62,734 results match your criteria inflammatory pain


Is 10/12 Fr Ureteral Access Sheath more Suitable for Flexible Ureteroscopic Lithotripsy?

Urol J 2021 Aug 4. Epub 2021 Aug 4.

Department of Urology, the Ninth People's Hospital Affiliated to Shanghai Jiao Tong University, Shanghai 200011, China.

Purpose: To choose the ideal UAS size for an unstented ureter in flexible ureteroscopic lithotripsy.

Materials And Methods: A retrospective case-control study was conducted with patients treated with flexible ureteroscopic lithotripsy for renal calculi from 2005 to 2020. The patients were divided into two groups: smaller (10/12 Fr) vs. Read More

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Recurrent myocarditis in the context of Behçet's disease: a case report.

Eur Heart J Case Rep 2021 Jul 30;5(7):ytab212. Epub 2021 Jul 30.

Department of Cardiology, Hospital Distrital de Santarém, Av. Bernardo Santareno, 2005-177 Santarém, Portugal.

Background: Behçet's syndrome is a multisystemic vasculitis of unknown aetiology. Cardiac involvement is rare, with described prevalence between 1% and 46%, with pericarditis, valvular insufficiency, intracardiac thrombosis, and eventually sinus of Valsalva aneurysms being the most common findings. Although previously reported, myocarditis is a very rare complication of Behçet's syndrome. Read More

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Takotsubo Cardiomyopathy as a Manifestation of Dysautonomia in Guillain-Barré Syndrome: A Case Series and Review of the Literature.

Cureus 2021 Jun 30;13(6):e16069. Epub 2021 Jun 30.

Neurology, University of Miami, Miami, USA.

Guillain-Barré syndrome (GBS) is an inflammatory polyneuropathy that classically presents with low back pain, sensory paresthesias, and rapidly progressive weakness. Patients with GBS can develop dysautonomia, and Takotsubo cardiomyopathy (TCM) is a rare potential manifestation of this dysautonomia. This association has been reported only 12 times in the literature so far, which we review here. Read More

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Management of lumbar disc herniation with radiculopathy: Results of an Iberian-Latin American survey.

Surg Neurol Int 2021 19;12:363. Epub 2021 Jul 19.

Department of Orthopedics, Clinica Alemana, Santiago, Chile.

Background: Lumbar disc herniation (LDH)/radiculopathy is the most frequent cause of lost workdays in people under 50 years of age. Although there is consensus about how to assess these patients, the optimal management strategy is still debated.

Methods: An online survey was sent to spine surgeons who are members of the Iberian-Latin American Spine Society to assess how they treat LDH with radiculopathy. Read More

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To cut or not to cut? A case report on pediatric intervertebral disc calcification.

Surg Neurol Int 2021 28;12:307. Epub 2021 Jun 28.

Department of Neurosurgery, Drexel University College of Medicine, Philadelphia, Pennsylvania, United States.

Background: Intervertebral disc calcification (IVDC) is a rare cause of acute spinal pain in pediatric patients. The most common symptom is back or neck pain, but muscle spasm, muscle weakness, and sensory loss also occur. Many patients have an alarming presentation and radiological findings concerning for spinal cord compression. Read More

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Molecular mechanisms of opioid tolerance: From opioid receptors to inflammatory mediators (Review).

Exp Ther Med 2021 Sep 15;22(3):1004. Epub 2021 Jul 15.

Key Laboratory of Acupuncture and Neurology of Zhejiang Province, Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, P.R. China.

Opioids are considered the most effective analgesics for the treatment of both acute and chronic pain. However, prolonged opioid use can induce a certain level of tolerance to its analgesic effects, leading to a reduction in its effectiveness, addiction and abuse. A better understanding of the mechanisms underlying opioid tolerance may provide insights into this phenomenon and aid in the development of novel methods to combat the side effects of opioid tolerance. Read More

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September 2021

Chronic recurrent multifocal osteomyelitis in a 3.5-year-old boy.

J Res Med Sci 2021 27;26:32. Epub 2021 May 27.

