2,776 results match your criteria influence intrauterine

Maternal vitamin B, folate during pregnancy and neurocognitive outcomes in young adults of the Pune Maternal Nutrition Study (PMNS) prospective birth cohort: study protocol.

BMJ Open 2021 Sep 22;11(9):e046242. Epub 2021 Sep 22.

Diabetes Unit, KEM Hospital Research Centre, Pune, Maharashtra, India.

Introduction: The Developmental Origins of Health and Disease (DOHaD) hypothesis proposes that intrauterine and early life exposures significantly influence fetal development and risk for disease in later life. Evidence from prospective birth cohorts suggests a role for maternal B and folate in influencing neurocognitive outcomes in the offspring. In the Indian setting, B deficiency is common during the pregnancy while rates of folate deficiency are lower. Read More

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September 2021

Vitiligo and pregnancy: How do each affect the other?

Ann Med Surg (Lond) 2021 Oct 8;70:102833. Epub 2021 Sep 8.

Department of Surgery, Faculty of Medicine and Health Sciences, Universiti Malaysia Sabah, Jalan UMS, 88400, Kota Kinabalu, Sabah, Malaysia.

Vitiligo is one of the dermatomes affecting the melanocytes resulting in their destruction and subsequent patchy depigmentation of the skin. It is postulated to occur due to an autoimmune problem. Despite being a disease with limited systemic involvement and lack of mortality, it has a severe psychological impact. Read More

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October 2021

Intrauterine immunizations trigger antigen-specific mucosal and systemic immunity in pigs and passive protection in suckling piglets.

Vaccine 2021 Sep 14. Epub 2021 Sep 14.

Vaccine and Infectious Disease Organization (VIDO), University of Saskatchewan, 120 Veterinary Road, Saskatoon, Saskatchewan S7N5E3, Canada; Department of Veterinary Microbiology, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Saskatchewan S7N 5B4, Canada. Electronic address:

We assessed whether vaccines administered to the uterus at breeding can lead to sufficient colostral antibodies to protect suckling piglets against Porcine Endemic Diarrhea Virus (PEDV). An antigen from Lawsonia intracellularis, a disease that impacts weanling intestinal health, was also included because we have extensive knowledge on the pig immune response to this antigen. Gilts were mock-bred at 2nd estrus with killed sperm including an intrauterine (i. Read More

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September 2021

Satisfaction and continuation with LNG-IUS 12: findings from the real-world kyleena satisfaction study.

Eur J Contracept Reprod Health Care 2021 Sep 16:1-11. Epub 2021 Sep 16.

ZEG - Berlin Center for Epidemiology and Health Research GmbH, Berlin, Germany.

Purpose: The Kyleena Satisfaction Study (KYSS) aimed to assess satisfaction and continuation with levonorgestrel-releasing intrauterine system (LNG-IUS) 12 (Kyleena) in routine clinical practice and to evaluate factors that influence satisfaction.

Materials And Methods: This prospective, observational, multicentre, single-arm cohort study, with 1-year follow-up, was conducted in Belgium, Canada, Germany, Mexico, Norway, Sweden, Spain and the United States from 2017 to 2018. During routine counselling, women who independently selected to use LNG-IUS 12 were invited to participate in the study. Read More

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September 2021

Endocrine regulation of fetal metabolism towards term.

Domest Anim Endocrinol 2021 Aug 10;78:106657. Epub 2021 Aug 10.

Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, CB2 3EG, UK; Department of Biological and Medical Sciences, Oxford Brookes University, Oxford OX3 0BP, UK.

Hormones have an important role in regulating fetal metabolism in relation to the prevailing nutritional conditions both in late gestation and during the prepartum period as the fetus prepares for birth. In particular, the pancreatic, thyroid and adrenal hormones all affect fetal uptake and utilization of nutrients for oxidative metabolism, tissue accretion and fuel storage. These hormones also influence the fetal metabolic preparations for the nutritional transition from intra- to extra-uterine life. Read More

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Association of Maternal Gestational Weight Gain With Left Ventricle Geometry and Function in Offspring at 4 Years of Age: A Prospective Birth Cohort Study.

Front Pediatr 2021 27;9:722385. Epub 2021 Aug 27.

Department of Pediatric Cardiology, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

Maternal gestational weight gain (GWG) may be associated with cardiovascular diseases in the offspring from childhood to adulthood. We aimed to investigate the association between maternal GWG and the left ventricle (LV) geometry and function in the offspring, and explore the influence of the intrauterine environment on early childhood cardiac change. Data of 981 mother-offspring pairs from the Shanghai Birth Cohort was used. Read More

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Social Network Influences on Young Women's Choice to Use Long-Acting Reversible Contraception: A Systematic Review.

