Brain Cogn 2021 Apr 28;151:105725. Epub 2021 Apr 28.
Neuroscience Graduate Program, McMaster University, Hamilton, ON, Canada; Department of Psychology Neuroscience & Behaviour, McMaster University, Hamilton, ON, Canada; Vector Institute for Artificial Intelligence, Toronto, ON, Canada; Centre for Advanced Research in Experimental and Applied Linguistics (ARiEAL), Department of Linguistics and Languages, McMaster University, Hamilton, ON, Canada; Rotman Research Institute, Baycrest Hospital, Toronto, ON, Canada. Electronic address:
The highly influential tri-network model proposed by Menon integrates 3 key intrinsic brain networks - the central executive network (CEN), the salience network (SN), and the default mode network (DMN), into a single cohesive model underlying normal behaviour and cognition. A large body of evidence suggests that abnormal intra- and inter- network connectivity between these three networks underlies the various behavioural and cognitive dysfunctions observed in patients with neuropsychiatric conditions such as PTSD and depression. An important prediction of the tri-network model is that the DMN and CEN networks are anti-correlated under the control of the SN, such that if a task engages one of the two, the SN inhibits the activation of the other. Read More