82,978 results match your criteria inflammatory bowel


Topical Management of Peristomal Pyoderma Gangrenosum: A Report of 3 Case Studies.

J Wound Ostomy Continence Nurs 2021 May 3. Epub 2021 May 3.

Tomohiro Toyoda, MD, Department of Dermatology, Toho University Sakura Medical Center, Sakura, Japan. Shinji Mitsuyama, MD, PhD, Department of Dermatology, Toho University Sakura Medical Center, Sakura, Japan. Eri Nagao, MD, Department of Dermatology, Toho University Sakura Medical Center, Sakura, Japan. Fumihito Abe, MD, Department of Dermatology, Toho University Sakura Medical Center, Sakura, Japan. Masaaki Kimura, MD, Department of Dermatology, Toho University Sakura Medical Center, Sakura, Japan. Yurie Seido, RN, WOC Nurse, Department of Nursing Care, Toho University Sakura Medical Center, Sakura, Japan. Tetsuya Higuchi, MD, PhD, Department of Dermatology, Toho University Sakura Medical Center, Sakura, Japan.

Background: Peristomal pyoderma gangrenosum (PPG) presents multiple challenges for healthcare providers. The diagnosis of PPG may be delayed, and it may be mistaken for an irritant dermatitis or an infection. Patients with ostomies secondary to inflammatory bowel disease (IBD) may experience PPG. Read More

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Hand-Sewn Versus Stapled Ileal Pouch Anal Anastomoses in Re-Do Setting: Indications, Patient Characteristics, Operative, Functional and Quality of Life Outcomes.

Dis Colon Rectum 2021 Apr 26. Epub 2021 Apr 26.

Inflammatory Bowel Disease Center, NYU Langone Health, NYU Grossman School of Medicine, NY, NY, USA Department of Surgery, Acibadem Mehmet Ali Aydinlar School of Medicine, Istanbul, Turkey.

Background: Impact of the type of anastomosis on the outcomes of re-do ileal pouch anal anastomosis (IPAA) is unknown.

Objective: The aim of this study is to assess the indications, peri-operative and functional outcomes in patients undergoing stapled vs hand-sewn re-do IPAA.

Design: This is a retrospective cohort study. Read More

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Antibiotic treatment for small intestinal bacterial overgrowth: Is a cocktail better than a single?

Authors:
Uday C Ghoshal

United European Gastroenterol J 2021 May 5. Epub 2021 May 5.

Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Science, Lucknow, India.

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Ustekinumab is more effective than azathioprine to prevent endoscopic postoperative recurrence in Crohn's disease.

United European Gastroenterol J 2021 May 5. Epub 2021 May 5.

Department of Gastroenterology, University Hospital of Besançon, University Bourgogne FrancheComté, Besançon, France.

Background: Preventing postoperative recurrence (POR) is a major concern in Crohn's disease (CD). While azathioprine is an option, no data is available on ustekinumab efficacy in this situation.

Aims: We compared the effectiveness of ustekinumab versus azathioprine in preventing endoscopic POR in CD. Read More

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Azathioprine-induced toxoplasma gondii infection in a patient with Crohn's disease with NUDT15 variation: A case report.

Medicine (Baltimore) 2021 May;100(18):e25781

Department of Gastroenterology, The Second Xiangya Hospital.

Introduction: Azathioprine (AZA) has been widely used for the treatment of various immune-related diseases and has become a mainstay in the treatment of inflammatory bowel disease. However, patients with genetic mutations may experience severe adverse events when treated with azathioprine. Most of the previous literature focused on the TPMP gene-related adverse reactions, herein, we report a case of Crohn's disease patient with nucleoside diphosphate-linked moiety X motif 15 gene (NUDT15) variation and wild-type TPMP gene who developed toxoplasma gondii infection after azathioprine treatment. Read More

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Communicating multiple tubular enteric duplication with toxic megacolon in an infant: A case report.

Medicine (Baltimore) 2021 May;100(18):e25772

Department of Surgery, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, Korea.