J Midwifery Womens Health 2021 Sep 7. Epub 2021 Sep 7.

College of Public Health, University of South Florida, Tampa, Florida.

Introduction: Long-acting reversible contraception (LARC; including intrauterine devices and implants) is recommended as the first-line contraceptive choice by several professional organizations (eg, American College of Obstetricians and Gynecologists); however, rates of uptake are lower than those of other contraceptive methods. A young woman's social network may influence the decision to use LARC. The purpose of this review was to determine the role of health care providers (HCPs), family, peers, and sexual partner(s) on young women's decisions to initiate LARC. Read More

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September 2021

Vacuum-assisted vaginal deliveries among parturients with congenital uterine anomalies; risk factors and outcomes.

Eur J Obstet Gynecol Reprod Biol 2021 Aug 26;265:113-118. Epub 2021 Aug 26.

Department of Obstetrics & Gynecology, Shaare Zedek Medical Center, Affiliated with the Hebrew University School of Medicine, Jerusalem, Israel; Department of Nursing, Jerusalem College of Technology, Jerusalem, Israel.

Objective: To evaluate the maternal and neonatal outcomes associated with vacuum-assisted vaginal delivery (VAVD) in a subset of parturients with congenital uterine anomalies.

Study Design: A retrospective database study was conducted at a single tertiary center between 2005 and 2019. Parturients with known congenital uterine anomalies who had vaginal deliveries were enrolled, whereas parturients with failed VAVD, didelphic uterus, and delivery after intrauterine fetal death were excluded. Read More

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Lycium barbarum polysaccharide attenuates emotional injury of offspring elicited by prenatal chronic stress in rats via regulation of gut microbiota.

Biomed Pharmacother 2021 Aug 31;143:112087. Epub 2021 Aug 31.

School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong. Electronic address:

Stress during pregnancy is not only detrimental to a woman's own physical and mental health, but can also cause changes in the intrauterine environment and even have an impact on later growth and development, this study was designed to understand the changes of gut microbiota in the maternal and offspring caused by prenatal chronic stress, and to explore the regulatory effect of LBP on gut microbiota, and then to improve the emotional damage caused by prenatal chronic stress in the offspring. A rat model of prenatal chronic stress was made and used LBP to intervene by gavage. Fresh feces of offspring were collected, the concentration of microbial metabolites were tested by ELISA. Read More

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Dietary N-carbamylglutamate or l-arginine supplementation improves hepatic energy status and mitochondrial function and inhibits the AMP-activated protein kinase-peroxisome proliferator-activated receptor γ coactivator-1α-transcription factor A pathway in intrauterine-growth-retarded suckling lambs.

Anim Nutr 2021 Sep 14;7(3):859-867. Epub 2021 Jul 14.

Laboratory of Metabolic Manipulation of Herbivorous Animal Nutrition, College of Animal Science and Technology, Yangzhou University, Yangzhou, 225009, China.

The objective of this study was to investigate the effects of dietary administration of l-arginine (Arg) or -carbamylglutamate (NCG) on hepatic energy status and mitochondrial functions in suckling Hu lambs with intrauterine growth retardation (IUGR). Forty-eight newborn Hu lambs of 7 d old were allocated into 4 treatment groups of 12 lambs each, in triplicate with 4 lambs per replicate (2 males and 2 females) as follows: CON (lambs of normal birth weight, 4.25 ± 0. Read More

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September 2021

Docosahexaenoic acid activates the Nrf2 signaling pathway to alleviate impairment of spleen cellular immunity in intrauterine growth restricted rat pups.

Saudi J Biol Sci 2021 Sep 5;28(9):4987-4993. Epub 2021 Jun 5.

Children's Institute of Three Gorges University, Yichang Central People's Hospital, The First College of Clinical Medical Sciences, China Three Gorges University, Yichang 443003, PR China.

Intrauterine growth retardation (IUGR) impairs immune function in children. IUGR is associated with an imbalance of oxidative stress and abnormal apoptosis. Therefore, an IUGR rats model was established to determine the antioxidant capacity and apoptosis in newborn IUGR rats and explored whether these effects were regulated after Docosahexaenoic acid (DHA) supplementation to rat pups. Read More

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September 2021

H19/let-7 axis mediates caffeine exposure during pregnancy induced adrenal dysfunction and its multi-generation inheritance.

Sci Total Environ 2021 Oct 11;792:148440. Epub 2021 Jun 11.

