160,835 results match your criteria influence age

Effects of oxygen concentration during incubation and broiler breeder age on embryonic heat production, chicken development, and 7-day performance.

Animal 2021 Jul 30;15(9):100323. Epub 2021 Jul 30.

Adaptation Physiology Group, Wageningen University and Research, P.O. Box 338, 6700 AH Wageningen, the Netherlands.

Older breeder flocks produce eggs with a relatively larger yolk and thereby a higher nutrient availability than young breeder flocks. To optimise nutrient utilisation and embryonic development throughout incubation and posthatch period, embryos originating from older breeder flocks may require a higher oxygen availability. The current study investigated effects of broiler breeder flock age and incubational oxygen concentration on embryonic metabolism and chicken development until 7-day posthatch. Read More

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The impact of indomethacin on the number of oocytes retrieved and IVF outcomes in patients with poor ovarian response.

Eur J Obstet Gynecol Reprod Biol 2021 Jul 24;264:266-270. Epub 2021 Jul 24.

Center for Assisted Reproduction, Department of Obstetrics and Gynecology, Ankara University Faculty of Medicine, Ankara, Turkey.

Objective: The aim of this retrospective case-control study was to analyze the effect of administering indomethacin after triggering final oocyte maturation in patients with poor ovarian response (POR) on the cycle cancellation rate due to premature ovulation (PO), the number of oocytes retrieved and the clinical outcomes of IVF cycles.

Study Design: A total of 214 patients with POR, diagnosed according to the Bologna criteria, who underwent fresh IVF cycle via flexible gonadotrophin-releasing hormone antagonist (GnRH-ant) protocol were enrolled in the study. The control group consisted of 100 patients, whereas the indomethacin group included 114 patients who received 100 mg rectal indomethacin administered twice within the same day (twelve hours apart) -starting at twelve hours after triggering. Read More

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Eco-friendly performance as a determining factor of the Adoption of Virtual Reality Applications in National Parks.

Sci Total Environ 2021 Jul 23;798:148990. Epub 2021 Jul 23.

Department of Business Management and Marketing, University of Sevilla, Sevilla, Spain; NECE-UBI Research Unit in Business Sciences, University of Beira Interior (UBI), Portugal.

The purpose of this study is to find the key factors of influence for the use and acceptance of Virtual Reality (VR) by tourists visiting National Parks in Costa Rica. The aim is to find whether tourists are willing to use VR to contribute to the eco-friendly performance of the area they visit and to determine whether they are willing to use VR in environmental tourism to protect flora and fauna. This study is quantitative and uses the theoretical Unified Theory of Acceptance and Use of Technology (UTAUT) Model and a survey as the research instrument to obtain data. Read More

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Urinary glyphosate concentration in pregnant women in relation to length of gestation.

Environ Res 2021 Jul 30:111811. Epub 2021 Jul 30.

Department of Environmental Medicine and Public Heath, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Electronic address:

Human exposure to glyphosate-based herbicides (GBH) is increasing rapidly worldwide. Most existing studies on health effects of glyphosate have focused on occupational settings and cancer outcomes and few have examined this common exposure in relation to the health of pregnant women and newborns in the general population. We investigated associations between prenatal glyphosate exposure and length of gestation in The Infant Development and the Environment Study (TIDES), a multi-center US pregnancy cohort. Read More

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Development of intraretinal fluid in neovascular age-related macular degeneration during anti-vascular endothelial growth factor treatment.

Am J Ophthalmol 2021 Jul 30. Epub 2021 Jul 30.

Kim's Eye Hospital, Konyang University College of Medicine, Seoul, South Korea.

Purpose: To identify the risk factors of intraretinal fluid (IRF) development during anti-vascular endothelial growth factor (VEGF) treatment for neovascular age-related macular degeneration (AMD).

Design: Retrospective cohort study.

Methods: A total of 425 treatment-naïve patients with neovascular AMD who completed 24 months of follow-up were enrolled. Read More

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Elevated plasma concentration of complement factor C5 is associated with risk of future venous thromboembolism.

Blood 2021 Aug 2. Epub 2021 Aug 2.

Division of Internal Medicine, University Hospital of North Norway, Tromsø, Norway.