Rationale: Gastrointestinal tract duplication is a rare congenial anomaly which can be found anywhere along the gastrointestinal tract. While many patients are incidentally diagnosed during operation, in some cases it can present with severe gastrointestinal symptoms. In this case report, the patient presented with signs of toxic megacolon leading to rapid aggravation of inflammatory shock. Read More

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JAK1 inhibition and inflammatory bowel disease.

Rheumatology (Oxford) 2021 May;60(Supplement_2):ii45-ii51

Department of Gastroenterology, University Hospital Southampton NHS Foundation Trust, Southampton, UK.

Primary non-response and secondary loss of response remain a significant issue with the currently available treatment options for a significant proportion of patients with inflammatory bowel disease (IBD). There are multiple unmet needs in the IBD treatment algorithm and new treatment options are required. As our understanding of the pathogenesis of IBD evolves, new therapeutic targets are being identified. Read More

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Association of TYK2 polymorphisms with autoimmune diseases: A comprehensive and updated systematic review with meta-analysis.

Genet Mol Biol 2021 3;44(2):e20200425. Epub 2021 May 3.

Hospital de Clínicas de Porto Alegre, Serviço de Endocrinologia, Porto Alegre, RS, Brazil.

Autoimmune diseases are characterized by the loss of self-tolerance, leading to immune-mediated tissue destruction and chronic inflammation. Tyrosine kinase 2 (TYK2) protein plays a key role in immunity and apoptosis pathways. Studies have reported associations between single nucleotide polymorphisms (SNPs) in the TYK2 gene and autoimmune diseases; however, results are still inconclusive. Read More

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Association Between Portal Vein Thrombosis and Pouchitis in Patients with Ulcerative Colitis.

Dig Dis Sci 2021 May 4. Epub 2021 May 4.

Center for Inflammatory Bowel Disease, Columbia University Irving Medical Center/New York Presbyterian Hospital, Herbert Irving Pavilion-Rm 843, 161 Fort Washington Ave, New York, NY, 10032, USA.

Background: Pouchitis is the most common long-term complication in patients requiring colectomy ileal pouch-anal anastomosis with medically refractory ulcerative colitis or colitis-associated neoplasia. A previous small case series suggests associated between portal vein thrombosis (PVT) and ischemic pouchitis.

Aim: To evaluate the association between PVT and other demographic and clinical factors and pouchitis. Read More

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Lip swelling with lymphangiectasia.

JAAD Case Rep 2021 May 26;11:93-95. Epub 2021 Mar 26.

Department of Dermatology, Tulane University, New Orleans, Louisiana.

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Pulmonary Manifestations of Inflammatory Bowel Disease.

Cureus 2021 Mar 31;13(3):e14216. Epub 2021 Mar 31.

Internal Medicine, Jinnah Postgraduate Medical Centre, Karachi, PAK.

The frequency of extraintestinal manifestations of inflammatory bowel disease (IBD) is observed in most of the patients. Extraintestinal manifestations of IBD have been implicated in all the anatomic sites of the pulmonary tree, and include airway inflammation of the bronchi and bronchioles and parenchymal inflammation. There is a wide range of pulmonary manifestations in IBD, and most of them look a lot like other diseases. Read More

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An unusual case of chronic abdominal pain: an association between Celiac disease and Crohn's disease.

Oxf Med Case Reports 2021 Apr 28;2021(4):omab008. Epub 2021 Apr 28.

Department of Pathology, Professor of pathology, Tishreen university hospital, Lattakia, Syria.

Inflammatory bowel diseases (IBD) and Celiac disease (CeD) are immune-mediated gastrointestinal diseases with incompletely understood etiology. Both diseases show a multifactorial origin with a complex interplay between genetic, environmental factors, and some components of the commensal microbiota. The coexistence of celiac disease with Crohn's disease is rarely reported in the literature. Read More

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Relevance of monitoring transmural disease activity in patients with Crohn's disease: current status and future perspectives.

