1,898 results match your criteria inflammation 301

High-frequency blood flow restricted resistance exercise results in acute and prolonged cellular stress more pronounced in type I than in type II fibers.

J Appl Physiol (1985) 2021 May 6. Epub 2021 May 6.

Center for Health and Performance, Department of Food and Nutrition, and Sport Science, University of Gothenburg, Sweden.

Myocellular stress with high-frequency blood flow restricted resistance exercise (BFRRE) was investigated by measures of heat shock protein (HSP) responses, glycogen content and inflammatory markers. Thirteen participants (24±2 years [mean±SD], 9 males) completed two 5-day-blocks of 7 BFRRE sessions, separated by 10 days. Four sets of unilateral knee extensions to failure at 20% of 1RM were performed. Read More

View Article and Full-Text PDF

Co-Targeting PIM Kinase and PI3K/mTOR in NSCLC.

Cancers (Basel) 2021 Apr 29;13(9). Epub 2021 Apr 29.

Department of Clinical Medicine, Trinity Translational Medicine Institute, St. James's Hospital, Dublin, Ireland.

PIM kinases are constitutively active proto-oncogenic serine/threonine kinases that play a role in cell cycle progression, metabolism, inflammation and drug resistance. PIM kinases interact with and stabilize p53, c-Myc and parallel signaling pathway PI3K/Akt. This study evaluated PIM kinase expression in NSCLC and in response to PI3K/mTOR inhibition. Read More

View Article and Full-Text PDF

Effects of Deoxynivalenol and Mycotoxin Adsorbent Agents on Mitogen-Activated Protein Kinase Signaling Pathways and Inflammation-Associated Gene Expression in Porcine Intestinal Epithelial Cells.

Toxins (Basel) 2021 04 23;13(5). Epub 2021 Apr 23.

Department of Biotechnology and Animal Science, National Ilan University, Yilan 26047, Taiwan.

Deoxynivalenol (DON) is the most prevalent mycotoxin in swine feedstuffs. The intestinal epithelial cells represent the first target for the DON. Here, we studied the effects of DON and mycotoxin adsorbent agents on mitogen-activated protein kinase (MAPK) signaling pathways and inflammation-associated gene expression in porcine intestinal epithelial cells (IPEC-J2). Read More

View Article and Full-Text PDF

Serum Adropin Levels in Patients on Hemodialysis.

Life (Basel) 2021 Apr 11;11(4). Epub 2021 Apr 11.

Department of Pathophysiology, University of Split School of Medicine, 21000 Split, Croatia.

Adropin is a novel pleotropic peptide involved in energy homeostasis, with possible contribution to cardiovascular protection through production of nitric oxide and subsequent blood pressure regulation. Given that patients undergoing hemodialysis (HD) are related with high cardiovascular risk, hyperlipidemia, chronic low-grade inflammation, and malnutrition the aim of our study was to investigate serum adropin levels in HD patients to evaluate possible associations with nutritional status and other relevant clinical and laboratory parameters. The study included 70 patients on HD and 60 healthy controls. Read More

View Article and Full-Text PDF

Chronic Inflammation Impairs Male Fertility-A Case-Control Study in Ulcerative Colitis Patients.

J Clin Med 2021 Apr 2;10(7). Epub 2021 Apr 2.

Department of Gastroenterology with IBD Unit of Clinical Hospital 2 in Rzeszow, 35-301 Rzeszow, Poland.

Recent evidence indicates that a systemic state of inflammation may exert a negative effect on male fertility. The aim of this study is to evaluate sperm quality parameters in male patients with ulcerative colitis (UC). Between December 2019 and December 2020 semen analyses are performed in 50 patients with UC in clinical remission. Read More

View Article and Full-Text PDF

Development of the Cerebrospinal Fluid in Early Stage after Hemorrhage in the Central Nervous System.

Life (Basel) 2021 Apr 1;11(4). Epub 2021 Apr 1.

Department of Neurosurgery, Masaryk Hospital Ústí nad Labem, J. E. Purkinje University, 401 13 Ústí nad Labem, Czech Republic.

Extravasation of blood in the central nervous system (CNS) represents a very strong damaged associated molecular patterns (DAMP) which is followed by rapid inflammation and can participate in worse outcome of patients. We analyzed cerebrospinal fluid (CSF) from 139 patients after the CNS hemorrhage. We compared 109 survivors (Glasgow Outcome Score (GOS) 5-3) and 30 patients with poor outcomes (GOS 2-1). Read More

View Article and Full-Text PDF

Undetected Jawbone Marrow Defects as Inflammatory and Degenerative Signaling Pathways: Chemokine RANTES/CCL5 as a Possible Link Between the Jawbone and Systemic Interactions?