Department of Pharmacology, Basic Medical School of Wuhan University, Wuhan 430071, China; Hubei Provincial Key Laboratory of Developmentally Originated Disorder, Wuhan 430071, China. Electronic address:

Previously, we systemically confirmed that prenatal caffeine exposure (PCE) could cause intrauterine growth retardation (IUGR) and adrenal steroid synthesis dysfunction in offspring rats. However, the multi-generation inheritance of adrenal dysfunction and its epigenetic mechanism has not been reported. In this study, the PCE rat model was established, part of the pregnant rats were executed on gestational day 20, while the others were delivered normally and the fetal rats were reared into adulthood. Read More

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October 2021

The effect of a hysteroscopic niche resection compared with Levonorgestrel-releasing intrauterine device on postmenstrual spotting in patients with a symptomatic niche in the uterine cesarean scar: A prospective cohort study.

Eur J Obstet Gynecol Reprod Biol 2021 Aug 17;265:66-73. Epub 2021 Aug 17.

Department of Obstetrics and Gynecology, Amsterdam Reproduction and Development Research Institute, Amsterdam University Medical Centre, Location AMC and VUmc, Amsterdam, the Netherlands.

Objective: To compare the effect of a hysteroscopic niche resection with a Levonorgestrel-releasing intrauterine device (LNG-IUD, 52 mg) on postmenstrual spotting duration in patients with a symptomatic niche in the uterine cesarean scar.

Study Design: This prospective cohort study was conducted at the International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiaotong University, China. Patients with postmenstrual spotting symptomatic niches were allocated to hysteroscopy group or LNG-IUD group based on the shared medical decision-making approach, and were followed up for 1 year after treatment. Read More

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Association of Parental Height With Offspring Stunting in 14 Low- and Middle-Income Countries.

Front Nutr 2021 11;8:650976. Epub 2021 Aug 11.

Department of Epidemiology, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, China.

Maternal height has been confirmed to be associated with offspring stunting in low- and middle-income countries (LMICs), but only limited studies have examined the paternal-offspring association, and few studies have examined the joint effect of maternal and paternal height on stunting. To investigate the association between parental height and stunting of children aged under five in LMICs. We obtained data from the Demographic and Health Surveys (DHS) conducted in 14 LMICs from 2006 to 2016. Read More

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A case of perinatal death after insertion of an intrauterine pressure catheter.

Eur J Obstet Gynecol Reprod Biol 2021 Aug 11. Epub 2021 Aug 11.

Department of Obstetrics and Gynaecology, Diakonessenhuis, Bosboomstraat 1, 3508 TG, Utrecht, the Netherlands.

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Intergenerational genetic programming mechanism and sex differences of the adrenal corticosterone synthesis dysfunction in offspring induced by prenatal ethanol exposure.

Toxicol Lett 2021 Aug 25;351:78-88. Epub 2021 Aug 25.

Department of Pharmacology, School of Basic Medical Sciences, Wuhan University, Wuhan 430071, China; Hubei Provincial Key Laboratory of Developmentally Originated Disease, Wuhan 430071, China. Electronic address:

We previously found that prenatal ethanol exposure (PEE) induced adrenal dysplasia in offspring, which was related to intrauterine maternal glucocorticoid overexposure. This study investigated the intergenerational genetic effect and sex differences of PEE-induced changes in the synthetic function of adrenal corticosterone in offspring, and to clarify the intrauterine origin programming mechanism. Wistar pregnant rats were gavaged with ethanol (4 g/kg bw/d) from gestation day (GD) 9-20, and F1 generation was born naturally. Read More

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The Importance of Rhythmic Stimulation for Preterm Infants in the NICU.

Children (Basel) 2021 Jul 29;8(8). Epub 2021 Jul 29.

Cognitions Humaine et Artificielle -EPHE-PSL, CHArt Laboratory, 93322 Aubervilliers, France.

The fetal environment provides the fetus with multiple potential sources of rhythmic stimulation that are not present in the NICU. Maternal breathing, heartbeats, walking, dancing, running, speaking, singing, etc., all bathe the fetus in an environment of varied rhythmic stimuli: vestibular, somatosensory, tactile, and auditory. Read More

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Vaginal birth after cesarean (VBAC): fear it or dare it? An evaluation of potential risk factors.

J Perinat Med 2021 Sep 24;49(7):773-782. Epub 2021 Aug 24.

Department of Obstetrics of Charité-Universitätsmedizin Berlin, Campus Virchow Clinic, Berlin, Germany.

Objectives: The consultation of women aspiring a vaginal birth after caesarean may be improved by integrating the individual evaluation of factors that predict their chance of success. Retrospective analysis of correlating factors for all trials of labor after caesarean that were conducted at the Department of Obstetrics of Charité-Universitätsmedizin Berlin, Campus Virchow Clinic from 2014 to October 2017.

