60,376 results match your criteria inflammatory process

Alterations in the lipid profile associate with a dysregulated inflammatory, prothrombotic, anti-fibrinolytic state and development of severe acute kidney injury in coronavirus disease 2019 (COVID-19): A study from Cincinnati, USA.

Diabetes Metab Syndr 2021 Apr 14;15(3):863-868. Epub 2021 Apr 14.

Section of Clinical Biochemistry, University of Verona, Verona, Italy.

Background And Aims: Reduction of atherogenic lipoproteins is often the ultimate goal of nutritional interventions, however this is complicated given that hypolipidemia is frequently observed in coronavirus disease 2019 (COVID-19) patients. We aimed to explore the association of hypolipidemia with patient outcomes in terms of immunothrombosis and multiorgan injury, focusing on specialized apolipoproteins apo A1 and apo B.

Methods: Lipid profiles of 50 COVID-19 patients and 30 sick controls presenting to the Emergency Department (ED) were measured in this prospective observational study. Read More

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2-Undecanone Protects against Fine Particle-Induced Kidney Inflammation via Inducing Mitophagy.

J Agric Food Chem 2021 Apr 20. Epub 2021 Apr 20.

Department of Food Nutrition and Safety, Dalian Medical University, No. 9W. Lushun South Road, Dalian 116044, China.

Exposure to particulate matter has been associated with diseases of the respiratory and cardiovascular systems. Owing to the dense vasculature of the kidney, it has also been identified as a PM target organ. A potential contributor to PM-mediated damage may be the promotion of inflammation. Read More

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Melatonin Receptor Agonist Ramelteon Suppresses LPS-Induced Neuroinflammation in Astrocytes.

ACS Chem Neurosci 2021 Apr 20. Epub 2021 Apr 20.

Department of Neurology, Chengdu Tianfu New District People's Hospital, Chengdu, Sichuan 610213, China.

Astrocytes-mediated neuroinflammation has been involved in the process of several neurodegenerative diseases. Ramelteon is a novel agonist of melatonin receptors and licensed for the management of insomnia. In this study, our results demonstrate that Ramelteon ameliorated lipopolysaccharide (LPS)-induced inflammatory responses in astrocytes. Read More

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Prediction of potential therapeutic drugs against SARS-CoV-2 by using Connectivity Map based on transcriptome data.

Eur Rev Med Pharmacol Sci 2021 Apr;25(7):3122-3131

Department of Respiration, the First Hospital of Jiaxing and Affiliated Hospital of Jiaxing University, Jiaxing, China.

Objective: Transcriptome data related to severe acute respiratory syndrome-related coronavirus 2 (a novel coronavirus discovered in 2019, SARS-CoV-2) in GEO database were downloaded. Based on the data, influence of SARS-CoV-2 on human cells was analyzed and potential therapeutic compounds against the SARS-CoV-2 were screened.

Materials And Methods: R package "DESeq2" was used for differential gene analysis on the data of cells infected or non-infected with SARS-CoV-2. Read More

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Xanthogranulomatous pyelonephritis in a pediatric patient.

J Bras Nefrol 2021 Apr 19. Epub 2021 Apr 19.

Universidade Federal do Triângulo Mineiro, Hospital de Clínicas, Pediatria, Uberaba, MG, Brasil.

Introduction: Xanthogranulomatous pyelonephritis consists of a chronic infectious and inflammatory process of the renal parenchyma, a variant of chronic obstructive pyelonephritis. It is more prevalent in middle-aged adults, rare in pediatric patients, with less than 300 cases reported in children worldwide.

Report: Preschooler, aged 2 years and 11 months, male, with 2 months of abdominal distention, increased temperature and intense pallor, associated with microcytic anemia refractory to the use of ferrous sulfate. Read More

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Blood tryptase and thymic stromal lymphopoietin levels predict the risk of exacerbation in severe asthma.

Sci Rep 2021 Apr 19;11(1):8425. Epub 2021 Apr 19.

Department of Chest Medicine, Taipei Veterans General Hospital, No. 201, Sec. 2, Shih-Pai Road, Taipei, 112, Taiwan, ROC.

Some patients with severe asthma experience exacerbations despite receiving multiple therapy. The risk of exacerbation and heterogeneous response to treatment may be associated with specific inflammatory molecules that are responsive or resistant to corticosteroids. We aimed to identify the independent factors predictive for the future risk of exacerbation in patients with severe asthma. Read More

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Role of p53-miRNAs circuitry in immune surveillance and cancer development: A potential avenue for therapeutic intervention.