J Inflamm Res 2021 21;14:1603-1612. Epub 2021 Apr 21.

Dental Surgeon, Clinic for Integrative Dentistry, Munich, Germany.

Background: Cytokines, especially chemokines, are of increasing interest in immunology. This study characterizes the little-known phenomenon of "bone marrow defects of the jawbone" (BMDJ) with known overexpression of the chemokine RANTES/CCL5 (R/C).

Purpose: Our investigation clarifies why BMDJ and the intensity of local R/C overexpression are challenging to detect, as examined in patients with seven different systemic immunological diseases. Read More

View Article and Full-Text PDF


Br J Pharmacol 2021 Apr 17. Epub 2021 Apr 17.

Cyclerion Therapeutics Inc., 301 Binney Street, Cambridge, MA, 02142, USA.

Background And Purpose: Reduced nitric oxide (NO) bioavailability, a hallmark of sickle cell disease (SCD), contributes to intravascular inflammation, vasoconstriction, vaso-occlusion, and organ damage observed in SCD patients. Soluble guanylyl cyclase (sGC) catalyzes synthesis of cyclic guanosine monophosphate (cGMP) in response to NO. cGMP amplifying agents, including NO donors and phosphodiesterase 9 inhibitors, alleviate tumor necrosis factor alpha (TNFα)-induced inflammation in wild-type C57BL/6 mice and in "humanized" mouse models of SCD. Read More

View Article and Full-Text PDF

[Correlation of damage-associated molecular pattern molecules with age and body mass index].

Zhonghua Yu Fang Yi Xue Za Zhi 2021 Apr;55(4):492-498

School of Clinical Medicine, Hunan University of Traditional Chinese Medicine, Changsha 410007, China.

To explore the correlation of damage-associated molecular pattern molecules(DAMPs) serum S100, C-reactive protein (CRP), serum amyloid A (SAA) and uric acid (UA) with age and body mass index (BMI) to provide direction for further study of metabolic inflammation and inflammaging. The observational study method was used,and three hundred and sixty-six healthy people (131 males and 235 females) were selected from the physical examination center of the Second People's Hospital of Hunan Province from May to October 2020. They were divided into three age groups according to the age interval of 20 years, including 156 (53 males and 103 females) aged 20-40 years, 110 (36 males and 74 females) aged 41-60 years, and 100 (42 males and 58 females) aged 61-80 years. Read More

View Article and Full-Text PDF

The Association Between Lung Fluorodeoxyglucose Metabolism and Smoking History in 347 Healthy Adults.

J Asthma Allergy 2021 31;14:301-308. Epub 2021 Mar 31.

Department of Nuclear Medicine, Hainan Medicine College Affiliated Hainan Hospital, Haikou, Hainan, 570311, People's Republic of China.

Objective: This study aimed to evaluate the relationship between fluorodeoxyglucose metabolism and smoking history in healthy adults by analyzing lung standardized uptake value (SUV).

Methods: The F-fluorodeoxyglucose positron emission tomography/computed tomography (F-FDG PET/CT) studies of 347 patients who did not show signs of having malignant diseases or lung inflammation were retrospectively evaluated. Four circular regions of interest (ROI) were manually drawn on the upper and lower lung regions. Read More

View Article and Full-Text PDF

The effect of Gestational Diabetes Mellitus on the fetal compartment.

J Reprod Immunol 2021 Mar 24;145:103314. Epub 2021 Mar 24.

Departamento de Obstetrícia, Escola Paulista de Medicina, Universidade Federal de São Paulo (EPM-UNIFESP), Rua Pedro de Toledo 669, 9 andar - 04939032, São Paulo, SP, Brazil. Electronic address:

In indicated preterm births such a Gestational Diabetes Mellitus (GDM), little is known about the role of the amnion membranes. Investigating the role of amnion membrane inflammation in response GDM may suggest novel pathophysiologic mechanisms. We hypothesize that increased GDM inflammatory mediators may weaken the amnion membrane predisposing them to infection. Read More

View Article and Full-Text PDF

Tick-Borne Encephalitis Virus Seropositivity among Tick Infested Individuals in Serbia.

Pathogens 2021 Mar 5;10(3). Epub 2021 Mar 5.

Anses, INRAE, Ecole Nationale Vétérinaire d'Alfort, UMR BIPAR, Laboratoire de Santé Animale, F-94700 Maisons-Alfort, France.