The role of complement in the pathogenesis of venous thromboembolism (VTE) is unclear. We aimed to (i) investigate whether plasma complement component C5 levels are influenced by genetic variants or chronic inflammation, and (ii) investigate the association between plasma C5 and risk of future VTE in a nested case-control study with 415 VTE patients and 848 age- and sex-matched controls derived from the Tromsø study. Plasma C5 levels were measured at inclusion. Read More

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Cardiac risk stratification in cancer patients: A longitudinal patient-patient network analysis.

PLoS Med 2021 Aug 2;18(8):e1003736. Epub 2021 Aug 2.

Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, United States of America.

Background: Cardiovascular disease is a leading cause of death in general population and the second leading cause of mortality and morbidity in cancer survivors after recurrent malignancy in the United States. The growing awareness of cancer therapy-related cardiac dysfunction (CTRCD) has led to an emerging field of cardio-oncology; yet, there is limited knowledge on how to predict which patients will experience adverse cardiac outcomes. We aimed to perform unbiased cardiac risk stratification for cancer patients using our large-scale, institutional electronic medical records. Read More

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Mortality from cardiovascular disease in women with breast cancer - a nationwide registry study.

Acta Oncol 2021 Aug 2:1-7. Epub 2021 Aug 2.

Department of Oncology, Copenhagen University Hospital, Copenhagen, Denmark.

Background: Only few existing studies have investigated the mortality from cardiovascular disease (CVD) in women with breast cancer (BC). The aim of this study was to investigate CVD mortality in patients with BC compared with a matched control group without BC using national registry data.

Material And Methods: We followed 16,505 Danish women diagnosed with BC in 2003-2007 up to 10 years after BC diagnosis compared with 165,042 matched controls from the general Danish population. Read More

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Improved risk estimation of locoregional recurrence, secondary contralateral tumors and distant metastases in early breast cancer: the INFLUENCE 2.0 model.

Breast Cancer Res Treat 2021 Aug 2. Epub 2021 Aug 2.

Department of Health Technology and Services Research, Technical Medical Centre, University of Twente, POBox 217, Enschede, 7500 AE, The Netherlands.

Purpose: To extend the functionality of the existing INFLUENCE nomogram for locoregional recurrence (LRR) of breast cancer toward the prediction of secondary primary tumors (SP) and distant metastases (DM) using updated follow-up data and the best suitable statistical approaches.

Methods: Data on women diagnosed with non-metastatic invasive breast cancer were derived from the Netherlands Cancer Registry (n = 13,494). To provide flexible time-dependent individual risk predictions for LRR, SP, and DM, three statistical approaches were assessed; a Cox proportional hazard approach (COX), a parametric spline approach (PAR), and a random survival forest (RSF). Read More

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CAFT: a deep learning-based comprehensive abdominal fat analysis tool for large cohort studies.

MAGMA 2021 Aug 2. Epub 2021 Aug 2.

Department of Diagnostic Radiology, Tan Tock Seng Hospital, 11 Jln Tan Tock Seng, Singapore, 308433, Singapore.

Background: There is increasing appreciation of the association of obesity beyond co-morbidities, such as cancers, Type 2 diabetes, hypertension, and stroke to also impact upon the muscle to give rise to sarcopenic obesity. Phenotypic knowledge of obesity is crucial for profiling and management of obesity, as different fat-subcutaneous adipose tissue depots (SAT) and visceral adipose tissue depots (VAT) have various degrees of influence on metabolic syndrome and morbidities. Manual segmentation is time consuming and laborious. Read More

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Lower BAFF Levels in Myasthenic Patients Treated with Glucocorticoids.

Arch Immunol Ther Exp (Warsz) 2021 Aug 2;69(1):22. Epub 2021 Aug 2.

Department of Neurology, Medical University of Warsaw, Banacha 1a, 02-097, Warsaw, Poland.

B-cell activating factor (BAFF), a member of tumor necrosis factor family, activates B cells, promotes their survival and proliferation. BAFF is considered to have an influence on development of autoimmune diseases including myasthenia gravis (MG). We aimed to evaluate BAFF serum levels in MG patients, their potential connection with therapy and course of MG. Read More

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Annual direct economic burden and influencing factors of dry eye disease in Central China.