Bone Joint and Related Tissues Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

We report an extremely rare case of multifocal bone disorder in a 3.5-year-old boy who appeared for left forearm and arm pain and multiple periods of fever with an unusual presentation of lymphoma/leukemia and highlight diagnostic challenges leading to a misdiagnosis, which was then diagnosed and treated for chronic recurrent multifocal osteomyelitis (CRMO). Based on a left arm biopsy and whole-body scans, he was eventually diagnosed with CRMO. Read More

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Molecular hydrogen is comparable to sulfasalazine as a treatment for DSS-induced colitis in mice.

EXCLI J 2021 29;20:1106-1117. Epub 2021 Jun 29.

Centre of Experimental Medicine, Institute for Heart Research, Slovak Academy of Sciences, Faculty of Natural Sciences of Comenius University, 841 04 Bratislava, Slovak Republic.

Colitis is an inflammatory condition of the bowels associated with abdominal pain, diarrhea, fatigue, and fever. Its etiology is multifactorial but related to the overproduction of inflammatory and oxidative mediators. There is currently no cure for this disease, and drugs used to manage it often have deleterious side effects. Read More

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Macrophage migration inhibitory factor: a potential biomarker for chronic low back pain in patients with Modic changes.

RMD Open 2021 Aug;7(2)

Faculty of Medicine, University of Oslo, Oslo, Norway.

Background: Low back pain (LBP) is a leading cause of disability worldwide, but the aetiology remains poorly understood. Finding relevant biomarkers may lead to better understanding of disease mechanisms. Patients with vertebral endplate bone marrow lesions visualised on MRI as Modic changes (MCs) have been proposed as a distinct LBP phenotype, and inflammatory mediators may be involved in the development of MCs. Read More

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Supported online self-management versus care as usual for symptoms of fatigue, pain and urgency/incontinence in adults with inflammatory bowel disease (IBD-BOOST): study protocol for a randomised controlled trial.

Trials 2021 Aug 3;22(1):516. Epub 2021 Aug 3.

Psychology Department, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.

Background: Despite being in clinical remission, many people with inflammatory bowel disease (IBD) live with fatigue, chronic abdominal pain and bowel urgency or incontinence that limit their quality of life. We aim to test the effectiveness of an online self-management programme (BOOST), developed using cognitive behavioural principles and a theoretically informed logic model, and delivered with facilitator support.

Primary Research Question: In people with IBD who report symptoms of fatigue, pain or urgency and express a desire for intervention, does a facilitator-supported tailored (to patient needs) online self-management programme for fatigue, pain and faecal urgency/incontinence improve IBD-related quality of life (measured using the UK-IBDQ) and global rating of symptom relief (0-10 scale) compared with care as usual?

Methods: A pragmatic two-arm, parallel group randomised controlled trial (RCT), of a 12-session facilitator-supported online cognitive behavioural self-management programme versus care as usual to manage symptoms of fatigue, pain and faecal urgency/incontinence in IBD. Read More

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A randomized controlled pilot study of Yoga Skills Training versus an attention control delivered during chemotherapy administration.

J Pain Symptom Manage 2021 Jul 31. Epub 2021 Jul 31.

Wake Forest School of Medicine, Winston-Salem, NC, USA.

Context: It is important to address fatigue and co-occurring symptoms during chemotherapy topreserve quality of life in patients with gastrointestinal (GI) cancer.

Objective: To conduct a randomized controlled pilot study of a Yoga Skills Training (YST) intervention compared to an attention control (AC) among adults diagnosed with GI cancer.

Methods: YST consisted of four 30-minute sessions delivered individually during chemotherapy plus home practice. Read More

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Multisystem inflammatory syndrome in children during severe acute respiratory syndrome coronavirus-2 pandemic in Turkey: A single-centre experience.

J Paediatr Child Health 2021 Aug 3. Epub 2021 Aug 3.

Department of Pediatric Infectious Disease, SBU Ankara Dr. Sami Ulus Maternity Child Health and Diseases Training and Research Hospital, Ankara, Turkey.

Aim: Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection may result in a life-threatening hyperinflammatory condition named multisystem inflammatory syndrome in children (MIS-C). We aimed to assess demographics, clinical presentations, laboratory characteristics and treatment outcomes of patients with MIS-C.

Methods: We performed a retrospective study of patients with MIS-C managed between August 2020 and March 2021 at Dr. Read More

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Dissection of Two Intracellular Pathways Involved in the Spinal Oxytocin-Induced Antinociception in the Rat.