Tick-borne encephalitis (TBE), caused by the TBE virus (TBEV), is a life-threatening disease with clinical symptoms ranging from non-specific to severe inflammation of the central nervous system. Despite TBE is a notifiable disease in Serbia since 2004, there is no active TBE surveillance program for the serologic or molecular screening of TBEV infection in humans in the country. This prospective cohort study aimed to assess the TBEV exposure among tick-infested individuals in Serbia during the year 2020. Read More

View Article and Full-Text PDF

Chromogranin A regulates gut permeability via the antagonistic actions of its proteolytic peptides.

Acta Physiol (Oxf) 2021 Mar 30:e13655. Epub 2021 Mar 30.

VA San Diego Healthcare System, San Diego, CA, USA.

Aim: A "leaky" gut barrier has been implicated in the initiation and progression of a multitude of diseases, for example, inflammatory bowel disease (IBD), irritable bowel syndrome and celiac disease. Here we show how pro-hormone Chromogranin A (CgA), produced by the enteroendocrine cells, and Catestatin (CST: hCgA ), the most abundant CgA-derived proteolytic peptide, affect the gut barrier.

Methods: Colon tissues from region-specific CST-knockout (CST-KO) mice, CgA-knockout (CgA-KO) and WT mice were analysed by immunohistochemistry, western blot, ultrastructural and flowcytometry studies. Read More

View Article and Full-Text PDF

The Genetic and Epigenetic Mechanisms Involved in Irreversible Pulp Neural Inflammation.

Dis Markers 2021 8;2021:8831948. Epub 2021 Mar 8.

Laboratory of Molecular Cell Biology, Beijing Tibetan Hospital, China Tibetology Research Center, 218 Anwaixiaoguanbeili Street, Chaoyang, Beijing 100029, China.

Aim: To identify the critical genetic and epigenetic biomarkers by constructing the long noncoding RNA- (lncRNA-) related competing endogenous RNA (ceRNA) network involved in irreversible pulp neural inflammation (pulpitis).

Materials And Methods: The public datasets regarding irreversible pulpitis were downloaded from the gene expression omnibus (GEO) database. The differential expression analysis was performed to identify the differentially expressed genes (DEGs) and DElncRNAs. Read More

View Article and Full-Text PDF

Short-term outcomes of intravitreal brolucizumab for treatment-naïve neovascular age-related macular degeneration with type 1 choroidal neovascularization including polypoidal choroidal vasculopathy.

Sci Rep 2021 Mar 24;11(1):6759. Epub 2021 Mar 24.

Department of Ophthalmology, Gunma University Graduate School of Medicine, 3-39-15 Showa-machi, Maebashi, Gunma, 371-8511, Japan.

We evaluated the efficacy and safety of loading phase treatment with intravitreal brolucizumab for neovascular age-related macular degeneration (nAMD) with type 1 choroidal neovascularization (CNV). We analyzed consecutive 42 eyes of 40 patients with treatment-naïve nAMD associated with type 1 CNV. Three monthly injections of brolucizumab were completed in 36 eyes (85. Read More

View Article and Full-Text PDF

Early alterations of neurovascular unit in the retina in mouse models of tauopathy.

Acta Neuropathol Commun 2021 03 24;9(1):51. Epub 2021 Mar 24.

Department of Ophthalmology and Visual Sciences, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX, 77555-0144, USA.

The retina, as the only visually accessible tissue in the central nervous system, has attracted significant attention for evaluating it as a biomarker for neurodegenerative diseases. Yet, most of studies focus on characterizing the loss of retinal ganglion cells (RGCs) and degeneration of their axons. There is no integrated analysis addressing temporal alterations of different retinal cells in the neurovascular unit (NVU) in particular retinal vessels. Read More

View Article and Full-Text PDF

Clonal architecture in mesothelioma is prognostic and shapes the tumour microenvironment.

Nat Commun 2021 03 19;12(1):1751. Epub 2021 Mar 19.

The Francis Crick Institute, London, UK.

Malignant Pleural Mesothelioma (MPM) is typically diagnosed 20-50 years after exposure to asbestos and evolves along an unknown evolutionary trajectory. To elucidate this path, we conducted multi-regional exome sequencing of 90 tumour samples from 22 MPMs acquired at surgery. Here we show that exomic intratumour heterogeneity varies widely across the cohort. Read More

View Article and Full-Text PDF

[Protective effects of cordycepin on renal proximal tubular cells injury induced by lipopolysaccharide].

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2021 Feb;33(2):203-206

Department of Critical Care Medicine, Hubei NO.3 People's Hospital of Jianghan University, Wuhan 430033, Hubei, China.

Objective: To investigate the protective effect and potential mechanism of cordycepin on renal proximal tubular cells injury induced by lipopolysaccharide (LPS).