Ophthalmic Epidemiol 2021 Aug 2:1-8. Epub 2021 Aug 2.

Aier Eye Hospital, Wuhan University, Wuhan, Hubei Province, China.

Purpose: To study the direct economic burden of dry eye diseases (DED) on Chinese residents and analyze the influencing factors of the direct economic burden of patients with DED.

Methods: Two hundred and twenty-one Chinese adults with DED who underwent treatment in Wuhan Aier Hankou Eye Hospital were enrolled in this health economics research from January 2018 to August 2018 and followed for at least 1 year. Examination, pharmacological therapy, and nonpharmacological therapy costs were collected to calculate the annual direct economic burden of DED on patients through the outpatient medical record system. Read More

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Health system influences on potentially avoidable hospital admissions by secondary mental health service use: A national ecological study.

J Health Serv Res Policy 2021 Aug 1:13558196211036739. Epub 2021 Aug 1.

Professor of Health Care Evaluation, NIHR ARC North Thames, Department of Applied Health Research, 4919University College London, University College London, UK.

Objectives: Potentially avoidable hospital admissions (PAAs) are costly to health services and potentially harmful for patients. This study aimed to compare area-level PAA rates among people using and not using secondary mental health services in England and to identify health system features that may influence between-area PAA variation.

Methods: National ecological study using linked English hospital admissions and secondary mental health services data (2016-2018). Read More

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Evaluation of circulating levels of Interleukin-10 and Interleukin-16 and dietary inflammatory index in Lebanese knee osteoarthritis patients.

Heliyon 2021 Jul 12;7(7):e07551. Epub 2021 Jul 12.

Faculty of Health Sciences, Beirut Arab University, Lebanon.

Objectives: To investigate plasma concentrations of Interleukin-16 (IL-16) and Interleukin-10 (IL-10) in Lebanese knee osteoarthritis (KOA) patients and to examine the association between the diet-associated inflammation and increased risk for KOA.

Methods: A total of 208 study participants were assigned to one of the 3 groups: Diagnosed Knee Osteoarthritis group (DKOA) (N = 78); Undiagnosed Knee Osteoarthritis group (UKOA) (N = 60) and controls matched on age, sex and sociodemographic characteristics (N = 70). UKOA represents KOA features before they are altered by therapeutic intervention and lifestyle modifications that follow the diagnosis. Read More

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Toxic elements in follicular fluid adversely influence the likelihood of pregnancy and live birth in women undergoing IVF.

Hum Reprod Open 2021 29;2021(3):hoab023. Epub 2021 Jul 29.

Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California at San Francisco, San Francisco, CA, USA.

Study Question: Are follicular fluid (FF), arsenic (As), mercury (Hg), cadmium (Cd) and lead (Pb) concentrations associated with IVF outcomes among women undergoing IVF?

Summary Answer: There was a non-linear association between higher FF Hg concentration and a lower likelihood of biochemical pregnancy and live birth. Higher FF Pb concentration was also associated with a lower probability of live birth.

What Is Known Already: Previous research suggests that toxic elements may affect fertility among couples conceiving with and without assistance. Read More

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Thiopurines in Inflammatory Bowel Disease. How to Optimize Thiopurines in the Biologic Era?

Front Med (Lausanne) 2021 16;8:681907. Epub 2021 Jul 16.

Department of Gastroenterology, University Clinic Hospital Lozano Blesa, Zaragoza, Spain.

Thiopurines have been a cornerstone in the treatment of inflammatory bowel disease (IBD). Although they have been used for more than 50 years, there are still some unsolved issues about their efficacy and, also, some safety concerns, mainly the risk of myelosuppression and life-threatening lymphoproliferative disorders. Furthermore, the development of biological therapy raises the question whether there is still a role for thiopurines in the IBD treatment algorithm. Read More

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Family Cohesion and Stress Consequences Among Chinese College Students During COVID-19 Pandemic: A Moderated Mediation Model.

Front Public Health 2021 15;9:703899. Epub 2021 Jul 15.

Center of Preschool Education, School of Education, Jiangxi Normal University, Nanchang, China.