ACS Chem Neurosci 2021 Aug 3. Epub 2021 Aug 3.

Departamento de Neurobiología del Desarrollo y Neurofisiología, Instituto de Neurobiología, Universidad Nacional Autónoma de México, Campus UNAM Juriquilla, Querétaro, QRO 76230, México.

Behavioral and electrophysiological data show that at the spinal level, oxytocin inhibits pain transmission by activation of oxytocin receptors (OTRs). Canonically, OTRs are coupled to G proteins, which induce a rise of intracellular Ca by activating the phospholipase C (PLC). However, data showed that OTRs cause a plethora of intracellular events, some related to the activation of G proteins. Read More

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Subclinical TRAPS treated with canakinumab.

Reumatismo 2021 Aug 3;73(2):131-134. Epub 2021 Aug 3.

Pediatric Nephrology and Rheumatology Unit with Dialysis, Department of Human Pathology in Adulthood and Childhood "G. Barresi"; AOU Policlinic "G. Martino", Messina University.

Tumor necrosis factor receptor-associated periodic syndrome (TRAPS) is a rare autoinflammatory disease characterized by recurrent episodes of fever and systemic inflammation. We describe the case of a 19-year-old patient who was referred to our attention with frequent subclinical TRAPS episodes characterized by mild arthralgias and crampy abdominal pain, without fever. Inflammatory markers, including serum amyloid A which increases the risk of long-term amyloidosis, were persistently high also when the patient was in good general conditions. Read More

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Epidemiology, diagnosis and management of Baastrup's diseases: a systematic review.

J Neurosurg Sci 2021 Aug 3. Epub 2021 Aug 3.

Department of Aging, Neurological, Orthopaedic and Head-Neck Sciences, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.

Introduction: Baastrup disease (BD) is a common cause of low back pain which is often underdiagnosed. It is characterized by adjacent interspinous processes contact and it can be associated with cystic lesions. The aim of this review is to evaluate the epidemiology, diagnosis, and treatment options of patients with BD. Read More

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Effects of inflammatory prostatitis on the development and progression of benign prostatic hyperplasia: A literature review.

Int J Urol 2021 Aug 2. Epub 2021 Aug 2.

Department of Urology, Faculty of Medicine, Kagawa University, Takamatsu, Kagawa, Japan.

Benign prostatic hyperplasia is a major disease that affects the quality of life of middle-aged and older men. Although >70% of men aged >70 years have pathological benign prostatic hyperplasia, its pathogenesis and progression remain unclear. In this article, we reviewed the scientific literature on this condition and examined the development of lower urinary tract symptoms. Read More

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Neonatal Anoxia Increases Nociceptive Response in Rats: Sex Differences and Lumbar Spinal Cord and Insula Alterations.

Int J Dev Neurosci 2021 Aug 3. Epub 2021 Aug 3.

Laboratory of Functional Neuroanatomy of Pain, Departamento de Anatomia, Instituto de Ciências Biomédicas, Universidade de Sao Paulo, São Paulo, SP, Brazil.

Neonatal anoxia is a well-known world health problem which results in neurodevelopmental deficits, such as sensory alterations that are observed in patients with cerebral palsy and autism disorder, for which oxygen deprivation is a risk factor. Nociceptive response, as part of the sensory system, has been reported as altered in these patients. To determine whether neonatal oxygen deprivation alters nociceptive sensitivity and promotes medium- and long-term inflammatory feedback in the central nervous system, Wistar rats of around 30 h old were submitted to anoxia (100% nitrogen flux for 25 min) and evaluated on PND23 (postpartum day) and PND90. Read More

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Chronic fatigue syndrome: an emerging sequela in COVID-19 survivors?

J Neurovirol 2021 Aug 2. Epub 2021 Aug 2.

Department of Neurosciences, Biomedicine and Movement Sciences, Neurology Section, University of Verona, Verona, Italy.

SARS-CoV-2 survivors may report persistent symptoms that resemble myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). We explored (a) ME/CFS-like symptom prevalence and (b) whether axonal, inflammatory, and/or lung changes may contribute to ME/CFS-like symptoms in SARS-CoV-2 survivors through clinical, neuropsychiatric, neuropsychological, lung function assessment, and serum neurofilament light chain, an axonal damage biomarker. ME/CFS-like features were found in 27% of our sample. Read More

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Crohn's Disease with Cutaneous Polyarteritis Nodosa in a Child: A Case Report.