Methods: Renal proximal tubular cells NRK-52E were incubated on a cell culture plated at a density of 1×10/mL for experiment, then divided into control group (Ctrl group), LPS group (cells were stimulated with 1 mg/L LPS), 10 μmol/L or 20 μmol/L cordycep in intervention groups (LPS+C 10 group and LPS+C 20 group). Cell viability was measured using cell counting kit-8 (CCK-8) reagent. Read More

View Article and Full-Text PDF
February 2021

Tannic acid/Sr-coated silk/graphene oxide-based meniscus scaffold with anti-inflammatory and anti-ROS functions for cartilage protection and delaying osteoarthritis.

Acta Biomater 2021 May 5;126:119-131. Epub 2021 Mar 5.

Institute of Orthopedics, Beijing Key Lab of Regenerative Medicine in Orthopedics, Key Lab of Musculoskeletal Trauma & War Injuries in PLA, Chinese PLA General Hospital, Beijing 100853, China. Electronic address:

Tissue engineering method provides a promising solution for meniscus repair and regeneration. However, the inflammatory environment that persists after meniscus injury in the knee joint impedes meniscus tissue regeneration. The purpose of this study was to investigate the applicability of silk/graphene oxide (GO)-based meniscus scaffold modified with tannic acid (TA)/Sr coating for the elimination of inflammatory cytokines and reactive oxygen species (ROS) under osteoarthritis (OA) environment along with cartilage protection by using a rat model. Read More

View Article and Full-Text PDF

Development of a dual delivery of levofloxacin and prednisolone acetate via PLGA nanoparticles/ thermosensitive chitosan-based hydrogel for postoperative management: An in-vitro and ex-vivo study.

Int J Biol Macromol 2021 Mar 4;180:365-374. Epub 2021 Mar 4.

Department of Ophthalmology, Taipei Veterans General Hospital, Taipei, Taiwan; National Yang-Ming University School of Medicine, Faculty of Medicine, Taipei, Taiwan. Electronic address:

Post-operative endophthalmitis (POE) is one of the most dreadful complications after intraocular surgery. For cataract surgery patients, both commercially available topical 0.5% levofloxacin and 1% prednisolone acetate (PA) ophthalmic solution require at least 3 to 4 times application daily. Read More

View Article and Full-Text PDF

Axl is related to inflammation in hemodialysis patients.

Mol Immunol 2021 May 2;133:146-153. Epub 2021 Mar 2.

Department of Nephrology & Rheumatology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, 301, Middle Yanchang Road, Shanghai, 200072, China. Electronic address:

Background: Hemodialysis (HD) patients often develop chronic inflammation, which is associated with an increased risk of cardiovascular complications and mortality. Axl and its ligand, growth arrest 6 (Gas6), have been reported to play key roles in regulating the immune response. However, the function of Axl in HD patients has not been clarified. Read More

View Article and Full-Text PDF

Pancreatic pseudocyst extending into psoas muscle mimicking acute complicated diverticulitis: A case report.

Int J Surg Case Rep 2021 Mar 9;80:105635. Epub 2021 Feb 9.

Department of Trauma & Acute Care Surgery, University of Texas Medical Branch Hospital, 301 University Blvd, Galveston, TX, 77555, United States.

Introduction And Importance: Pancreatic pseudocysts (PP) are known sequelae of pancreatitis. In this case, we present a patient with a pancreatic pseudocyst extending to the left psoas muscle, initially masquerading as acute complicated diverticulitis.

Case Presentation: A 43-year-old male with previous episode of pancreatitis presented with a one-week history of abdominal pain. Read More

View Article and Full-Text PDF

Associations of physical activity, sedentary time, and diet quality with biomarkers of inflammation in children.

Eur J Sport Sci 2021 Mar 14:1-10. Epub 2021 Mar 14.

Institute of Biomedicine, School of Medicine, University of Eastern Finland, Kuopio, Finland.

We investigated the associations of physical activity (PA), sedentary time (ST), and diet quality with biomarkers of inflammation in 390 children (192 girls, 198 boys) aged 6-8 years. PA energy expenditure (PAEE), light PA, moderate PA (MPA), vigorous PA (VPA), moderate-to-vigorous PA (MVPA), and ST were assessed by combined movement and heart rate sensor. Finnish Children Healthy Eating Index was calculated using data from 4 d food records. Read More

View Article and Full-Text PDF

Periodontitis and the outcome of atrial fibrillation ablation: Porphyromonas gingivalis is related to atrial fibrillation recurrence.