Family plays a pivotal role in individuals' mental health. During the COVID-19 epidemic, people were being quarantined at home to prevent the further spread of the virus. Therefore, the influence of family on individuals is more significant than usual. Read More

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Effects of 17β-Estradiol on Monocyte/Macrophage Response to : An Study.

Front Cell Infect Microbiol 2021 14;11:701391. Epub 2021 Jul 14.

Multidisciplinary Institute of Health, Federal University of Bahia (UFBA), Vitória da Conquista, Brazil.

To describe how 17β-estradiol (E2) influence in the monocyte/macrophage response induced by in models of murine peritoneal macrophages (MPMs) and human peripheral blood monocytes (HPBM). MPMs (2 x 10/ml) were isolated from sham (n=3) and ovariectomized (OVX) females (n = 3) and males (n = 3) after induction by thioglycolate. The MPMs obtained from OVX females and males were treated for 24 hours with 17β-estradiol (E2) (10 M), and after that, inoculation with was carried out for 6 hours. Read More

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Longitudinal bidirectional associations of physical activity and depressive symptoms: The CARDIA study.

Prev Med Rep 2021 Sep 12;23:101489. Epub 2021 Jul 12.

University of Iowa, USA.

Depression affects many aspects of health and may be attenuated through increases in physical activity. While bidirectional associations between physical activity (PA) and depressive symptoms have been examined, few studies have examined these associations using both self-reported and accelerometer-estimated measures. Using data from Years 20 (2005-06, age 38-50) and 30 of the Coronary Artery Risk Development in Young Adults (CARDIA) study (N = 2,871), the bidirectional associations between moderate to vigorous intensity physical activity (MVPA) and depressive symptoms were examined using a cross-lagged panel model. Read More

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September 2021

When the kids get guns - The effects of lowering the minimum age of firearm possession in Alabama.

Prev Med Rep 2021 Sep 12;23:101481. Epub 2021 Jul 12.

University of Alabama Birmingham, Children's of Alabama, United States.

At this time, the relationship between firearm minimum age laws and pediatric injury rates remains unclear. In September 2015, Alabama implemented Act 2015-341 (Act 341) which allowed minors to carry guns with parental permission. The purpose of this study was to evaluate the effect that Act 341 had on firearm injury rates. Read More

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September 2021

A Comparative Study of Ranibizumab and Aflibercept for Neovascular Age-Related Macular Degeneration: 12-Month Outcomes of Polish Therapeutic Program in Non-Tertiary Institution.

Cureus 2021 Jun 25;13(6):e15916. Epub 2021 Jun 25.

Department of Ophthalmology, Regional Specialist Hospital in Wroclaw, Research and Development Center, Wroclaw, POL.

Introduction This single-center study aimed to compare the 12-month treatment outcomes of ranibizumab with that of aflibercept in routine clinical practice. Methods Cohort of patients diagnosed with treatment-naïve neovascular age-related macular degeneration (AMD), treated using either ranibizumab (n = 33 eyes) or aflibercept (n = 44 eyes) monotherapy over a 12-month follow-up period was analyzed. Anonymous data were extracted from the electronic database dedicated to the drug program. Read More

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Age and Sex Variation in the Duration of Action and Corneal Touch Threshold (CTT) following Instillation of 0.5% Topical Ophthalmic Proparacaine and Tetracaine Hydrochlorides.

J Ophthalmol 2021 14;2021:8661098. Epub 2021 Jul 14.

School of Optometry and Vision Science, University of New South Wales, Sydney, Australia.

Purpose: We investigated the effect of age and sex on corneal touch threshold (CTT) and duration of action following administration of 0.5% topical ophthalmic proparacaine and tetracaine hydrochlorides.

Methods: A prospective, randomized, subject-masked, crossover study design was used. Read More

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Prevalence of Strongyle Infection and Associated Risk Factors in Horses and Donkeys in and around Mekelle City, Northern Part of Ethiopia.

Vet Med Int 2021 21;2021:9430824. Epub 2021 Jul 21.

College of Veterinary Medicine, Samara University, P.O. Box 132, Samara, Ethiopia.