Therap Adv Gastroenterol 2021 16;14:17562848211006672. Epub 2021 Apr 16.

Department of Gastroenterology, University Teaching Hospital Lueneburg, Bögelstraße 1, Lueneburg 21339, Germany.

Treatment targets of inflammatory bowel diseases (IBD), ulcerative colitis (UC) and Crohn's disease (CD) have evolved over the last decade. Goals of therapy consisting of symptom control and steroid sparing have shifted to control of disease activity with endoscopic remission being an important endpoint. Unfortunately, this requires ileocolonoscopy, an invasive procedure. Read More

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Rediscovering histology: what is new in endoscopy for inflammatory bowel disease?

Therap Adv Gastroenterol 2021 16;14:17562848211005692. Epub 2021 Apr 16.

IBD Center, Humanitas Clinical and Research Center, IRCCS, Via Manzoni 56, Rozzano, Milan, 20089, Italy.

The potential of endoscopic evaluation in the management of inflammatory bowel diseases (IBD) has undoubtedly grown over the last few years. When dealing with IBD patients, histological remission (HR) is now considered a desirable target along with symptomatic and endoscopic remission, due to its association with better long-term outcomes. Consequently, the ability of endoscopic techniques to reflect microscopic findings without having to collect biopsies has become of upmost importance. Read More

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Ocrelizumab-induced inflammatory bowel disease-like illness characterized by esophagitis and colitis.

Ann Gastroenterol 2021 27;34(3):447-448. Epub 2021 Jan 27.

Department of Gastroenterology (Alex Barnes, Dirk Hofmann, Réme Mountifield).

Ocrelizumab is an intravenous anti-CD20 monoclonal antibody, approved for use in primary progressive multiple sclerosis due to its selective depletion of B-lymphocytes. Herein we describe the case of a 56-year-old female who developed odynophagia and bloody diarrhea following treatment with ocrelizumab. This was characterized endoscopically by ulcerations in the esophagus and colon. Read More

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January 2021

Conjugal inflammatory bowel disease: a systematic review and European survey.

Ann Gastroenterol 2021 26;34(3):361-369. Epub 2021 Feb 26.

Division of Gastroenterology, Hospital Beatriz Ângelo, Loures, Portugal (Maria Pia Costa-Santos, Catarina Frias-Gomes, António Oliveira, Joana Torres).

Background: The frequency of inflammatory bowel disease (IBD) is increased after marriage to an individual with the disease. Importantly, the offspring of these couples have a significant risk for developing the disease. Herein, we aimed to better characterize conjugal IBD. Read More

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February 2021

Artificial intelligence and capsule endoscopy: unravelling the future.

Ann Gastroenterol 2021 26;34(3):300-309. Epub 2021 Feb 26.

Gastroenterology Department, Hospital de São João, Porto, Portugal.

The applicability of artificial intelligence (AI) in gastroenterology is a hot topic because of its disruptive nature. Capsule endoscopy plays an important role in several areas of digestive pathology, namely in the investigation of obscure hemorrhagic lesions and the management of inflammatory bowel disease. Therefore, there is growing interest in the use of AI in capsule endoscopy. Read More

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February 2021

Control Crohn Safe with episodic adalimumab monotherapy as first-line treatment study (CoCroS): study protocol for a randomised controlled trial.

BMJ Open 2021 May 4;11(5):e042885. Epub 2021 May 4.

Gastroenterology and Hepatology, Maastricht UMC+, Maastricht, The Netherlands.

Introduction: Crohn's disease (CD) is a chronic inflammatory bowel disease with a heterogeneous clinical presentation, relapse rate and treatment response. At present, no markers are available to adequately predict disease course at diagnosis. To prevent overtreatment of patients with a relative mild disease course, a step-up approach starting with corticosteroids is usually applied. Read More

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Point-of-care faecal calprotectin testing in patients with paediatric inflammatory bowel disease during the COVID-19 pandemic.