Semin Cell Dev Biol 2021 Apr 16. Epub 2021 Apr 16.

Molecular Cancer Genetics & Translational Research Lab, Section of Genetics, Department of Zoology, Aligarh Muslim University, Aligarh 202002, India. Electronic address:

The genome's guardian, p53, is a master regulatory transcription factor that occupies sequence-specific response elements in many genes and modulates their expression. The target genes transcribe both coding RNA and non-coding RNA involved in regulating several biological processes such as cell division, differentiation, and cell death. Besides, p53 also regulates tumor immunology via regulating the molecules related to the immune response either directly or via regulating other molecules, including microRNAs (miRNAs). Read More

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Compared with the monocyte to high-density lipoprotein ratio (MHR) and the neutrophil to lymphocyte ratio (NLR), the neutrophil to high-density lipoprotein ratio (NHR) is more valuable for assessing the inflammatory process in Parkinson's disease.

Lipids Health Dis 2021 Apr 19;20(1):35. Epub 2021 Apr 19.

Qinghai Provincial People's Hospital, Xining, China.

Background: The inflammatory response plays essential roles in the pathological process and prognosis of Parkinson's disease (PD). This research investigated the predictive value of the neutrophil to high-density lipoprotein ratio (NHR), neutrophil to lymphocyte ratio (NLR), and monocyte to high-density lipoprotein ratio (MHR) for PD.

Methods: Patients with PD (n = 98) were divided into three groups according to disease duration: < 6 years (n = 55), 6-10 years (n = 29) and > 10 years (n = 14). Read More

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[Medical Rehabilitation for Inflammatory Bowel Disease: Access, Process, and Results - Further Analyses of a Randomised Controlled Trial].

Rehabilitation (Stuttg) 2021 Apr 19. Epub 2021 Apr 19.

Institut für Sozialmedizin und Epidemiologie der Universität zu Lübeck.

Background: MERCED is a pragmatic randomised health care trial on the effectiveness and benefit of medical rehab in socially insured employees with chronic inflammatory bowel disease. After on average 8 months post rehab the intervention group showed, compared to continued routine care, a moderate but clinically relevant additional benefit in indicators of social participation, clinical and psychological status. However, no differences were observed for employment status, days off work, and subjective vocational prognosis. Read More

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The role of carbohydrate antigen 125 in COVID-19.

Esra Dökümcü

Med Hypotheses 2021 Mar 29;151:110590. Epub 2021 Mar 29.

Medical Biochemistry Laboratory, Edirne Public Health Institution, Turkey. Electronic address:

Coronavirus disease 2019 (COVID-19) is an inflammatory process with complex pathophysiology and by affecting the cardiovascular system directly or indirectly that causes life threatening cardiac injuries. Therefore, clarifying the effects of this infection on the cardiovascular system is of importance in terms of the clinical course of the disease. The increases in cardiac and inflammatory biomarkers in COVID-19 have been associated with poor prognosis and mortality. Read More

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FGF21 alleviates chronic inflammatory injury in the aging process through modulating polarization of macrophages.

Int Immunopharmacol 2021 Apr 16;96:107634. Epub 2021 Apr 16.

Northeast Agricultural University, Harbin, China. Electronic address:

Previous studies reported that FGF21 prolongs life span and delays the body senescence, but the mechanism is not clear. The present study was designed to investigate the effects of FGF21 on hepatic senescence in aging mice and further research the mechanism. The 14-month-old male mice were administered with PBS, FGF21 or metformin once daily for 6 months. Read More

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A Multi-Herb-Combined Remedy to Overcome Hyper-Inflammatory Response by Reprogramming Transcription Factor Profile and Shaping Monocyte Subsets.

Pharmacol Res 2021 Apr 16:105617. Epub 2021 Apr 16.

Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Dongcheng District, Beijing 100700, China. Electronic address:

Traditional Chinese multi-herb-combined prescriptions usually show better performance than a single agent since a group of effective compounds interfere multiple disease-relevant targets simultaneously. Huang-Lian-Jie-Du decoction is a remedy made of four herbs that are widely used to treat oral ulcers, gingivitis, and periodontitis. However, the active ingredients and underlying mechanisms are not clear. Read More

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Genetic ablation of Nrf2 exacerbates neurotoxic effects of acrylamide in mice.

Toxicology 2021 Apr 16:152785. Epub 2021 Apr 16.