Ann Dermatol 2021 Aug 1;33(4):365-368. Epub 2021 Jul 1.

Department of Dermatology, Hallym University Sacred Heart Hospital, Anyang, Korea.

A 10-year-old boy presented with a 1-day history of multiple painful erythematous skin lesions on his upper and lower extremities. He was admitted to the Department of Pediatrics with persistent right lower abdominal pain and diarrhea. Punch biopsy of a skin lesion on his lower leg showed necrotizing granulomatous vasculitis with septal panniculitis consistent with polyarteritis nodosa, and our differential diagnosis included cutaneous manifestations of Croh's disease. Read More

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Obstipation in pet pigs: 24 cases.

Can Vet J 2021 Aug;62(8):843-848

University of Florida College of Veterinary Medicine, Gainesville, Florida, USA (Hobbs, DeNotta, Gallastegui, Elane); University of Missouri College of Veterinary Medicine, Columbia, Missouri, USA (Rivero, Adkins); Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada (Gomez).

Clinical features and patient outcomes for pet pigs with obstipation are poorly defined. This retrospective study reports the clinical findings from 24 pet (non-production) pigs with obstipation presented to 2 veterinary teaching hospitals. Clinical features of obstipated pet pigs included anorexia or hyporexia in 24 pigs (100%), pain on abdominal palpation in 22 (90%), lethargy in 21 (88%), tachypnea in 19 (79%), vomiting in 14 (58%), and tachycardia in 13 (54%). Read More

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Predictive values for different cancers and inflammatory bowel disease of 6 common abdominal symptoms among more than 1.9 million primary care patients in the UK: A cohort study.

PLoS Med 2021 Aug 2;18(8):e1003708. Epub 2021 Aug 2.

Epidemiology of Cancer Healthcare and Outcomes (ECHO) Research Group, Department of Behavioural Science and Health, University College London, London, United Kingdom.

Background: The diagnostic assessment of abdominal symptoms in primary care presents a challenge. Evidence is needed about the positive predictive values (PPVs) of abdominal symptoms for different cancers and inflammatory bowel disease (IBD).

Methods And Findings: Using data from The Health Improvement Network (THIN) in the United Kingdom (2000-2017), we estimated the PPVs for diagnosis of (i) cancer (overall and for different cancer sites); (ii) IBD; and (iii) either cancer or IBD in the year post-consultation with each of 6 abdominal symptoms: dysphagia (n = 86,193 patients), abdominal bloating/distension (n = 100,856), change in bowel habit (n = 106,715), rectal bleeding (n = 235,094), dyspepsia (n = 517,326), and abdominal pain (n = 890,490). Read More

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Association of rs1800624 and rs1800625 gene polymorphisms with predisposition to optic neuritis and optic neuritis together with multiple sclerosis.

Ophthalmic Genet 2021 Aug 2:1-6. Epub 2021 Aug 2.

Medical Academy, Neuroscience Institute, Lithuanian University of Health Sciences, Kaunas, Lithuania.

Optic neuritis (ON) is demyelinating acute inflammatory disease which affects the optic nerve. ON is classified as a typical (demyelinating) or an atypical (idiopathic). Patients often complain having a periocular pain or a visual loss. Read More

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Pericarditis and pericardial effusion: one or two distinct diseases?

Minerva Cardiol Angiol 2021 Aug 2. Epub 2021 Aug 2.

First Cardiology Clinic, School of Medicine, Hippokration General Hospital, National and Kapodistrian University of Athens, Athens, Greece.

The main pericardial syndromes include acute and recurrent pericarditis, constrictive pericarditis and chronic pericardial effusion in the absence of overt inflammation. Despite recent advances in pericardial syndromes, certain clinical scenarios depict remarkable peculiarities and their management is often challenging for the clinician. Acute pericarditis is the most common pericardial disease and in most instances is accompanied by pericardial effusion. Read More

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Fragile X mental retardation protein-regulated proinflammatory cytokine expression in the spinal cord contributes to the pathogenesis of inflammatory pain induced by complete Freund's adjuvant.

J Neurochem 2021 Aug 2. Epub 2021 Aug 2.