Methods: Of 2,151 pregnant women with previous caesarean, 408 (19%) attempted a vaginal birth after cesarean. Read More

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September 2021

Dietary dihydroartemisinin supplementation alleviates intestinal inflammatory injury through TLR4/NOD/NF-κB signaling pathway in weaned piglets with intrauterine growth retardation.

Anim Nutr 2021 Sep 3;7(3):667-678. Epub 2021 May 3.

College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China.

The aim of present study was to evaluate whether diets supplemented with dihydroartemisinin (DHA) could alleviate intestinal inflammatory injury in weaned piglets with intrauterine growth retardation (IUGR). Twelve normal birth weight (NBW) piglets and 12 piglets with IUGR were fed a basal diet (NBW-CON and IUCR-CON groups), and another 12 piglets with IUGR were fed the basal diet supplemented with DHA at 80 mg/kg (IUGR-DHA group) from 21 to 49 d of age. At 49 d of age, 8 piglets with similar body weight in each group were sacrificed. Read More

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September 2021

The effect of bta-miR-26b in intrauterine extracellular vesicles on maternal immune system during the implantation period.

Biochem Biophys Res Commun 2021 Oct 9;573:100-106. Epub 2021 Aug 9.

Research Institute of Agriculture, Tokai University, Kumamoto, Japan.

Extracellular vesicles (EVs) in utero play a role in cellular interactions between endometrium-conceptuses (embryo plus extraembryonic membranes) during peri-implantation periods. However, how intrauterine EVs function on endometrium have not been well characterized. In our previous study, bta-miR-98 found in intrauterine EVs from uterine flushing fluids (UFs) on pregnant day 20 (a half day after initial conceptus attachment, P20) could regulate the maternal immune system and collaborate with other miRNAs and/or components of EVs for conceptus implantation. Read More

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October 2021

Advances in the role of silence information regulator family in pathological pregnancy.

Zhejiang Da Xue Xue Bao Yi Xue Ban 2021 Jun;50(3):335-344

Women's Hospital.

Aberrant maternal inflammation and oxidative stress are the two main mechanisms of pathological pregnancy. The silence information regulator (sirtuin) family is a highly conserved family of nicotinamide adenine dinucleotide (NAD)-dependent deacylases. By regulating the post-translational modification of proteins, sirtuin is involved in various biological processes including oxidative stress and inflammation. Read More

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Parvovirus b19 infection in pregnancy - A review.

Eur J Obstet Gynecol Reprod Biol 2021 Sep 28;264:358-362. Epub 2021 Jul 28.

Sheffield Teaching Hospital, 8 Beech Hill Road, Sheffield, South Yorkshire S10 2SB, UK. Electronic address:

Parvovirus B19 (B19V) is a widespread infection that may affect 1-5% of pregnant women, mainly with normal pregnancy outcome. Vertical transmission occurs in 33-51% of cases of maternal infection. B19V infection is an important cause of fetal morbidity (fetal anaemia and non-immune hydrops) and mortality, predominantly in the second trimester. Read More

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September 2021

Does Obesity Influence Body Mass Index Changes in Nulliparous Adolescent Users of Long-Acting Reversible Contraceptives?

J Pediatr Adolesc Gynecol 2021 Aug 11. Epub 2021 Aug 11.

Division of Adolescent Medicine, Albert Einstein College of Medicine, Children's Hospital at Montefiore, Bronx, New York. Electronic address:

Objectives: To compare body mass index (BMI) changes in adolescents using long-acting reversible contraceptives (LARCs), specifically, the etonogestrel subdermal implant (ENG-implant), levonorgestrel intrauterine device (LNG-IUD), and copper IUD (Cu-IUD), by initial BMI category from the time of LARC insertion to within 6-18 months after insertion.

Design: This was a single-center retrospective cohort study.

Setting And Participants: We reviewed electronic health records from our large health system to identify and follow a cohort of 196 adolescents aged 14-19 years with LARCs inserted from 2010 to 2016. Read More

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Advances in understanding the crosstalk between mother and fetus on iron utilization.

Semin Hematol 2021 Jul 7;58(3):153-160. Epub 2021 Jul 7.

Department of Physiology, Anatomy and Genetics, Universty of Oxford, OX UK. Electronic address:

A full-term pregnancy comes with significant demand for iron. Not meeting this demand has adverse effects on maternal health and on the intrauterine and postnatal development of the infant. In the infant, some of these adverse effects cannot be reversed by postnatal iron supplementation, highlighting the need to tackle iron deficiency in utero. Read More

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The selection and identification of compound housekeeping genes for quantitative real-time polymerase chain reaction analysis in rat fetal kidney.