Department of Occupational and Environmental Health, Tokyo University of Science, Noda, Japan. Electronic address:

Acrylamide (ACR), a recognized neurotoxicant in humans and experimental animals, is widely used in industry and in food generated through Maillard reaction. Nuclear factor erythroid 2-related factor 2 (Nrf2) is a master regulator of the cellular defense system and activates antioxidants and cytoprotective genes. The exact roles of Nrf2 in environmental electrophile-induced neurotoxicity is poorly understood. Read More

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Vascular Malformation and CAP Polyposis: A New Insight into Pathophysiology or Fortuitous Association?

Fetal Pediatr Pathol 2021 Apr 19:1-6. Epub 2021 Apr 19.

Department of Pathology and Immunology, Barnes-Jewish Hospital/St. Louis Children's Hospital, Washington University in St. Louis, School of Medicine, St. Louis, MO, USA.

Introduction: CAP polyposis is a benign colorectal process presenting with multiple colorectal polyps with a "CAP" of inflammatory granulation tissue whose etiology has remained largely unknown.

Case: A 24-year-old male presented with a long-standing history of repeated multiple sessile colonic polyps over a period of 17 years.

Results: The numerous polyps showed consistent histologic features of superficial erosion with a surface "CAP" of granulation tissue with minimal submucosa to evaluate over this period. Read More

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Fecal microbiota profile in patients with inflammatory bowel disease in Taiwan.

J Chin Med Assoc 2021 Apr 12. Epub 2021 Apr 12.

Division of Gastroenterology and Hepatology Endoscopic Center for Diagnosis and Therapy, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, ROC Keelung Hospital, Ministry of Health Welfare, Keelung, Taiwan, ROC National Yang Ming Chiao Tung University, School of Medicine Institute of Biomedical Informatics, Taipei, Taiwan, ROC.

Background: Inflammatory bowel disease (IBD) is a chronic inflammatory disease associated with complicated interaction between immune, gut microbiota, and environmental factors in a genetically vulnerable host. Dysbiosis is often seen in patients with IBD. We aimed to investigate the fecal microbiota in patients with IBD and compared them to a control group in Taiwan. Read More

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Adherence to Healthy Lifestyle Improved Clinical Outcomes in Coronary Artery Disease Patients After Coronary Intervention.

J Chin Med Assoc 2021 Apr 13. Epub 2021 Apr 13.

Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital Taoyuan Branch, Taiwan, ROC Health Care and Management Center, Taipei Veterans General Hospital, Taipei, Taiwan, ROC Cardiovascular Research Center, National Yang Ming Chiao Tung University, Taipei, Taiwan, ROC Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, ROC Division of Cardiology, Heart Center, Cheng-Hsin General Hospital, and School of Medicine, National Yang-Ming University, Taipei, Taiwan, ROC Department of Medical Imaging and Radiological Sciences, I-Shou University and Division of Cardiology, Department of Internal Medicine, E-Da Hospital, Kaohsiung, Taiwan, ROC Cardiology Division of Cardiovascular Medical Center and Department of Nuclear Medicine, Far Eastern Memorial Hospital, New Taipei City, Taiwan, ROC Division of Cardiology, Department of Internal Medicine, Kaohsiung Medical University Hospital and Kaohsiung Medical University, Kaohsiung, Taiwan, ROC Mackay Memorial Hospital, Mackay Medical College, New Taipei City, Taiwan, ROC Division of Cardiology, Department of Internal Medicine, China Medical University Hospital, and Graduate Institute of Clinical Medical Science, China Medical University, Taichung, Taiwan, ROC Department of Cardiology, Buddhist Tzu-Chi General Hospital, Tzu-Chi University, Hualien, Taiwan, ROC Division of Cardiology, Department of Internal Medicine, National Taiwan University College of Medicine and Hospital, Taipei, Taiwan, ROC Division of Cardiology, Department of Internal Medicine, National Taiwan University College of Medicine and Hospital, Taipei, Taiwan; Department of Primary Care Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan, ROC Institute of Pharmacology, National Yang-Ming Chiao Tung University, Taipei, Taiwan, ROC Institute of Clinical Medicine and Cardiovascular Research Center, National Yang Ming Chiao Tung University, Taipei, Taiwan, ROC.

Background: Lifestyle modification is suggested for patients with coronary artery disease (CAD), but the impact of adherence to a healthy lifestyle remains undetermined. The aim of this study is to investigate the association of adherence to a healthy lifestyle with future outcomes and biochemical markers in CAD patients.

Methods: The Biosignature CAD study examined 716 CAD patients who underwent a percutaneous coronary intervention (PCI). Read More

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Clinical application of heparin in the treatment of severe acute pancreatitis -- new discovery of the HMGB1 pathway.