BMJ Open Gastroenterol 2021 May;8(1)

Department of Paediatric Gastroenterology, Royal Hospital for Children, Glasgow, UK

Objectives: Following the disruption of normal paediatric inflammatory bowel disease (IBD) services during the peak of the COVID-19 pandemic, we prospectively audited the first-time use of home faecal calprotectin testing. We aimed to provide an alternative to laboratory tests and to assess the value of home testing as part of our regular services going forward.

Methods: Home test kits as well as accompanying user instructions were made available to our patients with paediatric IBD that required faecal calprotectin test between 17 April and 12 August 2020. Read More

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Melatonin-loaded chitosan nanoparticles endows nitric oxide synthase 2 mediated anti-inflammatory activity in inflammatory bowel disease model.

Mater Sci Eng C Mater Biol Appl 2021 May 20;124:112038. Epub 2021 Mar 20.

Chemical Biology Unit, Institute of Nano Science and Technology, Knowledge City, SAS Nagar, Punjab 140306, India. Electronic address:

Inflammatory Bowel Disease (IBD) is a complex inflammatory condition arising due to interactions of environmental and genetic factors that lead to dysregulated immune response and inflammation in intestine. Complementary and alternative medicine approaches have been utilized to treat IBD. However, chronic inflammatory diseases are not medically curable. Read More

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Ecological and network analyses identify four microbial species with potential significance for the diagnosis/treatment of ulcerative colitis (UC).

BMC Microbiol 2021 May 4;21(1):138. Epub 2021 May 4.

Department of Gastroenterology, The First Affiliated Hospital of Kunming Medical University, Yunnan Institute of Digestive Disease, Kunming, Yunnan, China.

Background: Ulcerative colitis (UC) is one of the primary types of inflammatory bowel disease (IBD), the occurrence of which has been increasing worldwide. Although IBD is an intensively studied human microbiome-associated disease, research on Chinese populations remains relatively limited, particularly on the mucosal microbiome. The present study aimed to analyze the changes in the mucosal microbiome associated with UC from the perspectives of medical ecology and complex network analysis. Read More

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ZFP90 drives the initiation of colitis-associated colorectal cancer via a microbiota-dependent strategy.

Gut Microbes 2021 Jan-Dec;13(1):1-20

State Key Laboratory for Oncogenes and Related Genes, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, Division of Gastroenterology and Hepatology, Shanghai Institute of Digestive Disease, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

Chronic inflammation and gut microbiota dysbiosis are risk factors for colorectal cancer. In clinical practice, patients with inflammatory bowel disease (IBD) have a greatly increased risk of developing colitis-associated colorectal cancer (CAC). However, the underlying mechanism of the initiation of CAC remains unknown. Read More

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Oral Administration of Ameliorates the Progression of Osteoarthritis by Inhibiting Joint Pain and Inflammation.

Cells 2021 Apr 29;10(5). Epub 2021 Apr 29.

Rheumatism Research Center, Catholic Research Institute of Medical Science, Catholic University of Korea, Seoul 06591, Korea.

Osteoarthritis (OA) is the most common form of arthritis and age-related degenerative joint disorder, which adversely affects quality of life and causes disability. However, the pathogenesis of OA remains unclear. This study was performed to examine the effects of in OA progression. Read More

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Peritoneal Tuberculosis during Infliximab Treatment in a Patient with Ulcerative Colitis Despite a Negative Quantiferon Test.

Pathogens 2021 Apr 29;10(5). Epub 2021 Apr 29.

IBD Unit, Department of Gastroenterology, Azienda Sanitaria Friuli Occidentale, Pordenone Hospital, 33170 Pordenone, Italy.

Infliximab is an IgG1 antitumor necrosis factor monoclonal antibody that is commonly used to treat inflammatory bowel disease (IBD) and other autoimmune disorders. However, it is known to increase the risk of reactivation of latent tuberculosis (LTBI) due to its capability to disrupt TB granulomas. We describe a case of extrapulmonary TB in a patient with ulcerative colitis who was treated with Infliximab after a negative Quantiferon Test. Read More

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Association of Immune Thrombocytopenia and Inflammatory Bowel Disease in Children.