Department of Pain Medicine, The First Affiliated Hospital, Zhejiang University School of Medicine.

Studies have verified that Fragile X mental retardation protein (FMRP), an RNA-binding protein, plays a potential role in the pathogenesis of formalin- and (RS)-3,5-dihydroxyphenylglycine (DHPG)-induced abnormal pain sensations. However, the role of FMRP in inflammatory pain has not been reported. Here, we showed an increase in FMRP expression in the spinal dorsal horn (SDH) in a rat model of inflammatory pain induced by complete Freund's adjuvant (CFA). Read More

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Design and synthesis of novel quinazolinones conjugated ibuprofen, indole acetamide, or thioacetohydrazide as selective COX-2 inhibitors: anti-inflammatory, analgesic and anticancer activities.

J Enzyme Inhib Med Chem 2021 Dec;36(1):1810-1828

Department of Medicinal Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt.

Novel quinazolinones conjugated with indole acetamide , ibuprofen ( or thioacetohydrazide ( and ) were designed to increase COX-2 selectivity. The three synthesised series exhibited superior COX-2 selectivity compared with the previously reported quinazolinones and their NSAID analogue and had equipotent COX-2 selectivity as celecoxib. Compared with celecoxib, , , and showed similar anti-inflammatory activity , while and showed superior inhibition of the inflammatory mediator nitric oxide, and showed greater antioxidant potential in macrophages cells. Read More

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December 2021

Role of multimodal anaesthetic in post-operative analgesic requirement for robotic assisted radical prostatectomy.

Urologia 2021 Aug 2:3915603211031869. Epub 2021 Aug 2.

Department of Anaesthesia and Critical care, New Cross Hospital, Wolverhampton, UK.

Purpose: Robotic assisted laparoscopic radical prostatectomy (RARP) is considered as standard of care for surgical management of localised prostate cancer. Procedure specific postoperative pain management (PROSPECT) guidelines are available for open radical prostatectomy. There is a lack of evidence for optimal pain management protocol in patients undergoing robotic radical prostatectomy. Read More

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Glucocorticoid Receptor Contributes to Electroacupuncture-Induced Analgesia by Inhibiting Nav1.7 Expression in Rats With Inflammatory Pain Induced by Complete Freund's Adjuvant.

Neuromodulation 2021 Aug 2. Epub 2021 Aug 2.

Department of Anesthesiology, General Hospital of Southern Theatre Command of PLA, Guangzhou, China.

Background: While electroacupuncture (EA) has been used traditionally for the treatment of chronic pain, its analgesic mechanisms have not been fully clarified. We observed in an earlier study that EA could reverse inflammatory pain and suppress high Nav1.7 expression. Read More

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Phytochemistry and Pharmacological Activities of Resin.

Biomed Res Int 2021 22;2021:8561696. Epub 2021 Jul 22.

Department of Biology, Faculty of Science, University of Tabuk, Tabuk, Saudi Arabia.

() is an endemic plant located in Socotra Island, Yemen. Deep red resin attained from different plant species including is commonly known as dragon's blood. In folk medicine, it is prescribed for the treatment of traumatic dermal, dental, and eye injuries as well as blood stasis, pain, and gastrointestinal diseases in humans. Read More

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Dorsal Root Ganglion (DRG) and Chronic Pain.

Anesth Pain Med 2021 Apr 28;11(2):e113020. Epub 2021 Mar 28.

Georgetown University School of Medicine, Washington, DC, USA.

Context: Chronic neuropathic pain is a common condition, and up to 11.9% of the population have been reported to suffer from uncontrolled neuropathic pain. Chronic pain leads to significant morbidity, lowered quality of life, and loss of workdays, and thus carries a significant price tag in healthcare costs and lost productivity. Read More

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Hereditary Chorea Associated With and Aggravated by Systemic Lupus Erythematosus.

Cureus 2021 Jun 28;13(6):e15992. Epub 2021 Jun 28.

Internal Medicine, Sandeman Provincial Hospital, Quetta, PAK.

Chorea is caused by a number of conditions, including genetic, metabolic derangements, infections, drugs, toxins, tumors, and disorders of the immune and inflammatory system of the body. Huntington's disease (HD) is the most common genetic cause of chorea. Systemic lupus erythematosus (SLE) is an autoimmune condition. Read More

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