J Cardiovasc Electrophysiol 2021 Feb 15. Epub 2021 Feb 15.

Department of Cardiovascular Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.

Introduction: Inflammation is one of the main causes of atrial fibrillation (AF) recurrence after ablation. Porphyromonas gingivalis is a key periodontal pathogen in the oral-systemic disease connection and serum immunoglobulin G (IgG) antibody titers against P. gingivalis reflect the clinical status of periodontitis. Read More

View Article and Full-Text PDF
February 2021

Unraveling the molecular mechanisms between inflammation and tumor angiogenesis.

Am J Cancer Res 2021 1;11(2):301-317. Epub 2021 Feb 1.

Department of Pathophysiology, School of Basic Medical Sciences, Nanchang University Nanchang 330006, Jiangxi Province, China.

Inflammatory mediators in tumor microenvironment influence cancer occurrence, growth and metastasis through complex signaling networks. Excessive inflammation is closely associated with elevated cancer risk and mortality, in part through inflammation-induced angiogenesis. Mechanistically, multiple tumor-associated inflammatory cells increase the release and accumulation of various inflammatory products in cancerous sites. Read More

View Article and Full-Text PDF
February 2021

Leukocyte Immunoglobulin-Like Receptor A3 (LILRA3): A Novel Marker for Lymphoma Development among Patients with Young Onset Sjogren's Syndrome.

J Clin Med 2021 Feb 8;10(4). Epub 2021 Feb 8.

Department of Physiology, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.

Background: Primary Sjogren's syndrome (SS) is an autoimmune disease with a strong predilection for lymphoma development, with earlier disease onset being postulated as an independent risk factor for this complication. Variations of the gene have been previously shown to increase susceptibility for both SS and non-Hodgkin B-cell lymphoma (B-NHL) in the general population. We aimed to investigate whether variations of the gene could predispose for lymphoma development in the context of SS. Read More

View Article and Full-Text PDF
February 2021

Administration of extracellular vesicles derived from human amniotic fluid stem cells: a new treatment for necrotizing enterocolitis.

Pediatr Surg Int 2021 Mar 10;37(3):301-309. Epub 2021 Feb 10.

Division of General and Thoracic Surgery, The Hospital for Sick Children, Toronto, ON, Canada.

Purpose: Necrotizing enterocolitis (NEC) is a devastating gastrointestinal disease. Amniotic fluid stem cells (AFSC) improve NEC injury but human translation remains difficult. We aimed to evaluate the use of extracellular vesicles (EV) derived from human AFSC. Read More

View Article and Full-Text PDF

Urinary fetuin-A peptides as a new marker for impaired kidney function in patients with type 2 diabetes.

Clin Kidney J 2021 Jan 23;14(1):269-276. Epub 2020 Oct 23.

Institute for Clinical Chemistry and Pathobiochemistry/Central Laboratory, University of Tübingen, Tübingen, Germany.

Background: The hepatokine fetuin-A, released by the human liver, promotes pro-inflammatory effects of perivascular fat. The involvement of inflammation in type 2 diabetes mellitus (T2DM) can affect the kidney and contribute to the development of diabetic kidney disease. Therefore we examined the association of urinary fetuin-A protein fragments with renal damage in T2DM patients. Read More

View Article and Full-Text PDF
January 2021

Identification of Three Significant Genes Associated with Immune Cells Infiltration in Dysfunctional Adipose Tissue-Induced Insulin-Resistance of Obese Patients via Comprehensive Bioinformatics Analysis.

Int J Endocrinol 2021 22;2021:8820089. Epub 2021 Jan 22.

Department of Cardiology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, 301 Middle Yanchang Road, Shanghai 200072, China.

Background: Low-grade chronic inflammation in dysfunctional adipose tissue links obesity with insulin resistance through the activation of tissue-infiltrating immune cells. Numerous studies have reported on the pathogenesis of insulin-resistance. However, few studies focused on genes from genomic database. Read More

View Article and Full-Text PDF
January 2021

Exosomes with high level of miR-181c from bone marrow-derived mesenchymal stem cells inhibit inflammation and apoptosis to alleviate spinal cord injury.

J Mol Histol 2021 Apr 6;52(2):301-311. Epub 2021 Feb 6.

Department of Orthopaedics, Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710004, Shaanxi Province, China.

Stem cell transplantation is a promising method in the treatment of spinal cord injury (SCI). Researches have shown that stem cell-derived exosomes as well as its contents such as microRNAs contribute to the protective effects of stem cell against SCI. However, the effects of exosomes derived from bone marrow stem cells on SCI and the underlying mechanisms remain unknown. Read More

View Article and Full-Text PDF