J Appl Toxicol 2021 Aug 10. Epub 2021 Aug 10.

Department of Pharmacology, Basic Medical School of Wuhan University, Wuhan, China.

During quantitative real-time polymerase chain reaction (RT-qPCR) data analysis, the selection of optimal housekeeping gene is necessary to ensure the accuracy of results. It is noteworthy that housekeeping genes commonly used in adult studies may not be applicable for fetus. However, the stability analysis of housekeeping gene in fetal kidney has not been reported. Read More

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[Effect of electroacupuncture at points on intrauterine residue and uterine volume restoration after uterine curettage of incomplete abortion].

Zhongguo Zhen Jiu 2021 Aug;41(8):871-5

Department of TCM, Foshan Women and Children Hospital, Foshan 528000, Guangdong Province, China.

Objective: To observe the clinical therapeutic effect of the combination of electroacupuncture (EA) at points (bilateral Shangliao [BL 31], Ciliao [BL 32], Zhongliao [BL 33] and Xialiao [BL 34]) and oral administration of mifepristone tablets and its influence on uterine volume restoration after uterine curettage of incomplete abortion as compared with simple oral administration of mifeprstone tablets.

Methods: A total of 58 patients after uterine curettage of incomplete abortion were randomized into an EA group and a western medication group, 29 cases in each one. In the western medication group, mifepristone tablets were administered orally, 2 tablets each time, once daily. Read More

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Maternally derived low glucocorticoid mediates adrenal developmental programming alteration in offspring induced by dexamethasone.

Sci Total Environ 2021 Nov 17;797:149084. Epub 2021 Jul 17.

Department of Pharmacology, Wuhan University School of Basic Medical Sciences, Wuhan 430071, China; Hubei Provincial Key Laboratory of Developmentally Originated Disease, Wuhan 430071, China. Electronic address:

Adverse environments during pregnancy can increase susceptibility to chronic diseases in adult offspring. The occurrence and development of fetal-originated diseases were associated with adrenal developmental programming and homeostasis alteration in offspring. Dexamethasone is widely used for preterm delivery-related pregnancy diseases, but the intrauterine programming alteration and its occurrence mechanism of prenatal dexamethasone exposure (PDE) on adrenal development in offspring have not been clarified. Read More

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November 2021

Hypoxia and the integrated stress response promote pulmonary hypertension and preeclampsia: Implications in drug development.

Drug Discov Today 2021 Jul 22. Epub 2021 Jul 22.

Lawrence D. Longo MD Center for Perinatal Biology, Division of Pharmacology, Department of Basic Sciences, Loma Linda University School of Medicine, Loma Linda, CA, USA. Electronic address:

Chronic hypoxia is a common cause of pulmonary hypertension, preeclampsia, and intrauterine growth restriction (IUGR). The molecular mechanisms underlying these diseases are not completely understood. Chronic hypoxia may induce the generation of reactive oxygen species (ROS) in mitochondria, promote endoplasmic reticulum (ER) stress, and result in the integrated stress response (ISR) in the pulmonary artery and uteroplacental tissues. Read More

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Levofloxacin or gonadotropin releasing hormone agonist treatment decreases intrauterine microbial colonization in human endometriosis.

Eur J Obstet Gynecol Reprod Biol 2021 Sep 9;264:103-116. Epub 2021 Jul 9.

Department of Obstetrics and Gynecology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kamigyo-ku, 602-8566 Kyoto, Japan.

Objective: We examined the hypothesis that antibiotic treatment with or without gonadotropin releasing hormone agonist (GnRHa) may decrease intrauterine infection with consequent decrease in tissue inflammation, cell proliferation and angiogenesis in human endometriosis.

Study Design: This is a prospective non-randomized observational study. Endometrial/endometriotic samples were collected during surgery from 53 women with endometriosis and 47 control women who were treated with levofloxacin (LVFX, 500 mg, once per os) or GnRHa (1. Read More

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September 2021

Intraperitoneal migration of an intrauterine device (IUD): A case report.

Ann Med Surg (Lond) 2021 Aug 8;68:102547. Epub 2021 Jul 8.

Head of Service in Obstetrics and Gynecology Department, Univesity Hospital Center Ibn Rochd, Casablanca, 20100, Morocco.

Introduction: The IUD is one of the most widely used reversible, long-term contraceptive methods in the world. About 80% of IUDs are found in the peritoneal cavity after uterine perforation.

Case Report: A 27-year-old female patient presented with chronic pelvic pain with minimal metrorrhagia for 8 months on IUD. Read More

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