus disease 2019 (COVID-19) is an emerging infectious disease that rapidly spreads worldwide and co-infection of COVID-19 and influenza may occur in some cases. We aimed to describe clinical features and outcomes of severe COVID-19 patients with co-infection of influenza virus.

Methods: Retrospective cohort study was performed and a total of 140 patients with severe COVID-19 were enrolled in designated wards of Sino-French New City Branch of Tongji Hospital between Feb 8th and March 15th in Wuhan city, Hubei province, China. Read More

View Article and Full-Text PDF

The Beneficial Effects of QIAPI 1® against Pentavalent Arsenic-Induced Lung Toxicity a Hypothetical Model for SARS CoV2-Induced Lung Toxicity.

Curr Pharm Biotechnol 2021 Apr 12. Epub 2021 Apr 12.

Research Institute of Human Morphology, 3 Tsyurupy Street, Moscow, 117418. Russian Federation.

Exposure to environmental toxicants such as Arsenic (As) can result in As-induced alterations in immune regulators. Consequently, people who are more prone to viral infections like influenza A or B, H1N1, SARS CoV (Severe Acute Respiratory Syndrome Coronavirus), and SARS CoV2 may develop susceptibility to immune responses in their lungs because our previous reports delineated the ability of QIAPI 1®, a melanin precursor, to dissociate water molecules with simultaneous therapeutic efficacy against central nervous system (CNS) diseases, retinopathy, and As-induced renal toxicity. Given the commonalities of lung pathology of SARS CoV and As-induced toxicity, the aim of this study is to decipher the efficacy of QIAPI 1® against pentavalent As-induced lung toxicity by examining the pulmonary pathology. Read More

View Article and Full-Text PDF

Assessing Vaccine Protection for Older Adults with Diabetes: A Systematic Review.

West J Nurs Res 2021 Apr 13:1939459211005710. Epub 2021 Apr 13.

Donald W. Reynolds Center of Geriatric Nursing Excellence, Fran and Earl Ziegler College of Nursing, The University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.

Immunosenescence and comorbidities increase the susceptibility of older adults with diabetes mellitus (DM) to vaccine-preventable diseases, hospitalization, disability, or death. This systematic review synthesizes research on protecting older adults with DM during pandemics, exploring vaccine safety, tolerance, and vaccination uptake by older adults in anticipation of seasonal influenza outbreaks during the current COVID-19 threat. Addressed were: (a) age-related factors influencing the effectiveness of vaccines against infectious disease in older adults; (b) vaccine safety, tolerance, effectiveness for older persons with DM; and (c) issues affecting older adults accepting immunization recommendations. Read More

View Article and Full-Text PDF

Vitamin D status in children with community acquired pneumonia and its association with severity: a hospital-based study.

Minerva Pediatr (Torino) 2021 Apr 12. Epub 2021 Apr 12.

Department of Microbiology, Pandit Bhagwat Dayal Sharma Post Graduate Institute of Medical Sciences, Rohtak, India.

Background: International and observational epidemiological studies provide evidence that vitamin D deficiency may confer increased risk of influenza and respiratory tract infection. This study was undertaken in an effort to evaluate the prevalence of vitamin D deficiency in pneumonia in children and assess its relationship with the severity.

Methods: Study group included children aged between 2 months to 5 years of age admitted as inpatients who presented with clinical features of pneumonia as per WHO classification. Read More

View Article and Full-Text PDF

Just a bad flu? Tackling the "infodemic" in Ireland through a comparative analysis of hospitalised cases of COVID-19 and influenza.

Public Health 2021 Mar 6;194:19-24. Epub 2021 Mar 6.

Health Intelligence, Strategic Planning and Transformation, 4th Floor, Jervis House, Jervis Street, Dublin 1, D01 W596, Ireland; Royal College of Surgeons in Ireland, Department of Epidemiology & Public Health Medicine, Beaux Lane House, Mercer Street Lower, Dublin 2, Ireland. Electronic address:

Objectives: COVID-19 infection has been compared to seasonal influenza as an argument against non-pharmacological population-based infection control measures known as "lockdowns". Our study sought to compare disease severity measures for patients in Ireland hospitalised with COVID-19 against those hospitalised with seasonal influenza.

Study Design: This is a retrospective population-based cohort study. Read More

View Article and Full-Text PDF

The cleavage of spike protein НА0→НА1/HA2 by trypsin permits activation of the M2 channel without its proteolytic cleavage in the influenza A virus.

Virology 2021 Apr 1;559:86-88. Epub 2021 Apr 1.

Schaller Research Group "Membrane Biology of Viral Infection", Department of Infectious Diseases, Virology, Heidelberg University, Heidelberg, Germany. Electronic address:

M2 plays numerous regulatory roles in influenza A virus infection confirming the old adage: "a little body often harbors a great sense". The comment here demonstrates that a small viral protein M2, having 14 kD m.w. Read More

View Article and Full-Text PDF

Inhaled budesonide in the treatment of early COVID-19 (STOIC): a phase 2, open-label, randomised controlled trial.

Lancet Respir Med 2021 Apr 9. Epub 2021 Apr 9.

Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK; National Institute for Health Research (NIHR), Oxford Biomedical Research Centre, Oxford, UK. Electronic address:

Background: Multiple early reports of patients admitted to hospital with COVID-19 showed that patients with chronic respiratory disease were significantly under-represented in these cohorts. We hypothesised that the widespread use of inhaled glucocorticoids among these patients was responsible for this finding, and tested if inhaled glucocorticoids would be an effective treatment for early COVID-19.

Methods: We performed an open-label, parallel-group, phase 2, randomised controlled trial (Steroids in COVID-19; STOIC) of inhaled budesonide, compared with usual care, in adults within 7 days of the onset of mild COVID-19 symptoms. Read More

View Article and Full-Text PDF