Immunology 2021 Apr 19. Epub 2021 Apr 19.

Southeast University, Medical School, Nanjing, China.

Severe acute pancreatitis is a clinically lethal disease of digestive system. However, due to its complex pathophysiological mechanism, there are still no effective intervention measures and drugs. Recent studies have shown that heparin has previously unknown value in the anti-inflammatory process of sepsis. Read More

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Sleep deficit in COVID-19 health-care workers may increase the infection risk.

Scand J Public Health 2021 Apr 19:14034948211007679. Epub 2021 Apr 19.

Departamento de Psicobiologia, Universidade Federal de São Paulo (UNIFESP), Brazil.

The COVID-19 pandemic has had negative effects on health-care workers. The rapid growth of the disease has led to overwhelmed health-care systems, overcrowded hospitals, an insufficient number of health-care professionals and shortages of medical equipment. The potential exposure of front-line health-care workers during the COVID-19 outbreak has led to self-isolation and the appearance of adverse feelings such as stress, anxiety and fear. Read More

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Small molecule natural compound targets the NF-κB signaling and ameliorates the development of osteoarthritis.

J Cell Physiol 2021 Apr 19. Epub 2021 Apr 19.

Department of Orthopaedics, The Second Affiliated Hospital of Jiaxing University, Jiaxing, Zhejiang, China.

Osteoarthritis (OA) is a multifactorial and chronic disease describing the destruction of cartilage that can lead to defects in the elderly. There is currently no practical strategy that can reverse the OA process. Here, we describe nepetin, a small natural compound with extracellular matrix (ECM) and inflammation regulating functions. Read More

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In Vivo Anti-inflammatory, Analgesic, and Sedative Studies of the Extract and Naphthoquinone Isolated from (Persimmon).

ACS Omega 2021 Apr 1;6(14):9852-9856. Epub 2021 Apr 1.

Department of Chemistry University of Swabi, Swabi, Anbar 23430, KPK, Pakistan.

Anti-inflammatory, analgesic, and sedative medicine is used with numerous side effects, including peptic ulcer, headache, addiction, and other complications. In this regard, discovery research is undergoing a process to discover effective, safe, and economical drugs with no side effects. The aim of this study was to assess chloroform extracts and isolated compounds for anti-inflammatory, analgesic, and sedative activities in animal models. Read More

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Innate Lymphoid Cells as Regulators of Epithelial Integrity: Therapeutic Implications for Inflammatory Bowel Diseases.

Front Med (Lausanne) 2021 30;8:656745. Epub 2021 Mar 30.

Department of Medicine 1, University Hospital of Erlangen, Erlangen, Germany.

The occurrence of epithelial defects in the gut relevantly contributes to the pathogenesis of inflammatory bowel diseases (IBD), whereby the impairment of intestinal epithelial barrier integrity seems to represent a primary trigger as well as a disease amplifying consequence of the chronic inflammatory process. Besides epithelial cell intrinsic factors, accumulated and overwhelmingly activated immune cells and their secretome have been identified as critical modulators of the pathologically altered intestinal epithelial cell (IEC) function in IBD. In this context, over the last 10 years increasing levels of attention have been paid to the group of innate lymphoid cells (ILCs). Read More

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Novel Immune Subsets and Related Cytokines: Emerging Players in the Progression of Liver Fibrosis.

Front Med (Lausanne) 2021 1;8:604894. Epub 2021 Apr 1.

Department of Hepatology, The First Hospital of Jilin University, Jilin University, Changchun, China.

Liver fibrosis is a pathological process caused by persistent chronic injury of the liver. Kupffer cells, natural killer (NK) cells, NKT cells, and dendritic cells (DCs), which are in close contact with T and B cells, serve to bridge innate and adaptive immunity in the liver. Meanwhile, an imbalanced inflammatory response constitutes a challenge in liver disease. Read More

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Krüppel-Like Factor 15 Modulates Signaling-Mediated Inflammatory Response Contributing to Angiotensin II-Induced Cardiac Remodeling.

Front Cell Dev Biol 2021 1;9:644954. Epub 2021 Apr 1.

Department of Cardiovascular Medicine, Ruijin Hospital and State Key Laboratory of Medical Genomics, Shanghai Key Laboratory of Hypertension, Shanghai Institute of Hypertension, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Inflammation is involved in cardiac remodeling. In response to pathological stimuli, activated cardiac fibroblasts (CFs) secreting inflammatory cytokines and chemokines play an important role in monocyte/macrophage recruitment. However, the precise mechanism of CF-mediated inflammatory response in hypertension-induced cardiac remodeling remains unclear. Read More

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Paraneoplastic ganglioradiculoneuritis in a cat with a plasma cell tumour.