J Clin Med 2021 Apr 30;10(9). Epub 2021 Apr 30.

UOC Oncoematologia Pediatrica-ARNAS Civico-Di Cristina-Benfratelli, 90127 Palermo, Italy.

Background: The association between inflammatory bowel disease (IBD) and immune thrombocytopenia (ITP) is still uncertain. In this multicenter retrospective study, the coexistence of both diseases was investigated in children diagnosed from 1 January 2000 to 31 December 2019.

Methods: Clinical characteristics of both IBD and ITP, onset of disorders, and patient's response to treatment were collected through a structured form sent to 55 Italian pediatric referring centers for hematological disorders. Read More

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Relationship between Metalloprotease-7 and -14 and Tissue Inhibitor of Metalloprotease 1 Expression by Mucosal Stromal Cells and Colorectal Cancer Development in Inflammatory Bowel Disease.

Biomedicines 2021 Apr 30;9(5). Epub 2021 Apr 30.

Research Unit, Fundación Hospital de Jove, Avda. Eduardo Castro, 161, 33290 Gijón, Spain.

Colorectal carcinoma (CRC) associated with inflammatory bowel disease (IBD) is an example of an inflammation-related cancer. Matrix metalloproteases (MMP) are known to be associated with both processes. The aim of the study was to compare the expression of MMP-7, MMP-14 and tissue inhibitor of metalloproteases-1 (TIMP-1) in sporadic CRC- and IBD-associated CRC, and to compare the expression in inflamed and non-inflamed colonic tissue samples from IBD patients without or with associated CRC. Read More

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Systematic Review: The Gut Microbiome and Its Potential Clinical Application in Inflammatory Bowel Disease.

Microorganisms 2021 Apr 30;9(5). Epub 2021 Apr 30.

Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria Princesa (IIS-IP), Universidad Autónoma de Madrid, 28006 Madrid, Spain.

Inflammatory bowel disease (IBD) is a chronic relapsing-remitting systemic disease of the gastrointestinal tract. It is well established that the gut microbiome has a profound impact on IBD pathogenesis. Our aim was to systematically review the literature on the IBD gut microbiome and its usefulness to provide microbiome-based biomarkers. Read More

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DNA Methylation Change Profiling of Colorectal Disease: Screening towards Clinical Use.

Authors:
Joo Mi Yi

Life (Basel) 2021 Apr 30;11(5). Epub 2021 Apr 30.

Department of Microbiology and Immunology, College of Medicine, Inje University, Busan 47392, Korea.

Colon cancer remains one of the leading causes of cancer-related deaths worldwide. Transformation of colon epithelial cells into invasive adenocarcinomas has been well known to be due to the accumulation of multiple genetic and epigenetic changes. In the past decade, the etiology of inflammatory bowel disease (IBD) which is characterized by chronic inflammation of the intestinal mucosa, was only partially explained by genetic studies providing susceptibility loci, but recently epigenetic studies have provided critical evidences affecting IBD pathogenesis. Read More

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The Relationship between Mucins and Ulcerative Colitis: A Systematic Review.

J Clin Med 2021 Apr 30;10(9). Epub 2021 Apr 30.

Centre for Host-Microbiome Interactions, Faculty of Dentistry, Oral & Craniofacial Science, King's College London, London SE1 9RT, UK.

Mucins are a family of glycosylated proteins which are the primary constituents of mucus and play a dynamic role in the regulation of the protective mucosal barriers throughout the human body. Ulcerative colitis (UC) is an Inflammatory Bowel Disease (IBD) characterised by continuous inflammation of the inner layer of the large intestine, and in this systematic review we analyse currently available data to determine whether alterations exist in mucin activity in the colonic mucosa of UC patients. Database searches were conducted to identify studies published between 1990 and 2020 that assess the role of mucins in cohorts of UC patients, where biopsy specimens were resected for analysis and control groups were included for comparison. Read More

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