Background: In Ethiopia, equines serve in traction power, carting, recreation, festival packing, riding, transportation, and other activities since time immemorial. Strongyles are common equine health problems in Ethiopia though research based data on equine strongyles are limited particularly in the study areas, in and around Mekelle city. Therefore, the present study was intended to estimate the prevalence of common equine strongyles in and around Mekelle city from November 2018 to April 2019 and to assess risk factors associated with infection of strongyle parasites as well. Read More

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Disentangling the Association of Hydroxychloroquine Treatment with Mortality in Covid-19 Hospitalized Patients through Hierarchical Clustering.

J Healthc Eng 2021 25;2021:5556207. Epub 2021 Jun 25.

UOC Malattie Infettive, Ospedale San Gerardo, ASST Monza, Monza, Italy.

The efficacy of hydroxychloroquine (HCQ) in treating SARS-CoV-2 infection is harshly debated, with observational and experimental studies reporting contrasting results. To clarify the role of HCQ in Covid-19 patients, we carried out a retrospective observational study of 4,396 unselected patients hospitalized for Covid-19 in Italy (February-May 2020). Patients' characteristics were collected at entry, including age, sex, obesity, smoking status, blood parameters, history of diabetes, cancer, cardiovascular and chronic pulmonary diseases, and medications in use. Read More

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Hypertension is associated with a variant in the gene in populations of Ouro Preto, Minas Gerais, Brazil: a cross-sectional study.

Int J Mol Epidemiol Genet 2021 15;12(3):40-51. Epub 2021 Jun 15.

Nucleus for Research in Biological Sciences, Federal University of Ouro Preto Ouro Preto, Brazil.

Background: Arterial hypertension (AH) is implicated in vascular health and contributes significantly to cardiovascular morbidity and mortality. In addition to the contribution of usual risk factors for AH, elucidating the influence of genetic factors is a promising area of investigation. Therefore, we evaluated the association between AH and cardiovascular risk factors (CVRFs) and genetic polymorphisms in communities in Southeast Brazil. Read More

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Overall Survival Analyses following Adjuvant Chemotherapy or Nonadjuvant Chemotherapy in Patients with Stage IB Non-Small-Cell Lung Cancer.

J Oncol 2021 17;2021:8052752. Epub 2021 Jul 17.

West China School of Nursing, Sichuan University, Chengdu 610041, Sichuan, China.

Background: Adjuvant chemotherapy (ACT) can improve prognosis for stages II-IIIA patients with non-small-cell lung cancer (NSCLC), but its implication in stage I patients is still an intractable puzzle. This study aims to seek ACT candidates for stage IB NSCLC and establish a nomogram to predict overall survival (OS) of specific patient for clinician's decision.

Method: We performed a retrospective study on 16,765 patients (ACT group:  = 2,187; non-ACT group:  = 14,578) from the Surveillance, Epidemiology, and End Results (SEER) database. Read More

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Chronic Obstructive Pulmonary Disease Patients Have Increased Levels of Plasma Inflammatory Mediators Reported Upregulated in Severe COVID-19.

Front Immunol 2021 15;12:678661. Epub 2021 Jul 15.

Institute for Immunological Research, University of Cartagena, Cartagena, Colombia.

Background: Chronic obstructive pulmonary disease (COPD) is associated with increased risk of severe COVID-19, but the mechanisms are unclear. Besides, patients with severe COVID-19 have been reported to have increased levels of several immune mediators.

Methods: Ninety-two proteins were quantified in 315 plasma samples from 118 asthmatics, 99 COPD patients and 98 healthy controls (age 40-90 years), who were recruited in Colombia before the COVID-19 pandemic. Read More

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Testing Moral Disengagement and Proteus Effect Predictions on Feelings of Guilt and Self-Empowerment Attributed to Bearing Guns.

Front Psychol 2021 16;12:695086. Epub 2021 Jul 16.

Department of Communication, University of California, Davis, Davis, CA, United States.

This study (179 participants, mean age 19. 98, 85% female) examined how violence justification via avatar role manipulations affected first-person shooter game players' subsequent feelings of guilt and self-empowerment attributed to bearing guns in the real-world. In support of the moral disengagement in violent video games model, an independent samples -test suggested that participants assigned to play as gang members shooting at police officers felt guiltier than those assigned to play as police officers shooting at gang members. Read More

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