JFMS Open Rep 2021 Jan-Jun;7(1):20551169211003806. Epub 2021 Mar 31.

Southfields Veterinary Specialists, Laindon, UK.

Case Summary: An 8-year-old neutered female domestic longhair cat was presented for investigation of a 48 h history of lethargy and pelvic limb ataxia. MRI of the spinal cord and vertebral column (C1 to sacrum) and brain was unremarkable. Lumbar cerebrospinal fluid analysis revealed pleocytosis and increased protein concentration. Read More

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De novo adenocarcinoma of the lacrimal gland: Case report.

Ann Med Surg (Lond) 2021 Apr 25;64:102234. Epub 2021 Mar 25.

Faculty of Medicine and Pharmacy, Hassan II University of Casablanca, B.P 5696, Casablanca, Morocco.

Adenocarcinoma of the lacrimal gland is an epithelial malignancy with an incidence according to the literature of 5-7%. It is clinically revealed by an upper palpebral mass often associated with an inflammatory exophthalmos. It is a high-grade malignancy and there are no pathognomonic clinical or radiological signs. Read More

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Inhibition of resistant triple-negative breast cancer cells with low-dose 6-mercaptopurine and 5-azacitidine.

Oncotarget 2021 Mar 30;12(7):626-637. Epub 2021 Mar 30.

Department of Breast Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

Highly adaptable breast cancer cells that can opportunistically switch between proliferation and quiescence are often responsible for disease relapse. We have developed a function-based selection strategy for such resistant cells, exemplified by SUM149-MA and FC-IBC02-MA triple-negative breast cancer cells. We have also reported that a lengthy treatment with low-dose 6-mercaptopurine, a clinically useful anti-inflammatory drug, inhibits such resistant cells. Read More

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Pseudotumor Cerebri Syndrome Complicated by Diffuse Ophthalmoparesis and Polyradiculopathy.

Neurohospitalist 2021 Jan 3;11(1):71-74. Epub 2020 Aug 3.

University of Pennsylvania, Philadelphia, PA, USA.

Pseudotumor cerebri syndrome (PTCS), also known as idiopathic intracranial hypertension (IIH), is defined by elevated intracranial pressure in the absence of a structural or cerebrospinal fluid (CSF) abnormality. Typical features include headache, visual symptoms, and pulsatile tinnitus. Cranial nerve deficits are seen in a minority of cases, most often sixth nerve palsies. Read More

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January 2021

The Gene Signature Associated with Hepatocellular Carcinoma in Patients with Nonalcoholic Fatty Liver Disease.

J Oncol 2021 2;2021:6630535. Epub 2021 Apr 2.

Department of Hepatobiliary Surgery, Fujian Provincial Hospital, The Shengli Clinical Medical College of Fujian Medical University, Fuzhou (350001), Fujian, China.

Background: Nonalcoholic fatty liver disease (NAFLD) is becoming a critical risk of hepatocellular carcinoma (HCC). As both NAFLD and HCC are heterogeneous diseases, this study aims to identify the similarity between the subtypes of NAFLD and HCC based on gene modules.

Methods: Coexpressed gene modules were extracted for both NAFLD and HCC. Read More

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Cells of the Immune System in Cardiac Remodeling: Main Players in Resolution of Inflammation and Repair After Myocardial Infarction.

Front Immunol 2021 2;12:664457. Epub 2021 Apr 2.

Department of Emergency Cardiology, Cardiology Research Institute, Tomsk National Research Medical Centre, Russian Academy of Sciences, Tomsk, Russia.

The burden of heart failure (HF), developing after myocardial infarction MI, still represents a major issue in clinical practice. Failure of appropriate resolution of inflammation during post-myocardial injury is associated with unsuccessful left ventricular remodeling and underlies HF pathogenesis. Cells of the immune system have been shown to mediate both protective and damaging effects in heart remodeling. Read More

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MicroLet-7b Regulates Neutrophil Function and Dampens Neutrophilic Inflammation by Suppressing the Canonical TLR4/NF-κB Pathway.

Front Immunol 2021 29;12:653344. Epub 2021 Mar 29.

Department of Blood Transfusion, Huashan Hospital, Fudan University, Shanghai, China.

Sepsis is a heterogeneous syndrome caused by a dysregulated host response during the process of infection. Neutrophils are involved in the development of sepsis due to their essential role in host defense. COVID-19 is a viral sepsis. Read More

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