Acta Physiol (Oxf) 2021 Mar 30:e13655. Epub 2021 Mar 30.
VA San Diego Healthcare System, San Diego, CA, USA.
Aim: A "leaky" gut barrier has been implicated in the initiation and progression of a multitude of diseases, for example, inflammatory bowel disease (IBD), irritable bowel syndrome and celiac disease. Here we show how pro-hormone Chromogranin A (CgA), produced by the enteroendocrine cells, and Catestatin (CST: hCgA ), the most abundant CgA-derived proteolytic peptide, affect the gut barrier.
Methods: Colon tissues from region-specific CST-knockout (CST-KO) mice, CgA-knockout (CgA-KO) and WT mice were analysed by immunohistochemistry, western blot, ultrastructural and flowcytometry studies. Read More